4-aminopyridine has been researched along with indomethacin in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 15 (46.88) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Sen, S; Sinha, N | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Ebong, OO; Zar, MA | 1 |
| Agrawal, R; Daniel, EE | 1 |
| Uchida, Y; Yoshinaka, Y | 1 |
| Driska, SP; Stein, PG | 1 |
| Horimoto, N; Nabekura, J; Ogawa, T | 1 |
| Edwards, G; Högestätt, ED; Larsson, B; Weston, AH; Zygmunt, PM | 1 |
| Ito, T; Mokuno, S; Murase, K; Okumura, K; Shinoda, M; Toki, Y | 1 |
| Besselsen, E; Breukel, AI; Ghijsen, WE; Lopes da Silva, FH | 1 |
| Grbović, L; Jovanović, A; Jovanović, S; Tulić, I | 1 |
| Caligiuri, G; Hansson, GK; Jiang, J; Pernow, J; Thorén, P | 1 |
| Cole, WC; Dong, H; Jiang, Y; Triggle, CR | 1 |
| Furue, M; Hirano, K; Kanaide, H; Nishimura, J; Ohnishi, Y | 1 |
| Boachie-Ansah, G; Grainger, J | 1 |
| El-Mahmoudy, A; Matsuyama, H; Shimizu, Y; Takewaki, T; Thapaliya, S | 1 |
| Berg, T | 1 |
| Cvetković, Z; Grbović, L; Nikolić, V; Pesić, S; Radenković, M; Stojić, D | 1 |
| Keum, EM; Kim, SC; Lee, MY; Myung, SC; Park, SY | 1 |
| Seyrek, M; Ulusoy, HB; Yildirim, V; Yildiz, O | 1 |
| Grbović, L; Pesić, S; Pesić, Z; Popović-Roganović, J; Radenković, M; Stojić, D | 1 |
| Bagcivan, I; Gursoy, S; Kaya Temiz, T; Turan, M; Yildirim, MK; Yildirim, S; Yilmaz, A | 1 |
| Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M | 1 |
| Basak, F; Cehreli, SB; Cehreli, ZC; Guven, G; Kaya, E; Seyrek, M; Ulku, C; Vural, IM; Yildiz, O | 1 |
| Chen, J; Chen, X; Liu, J; Wang, T; Xiao, H; Yang, J; Ye, Z; Yin, C | 1 |
| Achike, FI; Mustafa, MR; Subramaniam, G | 1 |
| Achike, FI; Tan, BT; Yeo, JL | 1 |
| Cehreli, ZC; Guven, G; Seyrek, M; Vural, IM; Yildiz, O | 1 |
| Ishii, K; Mori, A; Nakahara, T; Namekawa, R; Sakamoto, K | 1 |
| Sahinturk, S | 1 |
32 other study(ies) available for 4-aminopyridine and indomethacin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Failure of non-adrenergic transmission in the rat vas deferens.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Electric Stimulation; Epididymis; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Phentolamine; Potassium Chloride; Prostate; Rats; Rats, Inbred Strains; Reserpine; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens | 1989 |
Control of gap junction formation in canine trachea by arachidonic acid metabolites.
Topics: 4-Aminopyridine; 5,8,11,14-Eicosatetraynoic Acid; Aminopyridines; Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Carbachol; Catechols; Chromones; Dinoprostone; Dogs; Epoprostenol; Female; Indomethacin; Intercellular Junctions; Male; Masoprocol; Microscopy, Electron; Prostaglandins E; Serotonin; Trachea | 1986 |
Inhibition of 3,4-diaminopyridine-induced coronary oscillation by adenyl compounds.
Topics: 4-Aminopyridine; Adenine Nucleotides; Adenosine; Amifampridine; Aminophylline; Aminopyridines; Animals; Coronary Vessels; Dilazep; Dogs; Drug Interactions; In Vitro Techniques; Indomethacin; Membrane Potentials; Muscle, Smooth, Vascular | 1986 |
Histamine-induced rhythmic contraction of hog carotid artery smooth muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Carotid Arteries; Electrophysiology; Female; Histamine; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Endings; Norepinephrine; Ouabain; Potassium; Receptors, Histamine H1; Swine; Tetraethylammonium; Tetraethylammonium Compounds | 1984 |
Arachidonic acid activation of potassium channels in rat visual cortex neurons.
Topics: 4-Aminopyridine; Animals; Apamin; Arachidonic Acid; Barium; Charybdotoxin; Docosahexaenoic Acids; Egtazic Acid; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Quinidine; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetraethylammonium Compounds; Visual Cortex | 1997 |
Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Anti-Arrhythmia Agents; Apamin; Binding, Competitive; Biological Factors; Cerebral Cortex; Charybdotoxin; Chromans; Cyclooxygenase Inhibitors; Drug Interactions; Female; Hepatic Artery; Indoles; Indomethacin; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
Topics: 4-Aminopyridine; Adenosine Diphosphate; Animals; Apamin; Charybdotoxin; Glyburide; Hyperemia; In Vitro Techniques; Indomethacin; Male; Myocardial Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Potassium Channels; Rats; Rats, Wistar; Regional Blood Flow; Tetraethylammonium; Tetraethylammonium Compounds | 1997 |
Arachidonic acid inhibits uptake of amino acids and potentiates PKC effects on glutamate, but not GABA, exocytosis in isolated hippocampal nerve terminals.
Topics: 4-Aminopyridine; Adenosine Diphosphate; Adenosine Triphosphate; Amino Acids; Animals; Arachidonic Acid; Aspartic Acid; Biological Transport; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indomethacin; Kinetics; L-Lactate Dehydrogenase; Male; Masoprocol; Nerve Endings; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Sodium; Synaptosomes | 1997 |
Predominant role for nitric oxide in the relaxation induced by vasoactive intestinal polypeptide in human uterine artery.
Topics: 4-Aminopyridine; Adult; Arteries; Cyclooxygenase Inhibitors; Diethylcarbamazine; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Methylene Blue; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Potassium Channel Blockers; Receptors, Vasoactive Intestinal Peptide; Uterus; Vasoactive Intestinal Peptide; Vasodilation | 1998 |
Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Aorta; Arteriosclerosis; Calcium; Cholera Toxin; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Indomethacin; Ion Channel Gating; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Ouabain; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Ryanodine; Tetraethylammonium Compounds | 1999 |
Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Arachidonic Acids; Biological Factors; Cerebral Arteries; Charybdotoxin; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Ouabain; Oxadiazoles; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Vasodilation; Vasodilator Agents | 2000 |
Inhibitory effects of brefeldin A, a membrane transport blocker, on the bradykinin-induced hyperpolarization-mediated relaxation in the porcine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Animals; Apamin; Biological Factors; Bradykinin; Brefeldin A; Calcium; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Indomethacin; Male; Nitroarginine; Peptides; Potassium; Potassium Channel Blockers; Quaternary Ammonium Compounds; Substance P; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2001 |
Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Animals; Apamin; Arachidonic Acid; Arachidonic Acids; Barium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Receptors, Drug; Rimonabant; Sheep; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation | 2001 |
An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Apamin; Biological Factors; Charybdotoxin; Cricetinae; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Mesocricetus; Muscle, Smooth, Vascular; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ouabain; Pinacidil; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Synaptic Transmission; Tetraethylammonium; Time Factors; Triazines; Uridine Triphosphate; Vasodilator Agents | 2003 |
The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.
Topics: 4-Aminopyridine; Adrenalectomy; Adrenergic Antagonists; Amifampridine; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Indomethacin; Losartan; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Potassium Channel Blockers; Prazosin; Protein Kinase C; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Staurosporine; Sulfonamides; Vascular Resistance; Vasoconstriction | 2003 |
The relaxant effect of vasoactive intestinal polypeptide in the isolated canine uterine artery: the role of endothelium.
Topics: 4-Aminopyridine; Animals; Arteries; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; In Vitro Techniques; Indomethacin; Nitric Oxide; Potassium Channel Blockers; Uterus; Vasoactive Intestinal Peptide; Vasodilation; Vasodilator Agents | 2004 |
Vasomotor action of insulin on the rabbit normal cavernous smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Animals; Calcium Channels; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Insulin; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Penis; Potassium Channel Blockers; Potassium Channels; Prostaglandins; Prostaglandins H; Rabbits; Tetraethylammonium; Vasoconstrictor Agents | 2006 |
Testosterone relaxes isolated human radial artery by potassium channel opening action.
Topics: 4-Aminopyridine; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Humans; In Vitro Techniques; Indomethacin; NG-Nitroarginine Methyl Ester; Perfusion; Phenylephrine; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Potassium Chloride; Radial Artery; Testosterone; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation | 2007 |
Responses of the human submandibular artery to ACh and VIP.
Topics: 4-Aminopyridine; Acetylcholine; Adult; Arteries; Cholinergic Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Female; Humans; Indomethacin; Male; Middle Aged; Nitric Oxide Synthase; Nitroarginine; Potassium Channel Blockers; Submandibular Gland; Vasoactive Intestinal Peptide; Vasodilator Agents | 2007 |
Investigation of relaxant effects of propofol on sheep sphincter of Oddi.
Topics: 4-Aminopyridine; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Drug Combinations; Glyburide; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Propofol; Sheep; Sphincter of Oddi; Tetraethylammonium | 2007 |
Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed.
Topics: 4-Aminopyridine; Acetylcholine; Administration, Oral; Animals; Aorta; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Fructose; Glyburide; In Vitro Techniques; Indomethacin; Insulin; Insulin Resistance; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peptides; Phenylephrine; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Taurine; Tetraethylammonium; Vasoconstriction; Vasodilation | 2008 |
Vasorelaxant effect of a self-etch adhesive system through calcium antagonistic action.
Topics: 4-Aminopyridine; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dentin-Bonding Agents; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Glyburide; Indomethacin; Male; Materials Testing; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro.
Topics: 4-Aminopyridine; Animals; Benzylisoquinolines; Drugs, Chinese Herbal; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Nitroarginine; Oxadiazoles; Penis; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rabbits; Stephania tetrandra; Tetraethylammonium | 2009 |
Effect of acidosis on the mechanism(s) of insulin-induced vasorelaxation in normal Wistar-Kyoto (WKY) rat aorta.
Topics: 4-Aminopyridine; Acidosis; Animals; Aorta; Barium Compounds; Chlorides; Endothelium, Vascular; Glyburide; Hydrogen-Ion Concentration; Hypoglycemic Agents; Indomethacin; Insulin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Ouabain; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Inbred WKY; Tetraethylammonium; Vasoconstriction; Vasodilation | 2009 |
Exploring the mechanism of endothelial involvement in acidosis-induced vasodilatation of aortic tissues from normal and diabetic rats.
Topics: 4-Aminopyridine; Acidosis; Animals; Aorta; Barium Compounds; Chlorides; Diabetes Mellitus; Endothelium, Vascular; Glucose Clamp Technique; Glyburide; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Peptides; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation | 2010 |
Vasodilatory effect of hydroxyethyl methacrylate and triethylene glycol dimethacrylate in rat aorta through calcium antagonistic action.
Topics: 4-Aminopyridine; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium Chloride; Composite Resins; Cyclooxygenase Inhibitors; Dental Materials; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Male; Methacrylates; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Polyethylene Glycols; Polymethacrylic Acids; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Transducers; Vasoconstrictor Agents; Vasodilator Agents | 2011 |
4-Aminopyridine, a Voltage-Gated K
Topics: 4-Aminopyridine; Animals; Arterioles; Indomethacin; Male; Nitric Oxide; Potassium Channel Blockers; Rats, Wistar; Retinal Vessels; Vasodilation | 2020 |
Elabela relaxes rat pulmonary artery and trachea via BK
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Dideoxyadenosine; Endothelium, Vascular; Glyburide; Indomethacin; Male; Prostaglandins; Pulmonary Artery; Rats; Rats, Wistar; Trachea; Vascular Ring; Vasodilation; Vasodilator Agents | 2023 |