Compounds > 4-aminopyridine

4-aminopyridine and leucine

4-aminopyridine has been researched along with leucine in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's2 (28.57)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cahalan, MD; Chandy, KG; DeCoursey, TE; Gupta, S; McLaughlin, C1
Gomolka, D; Handwerger, BS; Peppler, R; Weir, MR1
Bever, CT; Judge, SI; Monteiro, MJ; Yeh, JZ1
Bever, CT; Goolsby, JE; Judge, SI; Monteiro, MJ; Yeh, JZ1
Goldstein, PA; Harrison, NL; Homanics, GE; Werner, DF; Ying, SW1
Bremova, T; Feil, K; Muth, C; Schniepp, R; Strupp, M; Teufel, J1
Feil, K; Kalla, R; Muth, C; Strupp, M; Teufel, J1

Reviews

2 review(s) available for 4-aminopyridine and leucine

ArticleYear
Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus.
    Cerebellum (London, England), 2016, Volume: 15, Issue:1

    Topics: 4-Aminopyridine; Cerebellar Ataxia; Chlorzoxazone; Drug Therapy; Humans; Leucine; Muscle Relaxants, Central; Nystagmus, Pathologic; Potassium Channel Blockers

2016
Update on the pharmacotherapy of cerebellar and central vestibular disorders.
    Journal of neurology, 2016, Volume: 263 Suppl 1

    Topics: 4-Aminopyridine; Cerebellar Diseases; Humans; Leucine; Male; Nystagmus, Pathologic; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Vestibular Diseases

2016

Other Studies

5 other study(ies) available for 4-aminopyridine and leucine

ArticleYear
Voltage-gated potassium channels are required for human T lymphocyte activation.
    The Journal of experimental medicine, 1984, Aug-01, Volume: 160, Issue:2

    Topics: 4-Aminopyridine; Aminopyridines; Cell Line; Diltiazem; Electrophoresis, Polyacrylamide Gel; Humans; Interleukin-2; Ion Channels; Kinetics; Leucine; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Phytohemagglutinins; Potassium; Protein Biosynthesis; T-Lymphocytes; Thymidine; Verapamil

1984
Mechanisms responsible for inhibition of lymphocyte activation by agents which block membrane calcium or potassium channels.
    Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1

    Topics: 4-Aminopyridine; Adult; Calcium; Calcium Channels; Cell Cycle; Cell Survival; Cells, Cultured; DNA Replication; Gene Expression; Humans; Interleukin-2; Leucine; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Potassium Channels; Rubidium; Stereoisomerism; Thymidine; Uridine; Verapamil

1993
Inactivation gating and 4-AP sensitivity in human brain Kv1.4 potassium channel.
    Brain research, 1999, Jun-12, Volume: 831, Issue:1-2

    Topics: 4-Aminopyridine; Amino Acid Substitution; Brain; Humans; Ion Channel Gating; Kv1.4 Potassium Channel; Leucine; Membrane Potentials; Mutation; Patch-Clamp Techniques; Phenylalanine; Potassium Channels; Potassium Channels, Voltage-Gated

1999
Determinants of 4-aminopyridine sensitivity in a human brain kv1.4 k(+) channel: phenylalanine substitutions in leucine heptad repeat region stabilize channel closed state.
    Molecular pharmacology, 2002, Volume: 61, Issue:4

    Topics: 4-Aminopyridine; Amino Acid Substitution; Brain; Cells, Cultured; Cloning, Molecular; Humans; Kv1.4 Potassium Channel; Leucine; Mutagenesis; Phenylalanine; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Repetitive Sequences, Amino Acid

2002
Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.
    Neuropharmacology, 2009, Volume: 56, Issue:2

    Topics: 4-Aminopyridine; Action Potentials; Alanine; Anesthetics, Inhalation; Animals; Biophysics; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid; Histidine; Inhibitory Postsynaptic Potentials; Isoflurane; Leucine; Mice; Mice, Transgenic; Mutation; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Pyridazines; Receptors, GABA-A; Serine; Thalamus; Time Factors

2009