Page last updated: 2024-08-24

4-aminoquinoline and chloroquine

4-aminoquinoline has been researched along with chloroquine in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (21.05)	18.7374
1990's	7 (12.28)	18.2507
2000's	20 (35.09)	29.6817
2010's	15 (26.32)	24.3611
2020's	3 (5.26)	2.80

Authors

Authors	Studies
Egan, TJ; Hunter, R; Kaschula, CH; Marques, HM; Misplon, A; Walden, J	1
Heering, J; Kilu, W; Merk, D; Ohrndorf, J; Willems, S	1
Bauchet, J; Hatin, I; Le Bras, J; Legros, F; Trape, JF	1
Brandling-Bennett, AD; Khan, B; Koech, DK; Ojoo, P; Oloo, AJ; Watkins, WM	1
Moreau, S; Veignie, E	1
Brandicourt, O; Carme, B; Gay, F; Gentilini, M; Le Bras, J; Mbitsi, A; Moudzeo, H; Ndounga, M; Sathounkazi, C	1
Fortier, B; Maalla, J; Moreau, S; Prensier, G	1
Lobel, HO; Roberts, JM; Somaini, B; Steffen, R	1
Panijpan, B; Ruenwongsa, P; Sirawaraporn, W; Yuthavong, Y	1
Charmot, G; Deloron, P; Le Bras, J	1
Juma, FD	1
Mack, RB	1
Peters, W	1
Dorn, A; Girometta, MA; Guenzi, A; Hofheinz, W; Huber, W; Jaquet, C; Jolidon, S; Masciadri, R; Matile, H; Peters, W; Richter, WF; Ridley, RG; Thaithong, S; Urwyler, H	1
Bray, PG; Hawley, SR; O'Neill, PM; Park, BK; Ward, SA	1
Capra, JD; Nguyen, TQ; Sontheimer, RD	1
Boelaert, JR; Giannulis, G; Leopardi, O; Ravagnani, F; Taramelli, D; Tognazioli, C	1
Lewis, RA; Lupski, JR; Shroyer, NF	1
Aktories, K; Bachmeyer, C; Barth, H; Benz, R; Gilbert, M; Popoff, MR	1
Benoit-Vical, F; Dechy-Cabaret, O; Meunier, B; Robert, A	1
Egan, TJ	1
Barkan, D; Deharo, E; Ginsburg, H; Golenser, J; Krugliak, M	1
CLYDE, DF; SHUTE, GT	1
ATDJIAN, M; HARRISON, JW; SCHERBEL, AL	1
SENSARMA, M	1
CAMERON, DG; MARCUS, DM; MILLER, MJ	1
Deady, LW; Kalkanidis, M; Klonis, N; Tilley, L; Tschan, S	1
Casey, GJ; Cowman, AF; Genton, B; Ginny, M; Mueller, I; Reeder, JC; Uranoli, M	1
Derisi, JL; Guy, RK; Liou, AP; Madrid, PB; Sherrill, J; Weisman, JL	1
Katti, SB; Puri, SK; Solomon, VR; Srivastava, K	1
Yielding, KL	1
Basilico, N; Novelli, F; Parapini, S; Romeo, S; Sparatore, A; Sparatore, F; Taramelli, D	1
Asadollaly, E; Berry, NG; Biagini, GA; Bray, PG; Jeyadevan, JP; O'Neill, PM; Park, BK; Ward, SA	1
Basilico, N; Brun, R; Casagrande, M; Parapini, S; Sparatore, A; Sparatore, F; Taramelli, D; Wittlin, S	1
Haq, W; Katti, SB; Puri, SK; Rajakumar, S; Smilkstein, M; Solomon, VR; Srivastava, K	1
Congpuong, K; Frank, C; Ley, B; Sirichaisinthop, J; Wernsdorfer, G; Wernsdorfer, WH	1
Borne, RF; Khan, MO; Khan, SI; Kimura, E; Levi, MS; Tekwani, BL	1
Chauhan, PM; Puri, SK; Rajakumar, S; Saxena, JK; Srivastava, K; Sunduru, N	1
Alumasa, J; de Dios, AC; Ekoue-Kovi, K; Iwaniuk, DP; Roepe, PD; Rosa, N; Whetmore, ED; Wolf, C	1
Fay, MP; Hayton, K; Reyes, S; Ringwald, P; Sá, JM; Twu, O; Wellems, TE	1
Khan, SI; Manohar, S; Rawat, DS	2
de Faria, DL; Menezes, CM; Otelo, VA; Sant'Ana, AC	1
De, D; Deng, H; Hocart, SJ; Krogstad, DJ; Krogstad, FM; Liu, H	1
Alihodžić, S; Ferrer, S; Herreros, E; Landek, G; Perić, M; Pešić, D; Spaventi, R; Starčević, K; Toplak, A	1
Aguiar, AC; Cortopassi, WA; Figueiredo, FJ; França, TC; Krettli, AU; Meneghetti, MR; Pimentel, AS; Santos, Rde M	1
Basilico, N; Bernetti, M; Bonache de Marcos, MC; Brogi, S; Brun, R; Butini, S; Caccia, S; Camodeca, C; Campiani, G; Gemma, S; Gorelli, B; Guiso, G; Joshi, BP; Lamponi, S; Martin, RE; Moretti, V; Novellino, E; Parapini, S; Rottmann, M; Sanna Coccone, S; Saponara, S; Savini, L; Summers, RL; Taramelli, D	1
Agarwal, P; Dola, VR; Haq, W; Katti, SB; Puri, SK; Sinha, M; Srivastava, K	1
Agarwal, P; Dola, VR; Haq, W; Katti, SB; Puri, SK; Sinha, M; Soni, A; Srivastava, K	1
Bohle, DS; Edaye, S; Georges, E; Tazoo, D	1
Agarwal, D; Alifrangis, M; Awasthi, SK; Gupta, RD; Nielsen, MA; Sharma, K; Sharma, M; Singh, AK; Singh, S	1
Barth, H; Beitzinger, C; Benz, R; Kronhardt, A	1
Gut, J; Kumar, V; Rani, A; Rosenthal, PJ; Singh, A	1
Berry, NG; Cooper, DL; Lawrenson, AS; O'Neill, PM	1
Agarwal, D; Awasthi, SK; Gupta, RD; Singh, S	1
Svensson, M	1
Chandrasekharan, SP; Dhami, A; Kumar, S; Mohanan, K; Nasreen, H; Shaham, SH; Sharma, A; Tripathi, R; Yadav, K	1

Reviews

6 review(s) available for 4-aminoquinoline and chloroquine

Article	Year
Biochemical aspects of drug action and resistance in malaria parasites. The Southeast Asian journal of tropical medicine and public health, 1985, Volume: 16, Issue:3 Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hemin; Plasmodium; Pyrimethamine; Sulfanilamides	1985
Practical therapeutics malaria chemoprophylaxis. East African medical journal, 1984, Volume: 61, Issue:3 Topics: Adult; Africa, Eastern; Aminoquinolines; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Sulfadoxine	1984
Antimalarial drug resistance: an increasing problem. British medical bulletin, 1982, Volume: 38, Issue:2 Topics: Aminoquinolines; Animals; Antimalarials; Aotus trivirgatus; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Mice; Microbial Sensitivity Tests; Plasmodium; Plasmodium falciparum; Plasmodium vivax; Primaquine; Quinine; Triazines	1982
4-Aminoquinolines--past, present, and future: a chemical perspective. Pharmacology & therapeutics, 1998, Volume: 77, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; DNA; Drug Design; Heme; Humans; Models, Molecular; Structure-Activity Relationship	1998
Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials. Mini reviews in medicinal chemistry, 2001, Volume: 1, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Hemoglobins; Humans; Malaria; Models, Molecular; Molecular Conformation; Plasmodium; Structure-Activity Relationship	2001
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs. Current topics in medicinal chemistry, 2006, Volume: 6, Issue:5 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chemical Phenomena; Chemistry, Physical; Chloroquine; Drug Resistance; Humans; Plasmodium falciparum; Structure-Activity Relationship	2006

Other Studies

51 other study(ies) available for 4-aminoquinoline and chloroquine

Article	Year
Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity. Journal of medicinal chemistry, 2000, Jan-27, Volume: 43, Issue:2 Topics: Aminoquinolines; Animals; Antimalarials; Hemin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plasmodium falciparum; Structure-Activity Relationship	2000
Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms. Journal of medicinal chemistry, 2021, 03-11, Volume: 64, Issue:5 Topics: Aminoquinolines; Astrocytes; Gene Expression; HEK293 Cells; Humans; Molecular Structure; Nuclear Receptor Subfamily 4, Group A, Member 2; Structure-Activity Relationship	2021
Susceptibility of Plasmodium falciparum strains to mefloquine in an urban area in Senegal. Bulletin of the World Health Organization, 1992, Volume: 70, Issue:3 Topics: Adolescent; Adult; Aminoquinolines; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; In Vitro Techniques; Infant; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum	1992
Plasmodium falciparum sensitivity to erythromycin and 4-aminoquinoline combinations in vitro. Annals of tropical medicine and parasitology, 1991, Volume: 85, Issue:2 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Interactions; Erythromycin; Plasmodium falciparum	1991
The mode of action of chloroquine. Non-weak base properties of 4-aminoquinolines and antimalarial effects on strains of Plasmodium. Annals of tropical medicine and parasitology, 1991, Volume: 85, Issue:2 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Erythrocytes; Mice; Microscopy, Immunoelectron; Plasmodium berghei; Structure-Activity Relationship	1991
[Plasmodium falciparum drug resistance in the Congo. Evaluation of surveys carried out from 1985 to 1989]. Bulletin de la Societe de pathologie exotique (1990), 1990, Volume: 83, Issue:2 Topics: Adolescent; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Congo; Drug Combinations; Drug Resistance; Humans; Infant; Malaria; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinine; Sulfadoxine	1990
Identification of distinct accumulation sites of 4-aminoquinoline in chloroquine sensitive and resistant Plasmodium berghei strains. European journal of cell biology, 1986, Volume: 42, Issue:2 Topics: Aminoquinolines; Animals; Cell Compartmentation; Chloroquine; Cytoplasmic Granules; Drug Resistance; Endocytosis; Plasmodium berghei	1986
Efficacy of malaria prophylaxis in American and Swiss travelers to Kenya. The Journal of infectious diseases, 1987, Volume: 155, Issue:6 Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Kenya; Malaria; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Sulfanilamides; Switzerland; Travel; United States	1987
Dichlorquinazine (alpha 4-aminoquinoline) effective in vitro against chloroquine-resistant Plasmodium falciparum. Lancet (London, England), 1983, Jan-01, Volume: 1, Issue:8314-5 Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Plasmodium falciparum	1983
4-aminoquinolines can be dangerous to your health: chloroquine (Aralen) intoxication. North Carolina medical journal, 1984, Volume: 45, Issue:4 Topics: Aminoquinolines; Antimalarials; Child; Child, Preschool; Chloroquine; Humans	1984
4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:8 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Malaria; Male; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Specific Pathogen-Free Organisms	1996
4-Aminoquinoline antimalarials enhance UV-B induced c-jun transcriptional activation. Lupus, 1998, Volume: 7, Issue:3 Topics: Aminoquinolines; Antimalarials; Chloroquine; Clone Cells; Humans; Proto-Oncogene Proteins c-jun; Recombinant Proteins; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Ultraviolet Rays	1998
Inhibition of intramacrophage growth of Penicillium marneffei by 4-aminoquinolines. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:5 Topics: Aminoquinolines; Animals; Antifungal Agents; Antimalarials; Chloroquine; Culture Media; Drug Interactions; Female; Humans; Hydrogen-Ion Concentration; Iron; Macrophages; Mice; Microbial Sensitivity Tests; Penicillium	2001
Analysis of the ABCR (ABCA4) gene in 4-aminoquinoline retinopathy: is retinal toxicity by chloroquine and hydroxychloroquine related to Stargardt disease? American journal of ophthalmology, 2001, Volume: 131, Issue:6 Topics: Aged; Aminoquinolines; ATP-Binding Cassette Transporters; Chloroquine; Genetic Predisposition to Disease; Humans; Hydroxychloroquine; Mutation, Missense; Polymorphism, Genetic; Reference Values; Retina; Retinal Diseases	2001
Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes and Vero cells: inhibition of channel function by chloroquine and related compounds in vitro and intoxification in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:9 Topics: Aminoquinolines; Animals; Antimalarials; Botulinum Toxins; Chlorocebus aethiops; Chloroquine; Drug Interactions; Lipid Bilayers; Membranes, Artificial; Osmolar Concentration; Vero Cells	2001
Preparation and antimalarial activities of "trioxaquines", new modular molecules with a trioxane skeleton linked to a 4-aminoquinoline. Chembiochem : a European journal of chemical biology, 2000, Nov-17, Volume: 1, Issue:4 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Citrates; Drug Resistance; In Vitro Techniques; Plasmodium falciparum; Sesquiterpenes; Structure-Activity Relationship	2000
Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels. Biochemical pharmacology, 2003, Sep-01, Volume: 66, Issue:5 Topics: Acetaminophen; Acetylcysteine; Aminoquinolines; Animals; Antimalarials; Chloroquine; Disulfiram; Drug Synergism; Glutathione; Indomethacin; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum	2003
4-Aminoquinoline prophylaxis of malaria amongst semi-immune African school children. The Central African journal of medicine, 1957, Volume: 3, Issue:12 Topics: Aminoquinolines; Antimalarials; Child; Chloroquine; Humans; Infant; Malaria	1957
Further observations on the use of 4-aminoquinoline compounds in patients with rheumatoid arthritis or related diseases. Cleveland Clinic quarterly, 1958, Volume: 25, Issue:2 Topics: Aminoquinolines; Arthritis; Arthritis, Rheumatoid; Chloroquine; Humans	1958
Toxic hazards of 4-aminoquinolines (chloroquine phosphate) in fever cases. Indian medical journal, 1962, Volume: 56 Topics: Aminoquinolines; Chloroquine; Humans; Hyperthermia, Induced	1962
LATENT INFECTIONS WITH PLASMODIUM OVALE MALARIA. Canadian Medical Association journal, 1965, Jun-12, Volume: 92 Topics: Africa, Western; Aminoquinolines; Canada; Chloroquine; Communicable Diseases; Diagnosis; Drug Therapy; Health Services Needs and Demand; Heart Failure; Hepatitis; Hepatitis A; Humans; Malaria; Malaria, Vivax; Male; Plasmodium; Plasmodium ovale; Preventive Medicine; Primaquine; Travel; Viral Vaccines	1965
Synergistic interaction of a chloroquine metabolite with chloroquine against drug-resistant malaria parasites. Biochemical pharmacology, 2004, Apr-01, Volume: 67, Issue:7 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Interactions; Drug Resistance; Drug Synergism; Hemeproteins; Hemin; Malaria; Parasitic Sensitivity Tests; Plasmodium falciparum	2004
Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea. The American journal of tropical medicine and hygiene, 2004, Volume: 70, Issue:3 Topics: Aminoquinolines; Amodiaquine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Papua New Guinea; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Treatment Failure	2004
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities. Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Resistance; Plasmodium falciparum; Structure-Activity Relationship	2005
Design and synthesis of new antimalarial agents from 4-aminoquinoline. Bioorganic & medicinal chemistry, 2005, Mar-15, Volume: 13, Issue:6 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Design; Drug Resistance; Hemin; Malaria; Mice; Microbial Sensitivity Tests; Molecular Structure; Plasmodium yoelii; Structure-Activity Relationship	2005
Inhibition of the replication of a bacterial DNA virus by chloroquine and other 4-aminoquinoline drugs. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 125, Issue:3 Topics: Aminoquinolines; Bacteria; Bacteriophage phi X 174; Chloroquine; Escherichia coli; Kinetics; Virus Replication	1967
4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity. Bioorganic & medicinal chemistry, 2005, Sep-15, Volume: 13, Issue:18 Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; Chloroquine; Mice; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Quinolizines	2005
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline. Bioorganic & medicinal chemistry letters, 2008, Jul-01, Volume: 18, Issue:13 Topics: Aminoquinolines; Animals; Antimalarials; Body Weight; Cell Line; Chloroquine; Humans; Malaria; Mice; Microsomes; Models, Chemical; Plasmodium berghei; Plasmodium falciparum; Pyrroles	2008
Synthesis and antimalarial activity of novel side chain modified antimalarial agents derived from 4-aminoquinoline. Medicinal chemistry (Shariqah (United Arab Emirates)), 2008, Volume: 4, Issue:5 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Inhibitory Concentration 50; Lysine; Ornithine; Parasitic Sensitivity Tests; Plasmodium falciparum; Solubility; Structure-Activity Relationship	2008
Pharmacodynamic interaction between 4-aminoquinolines and retinol in Plasmodium falciparum in vitro. Wiener klinische Wochenschrift, 2008, Volume: 120, Issue:19-20 Supp Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; In Vitro Techniques; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Thailand; Vitamin A; Vitamins	2008
Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:4 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Cyclams; Hemeproteins; Heterocyclic Compounds; Malaria; Male; Mice; Plasmodium berghei	2009
Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials. Bioorganic & medicinal chemistry letters, 2009, May-01, Volume: 19, Issue:9 Topics: Aminoquinolines; Animals; Antimalarials; Chemistry, Pharmaceutical; Chlorocebus aethiops; Chloroquine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Plasmodium falciparum; Plasmodium yoelii; Thiazolidinediones; Thiourea; Vero Cells	2009
Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain. Bioorganic & medicinal chemistry, 2009, Sep-15, Volume: 17, Issue:18 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Inhibitory Concentration 50; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum	2009
Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine. Proceedings of the National Academy of Sciences of the United States of America, 2009, Nov-10, Volume: 106, Issue:45 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Drug Resistance; Geography; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Protozoan Proteins; Quantitative Trait Loci; Selection, Genetic	2009
Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Hep G2 Cells; Humans; Plasmodium falciparum; Triazines; Vero Cells	2010
Molecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ). Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1 Topics: Aminoquinolines; Antimalarials; Chloroquine; Dibenzazepines; Hemin; Hydrogen-Ion Concentration; Imipramine; Molecular Dynamics Simulation; Plasmodium falciparum; Spectrophotometry, Ultraviolet	2011
4-aminoquinolines active against chloroquine-resistant Plasmodium falciparum: basis of antiparasite activity and quantitative structure-activity relationship analyses. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:5 Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship	2011
Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents. European journal of medicinal chemistry, 2012, Volume: 49 Topics: Aminoquinolines; Antimalarials; Azithromycin; Cell Line; Chloroquine; Humans; Macrolides; Malaria; Plasmodium falciparum	2012
Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites. PloS one, 2012, Volume: 7, Issue:5 Topics: Aminoquinolines; Animals; Antimalarials; Cell Line, Tumor; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Hemeproteins; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Malaria; Mice; Models, Molecular; Molecular Structure; Plasmodium berghei; Plasmodium falciparum; Protein Binding; Protein Conformation; Tetrazolium Salts; Thiazoles	2012
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 2012, Aug-09, Volume: 55, Issue:15 Topics: Aminoquinolines; Animals; Antimalarials; Biological Transport; Cell Line; Chloroquine; Clotrimazole; Drug Resistance; Female; Half-Life; Hemeproteins; Humans; Malaria; Male; Membrane Transport Proteins; Mice; Models, Molecular; Mutation; Oocytes; Piperazines; Plasmodium berghei; Plasmodium falciparum; Protozoan Proteins; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Ventricular Pressure; Xenopus laevis	2012
4-aminoquinoline-triazine-based hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum. Chemical biology & drug design, 2013, Volume: 81, Issue:5 Topics: Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Drug Resistance; Hep G2 Cells; Humans; Malaria, Falciparum; Plasmodium falciparum; Triazines; Vero Cells	2013
Antiplasmodial activity of new 4-aminoquinoline derivatives against chloroquine resistant strain. Bioorganic & medicinal chemistry, 2014, Jul-15, Volume: 22, Issue:14 Topics: Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Vero Cells	2014
Synthesis of chiral chloroquine and its analogues as antimalarial agents. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Malaria; Mice; Plasmodium falciparum; Plasmodium yoelii; Vero Cells	2014
3-Iodo-4-aminoquinoline derivative sensitises resistant strains of Plasmodium falciparum to chloroquine. International journal of antimicrobial agents, 2016, Volume: 47, Issue:6 Topics: Aminoquinolines; Antimalarials; Chloroquine; Halogenation; Humans; Plasmodium falciparum	2016
4-Aminoquinoline derivatives: Synthesis, in vitro and in vivo antiplasmodial activity against chloroquine-resistant parasites. European journal of medicinal chemistry, 2016, Oct-21, Volume: 122 Topics: Aminoquinolines; Animals; Antimalarials; Cell Line, Tumor; Chemistry Techniques, Synthetic; Chloroquine; Cost-Benefit Analysis; Drug Resistance; L-Lactate Dehydrogenase; Male; Mice; Molecular Docking Simulation; Plasmodium falciparum; Plasmodium vivax; Structure-Activity Relationship	2016
Chloroquine Analog Interaction with C2- and Iota-Toxin in Vitro and in Living Cells. Toxins, 2016, 08-10, Volume: 8, Issue:8 Topics: ADP Ribose Transferases; Aminoquinolines; Animals; Bacterial Toxins; Binding Sites; Biological Transport; Botulinum Toxins; Cell Membrane; Chlorocebus aethiops; Chloroquine; Lipid Bilayers; Mice; Molecular Structure; Protein Binding; Structure-Activity Relationship; Vero Cells	2016
Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. Chemical biology & drug design, 2017, Volume: 90, Issue:4 Topics: Aminoquinolines; Antimalarials; Chalcone; Chloroquine; Drug Resistance; Ferrous Compounds; HeLa Cells; Humans; Malaria, Falciparum; Piperazines; Plasmodium falciparum	2017
Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains. Journal of molecular modeling, 2018, Aug-17, Volume: 24, Issue:9 Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance; Machine Learning; Models, Molecular; Plasmodium falciparum	2018
In vitro synergistic interaction of potent 4-aminoquinolines in combination with dihydroartemisinin against chloroquine-resistant Plasmodium falciparum. Acta tropica, 2019, Volume: 199 Topics: Aminoquinolines; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Malaria, Falciparum; Plasmodium falciparum	2019
[Potential harms associated with 4-aminoquinoline treatment]. Lakartidningen, 2020, 04-23, Volume: 117 Topics: Aminoquinolines; Antimalarials; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; Humans; Hydroxychloroquine; Pandemics; Pneumonia, Viral; SARS-CoV-2	2020
Incorporation of Trifluoromethyltriazoline in the Side Chain of 4-Aminoquinolines: Synthesis and Evaluation as Antiplasmodial Agents. ChemMedChem, 2023, 06-01, Volume: 18, Issue:11 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Plasmodium falciparum	2023