4-aminopyridine has been researched along with pentylenetetrazole in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.68) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 10 (32.26) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Carcache, D; Kalkman, HO; Koller, M; Mattes, H | 1 |
| Baeyens, JM; Barrios, M; Del Pozo, E | 1 |
| Oyama, Y | 1 |
| Genovese, N; Klawans, HL | 1 |
| Aleman, V; de Muñoz, DM | 1 |
| Donevan, SD; Rogawski, MA; Yamaguchi, S | 1 |
| Duburs, G; Germane, SK; Karpova, MN; Klusha, VE; Pankov, OIu | 1 |
| Hu, PS; Ross, SB | 1 |
| Andersen, PH; Burns, CM; Chang, H; Crider, AM; el-Assadi, AA; Hinko, CN; Ho, B; Kliem, MA; Klitgaard, H; Seo, TH; Steinmiller, CL; Tietz, EI; Venkatarangan, P | 1 |
| De Vera, N; Giménez-Llort, L; Martínez, E | 1 |
| Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML | 1 |
| Berkovic, SF; Clark, M; Drago, J; Finkelstein, DI; Horne, MK; Massalas, JS; McColl, C; Powney, E; Ross, SA; Wong, JY | 1 |
| Armijo, JA; Bravo, J; Cuadrado, A | 1 |
| Nekrassov, V; Sitges, M | 1 |
| Amat, G; Armijo, JA; Cuadrado, A | 1 |
| Dimpfel, W | 1 |
| Henry, M; Hescheler, J; Kamp, M; Krieger, A; Radhakrishnan, K; Schneider, T; Weiergräber, M | 1 |
| Rensing, N; Rothman, SM; Thio, LL; Weisenfeld, AE; Wong, M; Xu, L; Yamada, KA; Yang, XF; Zhang, HX | 1 |
| Diano, S; Horvath, TL | 1 |
| Adamu, SS; Amos, S; Anuka, JA; Chindo, BA; Connelly, WK; Gamaniel, KS; Lees, G; McNeil, L; Yaro, AH | 1 |
| Bevan, SA; Hill, AJ; Jones, NA; Smith, I; Stephens, GJ; Whalley, BJ; Williams, CM | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Roman, SS; Wilhelm, EA | 1 |
| Haghdoost-Yazdi, H; Janahmadi, M; Rajaei, F | 1 |
| Ellis, LD; Seibert, J; Soanes, KH | 1 |
| Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M | 1 |
| Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J | 1 |
| Desalu, OO; Kolo, PM; Olarinoye, JK; Olatunji, LA; Sanya, EO; Soladoye, AO | 1 |
| Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER | 1 |
| Pavón Arocas, O; Reichert, S; Rihel, J | 1 |
| Lisgaras, CP; Mikroulis, A; Psarropoulou, C | 1 |
1 review(s) available for 4-aminopyridine and pentylenetetrazole
| Article | Year |
|---|---|
Pharmacology of dementia.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Aged; Aminopyridines; Central Nervous System Stimulants; Cerebrovascular Circulation; Clinical Trials as Topic; Dementia; Double-Blind Method; Humans; Levodopa; Nafronyl; Narcotic Antagonists; Nerve Tissue Proteins; Parasympathomimetics; Pentylenetetrazole; Physostigmine; Piracetam; Procainamide; Vasodilator Agents; Vasopressins | 1986 |
1 trial(s) available for 4-aminopyridine and pentylenetetrazole
| Article | Year |
|---|---|
Pharmacology of dementia.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Aged; Aminopyridines; Central Nervous System Stimulants; Cerebrovascular Circulation; Clinical Trials as Topic; Dementia; Double-Blind Method; Humans; Levodopa; Nafronyl; Narcotic Antagonists; Nerve Tissue Proteins; Parasympathomimetics; Pentylenetetrazole; Physostigmine; Piracetam; Procainamide; Vasodilator Agents; Vasopressins | 1986 |
30 other study(ies) available for 4-aminopyridine and pentylenetetrazole
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.
Topics: Analgesics; Animals; Anticonvulsants; Antipsychotic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Neuroprotective Agents; Protein Subunits; Receptors, AMPA | 2010 |
Effects of potassium channel openers on pentylenetetrazole-induced seizures in mice.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Cromakalim; Drug Antagonism; Female; Guanidines; Mice; Pentylenetetrazole; Pinacidil; Potassium Channels; Pyrroles; Seizures | 1990 |
Actions of convulsants, 4-aminopyridine and pentylenetetrazole, on the transient outward current of single isolated nodose ganglion neurons.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Convulsants; Ion Channels; Nodose Ganglion; Pentylenetetrazole; Rabbits; Vagus Nerve | 1987 |
Effect of different convulsant drugs on some seizure parameters in morphine-dependent mice.
Topics: 3-Mercaptopropionic Acid; 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; Brain; Convulsants; Humans; Mice; Morphine Dependence; Pentylenetetrazole; Receptors, Opioid; Seizures; Strychnine | 1983 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dihydropyridines; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electroshock; Epilepsies, Partial; Epilepsy, Generalized; Glutamates; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenobarbital; Rats; Rats, Wistar; Valproic Acid | 1993 |
NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
Topics: 4-Aminopyridine; Alanine; Animals; Behavior, Animal; Cerebellum; Convulsants; Cyclic GMP; Drug Interactions; Harmaline; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Selective Serotonin Reuptake Inhibitors; Valine | 1997 |
Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Anticonvulsants; Brain; Convulsants; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Molecular Structure; N-Methylaspartate; Neurotoxins; Nipecotic Acids; Pentylenetetrazole; Pipecolic Acids; Proline; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Seizures; Structure-Activity Relationship; Valproic Acid | 1996 |
Analysis of chemically-induced alterations of the motor activity in rats.
Topics: 4-Aminopyridine; Animals; Convulsants; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Wistar; Sodium Chloride; Status Epilepticus; Video Recording | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.
Topics: 4-Aminopyridine; Animals; Bicuculline; Binding, Competitive; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Genotype; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Potassium Channel Blockers; Receptors, GABA-A; Receptors, Nicotinic; Seizures; Strychnine | 2002 |
Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Synergism; Felbamate; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Lamotrigine; Mice; Pentylenetetrazole; Phenylcarbamates; Potassium Channel Blockers; Propylene Glycols; Rats; Seizures; Triazines | 2003 |
Effects of pentylenetetrazole and 4-aminopyridine on the auditory brainstem response (ABR) and on the hearing sensitivity in the guinea pig in vivo.
Topics: 4-Aminopyridine; Animals; Auditory Threshold; Convulsants; Electroencephalography; Epilepsy, Generalized; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hearing; Injections, Intraperitoneal; Male; Olivary Nucleus; Pentylenetetrazole; Reaction Time | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxicity Syndromes; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Reaction Time; Seizures; Toxicity Tests; Valproic Acid | 2003 |
Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Hesperidin; Hippocampus; In Vitro Techniques; Male; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tetraethylammonium | 2006 |
Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Calcium Channels; Calcium Channels, T-Type; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Electromyography; Genetic Predisposition to Disease; Hippocampus; Ion Channel Gating; Mice; Mice, Knockout; Pentylenetetrazole; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2006 |
Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents.
Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Convulsants; Hypothalamus; Janus Kinase 2; Leptin; Male; Mice; Mice, Knockout; Neurons; Pentylenetetrazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Leptin; Seizures; Synaptic Transmission | 2008 |
Anticonvulsant effects of leptin in epilepsy.
Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Convulsants; Hypothalamus; Janus Kinase 2; Leptin; Male; Mice; Mice, Knockout; Neurons; Pentylenetetrazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Leptin; Seizures; Synaptic Transmission | 2008 |
Anticonvulsant properties of saponins from Ficus platyphylla stem bark.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Cells, Cultured; Electroshock; Female; Ficus; Male; Membrane Potentials; Mice; Neurons; Pentylenetetrazole; Phytotherapy; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Saponins; Seizures; Strychnine | 2009 |
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Female; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Magnesium; Male; Pentylenetetrazole; Rats; Rats, Inbred WKY; Receptor, Cannabinoid, CB1; Seizures | 2010 |
Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Lipid Peroxidation; Male; Malonates; Mice; Nitroprusside; Organoselenium Compounds; Oxidative Stress; Pentylenetetrazole; Pilocarpine; Seizures; Thiobarbituric Acid Reactive Substances | 2010 |
Cerebellar Purkinje cells fire paroxysmal depolarization shift (PDS)-like events in response to epileptogenic drugs.
Topics: 4-Aminopyridine; Action Potentials; Animals; Bicuculline; Cerebellum; Convulsants; Male; Pentylenetetrazole; Purkinje Cells; Rats; Rats, Sprague-Dawley | 2011 |
Distinct models of induced hyperactivity in zebrafish larvae.
Topics: 4-Aminopyridine; Aconitine; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperkinesis; Neurons; Pentylenetetrazole; Zebrafish | 2012 |
The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Electroencephalography; Exploratory Behavior; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Sertraline; Vocalization, Animal | 2012 |
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Deficiency; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pilocarpine; Potassium; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Tissue Culture Techniques; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2014 |
Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats.
Topics: 4-Aminopyridine; Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Blood Glucose; Diet, Carbohydrate-Restricted; Diet, Ketogenic; Disease Models, Animal; Ketosis; Male; Pentylenetetrazole; Plant Oils; Rats, Wistar; Reaction Time; Seizures; Sodium; Strychnine; Sunflower Oil; Time Factors | 2017 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Combination; Ibuprofen; Indazoles; Male; Mice, Inbred Strains; Neurotoxins; Nitric Oxide; Pentylenetetrazole; Pilocarpine; Seizures; Thalidomide | 2018 |
The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity.
Topics: 4-Aminopyridine; Aconitine; Animals; Caffeine; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Galanin; Homeostasis; Mutation; Neurons; Pentylenetetrazole; Phosphorylation; Potassium Channel Blockers; Preoptic Area; Purinergic P1 Receptor Antagonists; Sleep; Sleep Deprivation; Voltage-Gated Sodium Channel Agonists; Wakefulness; Zebrafish | 2019 |
Region-specific Effects of Early-life Status Epilepticus on the Adult Hippocampal CA3 - Medial Entorhinal Cortex Circuitry In vitro: Focus on Interictal Spikes and Concurrent High-frequency Oscillations.
Topics: 4-Aminopyridine; Animals; Entorhinal Cortex; Hippocampus; Pentylenetetrazole; Rats; Status Epilepticus | 2021 |