4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid has been researched along with 1-9-dideoxyforskolin* in 1 studies
1 other study(ies) available for 4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid and 1-9-dideoxyforskolin
| Article | Year |
|---|---|
Volume-activated Cl- secretion and transepithelial vinblastine secretion mediated by P-glycoprotein are not correlated in cultured human T84 intestinal epithelial layers.
The relationship between the P-glycoprotein-mediated vinblastine secretion and cell-swelling activated Cl- secretion (conductance) in intact epithelial layers of human colonic adenocarcinoma T84 cells has been investigated. Whereas vinblastine secretion is effectively inhibited by 100 microM 1,9-dideoxy-forskolin, volume-stimulated Cl- secretion is unaffected. In contrast, 100 microM 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid (DIDS) inhibited the volume-stimulated Cl- secretion, but was without effect upon transepithelial vinblastine secretion. In addition, it was noted that some epithelial layers failed to express a volume-stimulated Cl- secretion but maintained a normal level of secretory vinblastine flux. Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Chloride Channels; Chlorides; Colforsin; Humans; Intestinal Mucosa; Membrane Glycoproteins; Membrane Proteins; Tumor Cells, Cultured; Vinblastine | 1992 |