4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine has been researched along with trimethoprim in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doweyko, AM | 1 |
| Crippen, GM; Ghose, AK | 3 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Dias, CB; Hansch, C; Khwaja, TA; Pentecost, S; Selassie, CD | 1 |
| Marlowe, CK; Santi, DV; Selassie, CD | 1 |
| Crippen, GM | 1 |
| Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M | 1 |
9 other study(ies) available for 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine and trimethoprim
| Article | Year |
|---|---|
The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules.
Topics: Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Lactoylglutathione Lyase; Lyases; Microcomputers; Models, Chemical; Models, Molecular; Molecular Conformation; Saccharomyces cerevisiae; Structure-Activity Relationship; Thermodynamics | 1988 |
Use of physicochemical parameters in distance geometry and related three-dimensional quantitative structure-activity relationships: a demonstration using Escherichia coli dihydrofolate reductase inhibitors.
Topics: Binding Sites; Escherichia coli; Folic Acid Antagonists; Models, Molecular; Protein Conformation; Structure-Activity Relationship | 1985 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L5178; Leukemia, Experimental; Mathematics; Methotrexate; Mice; Structure-Activity Relationship; Triazines | 1984 |
General distance geometry three-dimensional receptor model for diverse dihydrofolate reductase inhibitors.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallography; Folic Acid Antagonists; Liver; Models, Chemical; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Rats; Structure-Activity Relationship; Triazines | 1984 |
Combined distance geometry analysis of dihydrofolate reductase inhibition by quinazolines and triazines.
Topics: Chemical Phenomena; Chemistry; Folic Acid Antagonists; Molecular Conformation; Quinazolines; Streptococcus; Structure-Activity Relationship; Triazines | 1983 |
Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines.
Topics: Folic Acid Antagonists; Fungal Proteins; Kinetics; Pneumocystis; Structure-Activity Relationship; Triazines | 1995 |
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
Topics: Algorithms; Animals; Binding Sites; Computer Simulation; Folic Acid Antagonists; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Steroids; Testosterone; Tetrahydrofolate Dehydrogenase; Transcortin | 1997 |
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2017 |