Page last updated: 2024-08-18

4-butyrolactone and 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid

4-butyrolactone has been researched along with 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid in 100 studies

Research

Studies (100)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	62 (62.00)	29.6817
2010's	32 (32.00)	24.3611
2020's	6 (6.00)	2.80

Authors

Authors	Studies
Frehywot, GL; Kuhajda, FP; Li, JN; Mani, NS; Pizer, ES; Townsend, CA	1
Bouchard, C	1
Gabrielson, EW; Kuhajda, FP; Pinn, ML; Testa, JR	1
Bova, GS; Han, WF; Nelson, JB; Pflug, BR; Pizer, ES; Udan, MS	1
Tian, W; Wang, X	1
Kumar, MV; Lane, MD; Shimokawa, T	1
Kumar, MV; Lane, MD; Nagy, TR; Shimokawa, T	1
Senior, K	1
Makimura, H; Mobbs, CV	1
Kuhajda, FP; Landree, LE; Ronnett, GV; Thupari, JN	1
Hirsch, J	1
Borisy-Rudin, FF; Brown, P; Kim, EK; Kuhajda, FP; Landree, LE; Miller, I; Moran, TH; Ronnett, GV; Tihan, T; Townsend, CA; Witters, LA	1
Benoit, SC; Clegg, DJ; McOsker, CC; Seeley, RJ; Wortman, MD	1
Gao, S; Lane, MD	1
Clegg, DJ; D'Alessio, D; Seeley, RJ; Woods, SC; Wortman, MD	1
Cone, RD; Liu, H; Smart, JL; Takahashi, KA	1
Cha, SH; Chohnan, S; Hu, Z; Lane, MD	2
Kuhajda, FP; McFadden, JM; Medghalchi, SM; Pinn, ML; Ronnett, GV; Simpson, PJ; Townsend, CA; Vadlamudi, A; Zhou, W	1
Connolly, EC; Hanlon, AL; Huganir, RL; Kuhajda, FP; Landree, LE; Miller, IM; Richardson, C; Ronnett, GV; Rumbaugh, G; Strong, DW; Thupari, JN; Witters, LA	1
Kim, EK; Kuhajda, FP; Moran, TH; Ronnett, GV; Thupari, JN	1
Aja, S; Kim, EK; Kuhajda, FP; Landree, LE; McFadden, J; Miller, I; Moran, TH; Pinn, M; Ronnett, GV	1
Cha, SH; Hu, Z; Lane, MD	1
Aja, S; Miller, I; Moran, TH; Ronnett, GV	1
Colomer, R; Lupu, R; Mehmi, I; Menendez, JA; Oza, BP; Ropero, S; Vellon, L	1
Hu, YD; Kang, JL; Li, S; Liu, LH; Wang, LL; Wang, XK	1
Burris, L; Hammond, C; Kays, JS; Seng, TW; Skillman, TR; Yang, N	1
Alli, PM; Jaffee, EM; Kuhajda, FP; McFadden, JM; Pinn, ML	1
Kim, EK; Kuhajda, FP; Moran, TH; Pinn, ML; Ronnett, GV; Thupari, JN; Tu, Y	1
González, S; Haro, D; Llebaria, A; Marrero, PF; Napal, L; Nicot, C; Relat, J; Woldegiorgis, G	1
Hamilton, BS; Rippmann, JF; Schmid, B; Tadayyon, M	1
Cheng, D; Rendina, AR	1
Cha, SH; Hu, Z; Lane, MD; van Haasteren, G; Wang, J	1
Landree, LE; Li, H; McCullough, LD; McFadden, J; Ronnett, GV; Zeng, Z	1
Cheng, D; Chi, CL; Gan, J; Han, S; Largent, BL; O'Tanyi, EJ; Rohrbach, KW; Taub, R; Zhang, H	1
Altomare, DA; Di Cristofano, A; Kuhajda, FP; Poulikakos, PI; Skele, KL; Testa, JR; Wang, HQ	1
Kim, EK; Landree, LE; Ronnett, GV; Tu, Y	1
Kuhajda, FP; Landree, LE; Ronnett, GV	1
Aja, S; Bi, S; Knipp, SB; Kuhajda, FP; McFadden, JM; Moran, TH; Ronnett, GV	1
Asins, G; Bentebibel, A; Gómez-Puertas, P; Hegardt, FG; Herrero, L; López-Viñas, E; Sebastián, D; Serra, D	1
Chen, Y; Ding, J; Gao, Y; Hou, YT; Lin, LP; Zhu, CH	1
Gores, GJ; Malhi, H	1
Kim, EK; Kleman, AM; Landree, LE; Ronnett, GV; Tu, Y	1
Cha, SH; Chohnan, S; Lane, MD; Puigserver, P; Rodgers, JT	1
Cavener, DR; Guo, F	1
Alvey, S; Gabrielson, E; Gabrielson, K; Hagemann, RL; Kuhajda, FP; Lee, JS; Orita, H; Pomper, MG	1
Henke, A; Jarasch, N; Lottspeich, F; Munder, T; Rassmann, A; Saluz, HP	1
Brunet, J; Colomer, R; Menendez, JA; Vazquez-Martin, A	1
Brunet, J; Casals, G; Colomer, R; Haro, D; Marrero, PF; Menéndez, JA; Pétriz, J; Porta, R; Puig, T; Relat, J; Vázquez-Martín, A	1
Chi-Ming Chiu, L; Eng-Choon Ooi, V; Ho, TS; Ho, YP; Wong, WY; Wong, YS	1
Aja, S; Kleman, AM; Landree, LE; Ronnett, GV; Yuan, JY	1
Aja, S; Aplasca, A; Daniels, K; Hyun, J; Kemm, M; Kleman, AM; Kuhajda, FP; Landree, LE; McFadden, JM; Medghalchi, SM; Moran, TH; Plummer, E; Ronnett, GV; Thupari, JN; Townsend, CA; Vadlamudi, A	1
Accioly, MT; Bozza, PT; Carrossini, N; Kaufmann, C; Maya-Monteiro, CM; Morgado-Diaz, JA; Oliveira, SS; Pacheco, P; Robbs, BK; Viola, JP	1
Lewis, JS; Vāvere, AL	1
Colomer, R; Lupu, R; Menéndez, JA	1
Aja, S; Arnold, M; Geary, N; Kuhajda, FP; Langhans, W; Leonhardt, M; Mansouri, A; Moran, TH; Ronnett, G	1
Ahmed, M; Al-Dayel, F; Al-Kuraya, KS; Al-Nuaim, A; Al-Rasheed, M; Al-Sobhi, S; Bavi, P; Bu, R; Hussain, AR; Myers, JN; Siraj, AK; Uddin, S	1
Chen, Q; Li, LF; Liu, JY; Lu, YY; Xiong, W	1
Graham, A; Rae, C	1
Ariza, X; Asins, G; Bentebibel, A; Cordente, AG; García, J; Gómez-Puertas, P; Gurunathan, C; Hegardt, FG; Herrero, L; López-Viñas, E; Mera, P; Sebastián, D; Serra, D; Vázquez, I	1
Downs, SM; Klinger, J; Mosey, JL	1
Berger, W; Grunt, TW; Grusch, M; Lupu, R; Marian, B; Singer, CF; Wagner, R; Zielinski, CC	1
Ahmed, M; Ahmed, SO; Ajarim, D; Al-Dayel, F; Al-Kuraya, KS; Bavi, P; Bu, R; Hussain, AR; Uddin, S	1
Baek, JM; Boulbes, D; Esteva, FJ; Gomez-Cabello, D; Hawke, DH; Hortobagyi, GN; Hung, MC; Jin, Q; Lee, MH; Wang, YN; Yeung, SC; Yuan, LX	1
Amano, Y; Fukuhara, H; Ishihara, S; Ishimura, N; Kinoshita, Y; Mishima, Y; Sanchez-Siles, AA; Takahashi, Y; Tamagawa, Y; Uno, G; Yuki, T	1
Ahmed, M; Al-Dayel, F; Al-Kuraya, KS; Alyan, A; Bavi, P; Hussain, A; Jehan, Z; Uddin, S	1
Grunt, TW; Karlic, H; Singer, CF; Tomek, K; Varga, F; Wagner, R	1
Gu, F; Poh, MK; Shi, PY; Shui, G; Wenk, MR; Xie, X	1
Pellinen, J; Szentirmai, É	1
Bhatt, AP; Damania, B; Dittmer, DP; Freemerman, AJ; Jacobs, SR; Makowski, L; Rathmell, JC	1
Carvalho Navegantes, LC; Cassolla, P; Coimbra, CC; de Almeida Brito, N; do Carmo Kettelhut, I; Guimarães, JB; Kagohara Elias, LL; Mansur Machado, FS; Rissato Garófalo, MA; Uchoa, ET	1
Carballeira, NM; Cátala-Valentin, A; Chorna, NE; Chornyy, AP; de la Nuez, J; De Ortiz, SP; Morales, JL; Santos-Soto, IJ; Vázquez-Montes, A	1
Aziz, M; Kameoka, S; Matsuo, S; Wang, P; Yang, WL	1
Cao, K; Chen, C; Feng, Z; Han, X; Li, Y; Liu, J; Long, J; Xu, J; Yang, L; Zou, X	1
Dünisch, P; Ewald, C; Freitag, D; Grube, S; Kalff, R; Klausnitzer, M; Sakr, Y; Walter, J	1
Birnbaum, MJ; Buck, MD; Chang, CH; Curtis, JD; DiPlato, LM; Hsu, FF; Huang, SC; Lam, WY; O'Sullivan, D; Pearce, EJ; Pearce, EL; Qiu, J; Smith, AM; van der Windt, GJ	1
Gunter, JH; Lubik, AA; Nelson, CC; Pouwer, RH; Quinn, RJ; Sadowski, MC	1
Aja, S; Bandaru, VV; Haughey, NJ; Kim, EK; Kuhajda, FP; Li, Q; McFadden, JW; Ronnett, GV	1
Desmarchais, A; Dupont, J; Elis, S; Maillard, V; Monget, P; Uzbekova, S	1
Haile, AB; Li, J; Loor, JJ; Luo, J; Shi, HB; Sun, YT; Wu, M; Yu, K; Zhu, JJ	1
Aoki, T; Chang, SH; Chang, YH; Chen, YM; Hsieh, YC; Khoo, KH; Li, CY; Liang, SY; Lin, CY; Lin, SY; Wang, HC; Wang, YJ	1
Colbert, MC; Dasgupta, B; Johansson, G; Patel, AV; Ratner, N	1
Coppa, GF; Corbo, L; Idrovo, JP; Jacob, A; Nicastro, J; Wang, P; Yang, WL	1
Coppa, GF; Giangola, M; Jacob, A; Khader, A; Kuncewitch, M; Nicastro, J; Wang, P; Yang, WL	1
Babich, JW; Haberkorn, U; Mairs, RJ; Rae, C	1
Albanell, J; Arenas, EJ; Beltran, A; García-Rocha, M; Gomis, RR; Guinovart, JJ; Guiu, M; Lluch, A; Planet, E; Rojo, F; Rovira, A; Salvatella, X; Samino, S; Slebe, F; Testoni, G; Vinaixa, M; Yanes, O	1
Hanif, K; Jagavelu, K; Kaur, G; Manhas, A; Singh, N	1
Goswami, S; Sharma-Walia, N	1
Buxó, M; Corominas-Faja, B; Cuyàs, E; García, J; Lupu, R; Martin-Castillo, B; Menendez, JA; Serra, D; Vellon, L	1
Flaherty, S; Reynolds, JM; Sharma-Walia, N; Woodman, KM; Young, KE	1
Li, J; Li, Y; Li, Z; Liu, X; Sun, Y; Yue, Q	1
Banerjee, S; Bose, D; Chatterjee, N; Das, S; Saha, KD; Saha, M	1
Corsico, B; Garcia, KA; Rodriguez Sawicki, L; Scaglia, N	1
Hanif, K; Jagavelu, K; Shafiq, M; Singh, N	1
Cavalluzzi, MM; Denora, N; Gnocchi, D; Kapoor, S; Lentini, G; Mazzocca, A; Nitti, P; Sabbà, C	1
Chen, WY; Cuyàs, E; Lupu, R; Menendez, JA; Papadimitropoulou, A; Peirce, SK; Steen, TV; Vellon, L; Verdura, S	1
Baloch, AS; Chen, H; Cheng, Y; Go, YY; Liang, XD; Liu, CC; Liu, YY; Zhang, J; Zhou, B	1
Chen, J; Chen, S; Hou, C; Lin, S; Niu, Y; Sun, X; Xiao, T; Xie, L; Zhao, Y; Zong, Y	1
Gao, S; Li, D; Liu, Y; Lu, Y; Zhang, L	1
Sun, KY; Xiong, W; Zhang, X; Zhou, YH; Zhu, Y; Zou, X	1

Reviews

3 review(s) available for 4-butyrolactone and 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid

Article	Year
Inhibition of food intake by inhibitors of fatty acid synthase. The New England journal of medicine, 2000, Dec-21, Volume: 343, Issue:25 Topics: 4-Butyrolactone; Acetyl-CoA Carboxylase; Animals; Eating; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Mice; Neuropeptide Y; Obesity; Triglycerides; Weight Loss	2000
Fatty acid metabolism as a target for obesity treatment. Physiology & behavior, 2005, May-19, Volume: 85, Issue:1 Topics: 4-Butyrolactone; Animals; Body Weight; Carnitine O-Palmitoyltransferase; Cerulenin; Eating; Energy Metabolism; Fatty Acid Synthases; Fatty Acids; Gene Expression; Humans; Models, Biological; Obesity	2005
Fatty acid metabolism, the central nervous system, and feeding. Obesity (Silver Spring, Md.), 2006, Volume: 14 Suppl 5 Topics: 4-Butyrolactone; Central Nervous System; Eating; Energy Intake; Energy Metabolism; Fatty Acid Synthases; Fatty Acids; Gene Expression; Humans; Obesity; Oxidation-Reduction; Weight Loss	2006

Other Studies

97 other study(ies) available for 4-butyrolactone and 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid

Article	Year
Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-28, Volume: 97, Issue:7 Topics: 4-Butyrolactone; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Protein Binding; Tumor Cells, Cultured	2000
Increased fatty acid synthase is a therapeutic target in mesothelioma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:1 Topics: 4-Butyrolactone; Animals; Antifungal Agents; Antineoplastic Agents; Cerulenin; Disease Models, Animal; Fatty Acid Synthases; Humans; Immunoenzyme Techniques; Mesothelioma; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Mesothelial; Paraffin Embedding; Prognosis; Tumor Cells, Cultured	2001
Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression. The Prostate, 2001, May-01, Volume: 47, Issue:2 Topics: 4-Butyrolactone; Androgens; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Blotting, Western; Chromatography, Thin Layer; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Immunohistochemistry; Lipids; Male; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Random Allocation; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2001
Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. Biochemical and biophysical research communications, 2001, Nov-16, Volume: 288, Issue:5 Topics: 4-Butyrolactone; Acyltransferases; Animals; Binding, Competitive; Catechin; Chickens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acid Synthase, Type I; Kinetics; Multienzyme Complexes; NADP; Tea	2001
Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proceedings of the National Academy of Sciences of the United States of America, 2002, Jan-08, Volume: 99, Issue:1 Topics: 4-Butyrolactone; Animals; Blood Glucose; Body Weight; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Fatty Acid Synthases; Food Deprivation; Hypothalamic Hormones; Hypothalamus; Insulin; Melanins; Mice; Mice, Inbred BALB C; Mice, Obese; Models, Biological; Nerve Tissue Proteins; Neuropeptides; Pituitary Hormones; Pro-Opiomelanocortin; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA, Messenger; Time Factors; Up-Regulation	2002
Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proceedings of the National Academy of Sciences of the United States of America, 2002, Feb-19, Volume: 99, Issue:4 Topics: 4-Butyrolactone; Animals; Body Weight; Down-Regulation; Enzyme Inhibitors; Fatty Acid Synthases; Hypothalamus; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Ribonucleases; RNA, Messenger; Time Factors; Up-Regulation	2002
Thin mice and fat mice respond differently to appetite suppressant. Lancet (London, England), 2002, Feb-23, Volume: 359, Issue:9307 Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Fatty Acid Synthases; Mice; Obesity	2002
Block the FAS, lose the fat. Nature medicine, 2002, Volume: 8, Issue:4 Topics: 4-Butyrolactone; Animals; Anti-Obesity Agents; Cerulenin; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Hypothalamus; Mice; Mice, Obese; Models, Biological; Obesity	2002
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America, 2002, Jul-09, Volume: 99, Issue:14 Topics: 3T3 Cells; 4-Butyrolactone; Adenosine Triphosphate; Adipocytes; Animals; Carnitine O-Palmitoyltransferase; Diet; Energy Metabolism; Enzyme Inhibitors; Epoxy Compounds; Fatty Acid Synthases; Fatty Acids; Humans; Male; Malonyl Coenzyme A; Mice; Mice, Inbred C57BL; Obesity; Oxidation-Reduction; Tumor Cells, Cultured; Weight Loss	2002
The search for new ways to treat obesity. Proceedings of the National Academy of Sciences of the United States of America, 2002, Jul-09, Volume: 99, Issue:14 Topics: 4-Butyrolactone; Adipose Tissue; Animals; Carnitine O-Palmitoyltransferase; Cell Size; Cerulenin; Energy Intake; Fatty Acids; Ghrelin; Humans; Malonyl Coenzyme A; Obesity; Peptide Hormones; Peptides	2002
Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:5 Topics: 4-Butyrolactone; Acetyl-CoA Carboxylase; Adult; Aged; Amino Acid Sequence; Animals; Appetite; Arcuate Nucleus of Hypothalamus; Carboxy-Lyases; Conditioning, Psychological; Eating; Enzyme Inhibitors; Fasting; Fatty Acid Synthases; Female; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred BALB C; Middle Aged; Molecular Sequence Data; Neurons; Neuropeptide Y; Obesity; Paraventricular Hypothalamic Nucleus; RNA, Messenger; Taste	2002
Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion. Diabetes, 2002, Volume: 51, Issue:11 Topics: 4-Butyrolactone; Animals; Anorexia; Avoidance Learning; Body Weight; Cerebral Ventricles; Diet; Dose-Response Relationship, Drug; Energy Intake; Enzyme Inhibitors; Fatty Acid Synthases; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Rats; Rats, Long-Evans; Taste	2002
Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proceedings of the National Academy of Sciences of the United States of America, 2003, May-13, Volume: 100, Issue:10 Topics: 4-Butyrolactone; Animals; Brain Stem; Cells, Cultured; Enzyme Inhibitors; Fatty Acid Synthases; Hypothalamus; Injections, Intraperitoneal; Kinetics; Male; Mice; Mice, Inbred BALB C; Neurons; Proto-Oncogene Proteins c-fos; Reference Values	2003
C75 inhibits food intake by increasing CNS glucose metabolism. Nature medicine, 2003, Volume: 9, Issue:5 Topics: 4-Butyrolactone; Animals; Appetite Depressants; Brain; Eating; Fatty Acid Synthases; Glucose; Humans; Malonyl Coenzyme A	2003
The anorexigenic fatty acid synthase inhibitor, C75, is a nonspecific neuronal activator. Endocrinology, 2004, Volume: 145, Issue:1 Topics: 4-Butyrolactone; Action Potentials; Animals; Arcuate Nucleus of Hypothalamus; Eating; Fatty Acid Synthases; Feces; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neuropeptide Y; Patch-Clamp Techniques; Pro-Opiomelanocortin; Purkinje Cells; Weight Loss	2004
Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proceedings of the National Academy of Sciences of the United States of America, 2003, Oct-28, Volume: 100, Issue:22 Topics: 4-Butyrolactone; Animals; Fasting; Fatty Acid Synthases; Feeding Behavior; Hypothalamus; Injections, Intraventricular; Male; Malonyl Coenzyme A; Mice; Mice, Inbred BALB C	2003
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer research, 2003, Nov-01, Volume: 63, Issue:21 Topics: 4-Butyrolactone; Apoptosis; Breast Neoplasms; Carnitine O-Palmitoyltransferase; Cell Division; Cell Line, Tumor; Drug Interactions; Epoxy Compounds; Fatty Acid Synthases; Furans; Humans; Membrane Lipids; Phospholipids; S Phase	2003
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. The Journal of biological chemistry, 2004, Jan-30, Volume: 279, Issue:5 Topics: 4-Butyrolactone; Acetyl-CoA Carboxylase; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Blotting, Western; Carnitine O-Palmitoyltransferase; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Electrophysiology; Fatty Acid Synthases; Fatty Acids; Glucose; Hypothalamus; Immunohistochemistry; Models, Biological; Multienzyme Complexes; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Time Factors	2004
Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. American journal of physiology. Endocrinology and metabolism, 2004, Volume: 287, Issue:1 Topics: 4-Butyrolactone; Adipose Tissue; Animals; Body Weight; Carnitine O-Palmitoyltransferase; Chronic Disease; Diet; Eating; Fatty Acid Synthases; Fatty Acids; Fatty Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Oxidation-Reduction; Treatment Outcome	2004
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. The Journal of biological chemistry, 2004, May-07, Volume: 279, Issue:19 Topics: 4-Butyrolactone; Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anorexia; Arcuate Nucleus of Hypothalamus; Blotting, Northern; Blotting, Western; Eating; Fatty Acid Synthases; Feeding Behavior; Hypothalamus; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred BALB C; Models, Biological; Multienzyme Complexes; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleotides; RNA; Time Factors	2004
Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3. Biochemical and biophysical research communications, 2004, Apr-30, Volume: 317, Issue:2 Topics: 4-Butyrolactone; Adaptation, Physiological; Animals; Blood Glucose; Body Weight; Carrier Proteins; Dose-Response Relationship, Drug; Drinking; Drug Tolerance; Eating; Fatty Acid Synthases; Homeostasis; Hypothalamus; Ion Channels; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Muscle, Skeletal; Neuropeptides; Obesity; Reference Values; Treatment Outcome; Uncoupling Protein 3	2004
Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei. Neuroreport, 2004, Apr-09, Volume: 15, Issue:5 Topics: 4-Butyrolactone; Animals; Body Weight; Cell Count; Eating; Enzyme Inhibitors; Fasting; Hypothalamus; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-fos; Rhombencephalon; Time Factors	2004
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 2004, Jul-20, Volume: 101, Issue:29 Topics: 4-Butyrolactone; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Line; Cell Size; Cell Survival; Cerulenin; Fatty Acid Synthases; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; Ovarian Neoplasms; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Transcription Factors; Trastuzumab	2004
Effects of a fatty acid synthase inhibitor on adipocyte differentiation of mouse 3T3-L1 cells. Acta pharmacologica Sinica, 2004, Volume: 25, Issue:8 Topics: 3T3 Cells; 4-Butyrolactone; Adipocytes; Animals; Cell Differentiation; Down-Regulation; Fatty Acid Synthases; Gene Expression Regulation; Glycerolphosphate Dehydrogenase; Mice; PPAR gamma; RNA, Messenger	2004
C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:1 Topics: 4-Butyrolactone; Animals; Carnitine O-Palmitoyltransferase; Enzyme Activation; Humans; Malonyl Coenzyme A; Mitochondria, Heart; Rats; Recombinant Proteins; Tumor Cells, Cultured; Yeasts	2005
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. Oncogene, 2005, Jan-06, Volume: 24, Issue:1 Topics: 4-Butyrolactone; Animals; DNA-Binding Proteins; fas Receptor; Fatty Acid Synthases; Female; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mice; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured	2005
C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure. Endocrinology, 2005, Volume: 146, Issue:1 Topics: 4-Butyrolactone; Animals; Body Weight; Diet; Eating; Energy Metabolism; Fatty Acid Synthases; Fatty Acids; Gene Expression; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Obesity; Oxidation-Reduction; Thinness	2005
C75 activates malonyl-CoA sensitive and insensitive components of the CPT system. Biochemical and biophysical research communications, 2004, Dec-17, Volume: 325, Issue:3 Topics: 4-Butyrolactone; Animals; Carnitine O-Palmitoyltransferase; Enzyme Activation; Humans; Malonyl Coenzyme A; Pichia; Rats; Recombinant Proteins	2004
Inhibition of fatty acid synthase prevents preadipocyte differentiation. Biochemical and biophysical research communications, 2005, Mar-25, Volume: 328, Issue:4 Topics: 3T3-L1 Cells; 4-Butyrolactone; Adipocytes; Animals; Cell Differentiation; Cerulenin; Fatty Acid Synthases; Gene Silencing; Mice; Triclosan	2005
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates. The Biochemical journal, 2005, Jun-15, Volume: 388, Issue:Pt 3 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; 4-Butyrolactone; Acetyl Coenzyme A; Alcohol Oxidoreductases; Animals; Binding, Competitive; Dithiothreitol; Enzyme Activation; Fatty Acid Synthases; Kinetics; Liver; Malonyl Coenzyme A; NADP; Rats; Substrate Specificity; Temperature	2005
Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. Proceedings of the National Academy of Sciences of the United States of America, 2005, Mar-15, Volume: 102, Issue:11 Topics: 4-Butyrolactone; Animals; Fatty Acid Synthases; Ghrelin; Hypothalamus; Mice; Neuropeptides; Peptide Hormones; Proto-Oncogene Proteins c-fos; RNA, Messenger; Stomach	2005
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. The Journal of biological chemistry, 2005, May-27, Volume: 280, Issue:21 Topics: 4-Butyrolactone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain Ischemia; Cerebral Cortex; Constriction; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Synthases; Glucose; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Cerebral Artery; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Stroke	2005
Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents. European journal of pharmacology, 2005, Mar-21, Volume: 511, Issue:1 Topics: 4-Butyrolactone; Animals; Appetite Depressants; Behavior, Animal; Blotting, Northern; Cyclobutanes; Dose-Response Relationship, Drug; Fatty Acid Synthases; Fenfluramine; Food Deprivation; Hypothalamus; Immunoblotting; Injections, Intraperitoneal; Injections, Intraventricular; Kinetics; Male; Phentermine; Random Allocation; Rats; Rats, Inbred F344; RNA; Time Factors	2005
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene, 2005, May-19, Volume: 24, Issue:22 Topics: 4-Butyrolactone; Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Synthases; Feedback, Physiological; Female; Humans; Immunohistochemistry; Mice; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA, Small Interfering; Tumor Suppressor Proteins	2005
The connections between C75 and obesity drug-target pathways. Trends in pharmacological sciences, 2005, Volume: 26, Issue:11 Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Anorexia; Carnitine O-Palmitoyltransferase; Disease Models, Animal; Eating; Energy Metabolism; Enzyme Inhibitors; Fatty Acid Synthases; Fatty Acids; Feeding Behavior; Hypothalamus; Mice; Multienzyme Complexes; Obesity; Protein Serine-Threonine Kinases; Rats; Rhombencephalon	2005
Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 2005, Oct-11, Volume: 102, Issue:41 Topics: 4-Butyrolactone; Animals; Blotting, Western; Carnitine O-Palmitoyltransferase; Carrier Proteins; DNA Primers; Fatty Acid Synthases; Fatty Acids; Hypothalamus; Ion Channels; Malonyl Coenzyme A; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; Muscle, Skeletal; Oxidation-Reduction; Polymerase Chain Reaction; PPAR alpha; Signal Transduction; Sympathetic Nervous System; Uncoupling Protein 3	2005
Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 291, Issue:1 Topics: 4-Butyrolactone; Agouti-Related Protein; Animals; Body Weight; Feeding Behavior; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Male; Motor Activity; Peptide Hormones; Rats; Rats, Sprague-Dawley; RNA, Messenger	2006
Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation. Biochemistry, 2006, Apr-11, Volume: 45, Issue:14 Topics: 4-Butyrolactone; Acyl Coenzyme A; Animals; Carnitine O-Palmitoyltransferase; Cells, Cultured; Coenzyme A Ligases; Epoxy Compounds; Humans; Kinetics; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondria, Muscle; Oxidation-Reduction; Palmitic Acid; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2006
Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma. Cancer biology & therapy, 2006, Volume: 5, Issue:8 Topics: 4-Butyrolactone; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Cyclin A; Cyclin B; Cyclin B1; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; fas Receptor; Fatty Acid Synthases; Flow Cytometry; G2 Phase; Humans; Immunoprecipitation; Liver Neoplasms; p38 Mitogen-Activated Protein Kinases; Plasmids; RNA, Small Interfering; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2006
Cancer therapy: back to metabolism. Cancer biology & therapy, 2006, Volume: 5, Issue:8 Topics: 4-Butyrolactone; Carcinoma, Hepatocellular; Cell Cycle; fas Receptor; Fatty Acid Synthases; Fatty Acids; Humans; Liver Neoplasms; p38 Mitogen-Activated Protein Kinases; Tumor Suppressor Protein p53	2006
Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America, 2006, Oct-17, Volume: 103, Issue:42 Topics: 4-Butyrolactone; Animals; Cells, Cultured; Energy Metabolism; Fatty Acid Synthases; Gene Expression Regulation; Hypothalamus; Male; Malonyl Coenzyme A; Mice; Mice, Inbred BALB C; Mitochondria; Muscle, Skeletal; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Signal Transduction; Trans-Activators; Transcription Factors	2006
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell metabolism, 2007, Volume: 5, Issue:2 Topics: 4-Butyrolactone; Adipose Tissue; Animals; Eukaryotic Initiation Factor-2; Fatty Acid Synthases; Fatty Acid Transport Proteins; Fatty Acids; Fatty Liver; Female; Homeostasis; Leucine; Liver; Male; Mice; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Organ Size; Phosphorylation; PPAR gamma; Protein Serine-Threonine Kinases; Repressor Proteins; Sterol Regulatory Element Binding Protein 1; Triglycerides; Up-Regulation	2007
FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer. Pharmaceutical research, 2007, Volume: 24, Issue:6 Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Enzyme Inhibitors; Fatty Acid Synthases; Fluorodeoxyglucose F18; Lung Neoplasms; Positron-Emission Tomography; Rats	2007
The human fatty acid synthase: a new therapeutic target for coxsackievirus B3-induced diseases? Antiviral research, 2007, Volume: 76, Issue:2 Topics: 4-Butyrolactone; Amino Acid Sequence; Antiviral Agents; Cell Line; Cerulenin; Electrophoresis, Gel, Two-Dimensional; Enterovirus B, Human; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Molecular Sequence Data; Up-Regulation; Virus Replication	2007
Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells. International journal of oncology, 2007, Volume: 31, Issue:4 Topics: 4-Butyrolactone; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Fatty Acid Synthase, Type I; Fatty Acid Synthases; Gene Expression Regulation, Neoplastic; Humans; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Trastuzumab; Tumor Cells, Cultured	2007
Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75. Breast cancer research and treatment, 2008, Volume: 109, Issue:3 Topics: 4-Butyrolactone; Apoptosis; Breast Neoplasms; Carnitine O-Palmitoyltransferase; Catechin; Enzyme Inhibitors; Fatty Acid Synthases; Fatty Acids; Female; Humans; Signal Transduction	2008
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2007, Volume: 61, Issue:9 Topics: 4-Butyrolactone; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cerulenin; DNA, Neoplasm; Enzyme Inhibitors; fas Receptor; Fatty Acid Synthases; Flow Cytometry; Genes, bcl-2; Humans; Melanoma; Microscopy, Confocal; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles	2007
Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro. Journal of neuroscience methods, 2008, Jan-30, Volume: 167, Issue:2 Topics: 4-Butyrolactone; Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Glucose; Hypoglycemic Agents; Multienzyme Complexes; Neurons; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleotides; Time Factors	2008
Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:2 Topics: 4-Butyrolactone; Animals; Body Weight; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Epoxy Compounds; Fatty Acid Synthesis Inhibitors; Fatty Acids; Female; Hypothalamus; Injections, Intraventricular; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurons; Pregnancy; Rats	2008
Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. Cancer research, 2008, Mar-15, Volume: 68, Issue:6 Topics: 4-Butyrolactone; Adenocarcinoma; Aspirin; Caco-2 Cells; Cell Growth Processes; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; HCT116 Cells; HT29 Cells; Humans; Lipid Metabolism; Organelles; Subcellular Fractions	2008
Examining the relationship between Cu-ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines. Nuclear medicine and biology, 2008, Volume: 35, Issue:3 Topics: 4-Butyrolactone; Cell Hypoxia; Cell Line, Tumor; Coordination Complexes; Copper Radioisotopes; Dose-Response Relationship, Drug; Drug Synergism; Fatty Acid Synthases; Gene Expression; Humans; Male; Organometallic Compounds; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Thiosemicarbazones	2008
An easy, rapid and objective mathematical method to identify fatty acid synthase (oncogenic antigen-519) modulators with potential anticancer value. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2008, Volume: 10, Issue:4 Topics: 4-Butyrolactone; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fatty Acid Synthase, Type I; Fluorescent Antibody Technique; Humans; In Situ Nick-End Labeling; Models, Theoretical; Neoplasms; RNA Interference	2008
Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:3 Topics: 4-Butyrolactone; Animals; Carnitine O-Palmitoyltransferase; Conditioning, Psychological; Dose-Response Relationship, Drug; Eating; Fatty Acid Synthases; Fatty Acids; Feeding Behavior; Injections, Intraperitoneal; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Vagotomy; Vagus Nerve	2008
Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers. The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:10 Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Carcinoma, Papillary; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acid Synthases; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Middle Aged; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Thyroid Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2008
Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice. European journal of pharmacology, 2008, Oct-24, Volume: 595, Issue:1-3 Topics: 4-Butyrolactone; Acetyl-CoA Carboxylase; Animals; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fasting; Fatty Acid Synthases; Furans; Gastric Emptying; Gastrointestinal Transit; Ghrelin; Injections, Intraventricular; Male; Mice	2008
Fatty acid synthase inhibitor, C75, blocks resistin-induced increases in lipid accumulation by human macrophages. Diabetes, obesity & metabolism, 2008, Volume: 10, Issue:12 Topics: 4-Butyrolactone; Fatty Acid Synthases; Humans; Lipid Metabolism; Macrophages; Resistin	2008
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight. Biochemical pharmacology, 2009, Mar-15, Volume: 77, Issue:6 Topics: 4-Butyrolactone; Acyl Coenzyme A; Animals; Binding Sites; Body Weight; Carnitine O-Palmitoyltransferase; Eating; Female; Humans; Hypothalamus; Mice; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Weight Loss	2009
Fatty acid oxidation and meiotic resumption in mouse oocytes. Molecular reproduction and development, 2009, Volume: 76, Issue:9 Topics: 4-Butyrolactone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Cerulenin; Cumulus Cells; Epoxy Compounds; Fatty Acids; Female; Malonyl Coenzyme A; Meiosis; Mice; Mice, Inbred C57BL; Oocytes; Oxidation-Reduction; Palmitic Acid; Ribonucleotides	2009
Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells. Biochemical and biophysical research communications, 2009, Jul-31, Volume: 385, Issue:3 Topics: 4-Butyrolactone; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Fatty Acid Synthase, Type I; Female; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2	2009
Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma. Molecular cancer therapeutics, 2010, Volume: 9, Issue:5 Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fatty Acid Synthases; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Proto-Oncogene Proteins c-met; RNA, Small Interfering; Validation Studies as Topic	2010
Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast cancer research : BCR, 2010, Volume: 12, Issue:6 Topics: 4-Butyrolactone; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Fatty Acid Synthases; Female; Fluorescent Antibody Technique; Gene Expression; Humans; Lapatinib; Mass Spectrometry; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neuregulin-1; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction	2010
Fatty acid synthase expression in Barrett's esophagus: implications for carcinogenesis. Journal of clinical gastroenterology, 2011, Volume: 45, Issue:8 Topics: 4-Butyrolactone; Adenocarcinoma; Aged; Antigens, CD34; Apoptosis; Barrett Esophagus; Bile Acids and Salts; Biopsy; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chi-Square Distribution; Cyclooxygenase 2; Disease Progression; Enzyme Inhibitors; Esophageal Neoplasms; Esophagoscopy; Fatty Acid Synthase, Type I; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Japan; Logistic Models; Male; Middle Aged; Odds Ratio; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Risk Assessment; Risk Factors; RNA, Messenger; Time Factors	2011
Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis. Molecular medicine (Cambridge, Mass.), 2011, Volume: 17, Issue:7-8 Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Ovarian Epithelial; Cisplatin; Drug Synergism; Fatty Acid Synthases; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Middle Aged; Middle East; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; RNA Interference; Tissue Array Analysis; Xenograft Model Antitumor Assays; Young Adult	2011
Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer. Molecular cancer research : MCR, 2011, Volume: 9, Issue:12 Topics: 4-Butyrolactone; Adaptor Proteins, Signal Transducing; Apoptosis; Cell Cycle Proteins; Cell Proliferation; Chromones; ErbB Receptors; Fatty Acid Synthases; Female; Gene Expression Regulation, Neoplastic; Humans; Lipogenesis; Morpholines; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Proteolysis; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Ubiquitination	2011
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral research, 2012, Volume: 93, Issue:1 Topics: 4-Butyrolactone; Androstenes; Animals; Anticholesteremic Agents; Antiviral Agents; Biological Transport; Cell Line; Cholesterol; Cricetinae; Dengue Virus; Drug Synergism; Endosomes; Fatty Acid Synthases; Humans; Lysosomes; Virus Internalization; Virus Replication	2012
The effects of C75, an inhibitor of fatty acid synthase, on sleep and metabolism in mice. PloS one, 2012, Volume: 7, Issue:2 Topics: 4-Butyrolactone; Animals; Enzyme Inhibitors; Fatty Acid Synthases; Lipid Metabolism; Mice; Sleep	2012
Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 2012, Jul-17, Volume: 109, Issue:29 Topics: 4-Butyrolactone; B-Lymphocytes; Computational Biology; Fatty Acid Synthases; Fatty Acids; Glycolysis; Humans; Immunoblotting; Lymphoma, B-Cell; Lymphoma, Primary Effusion; Metabolic Networks and Pathways; Models, Biological; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases	2012
The central administration of C75, a fatty acid synthase inhibitor, activates sympathetic outflow and thermogenesis in interscapular brown adipose tissue. Pflugers Archiv : European journal of physiology, 2013, Volume: 465, Issue:12 Topics: 4-Butyrolactone; Adipose Tissue, Brown; Animals; Eating; Fatty Acid Synthase, Type I; Male; Motor Activity; Rats; Rats, Wistar; Skin Temperature; Sympathectomy; Thermogenesis	2013
Fatty acid synthase as a factor required for exercise-induced cognitive enhancement and dentate gyrus cellular proliferation. PloS one, 2013, Volume: 8, Issue:11 Topics: 4-Butyrolactone; Animals; Cell Proliferation; Cerebellum; Cognition; Dentate Gyrus; Enzyme Induction; Escape Reaction; Fatty Acid Synthase, Type I; Fatty Acids; Lipid Metabolism; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurogenesis; Running; Up-Regulation	2013
Fatty acid synthase inhibitor C75 ameliorates experimental colitis. Molecular medicine (Cambridge, Mass.), 2014, Jan-17, Volume: 20 Topics: 4-Butyrolactone; Animals; Chemokines; Colitis; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Disease Models, Animal; Fatty Acid Synthases; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II	2014
4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. The Journal of biological chemistry, 2014, Jun-13, Volume: 289, Issue:24 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; 4-Butyrolactone; Cell Survival; Enzyme Inhibitors; Fatty Acid Synthase, Type I; HEK293 Cells; Humans; Mitochondria; Reactive Oxygen Species; Thioctic Acid	2014
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis. Journal of neuro-oncology, 2014, Volume: 118, Issue:2 Topics: 4-Butyrolactone; Apoptosis; Autophagy; Brain; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Cerulenin; Dose-Response Relationship, Drug; Fatty Acid Synthase, Type I; Fatty Acid Synthesis Inhibitors; Glioblastoma; Glioma; Humans; Lactones; Neoplasm Grading; Orlistat; Tissue Culture Techniques	2014
Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity, 2014, Jul-17, Volume: 41, Issue:1 Topics: 4-Butyrolactone; Adoptive Transfer; Animals; CD8-Positive T-Lymphocytes; Cell Proliferation; Cell Survival; Cells, Cultured; Fatty Acid Synthases; Fatty Acids; Glucose; Immunologic Memory; Interleukin-15; Interleukin-2; Lipolysis; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen; Protein Kinases; RNA Interference; RNA, Small Interfering; Sterol Esterase	2014
The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget, 2014, Oct-15, Volume: 5, Issue:19 Topics: 3T3 Cells; 4-Butyrolactone; Animals; Anti-Infective Agents, Local; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Repositioning; Fatty Acid Synthase, Type I; Fatty Acid Synthesis Inhibitors; G1 Phase Cell Cycle Checkpoints; Humans; Lactones; Lipid Metabolism; Male; Mice; Orlistat; Prostatic Neoplasms; Structure-Activity Relationship; Triclosan	2014
Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation. PloS one, 2014, Volume: 9, Issue:12 Topics: 4-Butyrolactone; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Appetite Depressants; Cell Line; Cells, Cultured; Ceramides; Cholesterol Esters; Cricetinae; Glycerides; Glycerol-3-Phosphate O-Acyltransferase; Humans; Hypothalamus; Inflammation; Metabolome; Mice; Neurons; ortho-Aminobenzoates; Oxidation-Reduction; Palmitates; Reactive Oxygen Species; Stress, Physiological; Sulfonamides	2014
Cell proliferation and progesterone synthesis depend on lipid metabolism in bovine granulosa cells. Theriogenology, 2015, Mar-15, Volume: 83, Issue:5 Topics: 4-Butyrolactone; Animals; Cattle; Cell Proliferation; Enzyme Inhibitors; Epoxy Compounds; Female; Gene Expression Regulation; Granulosa Cells; Lipid Metabolism; Oxazines; Progesterone; Signal Transduction; Staining and Labeling	2015
Short communication: Effect of inhibition of fatty acid synthase on triglyceride accumulation and effect on lipid metabolism genes in goat mammary epithelial cells. Journal of dairy science, 2015, Volume: 98, Issue:5 Topics: 4-Butyrolactone; Animals; Down-Regulation; Epithelial Cells; Fatty Acid Synthases; Female; Goats; Lipid Metabolism; Mammary Glands, Animal; RNA, Messenger; RNA, Small Interfering; Triglycerides	2015
To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway. Developmental and comparative immunology, 2015, Volume: 53, Issue:1 Topics: 4-Butyrolactone; Acetyl Coenzyme A; Animals; Energy Metabolism; Fatty Acid Synthases; Fatty Acids; Hypoxia-Inducible Factor 1, alpha Subunit; Lipolysis; Penaeidae; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; White spot syndrome virus 1	2015
Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Neuro-oncology, 2015, Volume: 17, Issue:12 Topics: 4-Butyrolactone; Animals; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cell Survival; Fatty Acid Synthases; Humans; Lipid Droplets; Mice; Mice, Inbred C57BL; Neural Crest; Neurilemmoma; Schwann Cells; Xenograft Model Antitumor Assays	2015
Inhibition of lipogenesis reduces inflammation and organ injury in sepsis. The Journal of surgical research, 2016, Volume: 200, Issue:1 Topics: 4-Butyrolactone; Animals; Biomarkers; Enzyme Inhibitors; Hepatic Insufficiency; Inflammation; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Sepsis; Treatment Outcome	2016
Inhibition of fatty acid synthase with C75 decreases organ injury after hemorrhagic shock. Surgery, 2016, Volume: 159, Issue:2 Topics: 4-Butyrolactone; Animals; Biomarkers; Combined Modality Therapy; Crystalloid Solutions; Enzyme Inhibitors; Fatty Acid Synthases; Fluid Therapy; Isotonic Solutions; Lung Injury; Male; Rats; Rats, Sprague-Dawley; Rehydration Solutions; Resuscitation; Shock, Hemorrhagic; Treatment Outcome	2016
Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. Radiation research, 2015, Volume: 184, Issue:5 Topics: 4-Butyrolactone; Antioxidants; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Male; Prostatic Neoplasms; Radiation Tolerance; Spheroids, Cellular; X-Rays	2015
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth. Nature communications, 2016, Apr-05, Volume: 7 Topics: 4-Butyrolactone; Animals; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Doxycycline; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Hepatocyte Nuclear Factor 3-alpha; Hepatocyte Nuclear Factor 3-beta; Humans; Lactones; Lipase; Lipid Metabolism; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Invasiveness; Orlistat; RNA, Small Interfering; Signal Transduction; Xenograft Model Antitumor Assays	2016
Inhibition of fatty acid synthase is protective in pulmonary hypertension. British journal of pharmacology, 2016, Volume: 173, Issue:12 Topics: 4-Butyrolactone; Animals; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Hypertension, Pulmonary; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2016
Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis. Oncotarget, 2016, Sep-13, Volume: 7, Issue:37 Topics: 4-Butyrolactone; Breast Neoplasms; Carcinogenesis; Caspase 9; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Fatty Acid Synthases; Female; Humans; Lipid Droplets; Lipid Metabolism; Molecular Targeted Therapy; Osteoprotegerin; Protein Binding; Receptor Cross-Talk; Signal Transduction; Tumor Microenvironment	2016
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer. Histology and histopathology, 2017, Volume: 32, Issue:7 Topics: 4-Butyrolactone; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Enzyme Inhibitors; Fatty Acid Synthase, Type I; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Oncogenes; Prognosis; Receptor, ErbB-2; Survival Analysis	2017
Fatty acid synthase regulates the pathogenicity of Th17 cells. Journal of leukocyte biology, 2017, Volume: 102, Issue:5 Topics: 4-Butyrolactone; Animals; Cell Differentiation; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Fatty Acid Synthase, Type I; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-17; Interleukin-23; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Primary Cell Culture; Signal Transduction; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Toll-Like Receptor 2	2017
Inhibition of cellular fatty acid synthase impairs replication of budded virions of Autographa californica multiple nucleopolyhedrovirus in Spodoptera frugiperda cells. Virus research, 2018, 07-02, Volume: 252 Topics: 4-Butyrolactone; Animals; Cell Line; DNA Replication; Fatty Acid Synthases; Nucleopolyhedroviruses; Sf9 Cells; Viral Proteins; Virion; Virus Replication	2018
Inhibition of TGF-β induced lipid droplets switches M2 macrophages to M1 phenotype. Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 58 Topics: 4-Butyrolactone; Animals; Cell Line, Tumor; Cytokines; Female; Humans; Lipid Droplets; Macrophages; Male; Mice; Mice, Inbred BALB C; Neoplasms; Nitric Oxide; Phenotype; RAW 264.7 Cells; Reactive Oxygen Species; THP-1 Cells; Tumor Microenvironment	2019
Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:14 Topics: 4-Butyrolactone; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Cell Survival; Endoplasmic Reticulum; Etoposide; Fatty Acid Synthases; Fatty Acids; G2 Phase Cell Cycle Checkpoints; HeLa Cells; Humans; Lipogenesis; Lysophospholipids; Mitosis; Nuclear Envelope; Phosphatidylcholines	2019
Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension. Experimental cell research, 2019, 10-15, Volume: 383, Issue:2 Topics: 4-Butyrolactone; Animals; Animals, Newborn; Cells, Cultured; Fatty Acid Synthase, Type I; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Ventricular Remodeling	2019
Novel lysophosphatidic acid receptor 6 antagonists inhibit hepatocellular carcinoma growth through affecting mitochondrial function. Journal of molecular medicine (Berlin, Germany), 2020, Volume: 98, Issue:2 Topics: 4-Butyrolactone; Acetates; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice, Nude; Mitochondria; Receptors, Lysophosphatidic Acid	2020
Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer. Aging, 2020, 12-10, Volume: 12, Issue:24 Topics: 4-Butyrolactone; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Databases, Genetic; Fatty Acid Synthase, Type I; Humans; Interleukin-6; Prolactin; Promoter Regions, Genetic; Protein Isoforms; Receptor Cross-Talk; Receptors, Progesterone; Receptors, Prolactin; RNA, Messenger; Up-Regulation	2020
Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B. Journal of virology, 2021, 08-10, Volume: 95, Issue:17 Topics: 4-Butyrolactone; Animals; Classical Swine Fever; Classical Swine Fever Virus; Endoplasmic Reticulum; Fatty Acid Synthases; Host-Pathogen Interactions; rab GTP-Binding Proteins; Swine; Viral Nonstructural Proteins; Virus Replication	2021
The Emerging Role of Fatty Acid Synthase in Hypoxia-Induced Pulmonary Hypertensive Mouse Energy Metabolism. Oxidative medicine and cellular longevity, 2021, Volume: 2021 Topics: 4-Butyrolactone; Animals; Apoptosis; Energy Metabolism; Fatty Acid Synthases; Hypoxia; Mice; Mice, Inbred C57BL; Mitochondria; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Signal Transduction	2021
Palmitoylation of SARS-CoV-2 S protein is critical for S-mediated syncytia formation and virus entry. Journal of medical virology, 2022, Volume: 94, Issue:1 Topics: 4-Butyrolactone; Acyltransferases; Cell Line; Cell Membrane; COVID-19; Giant Cells; HEK293 Cells; Humans; Lipoylation; Protein Processing, Post-Translational; Spike Glycoprotein, Coronavirus; Virus Internalization	2022
Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt. Cell death & disease, 2021, 10-12, Volume: 12, Issue:10 Topics: 4-Butyrolactone; Animals; Cell Membrane; Colitis; Dextran Sulfate; Down-Regulation; Enzyme Activation; Fatty Acid Synthases; Inflammation; Intestinal Mucosa; Lipopolysaccharides; Lipoylation; Macrophages; Male; Metformin; Mice; Mice, Inbred C57BL; Palmitates; Phosphorylation; Proto-Oncogene Proteins c-akt; RAW 264.7 Cells; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factor RelA	2021