Page last updated: 2024-08-18

4-butyrolactone and 2,3-bis(3'-hydroxybenzyl)butane-1,4-diol

4-butyrolactone has been researched along with 2,3-bis(3'-hydroxybenzyl)butane-1,4-diol in 109 studies

Research

Studies (109)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (10.09)	18.7374
1990's	19 (17.43)	18.2507
2000's	38 (34.86)	29.6817
2010's	37 (33.94)	24.3611
2020's	4 (3.67)	2.80

Authors

Authors	Studies
Cheung, F; Robb, P; Serraino, M; Thompson, LU	1
Adlercreutz, H; Bannwart, C; Brunow, G; Fotsis, T; Hase, T; Wähälä, K	1
Adlercreutz, H; Benassayag, C; Garreau, B; Mäkelä, T; Nunez, EA; Vallette, G; Wähälä, K	1
Fukuoka, K; Hirano, T; Hosaka, K; Matsumoto, Y; Mitsuhashi, H; Naito, T; Oka, K	1
Axelson, M; Borriello, SP; Lawson, AM; Setchell, KD	1
Adlercreutz, H; Bannwart, C; Brunow, G; Fotsis, T; Hase, T; Mäkelä, T; Musey, PI; Wähälä, K	1
Calaf, G; Jordan, VC; Koch, R; Murphy, CS; Welshons, WV	1
Adlercreatz, H; Anderson, LC; Axelson, M; Borriello, SP; Gordon, H; Harkness, R; Kirk, DN; Lawson, AM; Morgan, DM; Setchell, KD	1
Adlercreutz, H; Dwyer, JT; Fotsis, T; Goldin, BR; Gorbach, SL; Heikkinen, R; Woods, M	1
Axelson, M; Setchell, KD	2
Axelson, M; Gustafsson, BE; Setchell, KD; Sjövall, J	1
Adlercreutz, H; Axelson, M; Fotsis, T; Heikkinen, R; Setchell, KD	1
Axelson, M; Kirk, DN; Lawson, AM; McLaughlin, LM; Patel, S; Setchell, KD	1
Axelson, M; Conway, E; Cooley, G; Farrant, RD; Kirk, DN; Lawson, AM; Setchell, KD; Taylor, NF; Wynn, S	1
Campbell, DR; Kirkman, LM; Lampe, JW; Martini, MC; Slavin, JL	1
Hutchins, AM; Lampe, JW; Slavin, JL	1
Griffiths, K; Morton, MS; Wahlqvist, ML; Wilcox, G	1
Kurzer, MS; Lampe, JW; Martini, MC; Phipps, WR; Slavin, JL	1
Atkinson, DA; Hill, HH; Shultz, TD	1
Benassayag, C; Haourigui, M; Martin, ME; Nunez, EA; Pelissero, C	1
Fong, HH; Luyengi, L; Orcheson, LJ; Rickard, SE; Seidl, MM; Thompson, LU	1
Abranches-Monteiro, L; Blacklock, N; Chan, PS; Cheng, C; Correia, R; Griffiths, K; Lloyd, S; Matos-Ferreira, A; Morton, MS	1
Jacobs, E; Kulling, SE; Metzler, M; Pfeiffer, E	1
Adlercreutz, H; Akhmedkhanov, A; Toniolo, P; Zeleniuch-Jacquotte, A	1
Lam, Y; Nesbitt, PD; Thompson, LU	1
Jacobs, E; Kulling, SE; Metzler, M	1
Jacobs, E; Metzler, M	1
Kitts, DD; Thompson, LU; Wijewickreme, AN; Yuan, YV	1
Honig, D; Jacobs, E; Kulling, SE; Lange-Böhmer, A; Metzler, M; Niemeyer, HB	1
Hase, TA; Mäkelä, TH; Wähälä, KT	1
Clark, WF; Muir, AD; Parbtani, A; Westcott, ND	1
Hattori, M; Li, Y; Meselhy, MR; Qin, GW; Wang, LQ	1
Bacigalupo, MA; Ius, A; Piazza, F; Roda, A; Setchell, KD; Simoni, P	1
Adlercreutz, H; Deyama, T; Heinonen, S; Liukkonen, K; Nishibe, S; Nurmi, T; Poutanen, K; Wähälä, K	1
Ayton, R; Dalais, FS; Grehan, M; Medley, G; Murkies, AL; Rice, GE; Strauss, BJ; Wahlqvist, ML	1
Wang, LQ	1
Ambrosone, CB; Freudenheim, JL; McCann, SE; Moysich, KB; Shields, PG	1
Eklund, P; Lehtilä, R; Lindholm, A; Mikkola, JP; Sjöholm, R; Smeds, A	1
Bingham, SA; Botting, NP; Fryatt, T; Grace, PB; Oldfield, MF; Taylor, JI	1
Andre, F; Antignac, JP; Cariou, R; Cravedi, JP; Le Bizec, B	1
Chen, J; Thompson, LU	1
Adlercreutz, H; Begum, AN; Fukushima, K; Heinonen, SM; Lapierre, C; Mila, I; Nagano, K; Nicolle, C; Rémésy, C; Scalbert, A	1
Chung, BC; Jung, BH; Kim, SY; Lee, SH	1
Arts, IC; Hollman, PC; Jansen, GH; Keijer, J; Müller, M; Nielen, MW	1
Arts, IC; Hollman, PC; Kuijsten, A; Vree, TB	1
Brooks, JD; Thompson, LU	1
Arts, IC; Buijsman, MN; Hollman, PC; Kuijsten, A; Mulder, PP	1
Chen, JM; Power, KA; Saarinen, NM; Thompson, LU	1
Coulman, KD; Hum, WQ; Liu, Z; Michaelides, J; Thompson, LU	1
Alpert, CA; Blaut, M; Clavel, T; Doré, J; Henderson, G; Philippe, C; Rigottier-Gois, L	1
Arts, IC; Hollman, PC; Kuijsten, A; van't Veer, P	1
Blaut, M; Clavel, T; Doré, J; Engst, W; Henderson, G	1
Chang-Claude, J; Linseisen, J; Piller, R	1
Arts, IC; Hollman, PC; Kampman, E; Kuijsten, A; van't Veer, P	1
Bergman Jungeström, M; Dabrosin, C; Thompson, LU	1
Arts, IC; Feskens, EJ; Hollman, PC; Kampman, E; Kuijsten, A; Milder, IE; Van 't Veer, P	1
Hu, C; Kitts, DD; Yuan, YV	1
Adlercreutz, H	1
Akao, T; Hattori, M; Jin, JS; Kakiuchi, N; Min, BS; Nakamura, N; Zhao, YF	1
Hattori, M; Jin, JS; Kakiuchi, N	1
Bennetau-Pelissero, C; Carreau, C; Flouriot, G; Potier, M	1
Feng, J; Shi, Z; Ye, Z	1
Airio, M; Dings, RP; Mäkelä, S; Saarinen, NM; Smeds, AI; Wärri, A	1
Arts, IC; Boer, JM; Bueno-de-Mesquita, HB; Hollman, PC; Kok, FJ; Kuijsten, A; van't Veer, P	1
Benchaar, C; Côrtes, C; da Silva, D; Gagnon, N; Petit, HV; Santos, GT	1
Cao, R; Cui, S; Gagnon, N; Mir, PS; Petit, HV	1
Kang, J; Price, WE	1
Blaut, M; Clavel, T; Loh, G; Woting, A	1
Boraso, MS; Corsini, E; De Fabiani, E; Dell'Agli, M; Facchi, A; Galli, CL; Lucchi, L; Marinovich, M	1
Hattori, M; Jin, JS	1
Eiler, H; Fecteau, KA; Oliver, JW	1
Amaretti, A; Leonardi, A; Raimondi, S; Roncaglia, L; Rossi, M	1
Abarzua, S; Briese, V; Piechulla, B; Richter, DU; Serikawa, T; Szewczyk, M	1
López-Romero, P; Peñalvo, JL	1
Buck, K; Chang-Claude, J; Flesch-Janys, D; Heinz, J; Linseisen, J; Vrieling, A; Zaineddin, AK	1
Debouche, C; During, A; Larondelle, Y; Raas, T	1
Martinchik, AN; Zubtsov, VV	1
Azrad, M; Brenner, DE; Demark-Wahnefried, W; Dewhirst, M; Madden, J; Moul, JW; Polascik, TJ; Ruffin, MT; Snyder, DC; Vollmer, RT	1
Frankenfeld, CL	2
Bastías, JM; Estévez, AM; Figuerola, F; Fuentealba, C; Muñoz, O	1
Barr, DB; Louis, GM; Maisog, JM; Mumford, SL; Parker, DL; Pfeiffer, CM; Rybak, ME; Schisterman, EF; Sundaram, R; Sweeney, AM	1
Alcorn, J; Krol, ES; Michel, D; Muir, AD; Mukker, JK	1
Eichholzer, M; Linseisen, J; Nicastro, HL; Platz, EA; Richard, A; Rohrmann, S	1
Cassidy, A; Franke, AA; Hu, FB; Pan, A; Rimm, EB; Sun, Q; Townsend, MK; van Dam, RM; Wedick, NM	1
Biasiotto, G; Cadei, M; Caimi, L; Di Lorenzo, D; Penza, M; Rossini, C; Smeds, AI; Zanella, I	1
Jan, KC; Liu, TC; Yang, BB	1
Atkinson, C; Beer, K; Copeland, WK; Hullar, MA; Lampe, JW; Lancaster, SM; Li, F; Newton, KM; Randolph, TW; Tseng, E; Wähälä, K	1
Alcorn, J; Krol, ES; Muir, AD; Mukker, JK; Singh, RS	1
Dikshit, A; Eilati, E; Gao, C; Gomes Filho, MA; Hales, DB; Klug, T; McGee, S; Small, C	1
Franke, AA; Hu, FB; Hu, Y; Song, Y; Sun, Q; van Dam, RM	1
Hori, S; Nakagawa, H; Sugahara, T; Tamura, M; Yamauchi, S	1
Aćimović, JM; Jovanović, VB; Mandić, LM; Pavićević, ID; Ristić-Medić, DK; Takić, MM; Uzelac, TN	1
Amaretti, A; García-Villalba, R; Leonardi, A; Quartieri, A; Raimondi, S; Rossi, M; Tomàs-Barberàn, F	1
Abarzua, S; Chrobak, M; Jeschke, U; Kuhn, C; Piechulla, B; Richter, DU; Schröder, L; Schulze, S; Weissenbacher, T	1
Brecchia, G; Cartoni Mancinelli, A; Castellini, C; Dal Bosco, A; Mattioli, S; Ruggeri, S; Sebastiani, B	1
Kawaguchi, K; Kiyama, R; Zhu, Y	1
Bao, HX; Gao, S; Gao, T; Hu, S; Johnston, RN; Li, QH; Li, T; Liu, H; Liu, J; Liu, SL; Liu, Y; Mastriani, E; Qi, Y; Shen, Z; Wang, H; Wang, S; Wang, X; Yu, M; Zeng, Z; Zhou, YJ	1
Brito, AF; Ghedini, CP; Moura, DC; Oliveira, AS; Whitehouse, NL	1
Balotra, S; Cahill, D; Kohler, HE; Lacey, MJ; Oakeshott, JG; Pandey, G; Rentsch, D; Shettigar, M; Warden, AC	1
Álvarez, AI; Alvarez-Fernández, I; Espín, JC; García-Mateos, D; García-Villalba, R; Merino, G; Otero, JA	1
Andreoli, R; Archetti, I; Biasiotto, G; Cadei, M; De Palma, G; Di Lorenzo, D; Luzzani, M; Monti, E; Mozzoni, P; Pacchetti, B; Predolini, F; Serana, F; Smeds, A; Zanella, I	1
Álvarez, I; Bravo, D; Gaya, P; Landete, JM; Peirotén, Á	1
Aura, AM; Bronze, M; Brunius, C; da Silva, AB; Eriksen, AK; Hålldin, E; Hanhineva, K; Landberg, R	1
Dong, X; Jiang, H; Sun, J; Wang, W; Zhang, D	1
Dhaini, J; Haykal, T; Hodroj, MH; Rizk, S; Tannous, S	1
Feng, X; Liu, L; Ma, CM; Xu, HY; Zhang, G; Zhang, L; Zheng, Z; Zhuang, CC	1
Alcorn, J; Guo, Y; Mustafa, R; Purdy, SK; Reaney, MJT; Shen, J; Tse, TJ; Yang, X	1

Reviews

4 review(s) available for 4-butyrolactone and 2,3-bis(3'-hydroxybenzyl)butane-1,4-diol

Article	Year
Mammalian phytoestrogens: enterodiol and enterolactone. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Sep-25, Volume: 777, Issue:1-2 Topics: 4-Butyrolactone; Female; Humans; Lignans; Male; Tumor Cells, Cultured	2002
Lignans and human health. Critical reviews in clinical laboratory sciences, 2007, Volume: 44, Issue:5-6 Topics: 4-Butyrolactone; Animals; Cardiovascular Diseases; Colorectal Neoplasms; Dietary Fiber; Edible Grain; Endometrial Neoplasms; Feeding Behavior; Female; Health Status; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Plants, Edible; Prostatic Neoplasms; Seeds; Vegetables	2007
[Phytoestrogenis properties of flaxseed lignans]. Voprosy pitaniia, 2012, Volume: 81, Issue:6 Topics: 4-Butyrolactone; Animals; Antioxidants; Flax; Humans; Lignans; Neoplasms, Experimental; Phytoestrogens	2012
Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans. Molecular nutrition & food research, 2019, Volume: 63, Issue:16 Topics: 4-Butyrolactone; Anti-Infective Agents; Body Mass Index; Female; Gastrointestinal Microbiome; Health Status; Humans; Lignans; Male; Nutrients	2019

Trials

10 trial(s) available for 4-butyrolactone and 2,3-bis(3'-hydroxybenzyl)butane-1,4-diol

Article	Year
Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutrition and cancer, 1995, Volume: 24, Issue:1 Topics: 4-Butyrolactone; Adult; Chromans; Colon; Cross-Over Studies; Diet; Equol; Female; Gas Chromatography-Mass Spectrometry; Genistein; Glycine max; Humans; Isoflavones; Lignans; Male; Sex Characteristics; Vegetables	1995
Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. Journal of the American Dietetic Association, 1995, Volume: 95, Issue:5 Topics: 4-Butyrolactone; Adult; Chromans; Cross-Over Studies; Defecation; Diet; Equol; Estrogens; Estrogens, Non-Steroidal; Fermentation; Food Handling; Genistein; Glycine max; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Plant Preparations; Taste	1995
Effect of flax seed ingestion on the menstrual cycle. The Journal of clinical endocrinology and metabolism, 1993, Volume: 77, Issue:5 Topics: 4-Butyrolactone; Adult; Diet; Estrogens; Female; Hormones; Humans; Lignans; Luteal Phase; Menstrual Cycle; Osmolar Concentration; Plants, Edible	1993
Human metabolism of mammalian lignan precursors in raw and processed flaxseed. The American journal of clinical nutrition, 1999, Volume: 69, Issue:3 Topics: 4-Butyrolactone; Administration, Oral; Adult; Body Mass Index; Cross-Over Studies; Dietary Fiber; Dose-Response Relationship, Drug; Double-Blind Method; Female; Flax; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Seeds; Time Factors	1999
Novel metabolites of the mammalian lignans enterolactone and enterodiol in human urine. The Journal of steroid biochemistry and molecular biology, 1999, Volume: 68, Issue:5-6 Topics: 4-Butyrolactone; Female; Flax; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Male; Molecular Structure; Seeds	1999
Effects of dietary phytoestrogens in postmenopausal women. Climacteric : the journal of the International Menopause Society, 1998, Volume: 1, Issue:2 Topics: 4-Butyrolactone; Aged; Bone Density; Diet; Double-Blind Method; Estrogens, Non-Steroidal; Female; Genistein; Glycine max; Hot Flashes; Humans; Isoflavones; Lignans; Linseed Oil; Middle Aged; Phytoestrogens; Plant Preparations; Postmenopause; Triticum	1998
Whole sesame seed is as rich a source of mammalian lignan precursors as whole flaxseed. Nutrition and cancer, 2005, Volume: 52, Issue:2 Topics: 4-Butyrolactone; Administration, Oral; Aged; Cross-Over Studies; Female; Flax; Humans; Lignans; Phytoestrogens; Postmenopause; Seeds; Sesamum	2005
The relative bioavailability of enterolignans in humans is enhanced by milling and crushing of flaxseed. The Journal of nutrition, 2005, Volume: 135, Issue:12 Topics: 4-Butyrolactone; Adolescent; Adult; Biological Availability; Cross-Over Studies; Diet; Dietary Supplements; Female; Flax; Food Handling; Humans; Lignans; Male; Middle Aged; Seeds	2005
Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. Journal of medicinal food, 2013, Volume: 16, Issue:4 Topics: 4-Butyrolactone; Aged; Antineoplastic Agents, Phytogenic; Biomarkers; Cell Proliferation; Dietary Supplements; Flax; Humans; Ki-67 Antigen; Lignans; Male; Middle Aged; Phytotherapy; Plant Extracts; Prostatic Neoplasms; Vascular Endothelial Growth Factor A	2013
Technical note: Quantification of lignans in the urine, milk, and plasma of flaxseed cake-fed dairy sheep. Journal of dairy science, 2021, Volume: 104, Issue:1 Topics: 4-Butyrolactone; Animal Feed; Animals; Butylene Glycols; Flax; Glucosides; Lignans; Milk; Seeds; Sheep	2021

Other Studies

95 other study(ies) available for 4-butyrolactone and 2,3-bis(3'-hydroxybenzyl)butane-1,4-diol

Article	Year
Mammalian lignan production from various foods. Nutrition and cancer, 1991, Volume: 16, Issue:1 Topics: 4-Butyrolactone; Animals; Bacteria; Butylene Glycols; Chromatography, Gas; Edible Grain; Fabaceae; Feces; Fermentation; Food; Fruit; Humans; Lignans; Lignin; Mammals; Plants, Edible; Plants, Medicinal; Seaweed; Vegetables	1991
Isotope dilution gas chromatographic-mass spectrometric method for the determination of lignans and isoflavonoids in human urine, including identification of genistein. Clinica chimica acta; international journal of clinical chemistry, 1991, Jul-15, Volume: 199, Issue:3 Topics: 4-Butyrolactone; Butylene Glycols; Chromans; Equol; Female; Furans; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Indicator Dilution Techniques; Isoflavones; Lignans; Lignin; Magnetic Resonance Spectroscopy; Male	1991
Phytoestrogens: new ligands for rat and human alpha-fetoprotein. Biochimica et biophysica acta, 1991, Sep-24, Volume: 1094, Issue:3 Topics: 4-Butyrolactone; Adult; alpha-Fetoproteins; Animals; Arachidonic Acid; Binding, Competitive; Butylene Glycols; Chromans; Equol; Estrogens; Estrogens, Non-Steroidal; Humans; Immunoelectrophoresis; Isoflavones; Ligands; Lignans; Masoprocol; Phytoestrogens; Plant Preparations; Rats; Rats, Inbred Strains	1991
Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR-75-1. Cancer investigation, 1990, Volume: 8, Issue:6 Topics: 4-Butyrolactone; Adenosine Triphosphatases; Animals; Benzyl Compounds; Breast Neoplasms; Butylene Glycols; Cell Division; Cell Line; Dogs; Dose-Response Relationship, Drug; Fluorouracil; Humans; Kidney Cortex; Lethal Dose 50; Lignans; Ouabain	1990
Production and metabolism of lignans by the human faecal flora. The Journal of applied bacteriology, 1985, Volume: 58, Issue:1 Topics: 4-Butyrolactone; Bacteria; Butylene Glycols; Clostridium; Feces; Humans; Lignans; Linseed Oil; Metronidazole; Plant Extracts	1985
Identification of lignans and phytoestrogens in urine of chimpanzees. Clinica chimica acta; international journal of clinical chemistry, 1986, Jul-30, Volume: 158, Issue:2 Topics: 4-Butyrolactone; Animals; Butylene Glycols; Chromans; Diet; Equol; Estrogens; Estrogens, Non-Steroidal; Isoflavones; Lignans; Male; Pan troglodytes; Phytoestrogens; Plant Extracts; Plant Preparations	1986
Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol. Breast cancer research and treatment, 1987, Volume: 10, Issue:2 Topics: 4-Butyrolactone; Benzopyrans; Breast Neoplasms; Butylene Glycols; Cell Division; Chromans; Equol; Estrogens; Female; Furans; Humans; Isoflavones; Lignans; Receptors, Progesterone; Tumor Cells, Cultured	1987
Lignan formation in man--microbial involvement and possible roles in relation to cancer. Lancet (London, England), 1981, Jul-04, Volume: 2, Issue:8236 Topics: 4-Butyrolactone; Bacteria; Butylene Glycols; Clostridium; Depression, Chemical; Female; Humans; Intestines; Lignans; Male; Menstruation; Metronidazole; Neoplasms; Oxytetracycline; Plant Extracts; Pregnancy	1981
Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet (London, England), 1982, Dec-11, Volume: 2, Issue:8311 Topics: 4-Butyrolactone; Aged; Benzopyrans; Breast Neoplasms; Butylene Glycols; Chromans; Diet; Diet, Vegetarian; Dietary Fiber; Energy Intake; Equol; Female; Furans; Humans; Isoflavones; Lignans; Menopause; Menstruation; Middle Aged; Plant Extracts	1982
Conjugation of lignans in human urine. FEBS letters, 1980, Dec-15, Volume: 122, Issue:1 Topics: 4-Butyrolactone; Adult; Age Factors; Butylene Glycols; Chromatography, Gas; Female; Furans; Glucuronates; Humans; Lignans; Male; Mass Spectrometry; Middle Aged; Plant Extracts; Pregnancy; Sex Factors	1980
The excretion of lignans in rats -- evidence for an intestinal bacterial source for this new group of compounds. FEBS letters, 1981, Jan-26, Volume: 123, Issue:2 Topics: 4-Butyrolactone; Animals; Bile; Butylene Glycols; Enterobacteriaceae; Enterohepatic Circulation; Female; Gas Chromatography-Mass Spectrometry; Germ-Free Life; Humans; Lignans; Male; Plant Extracts; Rats	1981
Origin of lignans in mammals and identification of a precursor from plants. Nature, 1982, Aug-12, Volume: 298, Issue:5875 Topics: 4-Butyrolactone; Animals; Biotransformation; Butylene Glycols; Diet; Enterobacteriaceae; Furans; Lignans; Plant Extracts; Rats; Seeds	1982
Capillary gas chromatographic method for the analysis of lignans in human urine. Clinica chimica acta; international journal of clinical chemistry, 1982, Jun-03, Volume: 121, Issue:3 Topics: 4-Butyrolactone; Adult; Butylene Glycols; Chromatography, Gas; Chromatography, Ion Exchange; Female; Gas Chromatography-Mass Spectrometry; Glucuronates; Humans; Lignans; Male; Middle Aged; Plant Extracts	1982
Measurement of enterolactone and enterodiol, the first mammalian lignans, using stable isotope dilution and gas chromatography mass spectrometry. Biomedical mass spectrometry, 1983, Volume: 10, Issue:3 Topics: 4-Butyrolactone; Adult; Animals; Butylene Glycols; Diet; Female; Furans; Gas Chromatography-Mass Spectrometry; Haplorhini; Humans; Hydrolysis; Lignans; Middle Aged	1983
The definitive identification of the lignans trans-2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol in human and animal urine. The Biochemical journal, 1981, Aug-01, Volume: 197, Issue:2 Topics: 4-Butyrolactone; Animals; Butylene Glycols; Chemical Phenomena; Chemistry; Chlorocebus aethiops; Chromatography, Gas; Chromatography, Thin Layer; Female; Furans; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pregnancy	1981
Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. The Journal of endocrinology, 1994, Volume: 142, Issue:2 Topics: 4-Butyrolactone; Australia; Chromans; Diet; Equol; Estrogens; Female; Food, Fortified; Gas Chromatography-Mass Spectrometry; Genistein; Glycine max; Humans; Isoflavones; Lignans; Linseed Oil; Middle Aged; Monoamine Oxidase Inhibitors; Neoplasms; Plants, Edible; Postmenopause	1994
Quantification of mammalian lignans in biological fluids using gas chromatography with ion mobility detection. Journal of chromatography, 1993, Aug-11, Volume: 617, Issue:2 Topics: 4-Butyrolactone; Adult; Animals; Body Fluids; Chromatography, Gas; Diet; Humans; Ions; Lignans; Male; Mammals; Spectrum Analysis	1993
Interactions between phytoestrogens and human sex steroid binding protein. Life sciences, 1996, Volume: 58, Issue:5 Topics: 4-Butyrolactone; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrogens, Non-Steroidal; Genistein; Humans; Immunoelectrophoresis, Two-Dimensional; Isoflavones; Kinetics; Lignans; Masoprocol; Phytoestrogens; Plant Preparations; Plants; Sex Hormone-Binding Globulin; Structure-Activity Relationship; Testosterone	1996
Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed. The Journal of nutrition, 1996, Volume: 126, Issue:8 Topics: 4-Butyrolactone; Animals; Butylene Glycols; Colon; Dietary Fiber; Female; Glycosides; In Vitro Techniques; Lignans; Lignin; Rats; Rats, Sprague-Dawley; Regression Analysis; Seeds	1996
Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong, and the United Kingdom. The Prostate, 1997, Jul-01, Volume: 32, Issue:2 Topics: 4-Butyrolactone; Adult; Aged; Chromans; Equol; Gas Chromatography-Mass Spectrometry; Hong Kong; Humans; Isoflavones; Lignans; Male; Middle Aged; Portugal; Prostate; Semen; United Kingdom	1997
Studies on the genotoxicity of the mammalian lignans enterolactone and enterodiol and their metabolic precursors at various endpoints in vitro. Mutation research, 1998, Aug-07, Volume: 416, Issue:1-2 Topics: 4-Butyrolactone; Aneuploidy; Animals; Bacteria; Butylene Glycols; Cattle; Cell Line; Cell-Free System; Cricetinae; Estrogens; Furans; Hypoxanthine Phosphoribosyltransferase; Intestinal Mucosa; Intestines; Lignans; Male; Micronucleus Tests; Microtubules; Mitosis; Mutagenicity Tests; Mutagens	1998
Reliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two-year period. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1998, Volume: 7, Issue:10 Topics: 4-Butyrolactone; Adult; Age Factors; Aged; Bias; Breast Neoplasms; Chromans; Equol; Feasibility Studies; Female; Genistein; Humans; Isoflavones; Lignans; Middle Aged; New York City; Pilot Projects; Postmenopause; Premenopause; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Time Factors	1998
Oxidative metabolism of the mammalian lignans enterolactone and enterodiol by rat, pig, and human liver microsomes. Journal of agricultural and food chemistry, 1999, Volume: 47, Issue:3 Topics: 4-Butyrolactone; Animals; Biotransformation; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Estrogens; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Lignans; Male; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Swine	1999
Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Molecular and cellular biochemistry, 1999, Volume: 202, Issue:1-2 Topics: 4-Butyrolactone; Animals; Antioxidants; Butylene Glycols; Emulsions; Estrogens; Flax; Free Radical Scavengers; Glucosides; Hydroxides; Lignans; Linoleic Acid; Lipid Peroxidation; Mammals; Oxidation-Reduction; Seeds	1999
Oxidative metabolites of the mammalian lignans enterodiol and enterolactone in rat bile and urine. Journal of agricultural and food chemistry, 2000, Volume: 48, Issue:7 Topics: 4-Butyrolactone; Animals; Bile; Female; Gas Chromatography-Mass Spectrometry; Lignans; Male; Oxidation-Reduction; Rats; Rats, Wistar	2000
Synthesis of enterolactone and enterodiol precursors as potential inhibitors of human estrogen synthetase (aromatase). Steroids, 2000, Volume: 65, Issue:8 Topics: 4-Butyrolactone; Aromatase Inhibitors; Catechols; Enzyme Inhibitors; Humans; Lignans; Phenols	2000
A novel treatment for lupus nephritis: lignan precursor derived from flax. Lupus, 2000, Volume: 9, Issue:6 Topics: 4-Butyrolactone; Animals; Blood Coagulation Factors; Flax; Humans; Lignans; Lupus Nephritis; Mice; Phytotherapy; Platelet Activating Factor; Seeds	2000
Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone. Chemical & pharmaceutical bulletin, 2000, Volume: 48, Issue:11 Topics: 4-Butyrolactone; Animals; Butylene Glycols; Culture Media; Estrogens; Eubacterium; Feces; Glucosides; Humans; Intestines; Lignans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Peptostreptococcus; Rats; Rats, Wistar	2000
Analytical performance of luminescent immunoassays of different format for serum daidzein analysis. Fresenius' journal of analytical chemistry, 2001, Volume: 370, Issue:1 Topics: 4-Butyrolactone; Cross Reactions; Dose-Response Relationship, Immunologic; Equilin; Female; Fluorescent Dyes; Genistein; Haptens; Horseradish Peroxidase; Humans; Immunoenzyme Techniques; Immunoglobulin Fc Fragments; Isoflavones; Lignans; Luminescent Measurements; Molecular Structure; Phenanthrolines; Polystyrenes; Radioimmunoassay; Serum Albumin, Bovine; Steroids	2001
In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. Journal of agricultural and food chemistry, 2001, Volume: 49, Issue:7 Topics: 4-Butyrolactone; Chromatography, High Pressure Liquid; Feces; Gas Chromatography-Mass Spectrometry; Lignans; Plant Extracts	2001
The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women. The Journal of nutrition, 2002, Volume: 132, Issue:10 Topics: 4-Butyrolactone; Adult; Aged; Breast Neoplasms; Case-Control Studies; Dose-Response Relationship, Drug; Female; Food Analysis; Genotype; Humans; Interviews as Topic; Lignans; Middle Aged; Odds Ratio; Premenopause; Risk Factors; Steroid 17-alpha-Hydroxylase	2002
Synthesis of (-)-matairesinol, (-)-enterolactone, and (-)-enterodiol from the natural lignan hydroxymatairesinol. Organic letters, 2003, Feb-20, Volume: 5, Issue:4 Topics: 4-Butyrolactone; Furans; Hydrogenation; Lignans; Picea; Stereoisomerism	2003
Quantification of isoflavones and lignans in urine using gas chromatography/mass spectrometry. Analytical biochemistry, 2003, Apr-01, Volume: 315, Issue:1 Topics: 4-Butyrolactone; Equol; Female; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Lignans; Molecular Structure; Phytoestrogens; Plant Preparations; Reproducibility of Results; Sensitivity and Specificity	2003
Identification of phytoestrogens in bovine milk using liquid chromatography/electrospray tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2003, Volume: 17, Issue:12 Topics: 4-Butyrolactone; Animals; Cattle; Chromans; Chromatography, Liquid; Coumestrol; Equol; Estrogens, Non-Steroidal; Genistein; Ions; Isoflavones; Lignans; Milk; Molecular Structure; Phytoestrogens; Plant Preparations; Spectrometry, Mass, Electrospray Ionization	2003
Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro. Breast cancer research and treatment, 2003, Volume: 80, Issue:2 Topics: 4-Butyrolactone; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Female; Humans; Lignans; Neoplasm Invasiveness; Neoplasm Metastasis; Phytotherapy; Receptors, Estrogen; Tamoxifen	2003
Dietary lignins are precursors of mammalian lignans in rats. The Journal of nutrition, 2004, Volume: 134, Issue:1 Topics: 4-Butyrolactone; Animals; Biological Availability; Cell Wall; Cellulases; Chromatography, Liquid; Deuterium; Diet; Gas Chromatography-Mass Spectrometry; Glycoside Hydrolases; Isoflavones; Lignans; Lignin; Male; Phytoestrogens; Plant Preparations; Rats; Rats, Wistar; Secale; Spectrometry, Mass, Electrospray Ionization; Triticum	2004
Determination of phytoestrogens in traditional medicinal herbs using gas chromatography--mass spectrometry. The Journal of nutritional biochemistry, 2004, Volume: 15, Issue:8 Topics: 4-Butyrolactone; Chemistry Techniques, Analytical; Fabaceae; Flavonoids; Gas Chromatography-Mass Spectrometry; Lignans; Phytoestrogens; Plants, Medicinal; Reproducibility of Results; Sensitivity and Specificity	2004
Uptake and metabolism of enterolactone and enterodiol by human colon epithelial cells. Archives of biochemistry and biophysics, 2005, Mar-01, Volume: 435, Issue:1 Topics: 4-Butyrolactone; Caco-2 Cells; Cell Line; Colon; HT29 Cells; Humans; Intestinal Mucosa; Lignans; Metabolic Clearance Rate	2005
Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside. The Journal of nutrition, 2005, Volume: 135, Issue:4 Topics: 4-Butyrolactone; Adult; Blood Specimen Collection; Butylene Glycols; Dietary Supplements; Female; Glucosides; Humans; Lignans; Male; Reference Values	2005
Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells. The Journal of steroid biochemistry and molecular biology, 2005, Volume: 94, Issue:5 Topics: 17-Hydroxysteroid Dehydrogenases; 4-Butyrolactone; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Estradiol; Female; Genistein; Humans; Lignans; Mammals; Phytoestrogens	2005
A validated method for the quantification of enterodiol and enterolactone in plasma using isotope dilution liquid chromatography with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Aug-05, Volume: 822, Issue:1-2 Topics: 4-Butyrolactone; Adult; Carbon Isotopes; Chromatography, Liquid; Drug Stability; Female; Humans; Lignans; Male; Mass Spectrometry; Middle Aged; Reproducibility of Results	2005
Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice. International journal of cancer, 2006, Mar-01, Volume: 118, Issue:5 Topics: 4-Butyrolactone; Animals; Apoptosis; Body Weight; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; Feeding Behavior; Genistein; Humans; Lignans; Mice; Mice, Nude; Neoplasms; Ovariectomy; Xenograft Model Antitumor Assays	2006
Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans. Applied and environmental microbiology, 2005, Volume: 71, Issue:10 Topics: 4-Butyrolactone; Actinobacteria; Adult; Bacteria, Anaerobic; Butylene Glycols; Colony Count, Microbial; Culture Media; Female; Flow Cytometry; Glucosides; Humans; In Situ Hybridization, Fluorescence; Intestines; Lignans; Male; Middle Aged; Peptostreptococcus; Phytoestrogens	2005
Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside. FEMS microbiology ecology, 2006, Volume: 55, Issue:3 Topics: 4-Butyrolactone; Bacteria, Anaerobic; Butylene Glycols; Culture Media; Glucosides; Humans; Intestines; Lignans; Phylogeny	2006
Plasma enterolactone and genistein and the risk of premenopausal breast cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2006, Volume: 15, Issue:3 Topics: 4-Butyrolactone; Adult; Breast Neoplasms; Case-Control Studies; Diet; Female; Genistein; Humans; Lignans; Middle Aged; Phytoestrogens; Plant Preparations; Premenopause; Risk Factors	2006
Plasma enterolignans are associated with lower colorectal adenoma risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Volume: 15, Issue:6 Topics: 4-Butyrolactone; Adenoma; Case-Control Studies; Chromatography, Liquid; Colorectal Neoplasms; Diet; Female; Humans; Incidence; Lignans; Middle Aged; Netherlands; Odds Ratio; Retrospective Studies; Spectrometry, Mass, Electrospray Ionization; Surveys and Questionnaires	2006
Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Feb-01, Volume: 13, Issue:3 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Endothelium, Vascular; Estradiol; Female; Flax; Humans; Lignans; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Phytoestrogens; Umbilical Veins; Vascular Endothelial Growth Factor A	2007
Relation between plasma enterodiol and enterolactone and dietary intake of lignans in a Dutch endoscopy-based population. The Journal of nutrition, 2007, Volume: 137, Issue:5 Topics: 4-Butyrolactone; Adenomatous Polyps; Adult; Aged; Case-Control Studies; Colonoscopy; Colorectal Neoplasms; Diet; Female; Humans; Lignans; Male; Middle Aged; Phytoestrogens	2007
Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:11 Topics: 4-Butyrolactone; Animals; Biphenyl Compounds; Butylene Glycols; Flax; Free Radical Scavengers; Glucosides; Hydrazines; Lignans; Liposomes; Mammals; Molecular Structure; Picrates; Seeds	2007
Enantioselective dehydroxylation of enterodiol and enterolactone precursors by human intestinal bacteria. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:11 Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biotransformation; Butylene Glycols; Eubacterium; Feces; Glucosides; Humans; Hydroxylation; Intestines; Lignans; Molecular Structure; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Stereoisomerism	2007
Enantioselective oxidation of enterodiol to enterolactone by human intestinal bacteria. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:11 Topics: 4-Butyrolactone; Chromatography, High Pressure Liquid; Chromatography, Liquid; Genes, Bacterial; Humans; Intestines; Lignans; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Ruminococcus; Sequence Analysis, RNA; Spectrophotometry, Ultraviolet; Stereoisomerism; Substrate Specificity	2007
Enterodiol and enterolactone, two major diet-derived polyphenol metabolites have different impact on ERalpha transcriptional activation in human breast cancer cells. The Journal of steroid biochemistry and molecular biology, 2008, Volume: 110, Issue:1-2 Topics: 4-Butyrolactone; Animals; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Estrogen Receptor alpha; Flavonoids; HeLa Cells; Humans; Lignans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenols; Phytoestrogens; Polyphenols; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation	2008
Effects of metabolites of the lignans enterolactone and enterodiol on osteoblastic differentiation of MG-63 cells. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:6 Topics: 4-Butyrolactone; Alkaline Phosphatase; Cell Differentiation; Cell Line; Cell Survival; Collagen Type I; Dose-Response Relationship, Drug; Humans; Lignans; Osteoblasts; Osteonectin; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transcription, Genetic	2008
Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. International journal of cancer, 2008, Sep-01, Volume: 123, Issue:5 Topics: 4-Butyrolactone; 9,10-Dimethyl-1,2-benzanthracene; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Butylene Glycols; Carcinogens; Cell Proliferation; Dietary Supplements; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Furans; Gene Expression Regulation, Neoplastic; Humans; Lignans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Ovariectomy; Phytoestrogens; Rats; Receptors, Progesterone; Transplantation, Heterologous	2008
Plasma enterolignans are not associated with nonfatal myocardial infarction risk. Atherosclerosis, 2009, Volume: 203, Issue:1 Topics: 4-Butyrolactone; Adult; Antioxidants; Cardiovascular Diseases; Case-Control Studies; Female; Humans; Lignans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Risk; Treatment Outcome	2009
In vitro metabolism of flax lignans by ruminal and faecal microbiota of dairy cows. Journal of applied microbiology, 2008, Volume: 105, Issue:5 Topics: 4-Butyrolactone; Animals; Cattle; Chromatography, High Pressure Liquid; Feces; Flax; Lignans; Plant Components, Aerial; Plant Extracts; Rumen; Seeds	2008
Milk concentration of the mammalian lignan enterolactone, milk production, milk fatty acid profile, and digestibility in dairy cows fed diets containing whole flaxseed or flaxseed meal. The Journal of dairy research, 2009, Volume: 76, Issue:3 Topics: 4-Butyrolactone; Animals; Butylene Glycols; Cattle; Diet; Digestion; Fatty Acids; Flax; Glucosides; Lactation; Lignans; Male; Milk; Seeds	2009
Occurrence of phytoestrogens in municipal wastewater and surface waters. Journal of environmental monitoring : JEM, 2009, Volume: 11, Issue:8 Topics: 4-Butyrolactone; Chromatography, Liquid; Coumestrol; Dairying; Environmental Monitoring; Fresh Water; Isoflavones; Lignans; Phytoestrogens; Spectrometry, Mass, Electrospray Ionization; Waste Disposal, Fluid; Water Pollutants, Chemical	2009
Bacterial transformation of dietary lignans in gnotobiotic rats. FEMS microbiology ecology, 2010, Volume: 72, Issue:3 Topics: 4-Butyrolactone; Animals; Biotransformation; Butylene Glycols; Cecum; Diet; Feces; Flax; Germ-Free Life; Gram-Positive Bacteria; Lignans; Rats; Rats, Sprague-Dawley	2010
Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB (NF-kappaB) signaling. Journal of agricultural and food chemistry, 2010, Jun-09, Volume: 58, Issue:11 Topics: 4-Butyrolactone; Cell Line; Cell Proliferation; Cells, Cultured; Humans; Immunologic Factors; Lignans; Lymphocytes; NF-kappa B; Signal Transduction; Tumor Necrosis Factor-alpha	2010
Human intestinal bacterium, strain END-2 is responsible for demethylation as well as lactonization during plant lignan metabolism. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:8 Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biotransformation; Butylene Glycols; Chromatography, High Pressure Liquid; Feces; Humans; Intestines; Lignans; Mass Spectrometry; Methylation; Molecular Structure; Stereoisomerism; Substrate Specificity	2010
Effect of combined lignan phytoestrogen and melatonin treatment on secretion of steroid hormones by adrenal carcinoma cells. American journal of veterinary research, 2011, Volume: 72, Issue:5 Topics: 4-Butyrolactone; Adrenal Glands; Animals; Aromatase; Cell Line; Cyclic AMP; Dogs; Humans; Lignans; Melatonin; Phytoestrogens; Steroids	2011
Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside. Applied microbiology and biotechnology, 2011, Volume: 92, Issue:1 Topics: 4-Butyrolactone; Bifidobacterium; Biotransformation; Butylene Glycols; Glucosides; Lignans	2011
Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20. Archives of gynecology and obstetrics, 2012, Volume: 285, Issue:4 Topics: 4-Butyrolactone; Anticarcinogenic Agents; Breast Neoplasms; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogens; Female; Furans; Humans; Lignans; Phytoestrogens; Selective Estrogen Receptor Modulators; Tamoxifen	2012
Urinary enterolignan concentrations are positively associated with serum HDL cholesterol and negatively associated with serum triglycerides in U.S. adults. The Journal of nutrition, 2012, Volume: 142, Issue:4 Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Cross-Sectional Studies; Dietary Fiber; Female; Humans; Lignans; Male; Middle Aged; Nutrition Surveys; Regression Analysis; Risk Factors; Triglycerides; United States; Young Adult	2012
The association between dietary lignans, phytoestrogen-rich foods, and fiber intake and postmenopausal breast cancer risk: a German case-control study. Nutrition and cancer, 2012, Volume: 64, Issue:5 Topics: 4-Butyrolactone; Aged; Breast Neoplasms; Carcinoma; Case-Control Studies; Cucurbita; Diet; Dietary Fiber; Female; Germany; Glycine max; Helianthus; Humans; Lignans; Middle Aged; Phytoestrogens; Postmenopause; Risk; Seeds	2012
Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells. The Journal of nutrition, 2012, Volume: 142, Issue:10 Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Butylene Glycols; Caco-2 Cells; Cell Differentiation; Chemokine CCL2; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Furans; Glucosides; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Intestines; Lignans; NF-kappa B; Plant Extracts; Signal Transduction	2012
Relationship of obesity and high urinary enterolignan concentrations in 6806 children and adults: analysis of National Health and Nutrition Examination Survey data. European journal of clinical nutrition, 2013, Volume: 67, Issue:8 Topics: 4-Butyrolactone; Adolescent; Adult; Bacteria; Biomarkers; Child; Female; Gastrointestinal Tract; Humans; Lignans; Logistic Models; Male; Microbiota; Obesity; Overweight; Risk Factors; Waist Circumference	2013
Bioaccessibility of lignans from flaxseed (Linum usitatissimum L.) determined by single-batch in vitro simulation of the digestive process. Journal of the science of food and agriculture, 2014, Volume: 94, Issue:9 Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biological Availability; Butylene Glycols; Colon; Fatty Acids, Volatile; Fermentation; Flax; Glucosides; Humans; In Vitro Techniques; Lignans; Seeds	2014
Higher urinary lignan concentrations in women but not men are positively associated with shorter time to pregnancy. The Journal of nutrition, 2014, Volume: 144, Issue:3 Topics: 4-Butyrolactone; Adolescent; Adult; Body Mass Index; Diet; Female; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Pregnancy; Prospective Studies; Socioeconomic Factors; Time-to-Pregnancy; Young Adult	2014
Permeability and conjugative metabolism of flaxseed lignans by Caco-2 human intestinal cells. Journal of natural products, 2014, Jan-24, Volume: 77, Issue:1 Topics: 4-Butyrolactone; Algorithms; Butylene Glycols; Caco-2 Cells; Chromatography, High Pressure Liquid; Flax; Glucosides; Humans; Intestinal Mucosa; Lignans; Molecular Structure; Permeability	2014
Urinary lignans and inflammatory markers in the US National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2008. Cancer causes & control : CCC, 2014, Volume: 25, Issue:3 Topics: 4-Butyrolactone; Adult; Aged; Biomarkers; C-Reactive Protein; Chronic Disease; Cross-Sectional Studies; Female; Humans; Inflammation; Leukocyte Count; Lignans; Male; Middle Aged; Nutrition Surveys; United States	2014
Gut microbiota metabolites of dietary lignans and risk of type 2 diabetes: a prospective investigation in two cohorts of U.S. women. Diabetes care, 2014, Volume: 37, Issue:5 Topics: 4-Butyrolactone; Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Diet; Female; Humans; Lignans; Microbiota; Middle Aged; Prospective Studies; Risk Factors	2014
Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro. European journal of nutrition, 2014, Volume: 53, Issue:8 Topics: 3T3-L1 Cells; 4-Butyrolactone; Adipocytes; Adipose Tissue; Adiposity; Animals; Cell Differentiation; Diet, High-Fat; Dietary Fats; Disease Models, Animal; Insulin Resistance; Lignans; Linseed Oil; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Sesame Oil	2014
Cardiometabolic risk factors are associated with high urinary enterolactone concentration, independent of urinary enterodiol concentration and dietary fiber intake in adults. The Journal of nutrition, 2014, Volume: 144, Issue:9 Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Dietary Fiber; Female; Humans; Lignans; Logistic Models; Male; Metabolic Syndrome; Middle Aged; Nutrition Surveys; Obesity; Odds Ratio; Phytoestrogens; Risk Factors; Triglycerides	2014
Gene expression profiling of sesaminol triglucoside and its tetrahydrofuranoid metabolites in primary rat hepatocytes. International journal of food sciences and nutrition, 2014, Volume: 65, Issue:8 Topics: 4-Butyrolactone; Animals; ATP-Binding Cassette Transporters; Cytochrome P-450 Enzyme System; Dioxoles; Furans; Gene Expression; Gene Expression Profiling; Glucosides; Hepatocytes; Inactivation, Metabolic; Lignans; Liver; Mammals; Plant Extracts; Rats, Sprague-Dawley; Seeds; Sesamum	2014
Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, Volume: 24, Issue:3 Topics: 4-Butyrolactone; Adult; Diet Records; Female; Gastrointestinal Tract; Humans; Lignans; Microbiota; Middle Aged; Phenotype; Premenopause; United States	2015
Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats. The British journal of nutrition, 2015, Mar-14, Volume: 113, Issue:5 Topics: 4-Butyrolactone; Administration, Oral; Animals; Biological Availability; Butylene Glycols; Dietary Supplements; Dose-Response Relationship, Drug; Estrogens; Flax; Glucosides; Half-Life; Injections, Intravenous; Intestinal Absorption; Kinetics; Lignans; Male; Metabolic Clearance Rate; Phytoestrogens; Random Allocation; Rats, Wistar; Seeds	2015
Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner. The British journal of nutrition, 2015, May-14, Volume: 113, Issue:9 Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Chickens; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP3A; Diet; Dietary Supplements; Dinoprostone; Estrogen Receptor alpha; Estrogens; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Flax; Hydroxyestrones; Lignans; Liver; Ovarian Neoplasms; Ovary; RNA, Messenger	2015
A Prospective Investigation of the Association Between Urinary Excretion of Dietary Lignan Metabolites and Weight Change in US Women. American journal of epidemiology, 2015, Sep-15, Volume: 182, Issue:6 Topics: 4-Butyrolactone; Adult; Aged; Body Weight; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Incidence; Lignans; Middle Aged; Prospective Studies; United States; Urinalysis	2015
Effects of an equol-producing bacterium isolated from human faeces on isoflavone and lignan metabolism in mice. Journal of the science of food and agriculture, 2016, Volume: 96, Issue:9 Topics: 4-Butyrolactone; Actinobacteria; Animals; Equol; Feces; Female; Gastrointestinal Microbiome; Humans; Isoflavones; Lignans; Lipids; Mice; Mice, Inbred ICR; Phytoestrogens	2016
Binding of enterolactone and enterodiol to human serum albumin: increase of cysteine-34 thiol group reactivity. Food & function, 2016, Volume: 7, Issue:2 Topics: 4-Butyrolactone; Antioxidants; Binding Sites; Cysteine; Humans; Lignans; Protein Binding; Serum Albumin; Spectrometry, Fluorescence; Sulfhydryl Compounds	2016
Detection of novel metabolites of flaxseed lignans in vitro and in vivo. Molecular nutrition & food research, 2016, Volume: 60, Issue:7 Topics: 4-Butyrolactone; Adult; Bifidobacterium pseudocatenulatum; Butylene Glycols; Dietary Supplements; Feces; Female; Flax; Furans; Gastrointestinal Microbiome; Glucosides; Humans; Intestinal Mucosa; Intestines; Lignans; Male; Middle Aged; Prebiotics; Probiotics; Young Adult	2016
Effects of Phytoestrogen Extracts Isolated from Elder Flower on Hormone Production and Receptor Expression of Trophoblast Tumor Cells JEG-3 and BeWo, as well as MCF7 Breast Cancer Cells. Nutrients, 2016, Oct-08, Volume: 8, Issue:10 Topics: 4-Butyrolactone; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Humans; Immunohistochemistry; Lignans; MCF-7 Cells; Phytoestrogens; Plant Extracts; Pregnancy; Progesterone; Receptors, Estrogen; Sambucus; Trophoblastic Neoplasms; Uterine Neoplasms	2016
Performance and egg quality of laying hens fed flaxseed: highlights on n-3 fatty acids, cholesterol, lignans and isoflavones. Animal : an international journal of animal bioscience, 2017, Volume: 11, Issue:4 Topics: 4-Butyrolactone; alpha-Linolenic Acid; Animal Feed; Animals; Butylene Glycols; Chickens; Cholesterol; Diet; Dietary Supplements; Eggs; Fatty Acids; Fatty Acids, Omega-3; Female; Flax; Isoflavones; Lignans; Phytoestrogens; Seeds	2017
Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. PloS one, 2017, Volume: 12, Issue:2 Topics: 4-Butyrolactone; Cell Cycle; Dioxoles; Estrogens; Furans; Gene Expression Profiling; Humans; Lignans; MCF-7 Cells; Oligonucleotide Array Sequence Analysis; Signal Transduction	2017
Enterolactone has stronger effects than enterodiol on ovarian cancer. Journal of ovarian research, 2017, Jul-24, Volume: 10, Issue:1 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Humans; Lignans; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Phytoestrogens; Tumor Burden; Wound Healing	2017
Short communication: The mammalian lignan enterolactone is absorbed by newborn dairy calves fed enterolactone-enriched milk. Journal of dairy science, 2017, Volume: 100, Issue:10 Topics: 4-Butyrolactone; Animal Feed; Animals; Animals, Newborn; Cattle; Diet; Humans; Lignans; Milk	2017
Isolation of the (+)-Pinoresinol-Mineralizing Pseudomonas sp. Strain SG-MS2 and Elucidation of Its Catabolic Pathway. Applied and environmental microbiology, 2018, 02-15, Volume: 84, Issue:4 Topics: 4-Butyrolactone; Benzaldehydes; Calcification, Physiologic; Furans; Gastrointestinal Microbiome; Humans; Lignans; Lignin; Metabolic Networks and Pathways; Minerals; Pseudomonas	2018
Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep. BMC veterinary research, 2018, Jan-15, Volume: 14, Issue:1 Topics: 4-Butyrolactone; Animal Feed; Animals; Anti-Bacterial Agents; Diet; Female; Flax; Fluoroquinolones; Food-Drug Interactions; Lignans; Milk; Seeds; Sheep	2018
7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet. The British journal of nutrition, 2018, Volume: 120, Issue:7 Topics: 3T3-L1 Cells; 4-Butyrolactone; Adipogenesis; Adipose Tissue; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Diet, High-Fat; Dietary Supplements; Fatty Liver; Gene Expression; Insulin Resistance; Lignans; Lipid Metabolism; Lipids; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Obesity; Picea; Plant Extracts	2018
Influence of different lignan compounds on enterolignan production by Bifidobacterium and Lactobacillus strains. International journal of food microbiology, 2019, Jan-16, Volume: 289 Topics: 4-Butyrolactone; Bifidobacterium; Diet; Humans; Lactobacillus; Lignans	2019
Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults. Nutrients, 2020, Jul-16, Volume: 12, Issue:7 Topics: 4-Butyrolactone; Adult; Age Factors; Aged; Biomarkers; Cross-Sectional Studies; Female; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Racial Groups; Sex Factors; Sleep; Sleep Wake Disorders	2020
The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 132 Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Apoptosis; Butylene Glycols; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Child; Female; Flax; Glucosides; Humans; Leukemia, Myeloid, Acute; Lignans; Plant Extracts; Reactive Oxygen Species; Seeds	2020
Oral Pharmacokinetics of Enriched Secoisolariciresinol Diglucoside and Its Polymer in Rats. Journal of natural products, 2021, 06-25, Volume: 84, Issue:6 Topics: 4-Butyrolactone; Animals; Biological Availability; Butylene Glycols; Female; Flax; Glucosides; Lignans; Molecular Structure; Polymers; Rats; Rats, Wistar; Seeds	2021