4-amino-n-(2,6-dimethylphenyl)phthalimide has been researched along with phenytoin in 3 studies
*Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [MeSH]
*Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [MeSH]
| Studies (4-amino-n-(2,6-dimethylphenyl)phthalimide) | Trials (4-amino-n-(2,6-dimethylphenyl)phthalimide) | Recent Studies (post-2010) (4-amino-n-(2,6-dimethylphenyl)phthalimide) | Studies (phenytoin) | Trials (phenytoin) | Recent Studies (post-2010) (phenytoin) |
|---|---|---|---|---|---|
| 5 | 0 | 0 | 14,105 | 758 | 1,497 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lambert, D; Masereel, B; Poupaert, JH; Stables, JP; Vamecq, J | 1 |
| Anger, T; Madge, DJ; Mulla, M; Riddall, D | 1 |
| Bailleux, V; Hamoir, G; Nuyts, JP; Poupaert, JH; Stables, JP; Vallée, L; Vamecq, J | 1 |
1 review(s) available for 4-amino-n-(2,6-dimethylphenyl)phthalimide and phenytoin
| Article | Year |
|---|---|
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Models, Molecular; Mutation; Nerve Tissue Proteins; Neuroprotective Agents; Protein Binding; Sodium Channel Blockers; Sodium Channels; Stroke | 2001 |
2 other study(ies) available for 4-amino-n-(2,6-dimethylphenyl)phthalimide and phenytoin
| Article | Year |
|---|---|
Anticonvulsant activity and interactions with neuronal voltage-dependent sodium channel of analogues of ameltolide.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Benzamides; Binding, Competitive; Brain; Electroshock; Injections, Intraperitoneal; Ion Channel Gating; Mice; Rats; Seizures; Sodium Channels; Structure-Activity Relationship; Synaptosomes | 1998 |
Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide and prototype antiepileptic drugs in mice and rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Rats, Sprague-Dawley; Seizures; Strychnine | 1995 |