Compounds > 4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid

4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid and diethyl-maleate

4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid has been researched along with diethyl-maleate* in 1 studies

Other Studies

1 other study(ies) available for 4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid and diethyl-maleate

Article	Year
Uptake of chromate by rat thymocytes and role of glutathione in its cytoplasmic reduction. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:6 1. Chromate is taken up by rat thymocytes over a wide range of extracellular chromate concentrations (0.074 +/- 5.0 mM). 2. Chromate uptake followed Michaelis-Menten kinetics and was inhibited by 4-acetamido-4'-isothiocyano-stilbene-2,2'-disulphonic acid, suggesting that the anion carrier was responsible for the uptake by rat thymocytes. 3. The decrease in chromate uptake by the thiol(SH)-blocking agent diethyl maleate, the increased chromate uptake caused by the thiol-protecting agent dithiothreitol, and the reduction of glutathione/glutathione disulphide ratio indicated that the maintenance of the integrity of SH-groups greatly influenced the uptake and reduction of Cr(VI), and that glutathione may be responsible for the intracellular reduction of Cr(VI) to Cr(III). Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Biological Transport; Cells, Cultured; Chromates; Chromium Radioisotopes; Dithiothreitol; Glutathione; Glutathione Disulfide; Kinetics; Maleates; Rats; Sodium Compounds; Thymus Gland	1988

Article

Year

Uptake of chromate by rat thymocytes and role of glutathione in its cytoplasmic reduction.

Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:6

1. Chromate is taken up by rat thymocytes over a wide range of extracellular chromate concentrations (0.074 +/- 5.0 mM). 2. Chromate uptake followed Michaelis-Menten kinetics and was inhibited by 4-acetamido-4'-isothiocyano-stilbene-2,2'-disulphonic acid, suggesting that the anion carrier was responsible for the uptake by rat thymocytes. 3. The decrease in chromate uptake by the thiol(SH)-blocking agent diethyl maleate, the increased chromate uptake caused by the thiol-protecting agent dithiothreitol, and the reduction of glutathione/glutathione disulphide ratio indicated that the maintenance of the integrity of SH-groups greatly influenced the uptake and reduction of Cr(VI), and that glutathione may be responsible for the intracellular reduction of Cr(VI) to Cr(III).

Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Biological Transport; Cells, Cultured; Chromates; Chromium Radioisotopes; Dithiothreitol; Glutathione; Glutathione Disulfide; Kinetics; Maleates; Rats; Sodium Compounds; Thymus Gland

1988