4-aminobenzoic acid has been researched along with vx 765 in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (6.25) | 29.6817 |
| 2010's | 23 (47.92) | 24.3611 |
| 2020's | 22 (45.83) | 2.80 |
| Authors | Studies |
|---|---|
| Charifson, P; Davies, R; Decker, C; Ford, P; Germann, UA; Ku, G; Kuida, K; Namchuk, M; Pollard, J; Randle, JC; Wannamaker, W; Weber, P | 1 |
| Chen, M; Dong, Y; Forslund, RE; Magdziak, D; Tanoury, GJ | 1 |
| Noé, F; Ravizza, T; Sifringer, M; Vaghi, V; Vezzani, A; Zardoni, D | 1 |
| Auld, DS; Boxer, MB; Jadhav, A; Leister, W; Quinn, AM; Shen, M; Simeonov, A; Thomas, CJ | 1 |
| Leslie, KS; Yu, JR | 1 |
| Balosso, S; French, J; Iori, V; Maroso, M; Ravizza, T; Vezzani, A; Wright, CI | 1 |
| Aker, RG; Akin, D; Carcak, N; Eryigit, T; Maroso, M; Onat, FY; Ravizza, T; Vanzulli, I; Vezzani, A | 1 |
| Banderó, CR; Bankstahl, M; Beltrame, L; Frigerio, F; Löscher, W; Marchini, S; Noe, FM; Polascheck, N; Ravizza, T; Vezzani, A | 1 |
| Jiang, CL; Liu, L; Liu, YZ; Shen, XL; Wang, W; Wang, YX; Wu, TY; Zhang, T; Zhang, Y | 1 |
| Boxer, MB; Burlak, C; Chataway, T; Chegini, F; Cookson, MR; Datta, D; Fisher, OS; Gai, WP; Guo, F; Hoang, QQ; Ju, S; Landeru, A; Miller, DW; Nguyen, LT; Petsko, GA; Ringe, D; Thomas, CJ; Wang, W; Wells, JA; Wu, CX; Wu, F | 1 |
| Bassil, F; Bezard, E; Fernagut, PO; Hoang, QQ; Leste-Lasserre, T; Meissner, WG; Petsko, GA; Pruvost, A; Ringe, D | 1 |
| Abrahams, VM; Chaemsaithong, P; Chaiworapongsa, T; Dong, Z; Gomez-Lopez, N; Hassan, SS; Plazyo, O; Romero, R; Tarca, AL; Than, NG; Unkel, R; Xu, Y; Yeo, L | 1 |
| Aronica, E; Beltrame, L; Brambilla, R; Cerovic, M; D'Incalci, M; Ferrari, M; Hill, C; Iori, V; Iyer, AM; Marchini, S; Molteni, M; Paracchini, L; Ravizza, T; Rossetti, C; Steve White, H; Vezzani, A; Zucchetti, M | 1 |
| Alcaraz, MJ; Aznar, E; Costero, AM; Ferrándiz, ML; García-Fernández, A; García-Laínez, G; Marcos, MD; Martínez-Máñez, R; Murguía, JR; Orzáez, M; Sancenón, F | 1 |
| Galanopoulou, AS; Li, Q; Liu, W; Moshé, SL; Mowrey, WB; Shandra, O | 1 |
| Deng, S; Han, R; Liu, T; Wu, D; Xie, H; Xu, Y; Zhang, T | 1 |
| Arjun, S; Davidson, SM; Do Carmo, H; Petrucci, O; Yellon, DM | 1 |
| Che, C; Hu, L; Jiang, N; Li, C; Li, J; Lin, J; Wang, Q; Xu, Q; Xu, R; You, J; Zhao, G | 1 |
| Feng, J; He, CM; Hua, ZY; Wei, Q | 1 |
| Boghozian, R; Branton, WG; Lu, JQ; Major, EO; Mamik, MK; McKenzie, BA; Monaco, MC; Power, C; Saito, LB | 1 |
| Flores, J; Foveau, B; LeBlanc, AC; Lecrux, C; Lynham, J; Noël, A | 1 |
| Cao, Y; Dai, Z; Li, Q; Wang, L | 1 |
| Chen, S; Gong, P; Jia, L; Li, J; Li, L; Liu, X; Wang, X; Zhang, N; Zhang, X | 1 |
| Bai, XJ; Li, ZF; Liu, L; Liu, QX; Liu, XH; Wang, CT; Wang, YC; Xu, XE; Zheng, Q | 1 |
| Feng, J; He, C; Hua, Z; Huang, H | 1 |
| Jin, T; Kombe, AJK; Li, B; Tao, J; Zahid, A | 1 |
| Catalano, D; Cho, Y; Coban, S; Lowe, PP; Szabo, G; Tornai, D | 1 |
| Dong, Z; Liu, D; Liu, H; Rao, J; Wang, Q; Wang, Y; Xiang, F | 1 |
| He, M; Li, Q; Li, Y; Meng, L; Niu, X; Xu, H; Zhang, J; Zhang, Z | 1 |
| Hao, JH; Li, J; Li, R; Li, XF; Liu, XH; Luo, X; Wang, MH; Wang, W; Yao, D; Yu, ZY | 1 |
| Huang, L; Nyanzu, M; Ru, J; Shen, J; Sun, Z; Wang, K; Wang, Z; Yang, S; Yu, E; Zhang, H; Zhu, X; Zhuge, Q | 1 |
| Chen, J; Chen, YQ; Ding, SQ; Duan, FX; Hu, JG; Lü, HZ; Shi, YJ; Wang, SN | 1 |
| Li, Y; Sun, T; Wang, JN; Wang, SC; Wang, YH; Wen, S; Zhao, QX | 1 |
| Gu, L; Huang, L; Huang, S; Ru, J; Sun, Z; Wang, K; Wang, Z; Wu, K; Yang, S; Zhuge, Q | 1 |
| Dong, X; Jiang, J; Jiang, Y; Liu, X; Ye, Y; Zhang, D; Zhu, R | 1 |
| Atrakchi, D; Bresler, Y; Cooper, I; Elhaik, S; Gosselet, F; Israelov, H; Liraz-Zaltsman, S; Omesi, L; Rand, D; Ravid, O; Schnaider Beeri, M; Twitto-Greenberg, R | 1 |
| Beauchet, O; Flores, J; Foveau, B; LeBlanc, AC; Noël, A | 1 |
| Gao, MR; Jia, YY; Liu, A; Qiu, C; Tian, DD; Wang, M; Wang, WJ; Wu, YM; Yang, CB; Yang, L; Yu, W; Zhang, K | 1 |
| Gao, X; Li, Y; Liang, ZJ; Liu, J; Pan, LX; Tang, YR; Wang, YH; Zhang, NN | 1 |
| Alsaadi, M; Arkhipova, SS; Garanina, EE; Gilazieva, ZE; Hamza, S; Khaiboullina, SF; Markelova, MI; Martinova, EV; McIntyre, A; Rizvanov, AA; Tezcan, G | 1 |
| Cui, Y; Hussain, T; Liao, Y; Liu, C; Luo, L; Sabir, N; Song, Y; Wang, H; Wang, J; Yang, L; Yao, J; Zhao, D; Zhou, X | 1 |
| Huang, K; Huang, X; Ma, H; Wang, X; Wu, T; Ye, C; Zhu, S | 1 |
| Deng, F; Fan, Q; Li, L; Li, X; Wen, S; Xu, L | 1 |
| Gu, L; Jiang, C; Li, J; Li, Y; Liu, W; Luo, X; Shen, J; Wu, J; Yu, Y; Zhang, X; Zhang, Y | 1 |
| Bai, H; Gao, L; Li, R; Li, S; Ma, X; Qiu, D; Shen, M; Zhang, Z | 1 |
| Chen, L; Chen, W; Dong, X; Feng, S; Huang, Z; Jang, X; Pan, H; Wang, L; Zhao, Y | 1 |
| He, X; Li, Z; Liang, F; Lin, F; Liu, C; Liu, H; Pan, L; Qin, Y; Wu, S; Ye, M | 1 |
| Huang, J; Lyu, H; Ni, H; Yu, G; Zhang, Q; Zhang, Z | 1 |
1 review(s) available for 4-aminobenzoic acid and vx 765
| Article | Year |
|---|---|
Pharmacological Inhibitors of the NLRP3 Inflammasome.
Topics: Animals; Dipeptides; Glyburide; Humans; Inflammasomes; Nitriles; NLR Family, Pyrin Domain-Containing 3 Protein; ortho-Aminobenzoates; para-Aminobenzoates; Sulfones | 2019 |
47 other study(ies) available for 4-aminobenzoic acid and vx 765
| Article | Year |
|---|---|
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inh
Topics: 4-Aminobenzoic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Arthritis, Experimental; Caspase Inhibitors; Dipeptides; Humans; Hypersensitivity, Delayed; Interleukin-18; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred DBA; Oxazolone; para-Aminobenzoates; Protease Inhibitors | 2007 |
Development of a novel Pd-catalyzed N-acyl vinylogous carbamate synthesis for the key intermediate of ICE inhibitor VX-765.
Topics: 4-Aminobenzoic Acid; Acrylamide; Carbamates; Caspase Inhibitors; Catalysis; Dipeptides; Hydrocarbons, Brominated; Molecular Structure; Palladium; para-Aminobenzoates; Stereoisomerism | 2008 |
Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production.
Topics: 4-Aminobenzoic Acid; Animals; Anticonvulsants; Astrocytes; Caspase 1; Caspase Inhibitors; Dipeptides; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Interleukin-1beta; Kindling, Neurologic; Male; para-Aminobenzoates; Prosencephalon; Rats; Rats, Sprague-Dawley | 2008 |
A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety.
Topics: 4-Aminobenzoic Acid; Animals; Binding Sites; Caspase 1; Caspase Inhibitors; Catalytic Domain; Computer Simulation; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Microsomes, Liver; para-Aminobenzoates; Propionates; Rats; Structure-Activity Relationship | 2010 |
Cryopyrin-associated periodic syndrome: an update on diagnosis and treatment response.
Topics: 4-Aminobenzoic Acid; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Juvenile; Biopsy; Carrier Proteins; Cryopyrin-Associated Periodic Syndromes; Delayed Diagnosis; Diagnosis, Differential; Dipeptides; Genetic Testing; Humans; Interleukin 1 Receptor Antagonist Protein; Mutation; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Phenotype; Quality of Life; Recombinant Fusion Proteins; Schnitzler Syndrome; Skin; Still's Disease, Adult-Onset; Treatment Outcome | 2011 |
Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice.
Topics: 4-Aminobenzoic Acid; Animals; Anticonvulsants; Convulsants; Dipeptides; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Inbred C57BL; para-Aminobenzoates; Seizures | 2011 |
IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence.
Topics: 4-Aminobenzoic Acid; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Brain Waves; Cell Count; Dipeptides; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Absence; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Interleukin-1beta; Male; para-Aminobenzoates; Proto-Oncogene Proteins c-fos; Rats; Rats, Mutant Strains; Rats, Wistar; Somatosensory Cortex; Statistics, Nonparametric; Thalamic Nuclei | 2011 |
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Dipeptides; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Lithium; Male; para-Aminobenzoates; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1 Type I | 2013 |
NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrier Proteins; Caspase 1; Chronic Disease; Corticosterone; Depressive Disorder; Dietary Sucrose; Dipeptides; Disease Models, Animal; Food Preferences; Hippocampus; Inflammation; Interleukin-1beta; Male; Mice, Inbred BALB C; Motor Activity; Neuroimmunomodulation; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Random Allocation; Stress, Psychological; Uncertainty | 2015 |
Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.
Topics: alpha-Synuclein; Alum Compounds; Caspase 1; Cell Line, Tumor; Cell Survival; Dipeptides; Gene Expression Regulation; Humans; Inflammasomes; Interleukin-1beta; Lewy Bodies; Lipopolysaccharides; Neurons; Nigericin; para-Aminobenzoates; Protein Aggregates; RNA, Small Interfering; Signal Transduction; Vitamin K 3 | 2016 |
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.
Topics: alpha-Synuclein; Animals; Caspase 1; Clinical Trials as Topic; Corpus Striatum; Dipeptides; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; Multiple System Atrophy; Neurons; Oligodendroglia; para-Aminobenzoates; Protein Aggregates; Proteolysis; Signal Transduction; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
Topics: Adolescent; Adult; Amnion; Caspase 1; Caspases, Initiator; Chorioamnionitis; Chorion; Dipeptides; Female; Humans; Inflammasomes; Interleukin-18; Interleukin-1beta; Labor, Obstetric; para-Aminobenzoates; Pregnancy; Term Birth; Tumor Necrosis Factor-alpha; Young Adult | 2017 |
Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Carbamazepine; Cyanobacteria; Dipeptides; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Mice, Inbred C57BL; MicroRNAs; Oligonucleotides; para-Aminobenzoates; Random Allocation; Receptors, Interleukin-1 Type I; Time Factors; Toll-Like Receptor 4 | 2017 |
Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles.
Topics: Animals; Anti-Inflammatory Agents; Caspase Inhibitors; Cell Line; Delayed-Action Preparations; Dipeptides; Drug Carriers; Humans; Inflammasomes; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Nanoparticles; para-Aminobenzoates; Silicon Dioxide | 2017 |
Preclinical Screening for Treatments for Infantile Spasms in the Multiple Hit Rat Model of Infantile Spasms: An Update.
Topics: Animals; Anticonvulsants; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Estradiol; GABA Antagonists; Humans; Infant; Lipopolysaccharides; Male; Organophosphorus Compounds; para-Aminobenzoates; Random Allocation; Rats; Rats, Sprague-Dawley; Spasms, Infantile; Treatment Outcome | 2017 |
Protective Effects of Flagellin A N/C Against Radiation-Induced NLR Pyrin Domain Containing 3 Inflammasome-Dependent Pyroptosis in Intestinal Cells.
Topics: Animals; Benzamides; Caspase 1; Caspase Inhibitors; Dipeptides; Female; Flagellin; Indazoles; Inflammasomes; Interleukin-1beta; Interleukins; Intestine, Small; Mice; Mice, Inbred BALB C; NLR Proteins; para-Aminobenzoates; Protein Kinase Inhibitors; Pyrin Domain; Pyroptosis; Radiation Injuries, Experimental; Radiation-Protective Agents; Random Allocation; Reactive Oxygen Species | 2018 |
The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway.
Topics: Animals; Caspase 1; Caspase Inhibitors; Cytoprotection; Dipeptides; Disease Models, Animal; Isolated Heart Preparation; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; para-Aminobenzoates; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pyroptosis; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Interleukin-32 induced thymic stromal lymphopoietin plays a critical role in the inflammatory response in human corneal epithelium.
Topics: Apoptosis; Caspase 1; Cell Proliferation; Cells, Cultured; Cytokines; Dipeptides; Epithelium, Corneal; Humans; Interleukin-6; Interleukins; NF-kappa B; para-Aminobenzoates; Quinazolines; Recombinant Proteins; Signal Transduction; Thymic Stromal Lymphopoietin; Tumor Necrosis Factor-alpha; Up-Regulation | 2018 |
[Role of caspase-1 activation in bilirubin-induced injury in cultured primary rat hippocampal neurons].
Topics: Animals; Apoptosis; Bilirubin; Caspase 1; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Dimethyl Sulfoxide; Dipeptides; Enzyme Activation; Hippocampus; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Rats; Rats, Sprague-Dawley | 2018 |
Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis.
Topics: Caspase 1; Caspase Inhibitors; Cells, Cultured; Dipeptides; Humans; Models, Biological; Multiple Sclerosis; Oligodendroglia; para-Aminobenzoates; Pyroptosis | 2018 |
Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Caspase 1; Caspase Inhibitors; Cognition; Cognition Disorders; Dipeptides; Disease Models, Animal; Humans; Memory; Memory Disorders; Mice, Knockout; para-Aminobenzoates | 2018 |
Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-κB activation.
Topics: Animals; Caspase 1; Caspase Inhibitors; Dipeptides; Disease Models, Animal; Infarction, Middle Cerebral Artery; Macrophage Activation; Macrophages; Male; Mice, Inbred C57BL; Microglia; Neuroprotection; Neuroprotective Agents; NF-kappa B; para-Aminobenzoates; Stroke | 2019 |
Inflammasome activation restrains the intracellular Neospora caninum proliferation in bovine macrophages.
Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Caspase 1; Cattle; Cattle Diseases; Cell Proliferation; Cells, Cultured; Coccidiosis; Cytoplasm; Dipeptides; Inflammasomes; Macrophages, Peritoneal; Neospora; para-Aminobenzoates | 2019 |
Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis.
Topics: Animals; Apoptosis; Brain; Brain Diseases; Caspase 1; Caspase Inhibitors; Cognitive Dysfunction; Dipeptides; Hippocampus; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophage Activation; Male; Mice; Mice, Inbred BALB C; para-Aminobenzoates; Phosphate-Binding Proteins; Pyroptosis; Sepsis; Sepsis-Associated Encephalopathy; Synapses | 2019 |
Caspase-1 involves in bilirubin-induced injury of cultured rat cortical neurons.
Topics: Animals; Apoptosis; Astrocytes; Bilirubin; Caspase 1; Cell Membrane; Cell Survival; Cells, Cultured; Cerebral Cortex; Dipeptides; Female; Hyperbilirubinemia; Interleukin-18; Interleukin-1beta; Neurons; NF-kappa B; para-Aminobenzoates; Rats; Signal Transduction | 2019 |
Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice.
Topics: Alcohol Drinking; Animals; Dipeptides; Female; Furans; Heterocyclic Compounds, 4 or More Rings; Indenes; Inflammasomes; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Sex Characteristics; Signal Transduction; Sulfonamides; Sulfones | 2020 |
Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia-Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models.
Topics: Alkaloids; Animals; Caspase 1; Caspase Inhibitors; Cell Line; Dipeptides; Hippocampus; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; Necrosis; Neuroprotective Agents; para-Aminobenzoates; Phosphate-Binding Proteins; Pyroptosis; Reperfusion Injury | 2020 |
VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Dipeptides; Disease Models, Animal; Disease Progression; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; para-Aminobenzoates; Pyroptosis | 2020 |
Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia.
Topics: Animals; Brain Ischemia; Caspase 1; Caspase Inhibitors; Cell Death; Dipeptides; Drug Delivery Systems; Inflammasomes; Male; Mice; Mice, Inbred C57BL; Neurons; para-Aminobenzoates; Pyroptosis | 2020 |
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-
Topics: Animals; Brain Injuries, Traumatic; Dipeptides; HMGB1 Protein; Male; Mice; NF-kappa B; para-Aminobenzoates; Pyroptosis; Toll-Like Receptor 4; Treatment Outcome | 2020 |
Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 1; Caspase Inhibitors; Dipeptides; Female; Gene Expression Profiling; Mice; Mice, Inbred C57BL; para-Aminobenzoates; Spinal Cord Injuries; Transcriptome | 2020 |
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Caspase 1; Caspase Inhibitors; Dipeptides; Docosahexaenoic Acids; Inflammasomes; Inflammation; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Male; Neuralgia; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Rats, Sprague-Dawley | 2020 |
VX-765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke-induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Autophagy; Dipeptides; Humans; Inflammation Mediators; Mesenchymal Stem Cells; para-Aminobenzoates; Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Stroke; TOR Serine-Threonine Kinases; Umbilical Cord | 2020 |
Cannabinoid 1 Receptor Antagonists Play a Neuroprotective Role in Chronic Alcoholic Hippocampal Injury Related to Pyroptosis Pathway.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Caspase 1; Caspase Inhibitors; Central Nervous System Depressants; Dipeptides; Ethanol; Hippocampus; Inflammation; Interleukin-18; Interleukin-1beta; Intracellular Signaling Peptides and Proteins; Mice; Morpholines; Neuroprotective Agents; Neurotoxicity Syndromes; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Phosphate-Binding Proteins; Piperidines; Pyrazoles; Pyroptosis; Receptor, Cannabinoid, CB1 | 2020 |
Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair.
Topics: Animals; Blood-Brain Barrier; Caspase 1; Cell Death; Cell Movement; Coculture Techniques; Dipeptides; Endothelial Cells; Humans; Inflammasomes; Interleukin-8; Male; Mice; para-Aminobenzoates; Pericytes | 2020 |
Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cognitive Dysfunction; Cytokines; Dipeptides; Disease Models, Animal; Encephalitis; Female; Humans; Inflammation; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; para-Aminobenzoates; Serpins; Spatial Memory; Viral Proteins | 2020 |
Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents; Behavior, Animal; CA1 Region, Hippocampal; Caspase Inhibitors; Caspases, Initiator; Cell Line; Dendritic Spines; Depression; Dipeptides; Glucosides; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microglia; Monoterpenes; para-Aminobenzoates; Phosphate-Binding Proteins; Pyroptosis; Reserpine; Signal Transduction | 2021 |
The anti-inflammatory and analgesic effects of intraperitoneal melatonin after spinal nerve ligation are mediated by inhibition of the NF-κB/NLRP3 inflammasome signaling pathway.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dipeptides; Inflammasomes; Male; Melatonin; Neuralgia; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Spinal Nerves | 2021 |
Therapeutic Potential of Pharmacological Targeting NLRP3 Inflammasome Complex in Cancer.
Topics: A549 Cells; Antineoplastic Agents; Cell Proliferation; Cell Survival; Cytokines; Dipeptides; Humans; Inflammasomes; Inflammation Mediators; MCF-7 Cells; Mitochondria; Molecular Targeted Therapy; Neoplasms; Neovascularization, Pathologic; Nigericin; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; PC-3 Cells; Signal Transduction | 2020 |
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
Topics: Animals; Caspase 1; Caspase Inhibitors; Cell Survival; Dipeptides; Female; Gene Expression Regulation, Enzymologic; Inflammasomes; Interferon Regulatory Factor-3; Interferon-beta; Mice; Mice, Inbred C57BL; Mycobacterium bovis; Nucleotidyltransferases; para-Aminobenzoates; Protein Serine-Threonine Kinases; Random Allocation | 2021 |
VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dipeptides; Down-Regulation; Extracellular Matrix; Inflammation; Male; NADPH Oxidase 1; NF-kappa B; para-Aminobenzoates; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Streptozocin | 2022 |
VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation.
Topics: Animals; Caspase 1; Cell Culture Techniques; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dipeptides; Fibrosis; Glucose; Humans; Inflammation; Kidney; Kidney Tubules; Male; Mice; para-Aminobenzoates; Pyroptosis | 2022 |
Pyroptosis inhibition improves the symptom of acute myocardial infarction.
Topics: Animals; Autophagy-Related Proteins; Biomarkers; Dipeptides; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; para-Aminobenzoates; Proteome; Pyroptosis; Signal Transduction; Transcriptome | 2021 |
Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats.
Topics: Animals; Animals, Newborn; Caspase 1; Caspase Inhibitors; Cognitive Dysfunction; Dipeptides; Excitatory Amino Acid Antagonists; Female; Furans; Hippocampus; Indenes; Ketamine; Male; Maze Learning; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; PC12 Cells; Pyroptosis; Rats; Rats, Sprague-Dawley; Sulfonamides | 2021 |
VX765 alleviates dextran sulfate sodium-induced colitis in mice by suppressing caspase-1-mediated pyroptosis.
Topics: Animals; Blotting, Western; Caspase 1; Caspase Inhibitors; Colitis; Dextran Sulfate; Dipeptides; Male; Mice; Mice, Inbred C57BL; para-Aminobenzoates; Pyroptosis; Real-Time Polymerase Chain Reaction | 2022 |
VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction.
Topics: Animals; Caspase 1; Caspase Inhibitors; Cells, Cultured; Dipeptides; Endothelial Cells; Inflammasomes; Inflammation; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL; para-Aminobenzoates; Pyroptosis; Reperfusion Injury; Signal Transduction | 2021 |
VX-765 prevents intestinal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome.
Topics: Animals; Caco-2 Cells; Dipeptides; Humans; Inflammasomes; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; para-Aminobenzoates; Reperfusion Injury | 2022 |