Compounds > 4-aminobenzoic acid

4-aminobenzoic acid and nutlin-3a

4-aminobenzoic acid has been researched along with nutlin-3a in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berry, P; Chen, L; Del Bello, F; Halliday, GC; Lunec, J; Middleton, SA; Newell, DR; Nichols, GL; Piergentili, A; Rousseau, RF; Tweddle, DA; Zhao, Y1
Esfandiari, A; Hawthorne, TA; Lunec, J; Nakjang, S1
Edmondson, RJ; Lunec, J; Zanjirband, M1
Andrew Johnson, C; Ayers, GD; Chen, SC; Cobb, P; Flaherty, D; Higgins, B; Johnson, DB; Johnston, JN; Kelley, MC; Malikayil, K; Raman, D; Richmond, A; Saleh, N; Vara, BA; Vilgelm, AE1
Aptullahoglu, E; Esfandiari, A; Ho, YH; Lovat, P; Lunec, J; Mahdi, AK; Wang, N; Wu, CE1
Chen, L; Esfandiari, A; Hogarty, MD; Lunec, J; Reaves, W; Tweddle, DA; Vu, A1

Other Studies

6 other study(ies) available for 4-aminobenzoic acid and nutlin-3a

ArticleYear
Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma.
    British journal of cancer, 2014, Aug-12, Volume: 111, Issue:4

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Neuroblastoma; para-Aminobenzoates; Piperazines; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Spiro Compounds; Tumor Suppressor Protein p53; Verapamil; Vincristine

2014
Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:3

    Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Catalysis; Cell Line, Tumor; Cell Survival; Dipeptides; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Humans; Imidazoles; Mutation; Neoplasms; para-Aminobenzoates; Piperazines; Protein Phosphatase 2C; Proteolysis; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Transcription, Genetic; Tumor Suppressor Protein p53; Ubiquitin

2016
Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer.
    Oncotarget, 2016, Jun-28, Volume: 7, Issue:26

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Cisplatin; DNA Repair; Female; Gene Expression Regulation, Neoplastic; Genotype; Humans; Imidazoles; Ovarian Neoplasms; para-Aminobenzoates; Piperazines; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Tumor Suppressor Protein p53

2016
MDM2 Antagonists Counteract Drug-Induced DNA Damage.
    EBioMedicine, 2017, Volume: 24

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azepines; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; DNA Replication; HCT116 Cells; Humans; Imidazoles; Melanoma; Mice; para-Aminobenzoates; Piperazines; Protein Binding; Proto-Oncogene Proteins c-mdm2; Pyrimidines; Pyrrolidines; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2017
Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma.
    British journal of cancer, 2018, 02-20, Volume: 118, Issue:4

    Topics: Aminopyridines; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dipeptides; Drug Synergism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Melanoma; Melanoma, Cutaneous Malignant; Mutagenesis, Site-Directed; para-Aminobenzoates; Phosphorylation; Piperazines; Protein Binding; Protein Phosphatase 2C; Protein Stability; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Skin Neoplasms; Tumor Suppressor Protein p53

2018
Characterisation of the p53 pathway in cell lines established from TH-MYCN transgenic mouse tumours.
    International journal of oncology, 2018, Volume: 52, Issue:3

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Humans; Imidazoles; Indoles; Mice; Mice, Transgenic; Mutation; N-Myc Proto-Oncogene Protein; Neuroblastoma; para-Aminobenzoates; Piperazines; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Radiation, Ionizing; Signal Transduction; Spiro Compounds; Tumor Suppressor Protein p53

2018