4-aminopyridine has been researched along with lidocaine in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.71) | 18.7374 |
| 1990's | 12 (34.29) | 18.2507 |
| 2000's | 16 (45.71) | 29.6817 |
| 2010's | 5 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Sen, S; Sinha, N | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| del Balzo, U; Rosen, MR | 1 |
| Leung, LW; Yim, CY | 1 |
| Drachman, D; Strichartz, G | 1 |
| Hsiung, GR; Puil, E | 1 |
| Singh, BN; Takanaka, C | 1 |
| Bacaner, MB; Brochu, RM; Clay, JR; Shrier, A | 1 |
| Herlofson, BB; Røed, A | 1 |
| Ginkawa, M; Kontani, H; Sakai, T | 1 |
| Kim, M; Mistretta, CM | 1 |
| Geller, JC; Rosen, MR | 1 |
| Avoli, M; Lopantsev, V | 1 |
| Bencsics, A; Nakai, T; Sato, T; Uchihashi, Y; Umeda, E; Vizi, ES | 1 |
| Kubota, I; Tachibana, H; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S | 1 |
| Chung, JM; Chung, K; Liu, X; Zhou, JL | 1 |
| Barrionuevo, G; González-Burgos, G | 1 |
| Krüger, T; Lebek, S; Reichel, H; Wohlrab, D | 1 |
| Persaud, N; Strichartz, GR | 1 |
| Gocmen, C; Gunay, I; Gunes, Y; Guven, M; Mert, T | 1 |
| Daglioglu, YK; Gocmen, C; Gunay, I; Mert, T | 1 |
| Francis, NN; Kantrowitz, JT; Perkins, KL; Salah, A | 1 |
| Favorov, OV; Lee, J; Tommerdahl, M; Whitsel, BL | 1 |
| Costantin, J; Finkel, A; Handran, S; Hughes, J; Wittel, A; Yang, N | 1 |
| Gunay, I; Gunes, Y; Mert, T; Ozcengiz, D; Polat, S | 1 |
| Bae, YC; Hirai, T; Kang, Y; Maeda, Y; Saito, M; Sato, H; Toyoda, H | 1 |
| Gunay, I; Gunes, Y; Mert, T | 1 |
| Bocchi, L; Vassalle, M | 1 |
| Kitano, H; Shinohara, H; Zakir Hossain, SM | 1 |
| Baylor, K; Stecker, MM | 2 |
| Alves, Ade M; Araújo, DA; Cruz, JS; Gonçalves, JC | 1 |
| Akaike, N; Maeda, M; Mizuno, Y; Nonaka, K; Shin, MC; Shoudai, K; Wakita, M; Yamaga, T | 1 |
| Li, WC | 1 |
35 other study(ies) available for 4-aminopyridine and lidocaine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
T wave changes persisting after ventricular pacing in canine heart are altered by 4-aminopyridine but not by lidocaine. Implications with respect to phenomenon of cardiac 'memory'.
Topics: 4-Aminopyridine; Animals; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Female; Heart Conduction System; Lidocaine; Male; Potassium Channels; Time Factors | 1992 |
Intrinsic membrane potential oscillations in hippocampal neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Barium; Cadmium; Calcium; Choline; Evoked Potentials; Hippocampus; In Vitro Techniques; Interneurons; Ion Channels; Kinetics; Lidocaine; Male; Membrane Potentials; Neurons; Neurotoxins; Pyramidal Tracts; Rats; Rats, Inbred Strains; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1991 |
Potassium channel blockers potentiate impulse inhibition by local anesthetics.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Animals; Bupivacaine; Isotonic Solutions; Lidocaine; Membrane Potentials; Potassium Channels; Rana catesbeiana; Ringer's Solution; Sciatic Nerve; Solutions; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Ionic dependencies of tetrodotoxin-resistant action potentials in trigeminal root ganglion neurons.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Cisplatin; Doxorubicin; Electrodes; Guinea Pigs; In Vitro Techniques; Lidocaine; Neurons; Potassium Channels; Sodium; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Trigeminal Ganglion | 1990 |
Barucainide, a novel class Ib antiarrhythmic agent with a slow kinetic property: electrophysiologic observations in isolated canine and rabbit cardiac muscle.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Cobalt; Dogs; Female; Heart; In Vitro Techniques; Kinetics; Lidocaine; Male; Membrane Potentials; Purkinje Fibers; Pyridines; Rabbits | 1990 |
Potassium channel blockade: A mechanism for suppressing ventricular fibrillation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bethanidine; Bretylium Compounds; Cesium; Chickens; Decapodiformes; Dogs; Guanethidine; Ion Channels; Lidocaine; Methylguanidine; Procainamide; Tetraethylammonium Compounds; Ventricular Fibrillation | 1986 |
Inhibitory effects of HgCl2 on excitation-secretion coupling at the motor nerve terminal and excitation-contraction coupling in the muscle cell.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Caffeine; Calcium; Dantrolene; Diaphragm; Electric Stimulation; In Vitro Techniques; Lidocaine; Magnesium; Mercuric Chloride; Methylmercury Compounds; Motor Neurons; Muscle Contraction; Muscle, Skeletal; Nerve Endings; Phrenic Nerve; Potassium Chloride; Rats; Rats, Wistar; Ruthenium Red; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats.
Topics: 4-Aminopyridine; Anesthesia; Animals; Benzopyrans; Cromakalim; Glyburide; Ion Channels; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Vasodilator Agents | 1993 |
4-Aminopyridine reduces chorda tympani nerve taste responses to potassium and alkali salts in rat.
Topics: 4-Aminopyridine; Alkalies; Animals; Barium; Barium Compounds; Cesium; Chlorides; Chorda Tympani Nerve; Female; Lidocaine; Male; Potassium; Potassium Channels; Potassium Chloride; Quinidine; Rats; Rats, Sprague-Dawley; Rubidium; Sodium Chloride; Sucrose; Taste; Tetraethylammonium Compounds; Tongue | 1993 |
Persistent T-wave changes after alteration of the ventricular activation sequence. New insights into cellular mechanisms of 'cardiac memory'.
Topics: 4-Aminopyridine; Action Potentials; Adaptation, Physiological; Animals; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Female; Heart Conduction System; Lidocaine; Male; Potassium Channels; Time Factors | 1993 |
Participation of GABAA-mediated inhibition in ictallike discharges in the rat entorhinal cortex.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Neurons; Potassium Acetate; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1998 |
Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Cold Temperature; Hypoglycemia; Hypoxia; Ischemia; Lidocaine; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spinal Cord; Tetrodotoxin | 1998 |
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyramide; Dogs; Electrocardiography; Flecainide; Injections; Lidocaine; Piperidines; Pyridines; Sodium Channels; Ventricular Fibrillation; Verapamil | 1999 |
Ion channels associated with the ectopic discharges generated after segmental spinal nerve injury in the rat.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cadmium; Calcium Channel Blockers; Calcium Channels; Cobalt; Ion Channels; Ion Transport; Lidocaine; Ligation; Male; Nerve Fibers; Nerve Tissue Proteins; Neurons, Afferent; Neurotoxins; Potassium Channels; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Spinal Nerves; Synaptic Transmission; Tetrodotoxin | 2001 |
Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Cadmium; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ion Channel Gating; Lidocaine; Male; Nickel; Organ Culture Techniques; Potassium Channel Blockers; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Channels; Synapses; Tetraethylammonium; Tetrodotoxin | 2001 |
Influence of ion channels on the proliferation of human chondrocytes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Aminopyridine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adult; Aged; Calcium Channel Blockers; Cartilage, Articular; Cell Cycle; Cell Division; Chloride Channels; Chondrocytes; Female; Flow Cytometry; Humans; Ion Channel Gating; Lidocaine; Male; Membrane Potentials; Middle Aged; Osteoarthritis, Knee; Potassium Channel Blockers; Sodium Channel Blockers; Tetraethylammonium; Verapamil | 2002 |
Micromolar lidocaine selectively blocks propagating ectopic impulses at a distance from their site of origin.
Topics: 4-Aminopyridine; Action Potentials; Anesthetics, Local; Animals; Cnidarian Venoms; Electric Stimulation; Lidocaine; Potassium Channel Blockers; Rana catesbeiana; Rana pipiens; Sciatica; Tetrodotoxin | 2002 |
Differential effects of lidocaine and tramadol on modified nerve impulse by 4-aminopyridine in rats.
Topics: 4-Aminopyridine; Action Potentials; Analgesics, Opioid; Anesthetics, Local; Animals; Drug Interactions; Electric Stimulation; Electrophysiology; Female; Lidocaine; Neural Conduction; Potassium Channel Blockers; Rats; Rats, Wistar; Sciatic Nerve; Tramadol | 2003 |
Changes in electrophysiological properties of regenerating rat peripheral nerves after crush injury.
Topics: 4-Aminopyridine; Action Potentials; Animals; Electric Stimulation; Electrophysiology; Female; Lidocaine; Nerve Crush; Nerve Regeneration; Neural Conduction; Peripheral Nerves; Potassium Channel Blockers; Rats; Sciatic Neuropathy; Sodium Channel Blockers; Tetraethylammonium; Time Factors; Wounds and Injuries | 2004 |
Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Drug Interactions; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Potassium Channel Blockers; Propanolamines; Pyridazines; Receptors, GABA-A; Synaptic Transmission | 2005 |
Optically recorded response of the superficial dorsal horn: dissociation from neuronal activity, sensitivity to formalin-evoked skin nociceptor activation.
Topics: 4-Aminopyridine; Anesthetics; Animals; Animals, Newborn; Calcium; Diagnostic Imaging; Drug Interactions; Electric Stimulation; Evoked Potentials; Fluoroacetates; Formaldehyde; Functional Laterality; Glutamic Acid; In Vitro Techniques; Lidocaine; Posterior Horn Cells; Potassium; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Spinal Cord; Time Factors | 2005 |
Population patch clamp improves data consistency and success rates in the measurement of ionic currents.
Topics: 4-Aminopyridine; Animals; Cell Membrane Permeability; CHO Cells; Computer Simulation; Cricetinae; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kv1.3 Potassium Channel; Lidocaine; Models, Biological; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; Reproducibility of Results; Sodium Channels; Tetracaine | 2006 |
Comparative effects of lidocaine and tramadol on injured peripheral nerves.
Topics: 4-Aminopyridine; Action Potentials; Analgesics, Opioid; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Lidocaine; Neural Conduction; Neuralgia; Potassium Channel Blockers; Rats; Rats, Wistar; Sciatic Nerve; Sodium Channels; Time Factors; Tramadol | 2006 |
Involvement of persistent Na+ current in spike initiation in primary sensory neurons of the rat mesencephalic trigeminal nucleus.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Lidocaine; Neurons, Afferent; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Riluzole; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Trigeminal Nuclei | 2007 |
Role of 4-aminopyridine-sensitive potassium channels in peripheral antinociception.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Female; Lidocaine; Pain; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Receptors, Opioid, mu; Tramadol | 2007 |
Characterization of the slowly inactivating sodium current INa2 in canine cardiac single Purkinje cells.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Calcium; Dogs; Electric Stimulation; Kinetics; Lidocaine; Membrane Potentials; Nickel; Patch-Clamp Techniques; Potassium Channel Blockers; Purkinje Fibers; Sodium; Sodium Channels | 2008 |
Drug assessment based on detection of L-glutamate released from C6 glioma cells using an enzyme-luminescence method.
Topics: 4-Aminopyridine; Animals; Brain Neoplasms; Carbamazepine; Cell Line, Tumor; Enzymes; Flunarizine; Glioma; Glutamic Acid; Lidocaine; Luminescence; Nickel; Nifedipine; Rats; Veratridine | 2008 |
Peripheral nerve at extreme low temperatures 2: pharmacologic modulation of temperature effects.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cold Temperature; Electrophysiology; Lidocaine; Models, Biological; Neural Conduction; Neurons; Peripheral Nerves; Rats; Sodium; Sodium Channels; Synaptic Transmission; Temperature | 2009 |
Peripheral nerve at extreme low temperatures 1: effects of temperature on the action potential.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cold Temperature; Electrophysiology; Equipment Design; Lidocaine; Models, Biological; Neural Conduction; Neurons; Peripheral Nerves; Rats; Synaptic Transmission; Temperature | 2009 |
Evaluation of the sesquiterpene (-)-alpha-bisabolol as a novel peripheral nervous blocker.
Topics: 4-Aminopyridine; Action Potentials; Analgesics; Animals; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Lidocaine; Mice; Monocyclic Sesquiterpenes; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Sciatic Nerve; Sesquiterpenes; Sodium Channel Blockers | 2010 |
Potent and direct presynaptic modulation of glycinergic transmission in rat spinal neurons by atrial natriuretic peptide.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cyclic GMP; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Inhibitory Postsynaptic Potentials; Lidocaine; Neurons; Peptides, Cyclic; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Wistar; Spinal Cord; Thionucleotides | 2013 |
Selective Gating of Neuronal Activity by Intrinsic Properties in Distinct Motor Rhythms.
Topics: 4-Aminopyridine; Action Potentials; Anesthetics, Local; Animals; Ataxins; Central Pattern Generators; Excitatory Postsynaptic Potentials; Female; Gonadotropins; Humans; Lidocaine; Locomotion; Male; Nerve Tissue Proteins; Neural Inhibition; Periodicity; Potassium Channel Blockers; Sensory Gating; Swimming; Xenopus | 2015 |