4-anisyltetrazolium-blue has been researched along with 3-nitropropionic-acid* in 1 studies
1 other study(ies) available for 4-anisyltetrazolium-blue and 3-nitropropionic-acid
| Article | Year |
|---|---|
Protective effect of S-allylcysteine on 3-nitropropionic acid-induced lipid peroxidation and mitochondrial dysfunction in rat brain synaptosomes.
3-Nitropropionic acid is a neurotoxin that irreversibly inhibits succinate dehydrogenase, a relevant enzyme constituting the complex II of the respiratory chain during mitochondrial electron transport. 3-Nitropropionic acid is known to produce oxidative/nitrosative stress and evokes an experimental model of Huntington's disease. In this work we evaluated the effects of the antioxidant compound and major organosulfur garlic derivative, S-allylcysteine, on lipid peroxidation and mitochondrial dysfunction induced by 3-nitropropionic acid in synaptosomal fractions from rat brain. 3-Nitropropionic acid, at concentrations ranging 0.75-2.5 mM, produced enhanced levels of lipid peroxidation, while increasing concentrations of S-allylcysteine (0.1-2 mM) decreased the peroxidative action of 3-nitropropionic acid (1 mM) in synaptosomal fractions in a concentration-dependent manner. S-Allylcysteine (0.75 mM) also prevented the 3-nitropropionic acid (1mM)-induced mitochondrial dysfunction. These findings suggest that the protective actions that S-allylcysteine exert on the in vitro neurotoxicity induced by 3-nitropropionic acid are mediated by its antioxidant properties. Topics: Animals; Brain; Cysteine; Dose-Response Relationship, Drug; Drug Interactions; Lipid Peroxidation; Male; Mitochondrial Diseases; Neuroprotective Agents; Nitro Compounds; Propionates; Rats; Rats, Wistar; Synaptosomes; Tetrazolium Salts; Thiobarbituric Acid Reactive Substances | 2006 |