Compounds > 4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid

4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid and cilazaprilat

4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid has been researched along with cilazaprilat* in 1 studies

Other Studies

1 other study(ies) available for 4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid and cilazaprilat

Article	Year
In vitro effect of cilazaprilat on sodium-potassium transport systems in human erythrocytes. Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:2 The in vitro effects of cilazaprilat in a concentration range of 10 nM to 1 mM were investigated on various Na+ and K+ transport systems in human red blood cells. Cilazaprilat inhibited the anion carrier or DIDS-sensitive LiCO3(-)-influx and the bumetanide-sensitive K(+)-efflux. However, no effect of cilazaprilat on the Na+, K(+)-pump activity, the number of active Na+ pump units and on the Na+, Li(+)-countertransport activity could be demonstrated. It is suggested that through a decreased anion carrier indicating a decreased Na(+)-influx, the lower intracellular Na+ concentration observed in vivo during angiotensin-converting enzyme inhibition, can be at least partly explained. Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Angiotensin-Converting Enzyme Inhibitors; Biological Transport; Cilazapril; Erythrocytes; Humans; In Vitro Techniques; Lithium; Male; Potassium; Pyridazines; Rubidium Radioisotopes; Sodium	1990

Article

Year

In vitro effect of cilazaprilat on sodium-potassium transport systems in human erythrocytes.

Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:2

The in vitro effects of cilazaprilat in a concentration range of 10 nM to 1 mM were investigated on various Na+ and K+ transport systems in human red blood cells. Cilazaprilat inhibited the anion carrier or DIDS-sensitive LiCO3(-)-influx and the bumetanide-sensitive K(+)-efflux. However, no effect of cilazaprilat on the Na+, K(+)-pump activity, the number of active Na+ pump units and on the Na+, Li(+)-countertransport activity could be demonstrated. It is suggested that through a decreased anion carrier indicating a decreased Na(+)-influx, the lower intracellular Na+ concentration observed in vivo during angiotensin-converting enzyme inhibition, can be at least partly explained.

Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Angiotensin-Converting Enzyme Inhibitors; Biological Transport; Cilazapril; Erythrocytes; Humans; In Vitro Techniques; Lithium; Male; Potassium; Pyridazines; Rubidium Radioisotopes; Sodium

1990