Compounds > 4-butyrolactone
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4-butyrolactone and 4-acetylantroquinonol b

4-butyrolactone has been researched along with 4-acetylantroquinonol b in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (66.67)24.3611
2020's5 (33.33)2.80

Authors

AuthorsStudies
Chiang, BH; Kuo, YH; Lin, YW; Liu, RH; Pan, JH; Sheen, LY1
Chiang, BH; Lin, YW1
Chen, KH; Chiang, BH; Chiang, CC; Huang, TN; Lin, YW1
Chang, CH; Chang, WL; Chung, CH; Hsu, CC; Huang, TF; Ko, FN; Lin, KT; Peng, HC; Wang, SW1
Adebayo, BO; Chang, TC; Deng, L; Hsiao, M; Huang, CC; Lee, WH; Lin, YC; Rao, YK; Tzeng, YM; Wang, LS; Wu, AT; Wu, CH; Yeh, CT1
Chang, TL; Chen, KH; Chiang, BH; Chou, KC; Lin, PY; Sheu, F; Wu, HL; Yang, SH1
Bamodu, OA; Deng, L; Hsiao, M; Huang, CC; Huang, WC; Lee, WH; Lin, YK; Liu, M; Tzeng, YM; Wu, ATH; Yeh, CT; Yuan, CC; Zucha, MA1
Chen, MC; Cho, TY; Kuo, YH; Lee, TH1
Chang, CH; Chang, WL; Chung, CH; Hsu, CC; Huang, WC; Lee, AS; Lin, KT; Peng, HC; Wang, SW1
Chiang, BH; Li, TY1
Lee, SY; Ou, CH; Wu, CH; Yen, IC1
Aryandono, T; Chao, TY; Deng, L; Fong, IH; Haryana, SM; Huang, CC; Huang, WC; Lin, CC; Liu, HW; Ong, JR; Satriyo, PB; Su, CM; Tzeng, YM; Yeh, CT1
Chang, TC; Lee, SY; Li, YF; Lin, PH; Tu, QW; Yen, IC1
Chen, YJ; Chung, CH; Hsueh, TY; Huang, TF; Lai, YW; Lin, CC; Lin, CH; Liu, SC; Wang, SW1
Deng, L; Jin, Y; Liu, H; Liu, J; Tzeng, YM; Wang, F; Xing, H1

Other Studies

15 other study(ies) available for 4-butyrolactone and 4-acetylantroquinonol b

ArticleYear
The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells.
    Journal of the science of food and agriculture, 2010, Aug-15, Volume: 90, Issue:10

    Topics: 4-Butyrolactone; Antineoplastic Agents; Antrodia; Biological Products; Carcinoma, Hepatocellular; Cell Proliferation; Cyclohexanones; Fermentation; Hep G2 Cells; Humans; Liver Neoplasms; Mycelium

2010
4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels.
    Journal of agricultural and food chemistry, 2011, Aug-24, Volume: 59, Issue:16

    Topics: 4-Butyrolactone; Antineoplastic Agents; Antrodia; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclohexanones; G1 Phase; Hep G2 Cells; Humans; S Phase; Tumor Suppressor Protein p53

2011
Enhancement of 4-acetylantroquinonol B production by supplementation of its precursor during submerged fermentation of Antrodia cinnamomea.
    Journal of agricultural and food chemistry, 2013, Sep-25, Volume: 61, Issue:38

    Topics: 4-Butyrolactone; Antineoplastic Agents; Antrodia; Cell Proliferation; Culture Media; Cyclohexanones; Fermentation; Gas Chromatography-Mass Spectrometry; Hep G2 Cells; Humans

2013
4-Acetylantroquinonol B suppresses tumor growth and metastasis of hepatoma cells via blockade of translation-dependent signaling pathway and VEGF production.
    Journal of agricultural and food chemistry, 2015, Jan-14, Volume: 63, Issue:1

    Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Antrodia; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cyclohexanones; Down-Regulation; Hep G2 Cells; Humans; Liver Neoplasms; Male; Metatarsal Bones; Mice, Nude; Mice, SCID; Phosphorylation; Protein Biosynthesis; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A

2015
4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype.
    Toxicology and applied pharmacology, 2015, Oct-15, Volume: 288, Issue:2

    Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Colorectal Neoplasms; Cyclohexanones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Leucovorin; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Organoplatinum Compounds; Phenotype; Signal Transduction; Spheroids, Cellular; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays

2015
Biosynthesis of Antroquinonol and 4-Acetylantroquinonol B via a Polyketide Pathway Using Orsellinic Acid as a Ring Precursor in Antrodia cinnamomea.
    Journal of agricultural and food chemistry, 2017, Jan-11, Volume: 65, Issue:1

    Topics: 4-Butyrolactone; Antrodia; Biosynthetic Pathways; Cyclohexanones; Fungal Proteins; Molecular Structure; Mycelium; Polyketides; Resorcinols; Ubiquinone

2017
4-Acetylantroquinonol B suppresses autophagic flux and improves cisplatin sensitivity in highly aggressive epithelial cancer through the PI3K/Akt/mTOR/p70S6K signaling pathway.
    Toxicology and applied pharmacology, 2017, 06-15, Volume: 325

    Topics: 4-Butyrolactone; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclohexanones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Mice, Inbred NOD; Mice, SCID; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

2017
Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea.
    Journal of natural products, 2017, 09-22, Volume: 80, Issue:9

    Topics: 4-Butyrolactone; Antrodia; Cyclohexanones; Fluorouracil; Fungi; Humans; Molecular Structure; Structure-Activity Relationship; Taiwan; Terpenes; Ubiquinone

2017
4-Acetylantroquinonol B inhibits lipopolysaccharide-induced cytokine release and alleviates sepsis through of MAPK and NFκB suppression.
    BMC complementary and alternative medicine, 2018, Mar-23, Volume: 18, Issue:1

    Topics: 4-Butyrolactone; Animals; Cell Survival; Cyclohexanones; Cytokines; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; RAW 264.7 Cells; Sepsis

2018
4-Acetylantroquinonol B from antrodia cinnamomea enhances immune function of dendritic cells against liver cancer stem cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109

    Topics: 4-Butyrolactone; Animals; Antrodia; Cell Survival; Coculture Techniques; Cyclohexanones; Dendritic Cells; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Immunity, Cellular; Liver Neoplasms; Mice; Neoplastic Stem Cells; RAW 264.7 Cells

2019
4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model.
    International journal of molecular sciences, 2020, Sep-22, Volume: 21, Issue:18

    Topics: 4-Butyrolactone; Animals; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cyclohexanones; Gene Expression Regulation; Mice; Osteoclasts; RAW 264.7 Cells; Signal Transduction; Weightlessness Simulation

2020
4-Acetylantroquinonol B induced DNA damage response signaling and apoptosis via suppressing CDK2/CDK4 expression in triple negative breast cancer cells.
    Toxicology and applied pharmacology, 2021, 07-01, Volume: 422

    Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclohexanones; DNA Damage; DNA Repair; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Mice, Inbred NOD; Mice, SCID; Signal Transduction; Triple Negative Breast Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays

2021
4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 138

    Topics: 4-Butyrolactone; Animals; Cyclohexanones; Endoplasmic Reticulum Stress; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RAW 264.7 Cells; Receptors, Cell Surface

2021
4-Acetylantroquinonol B Suppresses Prostate Cancer Growth and Angiogenesis via a VEGF/PI3K/ERK/mTOR-Dependent Signaling Pathway in Subcutaneous Xenograft and In Vivo Angiogenesis Models.
    International journal of molecular sciences, 2022, Jan-27, Volume: 23, Issue:3

    Topics: 4-Butyrolactone; Angiogenesis Inhibitors; Cell Movement; Cell Proliferation; Cell Survival; Cyclohexanones; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Male; PC-3 Cells; Phosphatidylinositol 3-Kinase; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2022
Application of Multiple Strategies to Improve the Production of the Potential Cancer Drug 4-Acetylantroquinonol B (4-AAQB) by the Rare Fungus Antrodia cinnamomea.
    Applied biochemistry and biotechnology, 2022, Volume: 194, Issue:6

    Topics: 4-Butyrolactone; Antineoplastic Agents; Cyclohexanones; Neoplasms; Polyporales

2022