4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride has been researched along with piperidines in 29 studies
| Studies (4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride) | Trials (4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride) | Recent Studies (post-2010) (4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 40 | 1 | 23 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 16 (55.17) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Bachy, A; Emerit, MB; Giudice, A; Gozlan, H; Hamon, M; Héaulme, M; Lefevre, IA; Manara, L; Michaud, JC; Souilhac, J | 1 |
| Gout, G; Le Fur, G; Perio, A; Poncelet, M; Simiand, J; Soubrie, P | 1 |
| Ashby, CR; Edwards, E; Hampton, E; Wang, RY; Zhang, J | 1 |
| Arvanov, VL; Liang, X; Wang, RY | 1 |
| Ashby, CR; Katsumori, H; Minabe, Y; Watanabe, K | 1 |
| Danjou, P; Le Fur, G; Linker, T; Luthringer, R; Macher, JP; Roegel, JC; Staner, L; Toussaint, M | 1 |
| Guertin, PA; Steuer, I | 1 |
| Abdel-Aziz, H; Ploch, M; Verspohl, EJ; Windeck, T | 1 |
| Grant, KA; Purdy, RH; Shannon, EE | 1 |
| Cho, JH; Jang, CG; Jeong, SM; Kim, HC; Lee, BH; Lee, KW; Lee, SY; Nah, SY; Yoo, JH; Yu, HS | 1 |
| Cools, AR; Groot Kormelink, T; Steenhof, M; Veenvliet, JV; Verheij, MM | 1 |
| Hayashi, T; Li, F; Natsume, M; Ohtani, A; Onuki, F; Satou, T; Senzaki, K; Shiga, T; Yoshikawa, M | 1 |
| Dehpour, AR; Ghaffarpour, M; Ghasemi, M; Gholipour, T; Riazi, K | 1 |
| Ali, U; Chen, L; Fan, LL; Gui, ZH; Hou, C; Li, LB; Liu, J; Wang, T; Wang, Y; Zhang, QJ | 1 |
| Ali, U; Feng, JJ; Gui, ZH; Hui, YP; Li, LB; Liu, J; Niu, XL; Wu, ZH; Zhang, QJ | 1 |
| Oostland, M; Sellmeijer, J; van Hooft, JA | 1 |
| Dubner, R; Gu, M; Guo, W; Miyoshi, K; Noguchi, K; Ren, K; Wei, F; Zou, S | 1 |
| Bétry, C; Ebert, B; Etiévant, A; Haddjeri, N; Pehrson, AL; Sánchez, C | 1 |
| Bègue, L; Bell, R; Duke, AA; Gilmore, PE; Page, D | 1 |
| Horii, A; Imai, T; Inohara, H; Ishida, Y; Kamakura, T; Kitahara, T; Kondo, M; Nakamura, Y; Nishiike, S; Okazaki, S; Shimada, S; Takimoto, Y; Uno, A; Yamada, T | 1 |
| Cui, R; Dong, X; Li, B; Liu, C; Lv, J; Shao, D; Song, Y; Sun, Z; Wang, L; Wang, P; Zhang, X; Zhao, J; Zhou, Y | 1 |
| Dubner, R; Gu, M; Guo, W; Li, M; Liu, J; Miyoshi, K; Noguchi, K; Ren, K; Wei, F; Yang, J; Zou, S | 1 |
| Ishida, Y; Kondo, M; Nakamura, Y; Shimada, S | 1 |
| Cui, R; Li, B; Liu, C; Luo, Y; Shao, D; Wang, P; Zhang, X | 1 |
| Kurosawa, N; Seki, K; Shimizu, K | 1 |
| Fujita, T; Kojima, K; Kojima, SI | 1 |
| Berrocoso, E; Meana, JJ; Mollinedo-Gajate, I; Ortega, JE; Perez-Palomar, B | 1 |
| Ding, F; Li, M; Tian, Y; Xu, Q; Zhang, M; Zhu, M | 1 |
| Kondo, M; Koyama, Y; Kubo, E; Masui, K; Mitani, O; Nakamura, Y; Okamoto, T; Shimada, S; Sumi, T; Usui, N | 1 |
1 trial(s) available for 4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride and piperidines
| Article | Year |
|---|---|
Effects of the selective activation of 5-HT3 receptors on sleep: a polysomnographic study in healthy volunteers.
Topics: Adolescent; Adult; Analysis of Variance; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Humans; Male; Middle Aged; Piperidines; Polysomnography; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Receptor Agonists; Sleep; Sleep, REM | 2001 |
28 other study(ies) available for 4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride and piperidines
| Article | Year |
|---|---|
SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo.
Topics: Animals; Blood-Brain Barrier; Brain; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Guinea Pigs; Ileum; Indoles; Male; Mice; Muscle Contraction; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Tropisetron | 1993 |
Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents.
Topics: Aggression; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Helplessness, Learned; Locomotion; Male; Mice; Mice, Inbred Strains; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists | 1995 |
5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization.
Topics: Animals; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Frontal Lobe; Glutamic Acid; Gyrus Cinguli; Hydrolysis; Indoles; Isomerism; Male; Neurons; Nicotinic Antagonists; Phosphatidylinositols; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tubocurarine | 1996 |
Inhibition of NMDA-receptor mediated response in the rat medial prefrontal cortical pyramidal cells by the 5-HT3 receptor agonist SR 57227A and 5-HT: intracellular studies.
Topics: Animals; Electric Stimulation; Hippocampus; Intracellular Membranes; Male; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission | 1998 |
Effect of acute administration of various 5-HT receptor agonists on focal hippocampal seizures in freely moving rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Complex Partial; Fluoxetine; Hippocampus; Kindling, Neurologic; Male; Piperidines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists | 1998 |
Ionotropic 5-HT3 receptor agonist-induced motor responses in the hindlimbs of paraplegic mice.
Topics: Animals; Biological Clocks; Hindlimb; Injections, Intraperitoneal; Ion Channels; Locomotion; Male; Mice; Muscle Contraction; Muscle, Skeletal; Paraplegia; Piperidines; Receptors, Serotonin, 5-HT3; Serotonin Receptor Agonists; Spinal Cord Injuries | 2005 |
Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.
Topics: Animals; Binding, Competitive; Carbon Radioisotopes; Catechols; Cations; Cell Line, Tumor; Dose-Response Relationship, Drug; Fatty Alcohols; Guanidine; Guinea Pigs; Humans; Ileum; Imidazoles; In Vitro Techniques; Indoles; Ion Channels; Isotonic Contraction; Male; Mice; Organic Cation Transport Proteins; Piperidines; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Sodium Channels; Substance P; Tritium; Tropisetron; Veratridine; Zingiber officinale | 2006 |
Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice.
Topics: Animals; Barbiturates; Benzodiazepines; Discrimination, Psychological; Dizocilpine Maleate; Ethanol; GABA Agents; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperidines; Pregnanolone; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists | 2005 |
Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study.
Topics: Algorithms; Animals; Autoradiography; Behavior, Animal; Dopamine Uptake Inhibitors; Imidazoles; Indoles; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microinjections; Motor Activity; Oocytes; Piperidines; Receptors, Serotonin, 5-HT3; RNA, Complementary; Serotonin Antagonists; Serotonin Receptor Agonists; Tropanes; Xenopus laevis | 2006 |
Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Exploratory Behavior; Fenfluramine; Individuality; Male; Maze Learning; Piperazines; Piperidines; Pyridines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists | 2009 |
Roles of serotonin 5-HT3 receptor in the formation of dendrites and axons in the rat cerebral cortex: an in vitro study.
Topics: Animals; Axons; Cerebral Cortex; Dendrites; Dose-Response Relationship, Drug; Embryo, Mammalian; Glutamate Decarboxylase; In Vitro Techniques; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Serotonin Receptor Agonists | 2010 |
Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide.
Topics: Animals; Anticonvulsants; Arginine; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Granisetron; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Piperidines; Receptors, Serotonin, 5-HT3; Seizures; Serotonin Antagonists | 2010 |
In vivo modulation of the firing activity of putative slow- and fast-spiking interneurons in the medial prefrontal cortex by 5-HT3 receptors in 6-hydroxydopamine-induced Parkinsonian rats.
Topics: Action Potentials; Animals; Cell Count; Dopamine; Interneurons; Male; Oxidopamine; Parkinson Disease; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists; Substantia Nigra; Ventral Tegmental Area | 2010 |
The pyramidal neurons in the medial prefrontal cortex show decreased response to 5-hydroxytryptamine-3 receptor stimulation in a rodent model of Parkinson's disease.
Topics: Action Potentials; Analysis of Variance; Animals; Bicuculline; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Indoles; Male; Oxidopamine; Parkinson Disease; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Serotonin Agents; Statistics, Nonparametric; Substantia Nigra; Tropisetron; Tyrosine 3-Monooxygenase | 2011 |
Transient expression of functional serotonin 5-HT3 receptors by glutamatergic granule cells in the early postnatal mouse cerebellum.
Topics: Animals; Cerebellum; Female; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Transgenic; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Receptor Agonists | 2011 |
Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade.
Topics: Animals; Behavior, Animal; Blotting, Western; Chemokines; CX3C Chemokine Receptor 1; Cytokines; Electric Stimulation; Excitatory Amino Acid Agonists; Gene Transfer Techniques; Glial Fibrillary Acidic Protein; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Interleukin-18; Interleukin-1beta; Male; Microinjections; Neuroglia; Neurons; Neurons, Afferent; Nociceptors; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Chemokine; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin, 5-HT3; Serotonin Receptor Agonists; Signal Transduction; Spinal Cord | 2011 |
The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT(3) receptor antagonism.
Topics: Action Potentials; Animals; Antidepressive Agents; Autoradiography; Drug Administration Schedule; Drug Delivery Systems; Electrolytes; Male; Neurons; Piperazines; Piperidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Sulfides; Time Factors; Vortioxetine | 2013 |
Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Male; Maze Learning; Oxazines; Piperidines; Propane; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides | 2014 |
5-HT(3) receptor expression in the mouse vestibular ganglion.
Topics: Animals; Calcium; Cell Size; Cells, Cultured; Ganglia, Sensory; In Situ Hybridization, Fluorescence; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Optical Imaging; Piperidines; Real-Time Polymerase Chain Reaction; Receptors, Serotonin, 5-HT3; RNA, Messenger; Serotonin 5-HT3 Receptor Agonists; Spiral Ganglion | 2014 |
The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Hippocampus; Male; Mice, Inbred ICR; Ondansetron; Pentylenetetrazole; Piperidines; Proto-Oncogene Proteins c-fos; Seizures; Survival Analysis | 2014 |
Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Male; Neuralgia; Neuroglia; Neurons; Pain Perception; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction; Spinal Cord; Spinal Nerves | 2014 |
The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.
Topics: Animals; Antidepressive Agents; Bromodeoxyuridine; Cell Proliferation; Conditioning, Psychological; Doublecortin Domain Proteins; Exploratory Behavior; Fear; Hindlimb Suspension; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Phosphopyruvate Hydratase; Physical Conditioning, Animal; Piperidines; Receptors, Serotonin, 5-HT3; Serotonin Agents; Swimming | 2015 |
Role of 5-HT3 receptor on food intake in fed and fasted mice.
Topics: Adrenocorticotropic Hormone; Animals; Brain Stem; Corticosterone; Eating; Fasting; Gene Expression Regulation, Enzymologic; Hypothalamus; Male; Mice; Piperidines; Proto-Oncogene Proteins c-fos; Receptors, Serotonin, 5-HT3; Tyrosine 3-Monooxygenase | 2015 |
The role of the AMPA receptor and 5-HT(3) receptor on aggressive behavior and depressive-like symptoms in chronic social isolation-reared mice.
Topics: Aggression; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Depression; Food Preferences; Glutamate Decarboxylase; Hypothalamus; Injections, Intraperitoneal; Male; Mice; Microinjections; Motor Activity; Neurons; Ondansetron; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, Serotonin, 5-HT3; Social Isolation | 2016 |
Investigation of 5-HT
Topics: Animals; Colon; Endocrine Cells; Guinea Pigs; Intestinal Mucosa; Male; Peptide YY; Piperidines; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists | 2017 |
Serotonin 5-HT
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Exploratory Behavior; Locus Coeruleus; Male; Mice; Microdialysis; Norepinephrine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2018 |
Sensation of TRPV1 via 5-hydroxytryptamine signaling modulates pain hypersensitivity in a 6-hydroxydopamine induced mice model of Parkinson's disease.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Hyperalgesia; Male; Mice, Inbred C57BL; Oxidopamine; Pain Threshold; Parkinson Disease; Piperidines; Receptors, Serotonin, 5-HT3; Serotonin; Signal Transduction; Trigeminal Caudal Nucleus; TRPV Cation Channels | 2020 |
SR 57227A, a serotonin type-3 receptor agonist, as a candidate analgesic agent targeting nociplastic pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Mice; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists | 2022 |