4-aminopyridine has been researched along with gamma-aminobutyric acid in 144 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (11.81) | 18.7374 |
| 1990's | 48 (33.33) | 18.2507 |
| 2000's | 45 (31.25) | 29.6817 |
| 2010's | 33 (22.92) | 24.3611 |
| 2020's | 1 (0.69) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Avoli, M; Perreault, P | 3 |
| Hofmann, HD; Huba, R; Schneider, H | 1 |
| Bijak, M; Brunner, H; Misgeld, U | 1 |
| Avoli, M; Siniscalchi, A | 1 |
| Black, JA; Kocsis, JD; Utzschneider, D | 1 |
| Fredholm, BB; Hu, PS; Jin, S | 1 |
| Carvalho, AP; Rodriguez, R; Santos, MS | 1 |
| Aram, JA; Michelson, HB; Wong, RK | 1 |
| Lazdunski, M; Schaeffer, P | 1 |
| Sherman, AD | 1 |
| Segal, M | 2 |
| Bernath, S; Zigmond, MJ | 1 |
| Gage, PW; Saint, DA; Thomas, T | 1 |
| Mitsoglou, GM; Padjen, AL | 1 |
| Zeise, M | 1 |
| Tapia, R | 1 |
| Massieu, L; Tapia, R | 1 |
| Liske, S; Morris, ME | 1 |
| Barker, JL; Schaffner, AE; St John, PA | 1 |
| Avoli, M; Olivier, A; Perreault, P; Villemure, JG | 1 |
| Morales, E; Sitges, M; Tapia, R | 1 |
| Jabbur, SJ; Saadé, N; Wall, PD | 1 |
| Bayón, A; Possani, LD; Sitges, M | 1 |
| Arzate, ME; Morán, J; Pasantes-Morales, H | 1 |
| Potapov, AA | 1 |
| Sitges, M; Tapia, R | 1 |
| Edman, A; Gestrelius, S; Grampp, W | 1 |
| Brailowsky, S; Knight, RT | 1 |
| Stone, TW | 1 |
| Galvan, M; Grafe, P; ten Bruggencate, G | 1 |
| Avoli, M; Fueta, Y; Siniscalchi, A; Tancredi, V | 1 |
| Malouf, AT; Ricciardi, TN | 1 |
| Boos, R; Schneider, H; Wässle, H | 1 |
| Avoli, M; Mattia, D; Perreault, P; Siniscalchi, A; Tomaiuolo, F | 1 |
| Bargas, J; Flores-Hernández, J; Galarraga, E; Pineda, JC | 1 |
| Bijak, M; Misgeld, U | 1 |
| Michelson, HB; Wong, RK | 1 |
| Avoli, M; Psarropoulou, C | 1 |
| Bijak, M; Demmelhuber, J; Jarolimek, W; Misgeld, U | 1 |
| Jarolimek, W; Misgeld, U | 1 |
| Eisig, M; Jaffé, E; Sevcik, C | 1 |
| Bragin, A; Buzsáki, G; Hsu, M; Mody, I; Otis, TS | 1 |
| Avoli, M; Barbarosie, M; Köhling, R; Lopantsev, V; Lücke, A; Nagao, T | 1 |
| Avoli, M; Morris, ME; Obrocea, GV | 1 |
| Barish, ME; Ichikawa, M; Iijima, T; Matsumoto, G; Tominaga, T | 1 |
| Chikwendu, A; McBain, CJ | 1 |
| Avoli, M; Köhling, R; Lücke, A; Mattia, D; Nagao, T | 1 |
| Avoli, M; Barbarosie, M; Köhling, R | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Yonekawa, WD | 1 |
| Bernardi, G; Calabresi, P; Mercuri, NB; Siniscalchi, A | 1 |
| Kaila, K; Lamsa, K | 1 |
| Besselsen, E; Breukel, AI; Ghijsen, WE; Lopes da Silva, FH | 1 |
| Dooley, DJ; Pugsley, TA; Whetzel, SZ | 1 |
| Himmelreich, NH; Pozdnyakova, NG; Storchak, LG | 1 |
| Ehmke, H; Jonas, P; Martina, M; Monyer, H; Schultz, JH | 1 |
| Avoli, M; Kawasaki, H; Methot, M | 1 |
| Bagley, EE; Christie, MJ; Connor, M; Ingram, SL; Vaughan, CW | 1 |
| Albuquerque, EX; Braga, MF; Pereira, EF | 1 |
| Jensen, K; Jensen, MS; Lambert, JD | 1 |
| Batini, C; Vigot, R | 1 |
| Kardos, J; Kovács, I; Nyitrai, G; Skuban, N | 1 |
| Schoppa, NE; Westbrook, GL | 1 |
| Thio, LL; Wong, M; Yamada, KA | 1 |
| Ahnert-Hilger, G; Draguhn, A; Grosse, G; Höhne, L; Tapp, R; Veh, RW | 1 |
| Coulter, DA; Gibbs, JW; Shumate, MD; Zhang, YF | 1 |
| Brückner, C; Heinemann, U | 1 |
| Hu, HJ; Pan, ZH | 1 |
| Bingmann, D; Bonnet, U; Hufnagel, A; Leniger, T; Wiemann, M | 1 |
| Peña, F; Tapia, R | 1 |
| Himmelreich, NH; Kravchuk, MV; Storchak, LG | 1 |
| Carvalho, AP; Carvalho, CM; Malva, JO; Sequeira, SM | 1 |
| Barna, B; Kuhnt, U; Siklós, L | 1 |
| Avoli, M; Devaux, B; Esposito, V; Kurcewicz, I; Louvel, J; Papatheodoropoulos, C; Pumain, R; Siniscalchi, A; Turak, B; Villemeure, JG | 1 |
| Bernardi, G; Federici, M; Mercuri, NB; Natoli, S | 1 |
| Zheng, LX | 1 |
| Himmelreich, NH; Linetska, MV; Storchak, LG | 1 |
| Hemmings, HC; Westphalen, RI | 2 |
| Armijo, JA; Bravo, J; Cuadrado, A | 1 |
| Buhl, EH; Hormuzdi, SG; LeBeau, FE; Monyer, H; Pais, I; Traub, RD; Whittington, MA; Wood, IC | 1 |
| Amat, G; Armijo, JA; Cuadrado, A | 1 |
| Abarca, C; Gutiérrez, Mdel C; Possani, LD | 1 |
| Namba, H; Nawa, H; Takei, N | 1 |
| Ge, SY; Gu, Y; Ruan, DY | 1 |
| Feuerstein, TJ; Freiman, TM; Surges, R | 1 |
| Fujita, T; Kumamoto, E; Yang, K | 1 |
| Cook, CJ | 1 |
| Boyd, JD; Davison, IG; Delaney, KR | 1 |
| Brown, JT; Collingridge, GL; Davies, CH; Randall, AD; Richardson, JC | 1 |
| Elovic, E; Lombard, L; Zafonte, R | 1 |
| Francis, NN; Kantrowitz, JT; Perkins, KL; Salah, A | 1 |
| DeFazio, RA; Hablitz, JJ | 1 |
| Asl, MN; Carlen, PL; Wong, T; Wu, CP; Zhang, L; Zhang, XL | 1 |
| Fukuda, S; Hisatsune, T; Namba, T; Seki, T; Tozuka, Y | 1 |
| Avruch, J; Lenz, G | 1 |
| Appel, SB; Koyama, S | 1 |
| Granados-Soto, V; Medina-Tato, DA; Ortiz, MI; Palma-Martínez, J; Sarmiento-Heredia, D | 1 |
| Arias-Montaño, JA; Garduño-Torres, B; Gutiérrez, R; Treviño, M | 1 |
| Carvalho, RA; Cunha, RA; Duarte, JM | 1 |
| Chen, Q; Pan, HL | 1 |
| Avoli, M; Sudbury, JR | 1 |
| Ben-Ari, Y; Represa, A; Rheims, S; Zilberter, Y | 1 |
| Jahn, K; Kalla, R; Rettinger, N; Spiegel, R; Strupp, M; Wagner, J | 1 |
| Goldstein, PA; Harrison, NL; Homanics, GE; Werner, DF; Ying, SW | 1 |
| Hou, X; Wang, X; Yang, B; Yu, G; Zhang, L; Zhou, J | 1 |
| Adesnik, H; Hull, C; Scanziani, M | 1 |
| Rode, DL; Rothman, SM; Schmidt, BF; Yang, XF | 1 |
| Fernández, M; Lao-Peregrín, C; Martín, ED | 1 |
| Markwardt, SJ; Overstreet-Wadiche, LS; Wadiche, JI | 1 |
| Halasy, K; Henderson, Z; Janzsó, G; Lu, CB; Matto, N; McKinley, CE; Yanagawa, Y | 1 |
| Engel, D; Seutin, V | 1 |
| Hemmings, HC; Jih, TY; Krivitski, M; Westphalen, RI; Yu, J | 1 |
| Ascoli, GA; Gasparini, S; Medinilla, V; Migliore, M | 1 |
| Kilb, W; Luhmann, HJ; Richter, D | 1 |
| Bateman, RJ; Mendelowitz, D; Philbin, KE | 1 |
| Canning, BJ; Mori, N | 1 |
| Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J | 1 |
| Lagrèze, WA; Pieh-Beisse, C | 1 |
| Beaumont, M; Maccaferri, G | 1 |
| Buhlman, L; Jin, G; Khan, GM; Lukas, RJ; McIntosh, JM; Nichols, RA; Whiteaker, P; Wu, J; Yang, K | 1 |
| He, D; Liu, WH; Liu, Y; Yin, XQ | 1 |
| Cid, MP; Roth, GA; Rupil, LL; Salvatierra, NA; Vilcaes, AA | 1 |
| Aldana, BI; Chiu, LM; Guarneros, A; Sanchez-Tafolla, BM; Sitges, M | 1 |
| Liu, WH; Liu, Y; Wang, SB; Yin, XQ; Yu, X | 1 |
| Desai, KM; Hemmings, HC; Westphalen, RI | 1 |
| Grosser, S; Lalchandani, RR; Queenan, BN; Vicini, S | 1 |
| Avoli, M; Lévesque, M; Manseau, F; Shiri, Z; Williams, S | 1 |
| Granger, AJ; Sabatini, BL; Saunders, A | 1 |
| Baselga, MJA; Capo, MA; Del Pino, J; Díaz, MJ; Frejo, MT; García, JM; Moyano, P | 1 |
| Avoli, M; Hamidi, S | 1 |
| Li, G; Liu, ZL; Yang, K; Zhang, WN | 1 |
| Baines, RA; Fan, YN; Masullo, L; Streit, AK | 1 |
| Berggren, M; Bernard, C; Inal, S; Jonsson, A; Kergoat, L; Khodagholy, D; Malliaras, GG; Rivnay, J; Simon, DT; Uguz, I; Williamson, AJ | 1 |
| Baldelli, P; Benfenati, F; Cappetti, B; Forte, N; Medrihan, L | 1 |
| Muthuchamy, M; Reddy, DS; Wu, X | 1 |
| Dodridge, CS; Evans, JR; Garcia-Finana, M; Hanna, K; Howard, C; Jarvis, KA; Maan, T; MacDiarmid, SL; Noonan, CP; North, L; Rodgers, H; Rowe, FJ | 1 |
| Derbenev, AV; Gao, H; Heesch, CM; Korim, WS; Yao, ST | 1 |
| Kaszas, A; Malliaras, GG; Proctor, CM; Slezia, A; Williamson, A | 1 |
| Avoli, M; Kfoury, C; Lévesque, M; Marion, A; Wang, S | 1 |
4 review(s) available for 4-aminopyridine and gamma-aminobutyric acid
| Article | Year |
|---|---|
Effects of drugs on neurotransmitter release: experiments in vivo and in vitro.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Cell Membrane Permeability; Edetic Acid; Egtazic Acid; gamma-Aminobutyric Acid; Lanthanum; Mice; Motor Activity; Neurotransmitter Agents; Ruthenium Red; Sodium; Substantia Nigra; Synapses; Synaptosomes; Veratridine | 1985 |
Antispasticity medications: uses and limitations of enteral therapy.
Topics: 4-Aminopyridine; Acetates; Adrenergic alpha-Agonists; Amines; Baclofen; Benzodiazepines; Cyclohexanecarboxylic Acids; Cyproheptadine; Dantrolene; Dronabinol; Gabapentin; gamma-Aminobutyric Acid; Glycine; Humans; Muscle Relaxants, Central; Muscle Spasticity; Neuroprotective Agents; Piracetam; Serotonin Antagonists | 2004 |
[Pharmacotherapy of central oculomotor disorders].
Topics: 4-Aminopyridine; Amifampridine; Amines; Baclofen; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Schedule; Gabapentin; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Memantine; Nystagmus, Pathologic; Vestibular Nuclei | 2008 |
Interventions for eye movement disorders due to acquired brain injury.
Topics: 4-Aminopyridine; Abducens Nerve Diseases; Amifampridine; Amines; Baclofen; Botulinum Toxins; Brain Injuries; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Neuromuscular Agents; Nystagmus, Pathologic; Ocular Motility Disorders; Randomized Controlled Trials as Topic; Vision, Binocular; Watchful Waiting | 2018 |
140 other study(ies) available for 4-aminopyridine and gamma-aminobutyric acid
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
4-aminopyridine-induced epileptiform activity and a GABA-mediated long-lasting depolarization in the rat hippocampus.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Cerebellar Nuclei; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Neurotransmitter; Synapses | 1992 |
Voltage-gated currents of putative GABAergic amacrine cells in primary cultures and in retinal slice preparations.
Topics: 4-Aminopyridine; Animals; Calcium Channels; Cells, Cultured; Chick Embryo; Cobalt; Electric Conductivity; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Neurons; Phenotype; Potassium Channels; Retina; Sodium Channels; Tetraethylammonium Compounds; Tetrodotoxin | 1992 |
Granule cell inhibition and the activity of hilar neurons.
Topics: 4-Aminopyridine; Animals; Axons; Baclofen; Dendrites; Evoked Potentials; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Neural Inhibition; Neural Pathways; Neurons; Picrotoxin; Potassium Channels; Receptors, GABA-A; Synapses | 1992 |
Modulation by GABAB receptors of spontaneous synchronous activities induced by 4-aminopyridine in the rat hippocampus.
Topics: 4-Aminopyridine; Animals; Baclofen; Dose-Response Relationship, Drug; Epilepsy; Evoked Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1992 |
Conduction properties of spinal cord axons in the myelin-deficient rat mutant.
Topics: 4-Aminopyridine; Animals; Axons; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyric Acid; Male; Membrane Potentials; Microscopy, Electron; Myelin Sheath; Neural Conduction; Rats; Rats, Mutant Strains; Reference Values; Spinal Cord; Tetrodotoxin | 1992 |
Glycine and GABA potentiate 4-aminopyridine and/or N-methyl-D-aspartate induced [3H]-noradrenaline release from rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Rats | 1992 |
Effect of depolarizing agents on the Ca(2+)-independent and Ca(2+)-dependent release of [3H]GABA from sheep brain synaptosomes.
Topics: 4-Aminopyridine; Animals; Brain; Calcium; gamma-Aminobutyric Acid; Membrane Potentials; Onium Compounds; Organophosphorus Compounds; Ouabain; Potassium Chloride; Sheep; Sodium Chloride; Synaptosomes; Veratridine | 1992 |
Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Synapses | 1991 |
Synchronized GABAergic IPSPs recorded in the neocortex after blockade of synaptic transmission mediated by excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Picrotoxin; Quinoxalines; Synapses; Synaptic Transmission | 1991 |
K+ efflux pathways and neurotransmitter release associated to hippocampal ischemia: effects of glucose and of K+ channel blockers.
Topics: 4-Aminopyridine; Animals; Apamin; Aspartic Acid; Barium; Barium Compounds; Brain Ischemia; Calcium Chloride; Charybdotoxin; Chlorides; Elapid Venoms; gamma-Aminobutyric Acid; Glipizide; Glucose; Glyburide; Hippocampus; In Vitro Techniques; Kinetics; Potassium; Potassium Channels; Rats; Rats, Inbred Strains; Rubidium; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Depolarization and synaptosomal glutamine utilization.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cell Fractionation; Centrifugation, Zonal; gamma-Aminobutyric Acid; Glutamine; Ibotenic Acid; Male; Potassium Chloride; Rats; Rats, Inbred Strains; Synaptosomes; Veratridine | 1991 |
A subset of local interneurons generate slow inhibitory postsynaptic potentials in hippocampal neurons.
Topics: 4-Aminopyridine; Action Potentials; Animals; Baclofen; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Interneurons; Neural Inhibition; Rats; Receptors, GABA-A | 1990 |
Calcium-independent GABA release from striatal slices: the role of calcium channels.
Topics: 4-Aminopyridine; Animals; Calcium; Calcium Channels; Corpus Striatum; gamma-Aminobutyric Acid; Magnesium; Male; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin; Verapamil | 1990 |
Serotonin attenuates a slow inhibitory postsynaptic potential in rat hippocampal neurons.
Topics: 4-Aminopyridine; 5,7-Dihydroxytryptamine; Administration, Topical; Animals; Baclofen; Electric Conductivity; Electrophysiology; Fenfluramine; gamma-Aminobutyric Acid; Hippocampus; Male; Neural Inhibition; Neurons; Rats; Rats, Inbred Strains; Serotonin; Synapses | 1990 |
GABAB agonists modulate a transient potassium current in cultured mammalian hippocampal neurons.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Baclofen; Cells, Cultured; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Neurons; Potassium Channels; Rats | 1990 |
Some characteristics of baclofen-evoked responses of primary afferents in frog spinal cord.
Topics: 4-Aminopyridine; Action Potentials; Animals; Baclofen; Barium; gamma-Aminobutyric Acid; In Vitro Techniques; Neurons, Afferent; Potassium; Rana pipiens; Spinal Cord; Tetrodotoxin | 1990 |
Taurine on hippocampal slices: comparison to GABA and glycine, and antagonism by 4-aminopyridine.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Chlorides; gamma-Aminobutyric Acid; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Ion Channels; Membrane Potentials; Neurotransmitter Agents; Taurine | 1985 |
Relationship of dihydropyridine binding sites with calcium-dependent neurotransmitter release in synaptosomes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Aminopyridines; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; gamma-Aminobutyric Acid; Ion Channels; Isradipine; Lanthanum; Male; Mice; Neurotransmitter Agents; Nifedipine; Nitrendipine; Oxadiazoles; Potassium; Receptors, Nicotinic; Ruthenium Red; Synaptosomes | 1988 |
Ionic mechanisms of action of GABA on dorsal and ventral root myelinated fibers: effects of K+ channel blockers.
Topics: 4-Aminopyridine; Animals; Barium; Barium Compounds; Cesium; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Motor Neurons; Neurons; Neurons, Afferent; Potassium; Potassium Channels; Rana catesbeiana; Tetraethylammonium Compounds | 1989 |
Fluorescence-activated cell sorting of embryonic mouse and rat motoneurons and their long-term survival in vitro.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Antibodies; Cell Separation; Cell Survival; Flow Cytometry; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Mice; Motor Neurons; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Time Factors | 1987 |
A depolarizing inhibitory postsynaptic potential activated by synaptically released gamma-aminobutyric acid under physiological conditions in rat hippocampal pyramidal cells.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Male; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses | 1988 |
4-Aminopyridine induces a long-lasting depolarizing GABA-ergic potential in human neocortical and hippocampal neurons maintained in vitro.
Topics: 4-Aminopyridine; Aminopyridines; Bicuculline; Cerebral Cortex; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Neurons | 1988 |
Mechanism of the calcium-dependent stimulation of transmitter release by 4-aminopyridine in synaptosomes.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Brain; Calcium; Choline; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred Strains; Neurotransmitter Agents; Sodium; Synaptosomes; Tetrodotoxin; Tritium | 1985 |
Effects of 4-aminopyridine, GABA and bicuculline on cutaneous receptive fields of cat dorsal horn neurons.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; Cats; gamma-Aminobutyric Acid; Neurons, Afferent; Sensation; Skin; Spinal Cord; Synaptic Transmission | 1985 |
Noxiustoxin, a short-chain toxin from the Mexican scorpion Centruroides noxius, induces transmitter release by blocking K+ permeability.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Brain; Cell Membrane Permeability; Electrophysiology; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Potassium; Scorpion Venoms; Synaptosomes | 1986 |
Inhibitory effect of taurine on 4-aminopyridine-stimulated release of labelled dopamine from striatal synaptosomes.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glycine; Rats; Rats, Inbred Strains; Synaptosomes; Taurine | 1986 |
[Pharmacologic study of the inhibition of the glomerular input to the olfactory tubercle of the frog induced by a puff of air on the olfactory mucosa].
Topics: 4-Aminopyridine; Aminooxyacetic Acid; Aminopyridines; Animals; beta-Alanine; Bicuculline; gamma-Aminobutyric Acid; Male; Neuroglia; Olfactory Bulb; Olfactory Mucosa; Physical Stimulation; Rana temporaria; Synaptic Transmission | 1987 |
Effect of 4-aminopyridine on transmitter release in synaptosomes.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Brain; Calcium; Culture Techniques; gamma-Aminobutyric Acid; Mice; Neurotransmitter Agents; Potassium; Stimulation, Chemical; Synaptic Transmission; Synaptosomes | 1982 |
Intracellular ion control in lobster stretch receptor neurone.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Cell Membrane Permeability; gamma-Aminobutyric Acid; Intracellular Fluid; Ion Channels; Ion Exchange; Mechanoreceptors; Models, Biological; Nephropidae; Neurons; Potassium; Sodium; Tetraethylammonium Compounds; Tetrodotoxin | 1983 |
Inhibitory modulation of cat somatosensory cortex: a pharmacological study.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; Cats; Evoked Potentials; Evoked Potentials, Somatosensory; Female; gamma-Aminobutyric Acid; Neural Inhibition; Picrotoxin; Somatosensory Cortex; Taurine | 1984 |
The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid.
Topics: 4-Aminopyridine; Adenosine; Aminopyridines; Animals; Calcium; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium Chloride; Quinidine; Tetraethylammonium Compounds; Vas Deferens | 1981 |
4-Aminopyridine reveals presynaptic GABA actions in rat sympathetic ganglia.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; gamma-Aminobutyric Acid; Ganglia, Sympathetic; Rats; Synapses | 1981 |
Extracellular magnesium and anticonvulsant effects of valproate in young rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Ionophores; Magnesium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1995 |
Differential effects of zinc on hyperpolarizing and depolarizing GABAA synaptic potentials in hippocampal slice cultures.
Topics: 4-Aminopyridine; Animals; Culture Techniques; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Zinc | 1995 |
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cobalt; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium Channels; Quinoxalines; Rats; Receptors, Amino Acid; Retina; Retinal Ganglion Cells; Sodium Channels; Strychnine; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1993 |
Pharmacology and electrophysiology of a synchronous GABA-mediated potential in the human neocortex.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Humans; Male; Piperazines; Tetrodotoxin | 1994 |
Patterns of excitatory and inhibitory synaptic transmission in the rat neostriatum as revealed by 4-AP.
Topics: 4-Aminopyridine; Animals; Calcium Channels; Culture Techniques; Female; gamma-Aminobutyric Acid; Interneurons; Male; Membrane Potentials; Neostriatum; Neural Inhibition; Neural Pathways; Neurons; Rats; Synaptic Transmission; Thalamic Nuclei | 1994 |
Role of glutamatergic synaptic transmission in synchronized discharges of hilar neurons in guinea pig hippocampal slices.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Neurons; Picrotoxin; Quinoxalines; Receptors, GABA-B; Receptors, Glutamate; Synaptic Transmission; Time Factors | 1993 |
Synchronization of inhibitory neurones in the guinea-pig hippocampus in vitro.
Topics: 4-Aminopyridine; Animals; Baclofen; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Microelectrodes; Neurons; Picrotoxin; Pyramidal Cells; Synaptic Transmission | 1994 |
4-Aminopyridine-induced spreading depression episodes in immature hippocampus: developmental and pharmacological characteristics.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cortical Spreading Depression; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1993 |
CGP 55845A blocks baclofen, gamma-aminobutyric acid and inhibitory postsynaptic potassium currents in guinea pig CA3 neurons.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Picrotoxin; Potassium Channels; Quinoxalines; Synapses | 1993 |
4-Aminopyridine-induced synaptic GABAB currents in granule cells of the guinea-pig hippocampus.
Topics: 4-Aminopyridine; Animals; Electric Conductivity; gamma-Aminobutyric Acid; Granulocytes; Guinea Pigs; Hippocampus; Neural Inhibition; Potassium; Receptors, GABA; Synapses; Synaptic Transmission | 1993 |
Effect of a toxin isolated from the sponge Haliclona viridis on the release of gamma-aminobutyric acid from rat olfactory bulb.
Topics: 4-Aminopyridine; Animals; Calcium; Dopamine; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Marine Toxins; Membranes; Olfactory Bulb; Porifera; Potassium; Rats; Rats, Sprague-Dawley; Sodium Channels; Valinomycin | 1993 |
GABAergic inhibition of granule cells and hilar neuronal synchrony following ischemia-induced hilar neuronal loss.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Survival; Dentate Gyrus; Electric Conductivity; Female; gamma-Aminobutyric Acid; Ischemia; Neural Inhibition; Neurons; Rats; Rats, Wistar; Synapses | 1995 |
Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Disease Models, Animal; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Limbic System; Male; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Piperazines; Potassium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists | 1996 |
Extracellular K+ accumulations and synchronous GABA-mediated potentials evoked by 4-aminopyridine in the adult rat hippocampus.
Topics: 4-Aminopyridine; Animals; Baclofen; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Potassium; Rats; Rats, Sprague-Dawley | 1996 |
Enhanced fast synaptic transmission and a delayed depolarization induced by transient potassium current blockade in rat hippocampal slice as studied by optical recording.
Topics: 4-Aminopyridine; Animals; Bicuculline; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glutamine; Hippocampus; In Vitro Techniques; Male; Microelectrodes; Optics and Photonics; Potassium; Presynaptic Terminals; Rats; Signal Transduction; Synapses; Synaptic Transmission; Time Factors | 1996 |
Two temporally overlapping "delayed-rectifiers" determine the voltage-dependent potassium current phenotype in cultured hippocampal interneurons.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Cells, Cultured; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Interneurons; Ion Channel Gating; Kinetics; Membrane Potentials; Neuroglia; Phenotype; Potassium Channels; Rats; Rats, Sprague-Dawley; Tetraethylammonium Compounds | 1996 |
Synchronization of rat hippocampal neurons in the absence of excitatory amino acid-mediated transmission.
Topics: 4-Aminopyridine; Animals; Electrophysiology; Excitatory Amino Acids; gamma-Aminobutyric Acid; Hippocampus; Male; Neurons; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors | 1996 |
Anoxia blocks the presynaptic control of GABA release at inhibitory terminals in the rat hippocampus.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Baclofen; Cell Hypoxia; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Neurons; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 1996 |
The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Nerve Tissue Proteins; Neurotransmitter Agents; Phenylenediamines; Rats; Rats, Inbred Strains; Tetrodotoxin | 1995 |
Epileptiform discharge induced by 4-aminopyridine in magnesium-free medium in neocortical neurons: physiological and pharmacological characterization.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Culture Media; Dendrites; Dopamine; Epilepsy; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Magnesium; Male; Membrane Potentials; Neocortex; Neurons; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1997 |
Ionic mechanisms of spontaneous GABAergic events in rat hippocampal slices exposed to 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Benzolamide; Bicarbonates; Carbonic Anhydrases; Enzyme Inhibitors; Ethoxzolamide; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Hippocampus; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Models, Neurological; Pentobarbital; Picrotoxin; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Receptors, Metabotropic Glutamate | 1997 |
Arachidonic acid inhibits uptake of amino acids and potentiates PKC effects on glutamate, but not GABA, exocytosis in isolated hippocampal nerve terminals.
Topics: 4-Aminopyridine; Adenosine Diphosphate; Adenosine Triphosphate; Amino Acids; Animals; Arachidonic Acid; Aspartic Acid; Biological Transport; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indomethacin; Kinetics; L-Lactate Dehydrogenase; Male; Masoprocol; Nerve Endings; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Sodium; Synaptosomes | 1997 |
Reduction of 3,4-diaminopyridine-induced biogenic amine synthesis and release in rat brain by gabapentin.
Topics: 4-Aminopyridine; 5-Hydroxytryptophan; Acetates; Amifampridine; Amines; Animals; Anticonvulsants; Biogenic Monoamines; Brain; Cyclohexanecarboxylic Acids; Dihydroxyphenylalanine; Dopamine; Gabapentin; gamma-Aminobutyric Acid; Male; Rats; Rats, Sprague-Dawley | 1998 |
Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Biological Transport; Brain Chemistry; Calcium; Carbon Radioisotopes; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Potassium Chloride; Rats; Sphingosine; Spider Venoms; Staurosporine; Sulfonamides; Synaptosomes | 1998 |
Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus.
Topics: 4-Aminopyridine; Action Potentials; Animals; Delayed Rectifier Potassium Channels; Electric Stimulation; gamma-Aminobutyric Acid; Gene Expression; Hippocampus; Interneurons; Ion Channel Gating; Kv1.1 Potassium Channel; Neuropeptides; Organ Culture Techniques; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pyramidal Cells; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Shal Potassium Channels; Shaw Potassium Channels; Tetraethylammonium; Transcription, Genetic | 1998 |
GABA-dependent generation of ectopic action potentials in the rat hippocampus.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Piperazines; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors | 1998 |
Enhanced opioid efficacy in opioid dependence is caused by an altered signal transduction pathway.
Topics: 4-Aminopyridine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Clonidine; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Tolerance; Elapid Venoms; Evoked Potentials; Excitatory Postsynaptic Potentials; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Potentiation; Narcotics; Neurons; Neurotoxins; Opioid-Related Disorders; Patch-Clamp Techniques; Periaqueductal Gray; Potassium Channels; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Signal Transduction; Synaptic Transmission | 1998 |
Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Edetic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kinetics; Lead; Membrane Potentials; Neurons; Patch-Clamp Techniques; Picrotoxin; Potassium Channels; Sodium Channels; Synaptic Transmission; Tetrodotoxin | 1999 |
Activity-dependent depression of GABAergic IPSCs in cultured hippocampal neurons.
Topics: 4-Aminopyridine; Animals; Calcium; Cells, Cultured; Chelating Agents; Egtazic Acid; Electric Stimulation; Evoked Potentials; Fetus; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Neurons; Organophosphorus Compounds; Phosphinic Acids; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Synaptic Transmission | 1999 |
Purkinje cell inhibitory responses to 3-APPA (3-aminopropylphosphinic acid) in RAT cerebellar slices.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Cerebellum; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Organophosphorus Compounds; Phosphinic Acids; Propanolamines; Purkinje Cells; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1999 |
Inhibition of [3H]D-aspartate release by deramciclane.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Aspartic Acid; Camphanes; Cell Membrane; Cerebral Cortex; Depression, Chemical; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Nerve Endings; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Wistar; Receptors, GABA-A; Tiagabine | 1999 |
Regulation of synaptic timing in the olfactory bulb by an A-type potassium current.
Topics: 4-Aminopyridine; Action Potentials; Animals; Dendrites; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Ion Channel Gating; Kinetics; Olfactory Bulb; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Sodium Channels; Synapses; Synaptic Transmission | 1999 |
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission.
Topics: 3-Hydroxybutyric Acid; 4-Aminopyridine; Acetoacetates; Animals; Cells, Cultured; Diet; Entorhinal Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Agonists; Fasting; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Ketosis; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, GABA-A; Receptors, Glycine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synaptic Membranes; Synaptic Transmission | 2000 |
Expression of Kv1 potassium channels in mouse hippocampal primary cultures: development and activity-dependent regulation.
Topics: 4-Aminopyridine; Animals; Axons; Botulinum Toxins, Type A; Cells, Cultured; Delayed Rectifier Potassium Channels; Dentate Gyrus; Fetus; gamma-Aminobutyric Acid; Kv1.1 Potassium Channel; Kv1.2 Potassium Channel; Kv1.3 Potassium Channel; Kv1.4 Potassium Channel; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred Strains; Microscopy, Electron; Nerve Tissue Proteins; Neuroglia; Neuromuscular Agents; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Pyramidal Cells; R-SNARE Proteins; Synaptosomal-Associated Protein 25; Tetanus Toxin; Tetrodotoxin | 2000 |
Regionally selective blockade of GABAergic inhibition by zinc in the thalamocortical system: functional significance.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Coloring Agents; Excitatory Amino Acid Antagonists; Extracellular Space; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Neurons; Patch-Clamp Techniques; Rats; Somatosensory Cortex; Subthalamic Nucleus; Thalamic Nuclei; Ventral Thalamic Nuclei; Zinc | 2000 |
Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamazepine; Entorhinal Cortex; Epilepsies, Partial; Female; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Male; Pentobarbital; Phenobarbital; Phenytoin; Prohibitins; Rats; Rats, Wistar; Valproic Acid | 2000 |
Voltage-dependent Na(+) currents in mammalian retinal cone bipolar cells.
Topics: 4-Aminopyridine; Animals; Bicuculline; Calcium; Cobalt; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Mammals; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Receptors, GABA; Retina; Retinal Cone Photoreceptor Cells; Sodium; Sodium Channels; Tetrodotoxin; Visual Pathways | 2000 |
Different effects of GABAergic anticonvulsants on 4-aminopyridine-induced spontaneous GABAergic hyperpolarizations of hippocampal pyramidal cells--implication for their potency in migraine therapy.
Topics: 4-Aminopyridine; Acetates; Amines; Analgesics; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Humans; Membrane Potentials; Migraine Disorders; Nipecotic Acids; Pyramidal Cells; Tiagabine; Time Factors; Valproic Acid; Vigabatrin | 2000 |
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Ion Channels; Male; Nerve Degeneration; Neurons; Neurotoxins; omega-Conotoxin GVIA; Potassium Channels; Rats; Rats, Wistar; Receptors, Glutamate; Riluzole; Seizures; Sodium Channel Blockers; Sodium Channels; Synaptic Transmission | 2000 |
Okadaic acid and cyclosporin A modulate [(3)H]GABA release from rat brain synaptosomes.
Topics: 4-Aminopyridine; Animals; Brain; Calcium; Cyclosporine; gamma-Aminobutyric Acid; Okadaic Acid; Rats; Spider Venoms; Synaptosomes; Tritium | 2001 |
Presynaptic N-methyl-D-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nitric Oxide; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Tritium | 2001 |
Chloride distribution in the CA1 region of newborn and adult hippocampus by light microscopic histochemistry.
Topics: 4-Aminopyridine; Age Factors; Animals; Animals, Newborn; Chlorides; Freeze Substitution; gamma-Aminobutyric Acid; Hippocampus; Histocytochemistry; Neural Inhibition; Potassium Channel Blockers; Pyramidal Cells; Rats; Rats, Wistar; Silver; Spectrum Analysis | 2001 |
GABA-mediated synchronization in the human neocortex: elevations in extracellular potassium and presynaptic mechanisms.
Topics: 4-Aminopyridine; Adult; Cortical Synchronization; Excitatory Amino Acid Antagonists; Extracellular Space; gamma-Aminobutyric Acid; Humans; Neocortex; Neural Inhibition; Potassium; Presynaptic Terminals; Receptors, GABA; Receptors, GABA-B; Receptors, Metabotropic Glutamate | 2001 |
Dopamine selectively reduces GABA(B) transmission onto dopaminergic neurones by an unconventional presynaptic action.
Topics: 4-Aminopyridine; Animals; Dopamine; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; gamma-Aminobutyric Acid; Hypoglycemic Agents; Levodopa; Male; Membrane Potentials; Neural Inhibition; Neurons; Organ Culture Techniques; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, GABA-B; Receptors, Presynaptic; Serotonin; Synaptic Transmission; Tolbutamide | 2002 |
[Effect of 4-aminopyridine on taurine-regulated release of amino acid from rat cortical synaptosomes].
Topics: 4-Aminopyridine; Animals; Aspartic Acid; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Synaptosomes; Taurine | 2001 |
Phenylarsine oxide inhibits alpha-latrotoxin-stimulated [3H]GABA release from rat brain synaptosomes.
Topics: 4-Aminopyridine; Animals; Arsenicals; Brain; Carrier Proteins; Cell Membrane; Cytosol; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Male; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Rats; Rats, Wistar; Spider Venoms; Synaptosomes; Tritium | 2003 |
Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals.
Topics: 4-Aminopyridine; Anesthetics, General; Animals; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Isoflurane; Male; Potassium; Rats; Rats, Sprague-Dawley; Synaptosomes | 2003 |
Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Synergism; Felbamate; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Lamotrigine; Mice; Pentylenetetrazole; Phenylcarbamates; Potassium Channel Blockers; Propylene Glycols; Rats; Seizures; Triazines | 2003 |
Sharp wave-like activity in the hippocampus in vitro in mice lacking the gap junction protein connexin 36.
Topics: 4-Aminopyridine; Action Potentials; Animals; Carbenoxolone; Connexins; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Gap Junction delta-2 Protein; Gap Junctions; Hippocampus; In Vitro Techniques; Interneurons; Kainic Acid; Male; Mice; Mice, Knockout; Neural Inhibition; Neural Pathways; Periodicity; Potassium Channel Blockers | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxicity Syndromes; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Reaction Time; Seizures; Toxicity Tests; Valproic Acid | 2003 |
A toxic fraction from scolopendra venom increases the basal release of neurotransmitters in the ventral ganglia of crustaceans.
Topics: 4-Aminopyridine; Animals; Arthropod Venoms; Calcium; Crustacea; Electrophoresis, Polyacrylamide Gel; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Glutamic Acid; Neurotransmitter Agents; Tetrodotoxin | 2003 |
Transforming growth factor-alpha changes firing properties of developing neocortical GABAergic neurons by down-regulation of voltage-gated potassium currents.
Topics: 4-Aminopyridine; Action Potentials; Anesthetics, Local; Animals; Cadmium; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; gamma-Aminobutyric Acid; Gene Expression Regulation; Humans; Neocortex; Neurons; Organ Culture Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyramidal Cells; Rats; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Shab Potassium Channels; Tetrodotoxin; Transforming Growth Factor alpha | 2003 |
Effect of 4-aminopyridine on synaptic transmission in rat hippocampal slices.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Synaptic Transmission; Time Factors | 2004 |
Input resistance is voltage dependent due to activation of Ih channels in rat CA1 pyramidal cells.
Topics: 4-Aminopyridine; Acetates; Amines; Animals; Animals, Newborn; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Radiation; Electric Impedance; Electric Stimulation; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channel Gating; Ion Channels; Membrane Potentials; Nickel; Patch-Clamp Techniques; Potassium Channel Blockers; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar; Tetrodotoxin | 2004 |
Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons.
Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Colforsin; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Neurons; Pain; Phorbol 12,13-Dibutyrate; Potassium Channel Blockers; Potassium Channels; Rats; Substantia Gelatinosa; Synaptic Transmission | 2004 |
Stress induces CRF release in the paraventricular nucleus, and both CRF and GABA release in the amygdala.
Topics: 4-Aminopyridine; Amygdala; Animals; Corticotropin-Releasing Hormone; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hydrocortisone; Microdialysis; Paraventricular Hypothalamic Nucleus; Potassium Channel Blockers; Saliva; Sheep; Stress, Psychological | 2004 |
Dopamine inhibits mitral/tufted--> granule cell synapses in the frog olfactory bulb.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Calcium Channels; Dendrites; Depression, Chemical; Dopamine; Dopamine Agonists; Evoked Potentials; Feedback, Physiological; gamma-Aminobutyric Acid; Glutamic Acid; Ion Transport; Male; Mammals; Neurons; Odorants; Olfactory Bulb; Patch-Clamp Techniques; Potassium; Potassium Channels; Quinpirole; Rana pipiens; Receptors, Dopamine D2; Receptors, GABA-A; Smell; Synapses; Synaptic Transmission | 2004 |
Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice.
Topics: 4-Aminopyridine; Action Potentials; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cortical Synchronization; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Long-Term Potentiation; Mice; Mice, Transgenic; Mutation; Nerve Net; Neural Inhibition; Neural Pathways; Organ Culture Techniques; Potassium Channel Blockers; Presynaptic Terminals; Quinoxalines; Synaptic Transmission | 2005 |
Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Drug Interactions; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Potassium Channel Blockers; Propanolamines; Pyridazines; Receptors, GABA-A; Synaptic Transmission | 2005 |
Horizontal spread of activity in neocortical inhibitory networks.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Antagonists; Fluorescent Dyes; gamma-Aminobutyric Acid; In Vitro Techniques; Kynurenic Acid; Linear Models; Neocortex; Nerve Net; Neural Inhibition; Potassium Channel Blockers; Pyridinium Compounds; Rats; Reaction Time; Time Factors | 2005 |
Postnatal development of intrinsic GABAergic rhythms in mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Animals, Newborn; Bicuculline; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Periodicity; Potassium Channel Blockers | 2005 |
GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basic Helix-Loop-Helix Transcription Factors; Bicuculline; Bromodeoxyuridine; Calbindins; Calcium; Cell Count; Cell Differentiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Green Fluorescent Proteins; Hippocampus; History, Ancient; Immunohistochemistry; In Vitro Techniques; Intermediate Filament Proteins; Ki-67 Antigen; Membrane Potentials; Mice; Mice, Transgenic; Microscopy, Immunoelectron; N-Methylaspartate; Nerve Tissue Proteins; Nestin; Neural Cell Adhesion Molecule L1; Neurons; Nickel; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Potassium Channel Blockers; S100 Calcium Binding Protein G; Sialic Acids; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Stem Cells; Tetrodotoxin; Vesicular Inhibitory Amino Acid Transport Proteins | 2005 |
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release.
Topics: 4-Aminopyridine; Anesthetics, Inhalation; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Enflurane; gamma-Aminobutyric Acid; Glutamic Acid; Halothane; In Vitro Techniques; Isoflurane; Male; Nerve Endings; Neurotransmitter Agents; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 2006 |
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Bicuculline; Calcium; Calcium Channels; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dopamine; gamma-Aminobutyric Acid; Glutamine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Norepinephrine; Peptide Elongation Factor 2; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium Channels; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; Sirolimus; Synapses; Time Factors; TOR Serine-Threonine Kinases | 2005 |
A-type K+ current of dopamine and GABA neurons in the ventral tegmental area.
Topics: 4-Aminopyridine; Action Potentials; Algorithms; Animals; Biophysical Phenomena; Biophysics; Cadmium; Dopamine; Electrophysiology; gamma-Aminobutyric Acid; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Inbred F344; Ventral Tegmental Area | 2006 |
Possible activation of the NO-cyclic GMP-protein kinase G-K+ channels pathway by gabapentin on the formalin test.
Topics: 4-Aminopyridine; Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indoles; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2006 |
Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus.
Topics: 4-Aminopyridine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Histamine; Histamine Antagonists; Imidazoles; In Vitro Techniques; Male; Methylhistamines; Pertussis Toxin; Presynaptic Terminals; Protein Binding; Rats; Rats, Wistar; Receptors, Histamine H3; Synaptosomes; Thalamus; Thiourea; Tritium | 2007 |
Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy.
Topics: 4-Aminopyridine; Acetates; Action Potentials; Animals; Astrocytes; Carbon Radioisotopes; Energy Metabolism; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Hippocampus; Magnetic Resonance Spectroscopy; Male; Neurons; Organ Culture Techniques; Potassium Channel Blockers; Rats; Rats, Wistar; Time Factors; Tricarboxylic Acids; Up-Regulation | 2007 |
Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons.
Topics: 4-Aminopyridine; Analysis of Variance; Angiotensin II; Animals; Bicuculline; Deferoxamine; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Laminectomy; Male; Metalloporphyrins; Neurons, Afferent; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Signal Transduction | 2007 |
Epileptiform synchronization in the rat insular and perirhinal cortices in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Cortical Synchronization; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Nerve Net; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Signal Transduction | 2007 |
Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Animals, Newborn; Bumetanide; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Mice; Neocortex; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Potassium Channel Blockers; Reaction Time; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Synapses; Synaptic Transmission | 2008 |
Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.
Topics: 4-Aminopyridine; Action Potentials; Alanine; Anesthetics, Inhalation; Animals; Biophysics; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid; Histidine; Inhibitory Postsynaptic Potentials; Isoflurane; Leucine; Mice; Mice, Transgenic; Mutation; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Pyridazines; Receptors, GABA-A; Serine; Thalamus; Time Factors | 2009 |
Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Bicuculline; Calcium-Calmodulin-Dependent Protein Kinase Type 2; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred ICR; Neural Inhibition; Neurons; Organ Culture Techniques; Potassium Channel Blockers; Protein Kinase Inhibitors; Receptors, GABA-A; Thalamic Nuclei | 2010 |
Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Biophysics; Channelrhodopsins; Dendrites; Electric Stimulation; Electroporation; Embryo, Mammalian; gamma-Aminobutyric Acid; Glutamic Acid; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Mice; Mice, Inbred ICR; Mice, Transgenic; Neocortex; Neural Inhibition; Parvalbumins; Patch-Clamp Techniques; Photic Stimulation; Potassium Channel Blockers; Rats; Rats, Wistar; Reaction Time; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2009 |
Optical suppression of experimental seizures in rat brain slices.
Topics: 4-Aminopyridine; Animals; Convulsants; Disease Models, Animal; Epilepsies, Partial; GABA Agents; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Photochemical Processes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Ultraviolet Rays | 2010 |
Flufenamic acid suppresses epileptiform activity in hippocampus by reducing excitatory synaptic transmission and neuronal excitability.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Epilepsy; Excitatory Postsynaptic Potentials; Flufenamic Acid; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2010 |
Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus.
Topics: 4-Aminopyridine; Adult Stem Cells; Analysis of Variance; Animals; Biophysics; Calcium; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Pro-Opiomelanocortin; Promoter Regions, Genetic; Signal Transduction; Statistics, Nonparametric | 2009 |
Distribution and role of Kv3.1b in neurons in the medial septum diagonal band complex.
Topics: 4-Aminopyridine; Animals; Calcium; Choline O-Acetyltransferase; Diagonal Band of Broca; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Parvalbumins; Presynaptic Terminals; Rats; Rats, Wistar; Shaw Potassium Channels; Vesicular Acetylcholine Transport Proteins; Vesicular Glutamate Transport Protein 2 | 2010 |
Differences in Na+ conductance density and Na+ channel functional properties between dopamine and GABA neurons of the rat substantia nigra.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; gamma-Aminobutyric Acid; In Vitro Techniques; Neural Conduction; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels; Substantia Nigra; Tetraethylammonium; Tetrodotoxin | 2010 |
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.
Topics: 4-Aminopyridine; Aniline Compounds; Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Interactions; Furans; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Male; Potassium Channel Blockers; Presynaptic Terminals; Protein Subunits; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Veratridine | 2010 |
Local control of postinhibitory rebound spiking in CA1 pyramidal neuron dendrites.
Topics: 4-Aminopyridine; Action Potentials; Animals; Barium Compounds; CA1 Region, Hippocampal; Computer Simulation; Cyclic Nucleotide-Gated Cation Channels; Dendrites; gamma-Aminobutyric Acid; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Models, Neurological; Neural Inhibition; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2010 |
Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Anisoles; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; In Vitro Techniques; Magnesium; Mice; Mice, Inbred C57BL; Nipecotic Acids; Patch-Clamp Techniques; Potassium Channel Blockers; Pyridazines; Receptors, GABA-A; Tiagabine | 2010 |
Clonidine, an alpha2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Clonidine; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Heart; Medulla Oblongata; Neurons; Pyridazines; Rats; Synaptic Transmission; Vagus Nerve | 2010 |
Encoding of the cough reflex in anesthetized guinea pigs.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthesia; Animals; Biphenyl Compounds; Citric Acid; Cough; Dose-Response Relationship, Drug; Electric Stimulation; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guinea Pigs; Male; Mechanoreceptors; Propionates; Quinoxalines; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Recurrent Laryngeal Nerve; Reflex; Respiratory Mucosa; Sensory Receptor Cells; Solitary Nucleus; Substance P; Trachea; Vagus Nerve; Valine | 2011 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex | 2011 |
[Pharmacological treatment of nystagmus].
Topics: 4-Aminopyridine; Amines; Anticonvulsants; Baclofen; Cyclohexanecarboxylic Acids; Dopamine Agents; Gabapentin; gamma-Aminobutyric Acid; Humans; Memantine; Muscle Relaxants, Central; Nystagmus, Pathologic; Potassium Channel Blockers | 2011 |
Is connexin36 critical for GABAergic hypersynchronization in the hippocampus?
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbenoxolone; Connexins; Epilepsy; gamma-Aminobutyric Acid; Gap Junction delta-2 Protein; Gap Junctions; Hippocampus; In Vitro Techniques; Interneurons; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Patch-Clamp Techniques; Pregnenolone; Receptors, GABA-A | 2011 |
Functional nicotinic acetylcholine receptors containing α6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons.
Topics: 4-Aminopyridine; Acetylcholine; Aconitine; Animals; Animals, Newborn; Bungarotoxins; Calcium; Conotoxins; Dihydro-beta-Erythroidine; Dopamine; Drug Interactions; Excitatory Amino Acid Agents; Female; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Knockout; Neurons; Nicotine; Nicotinic Antagonists; Potassium Channel Blockers; Presynaptic Terminals; Protein Binding; Rats; Rats, Wistar; Receptors, Nicotinic; Synaptosomes; Ventral Tegmental Area | 2011 |
[Design, synthesis and antiepileptic activity of 4-(2-acetoxybenzoylamino) butyrate derivatives].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Butyrates; Drug Design; Epilepsy; Female; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Molecular Structure; Random Allocation; Structure-Activity Relationship | 2011 |
Participation of the GABAergic system on the glutamate release of frontal cortex synaptosomes from Wistar rats with experimental autoimmune encephalomyelitis.
Topics: 4-Aminopyridine; Animals; Calcium; Encephalomyelitis, Autoimmune, Experimental; Flunitrazepam; Frontal Lobe; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Nerve Endings; Phosphorylation; Rats; Rats, Wistar; Receptors, GABA-A; Synapsins; Synaptosomes | 2011 |
Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Carbamazepine; Drug Interactions; Epilepsy; Fructose; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Lamotrigine; Male; Nerve Endings; Oxcarbazepine; Phenytoin; Potassium Channel Blockers; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers; Tetrodotoxin; Topiramate; Triazines; Tritium; Vinca Alkaloids | 2011 |
[Design, synthesis and activities of 4-(2-acetoxybenzoylamino) butyramide derivatives].
Topics: 4-Aminopyridine; Amides; Animals; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Mice; Molecular Structure; Random Allocation; Structure-Activity Relationship | 2012 |
Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane.
Topics: 4-Aminopyridine; Acetylcholine; Anesthetics, Inhalation; Animals; Central Nervous System; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Male; Methyl Ethers; Neurotransmitter Agents; Norepinephrine; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Sevoflurane; Stimulation, Chemical | 2013 |
Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Interneurons; Mice; Somatostatin | 2014 |
Interneuron activity leads to initiation of low-voltage fast-onset seizures.
Topics: 4-Aminopyridine; Animals; Electrophysiological Phenomena; Entorhinal Cortex; GABAergic Neurons; gamma-Aminobutyric Acid; Interneurons; Mice; Nerve Net; Optogenetics; Parvalbumins; Patch-Clamp Techniques; Seizures | 2015 |
Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Choline O-Acetyltransferase; Cholinergic Neurons; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Membrane Potentials; Mice, Transgenic; Microscopy, Confocal; Microscopy, Fluorescence, Multiphoton; Patch-Clamp Techniques; Potassium Channel Blockers; Prosencephalon; Receptors, GABA-A; Receptors, Nicotinic; Sodium Channel Blockers; Synaptic Transmission; Tetrodotoxin; Vesicular Inhibitory Amino Acid Transport Proteins | 2015 |
Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.
Topics: 4-Aminopyridine; Animals; Apoptosis; Caspase 3; Caspase 7; Cell Survival; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Kv Channel-Interacting Proteins; Neuroprotective Agents; Potassium Channel Blockers; Primary Cell Culture; Rats, Wistar; RNA Interference; Semicarbazides; Shal Potassium Channels; Synaptic Transmission; Time Factors; Transfection | 2015 |
Carbonic anhydrase inhibition by acetazolamide reduces in vitro epileptiform synchronization.
Topics: 4-Aminopyridine; Acetazolamide; Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cerebral Cortex; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Male; Microelectrodes; Period Circadian Proteins; Rats, Sprague-Dawley; Tissue Culture Techniques; Xenopus Proteins | 2015 |
Blockade of presynaptic 4-aminopyridine-sensitive potassium channels increases initial neurotransmitter release probability, reinstates synaptic transmission altered by GABAB receptor activation in rat midbrain periaqueductal gray.
Topics: 4-Aminopyridine; Animals; Barium; Cations, Divalent; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Neural Inhibition; Patch-Clamp Techniques; Periaqueductal Gray; Potassium Channel Blockers; Potassium Channels; Presynaptic Terminals; Probability; Rats, Sprague-Dawley; Receptors, GABA-B; Synaptic Transmission; Tissue Culture Techniques | 2016 |
Calcium Imaging of Neuronal Activity in Drosophila Can Identify Anticonvulsive Compounds.
Topics: 4-Aminopyridine; Adult; Amines; Animals; Anticonvulsants; Antipain; Calcium; Calmodulin; Central Nervous System; Convulsants; Cyclohexanecarboxylic Acids; Dipyridamole; Drosophila melanogaster; Drosophila Proteins; Female; Gabapentin; gamma-Aminobutyric Acid; Gene Expression; Genes, Reporter; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Larva; Male; Molecular Imaging; Motor Neurons; Phenytoin; Picrotoxin; Primary Cell Culture; Sodium Channels | 2016 |
Bioelectronic neural pixel: Chemical stimulation and electrical sensing at the same site.
Topics: 4-Aminopyridine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Electric Conductivity; Electrodes, Implanted; Electronic Nose; Epilepsy; Equipment Design; gamma-Aminobutyric Acid; Hippocampus; Mice; Neurons; Organ Culture Techniques; Polymers; Polystyrenes; Potassium Channel Blockers; Single-Cell Analysis; Stimulation, Chemical | 2016 |
2-Deoxy-d-glucose enhances tonic inhibition through the neurosteroid-mediated activation of extrasynaptic GABA
Topics: 4-Aminopyridine; Animals; Antimetabolites; Antineoplastic Agents; Bicuculline; Deoxyglucose; Enzyme Inhibitors; Female; Finasteride; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glyburide; Hippocampus; Hypoglycemic Agents; In Vitro Techniques; Iodoacetates; Isoquinolines; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Potassium Channel Blockers; Receptors, GABA; Statistics, Nonparametric | 2016 |
Atomic force microscopy investigations of fibronectin and α5β1-integrin signaling in neuroplasticity and seizure susceptibility in experimental epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonists; Fibronectins; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Integrin alpha6beta1; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Microscopy, Atomic Force; Neuronal Plasticity; Neurons; Potassium Channel Blockers; Signal Transduction; Sodium Channel Blockers; Tetrodotoxin | 2017 |
Glycinergic neurotransmission in the rostral ventrolateral medulla controls the time course of baroreflex-mediated sympathoinhibition.
Topics: 4-Aminopyridine; Animals; Baroreflex; Bicuculline; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Inhibitory Postsynaptic Potentials; Male; Medulla Oblongata; Muscimol; Neural Inhibition; Neurons; Potassium Channel Blockers; Rats, Sprague-Dawley; Strychnine; Sympathetic Nervous System; Synaptic Transmission; Tetrodotoxin | 2019 |
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice.
Topics: 4-Aminopyridine; Animals; Brain; Craniotomy; Disease Models, Animal; Electrophoresis; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Mice; Microfluidics; Seizures | 2019 |
Modulation of in vitro epileptiform activity by optogenetic stimulation of parvalbumin-positive interneurons.
Topics: 4-Aminopyridine; Animals; gamma-Aminobutyric Acid; Interneurons; Mice; Mice, Transgenic; Opsins; Optogenetics; Parvalbumins | 2022 |