4-aminopyridine has been researched along with kainic acid in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Boegman, RJ; Ludwin, SK; Metcalf, R; Riopelle, RJ | 1 |
| Burnett, JP; Desai, MA; Schoepp, DD | 1 |
| Baraban, SC; Hochman, DW; Owens, JW; Schwartzkroin, PA | 1 |
| Boos, R; Schneider, H; Wässle, H | 1 |
| Donevan, SD; Rogawski, MA; Yamaguchi, S | 1 |
| Little, HJ; Watson, WP | 1 |
| Cramer, CL; Knowles, MA; Palmer, GC; Stagnitto, ML | 1 |
| De Vera, N; Giménez-Llort, L; Martínez, E | 1 |
| Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML | 1 |
| Perkinton, MS; Sihra, TS | 1 |
| Thio, LL; Wong, M; Yamada, KA | 1 |
| Hu, HJ; Pan, ZH | 1 |
| Carvalho, AP; Carvalho, CM; Malva, JO; Sequeira, SM | 1 |
| Berkovic, SF; Clark, M; Drago, J; Finkelstein, DI; Horne, MK; Massalas, JS; McColl, C; Powney, E; Ross, SA; Wong, JY | 1 |
| Buhl, EH; Hormuzdi, SG; LeBeau, FE; Monyer, H; Pais, I; Traub, RD; Whittington, MA; Wood, IC | 1 |
| Grebenyuk, S; Kirichok, Y; Krishtal, O; Lozovaya, N; Melnik, S; Tsintsadze, T | 1 |
| Nagashima, R; Ogita, K; Okuda, H; Sugiyama, C; Watanabe, M; Yoneda, Y | 1 |
| Derst, C; Gruber, C; Heinemann, U; Tolner, EA; Veh, RW; Zahn, RK | 1 |
| Baracskay, P; Czurkó, A; Juhász, G; Kékesi, KA; Kiglics, V | 1 |
| Bertsche, A; Bruehl, C; Draguhn, A; Pietz, J | 1 |
| Chu, K; Jeon, D; Jung, S; Kim, BS; Lee, SK; Yang, H | 1 |
| Bird, A; Cobb, SR; Ganley, R; McLeod, F; Selfridge, J; Williams, L | 1 |
| Huang, WJ; Lin, TY; Lu, CW; Wang, SJ; Wu, CC | 1 |
| Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Világi, I | 1 |
| Cao, Z; Cui, Y; Hulsizer, S; Lein, PJ; Pessah, IN; Wulff, H; Zou, X | 1 |
| Genov, R; Kassiri, H; Perez Velazquez, JL; Salam, MT | 1 |
| Chang, CY; Chou, SS; Huang, SK; Lin, TY; Lu, CW; Wang, SJ; Wang, YC | 1 |
| Ayata, C; Chung, DY; de Morais, AL; Endres, M; Loonen, ICM; Misra, A; Qin, T; Schiff, SJ; Schlunk, F; Tamim, I | 1 |
29 other study(ies) available for 4-aminopyridine and kainic acid
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Neurotoxicity of quinolinate in the rat nucleus basalis magnocellularis.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Basal Ganglia; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Kainic Acid; Magnesium; Male; Microinjections; Neural Pathways; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats | 1987 |
Cyclothiazide selectively potentiates AMPA- and kainate-induced [3H]norepinephrine release from rat hippocampal slices.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Drug Synergism; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Tritium; Veratridine | 1994 |
Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Entorhinal Cortex; Extracellular Space; Female; Furosemide; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; Membrane Potentials; Potassium; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Status Epilepticus; Synaptic Transmission | 1995 |
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cobalt; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium Channels; Quinoxalines; Rats; Receptors, Amino Acid; Retina; Retinal Ganglion Cells; Sodium Channels; Strychnine; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1993 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
Identification of distinct components, with different time courses, of the changes in response to convulsive stimuli during ethanol withdrawal.
Topics: 4-Aminopyridine; Aminophylline; Animals; Ethanol; Kainic Acid; Male; Mice; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1995 |
Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of anti-epileptic agents and calcium antagonists.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium Channel Blockers; Dizocilpine Maleate; Ion Channel Gating; Kainic Acid; Male; Mice; Seizures | 1994 |
Analysis of chemically-induced alterations of the motor activity in rats.
Topics: 4-Aminopyridine; Animals; Convulsants; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Wistar; Sodium Chloride; Status Epilepticus; Video Recording | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
A high-affinity presynaptic kainate-type glutamate receptor facilitates glutamate exocytosis from cerebral cortex nerve terminals (synaptosomes).
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Agonists; Exocytosis; Glutamic Acid; Kainic Acid; Male; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Synaptosomes | 1999 |
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission.
Topics: 3-Hydroxybutyric Acid; 4-Aminopyridine; Acetoacetates; Animals; Cells, Cultured; Diet; Entorhinal Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Agonists; Fasting; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Ketosis; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, GABA-A; Receptors, Glycine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synaptic Membranes; Synaptic Transmission | 2000 |
Voltage-dependent Na(+) currents in mammalian retinal cone bipolar cells.
Topics: 4-Aminopyridine; Animals; Bicuculline; Calcium; Cobalt; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Mammals; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Receptors, GABA; Retina; Retinal Cone Photoreceptor Cells; Sodium; Sodium Channels; Tetrodotoxin; Visual Pathways | 2000 |
Presynaptic N-methyl-D-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nitric Oxide; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Tritium | 2001 |
Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.
Topics: 4-Aminopyridine; Animals; Bicuculline; Binding, Competitive; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Genotype; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Potassium Channel Blockers; Receptors, GABA-A; Receptors, Nicotinic; Seizures; Strychnine | 2002 |
Sharp wave-like activity in the hippocampus in vitro in mice lacking the gap junction protein connexin 36.
Topics: 4-Aminopyridine; Action Potentials; Animals; Carbenoxolone; Connexins; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Gap Junction delta-2 Protein; Gap Junctions; Hippocampus; In Vitro Techniques; Interneurons; Kainic Acid; Male; Mice; Mice, Knockout; Neural Inhibition; Neural Pathways; Periodicity; Potassium Channel Blockers | 2003 |
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Dizocilpine Maleate; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Models, Neurological; N-Methylaspartate; Neural Inhibition; Neurons; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Synapses | 2004 |
In vivo treatment with the K+ channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Behavior, Animal; Blotting, Western; Cell Count; Cell Death; Dizocilpine Maleate; DNA, Single-Stranded; Drug Interactions; Endodeoxyribonucleases; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Neurons; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Staining and Labeling; Time Factors | 2005 |
Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats.
Topics: 4-Aminopyridine; Animals; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Entorhinal Cortex; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2008 |
Status epilepticus affects the gigantocellular network of the pontine reticular formation.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Shape; Electrodes, Implanted; Electroencephalography; Excitatory Amino Acid Agonists; Kainic Acid; Male; Muscarinic Agonists; Nerve Net; Neurons; Pilocarpine; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Reticular Formation; Seizures; Signal Processing, Computer-Assisted; Silver Staining; Status Epilepticus | 2009 |
Region- and pattern-specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neurons; Neurotransmitter Uptake Inhibitors; Rats; Rats, Wistar; Synaptic Transmission | 2010 |
The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Animals; Cyclosporine; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Immunosuppressive Agents; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Recurrence; Seizures | 2012 |
Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Waves; Disease Models, Animal; Excitatory Amino Acid Agonists; GABA-A Receptor Antagonists; Hippocampus; Kainic Acid; Methyl-CpG-Binding Protein 2; Mice; Nerve Net; Neurons; Potassium Channel Blockers; Rett Syndrome; Seizures | 2013 |
Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats.
Topics: 4-Aminopyridine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Death; Flavones; Glutamic Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Microglia; Nerve Endings; Neurons; Neurotoxins; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sodium; Synaptosomes | 2014 |
Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Benzodiazepines; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Protein Subunits; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 2015 |
Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Cells, Cultured; High-Throughput Screening Assays; Hippocampus; Kainic Acid; Lamotrigine; Mice, Inbred C57BL; Muscarinic Agonists; Nerve Net; Neurons; Potassium Channel Blockers; Receptors, Kainic Acid; Seizures; Triazines | 2015 |
Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms.
Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Electroencephalography Phase Synchronization; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Neurofeedback; Potassium Channel Blockers; Rats; Seizures | 2015 |
Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hesperidin; Hippocampus; Kainic Acid; Male; Membrane Potentials; Neuroprotective Agents; Neurotoxicity Syndromes; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptosomes; Tetrodotoxin | 2015 |
Spreading depression as an innate antiseizure mechanism.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Stem; Cortical Spreading Depression; Depression; Female; Gene Knock-In Techniques; Kainic Acid; Male; Mice; Nervous System; Optogenetics; Penicillins; Potassium Channel Blockers; Seizures; Tetrodotoxin | 2021 |