Compounds > 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine
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4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine and 2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine

4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine has been researched along with 2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19906 (66.67)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blaney, JM; Dietrich, SW; Guo, ZR; Hansch, C; Hathaway, BA; Kaufman, BT; Langridge, R; Selassie, CD; Volz, KW1
Delcamp, TJ; Freisheim, JH; Guo, ZR; Hansch, C; Hathaway, BA; Susten, SS1
Dias, CB; Hansch, C; Khwaja, TA; Pentecost, S; Selassie, CD1
Crippen, GM; Ghose, AK2
Dietrich, SW; Fukunaga, JY; Hansch, C1
Crippen, GM1
Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y1
Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M1

Other Studies

9 other study(ies) available for 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine and 2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine

ArticleYear
Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:2

    Topics: Animals; Chickens; Computers; Folic Acid Antagonists; Lacticaseibacillus casei; Liver; Mathematics; Models, Molecular; Molecular Conformation; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines; X-Ray Diffraction

1984
Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:2

    Topics: Animals; Cattle; Cell Line; Folic Acid Antagonists; Humans; Lymphocytes; Mathematics; Mice; Molecular Conformation; Structure-Activity Relationship; Triazines

1984
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:3

    Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L5178; Leukemia, Experimental; Mathematics; Methotrexate; Mice; Structure-Activity Relationship; Triazines

1984
General distance geometry three-dimensional receptor model for diverse dihydrofolate reductase inhibitors.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:7

    Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallography; Folic Acid Antagonists; Liver; Models, Chemical; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Rats; Structure-Activity Relationship; Triazines

1984
Combined distance geometry analysis of dihydrofolate reductase inhibition by quinazolines and triazines.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:7

    Topics: Chemical Phenomena; Chemistry; Folic Acid Antagonists; Molecular Conformation; Quinazolines; Streptococcus; Structure-Activity Relationship; Triazines

1983
Inhibition of bovine and rat liver dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-substituted-phenyl)-s-triazines.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:5

    Topics: Animals; Cattle; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Liver; Rats; Structure-Activity Relationship; Triazines

1981
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
    Journal of medicinal chemistry, 1997, Sep-26, Volume: 40, Issue:20

    Topics: Algorithms; Animals; Binding Sites; Computer Simulation; Folic Acid Antagonists; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Steroids; Testosterone; Tetrahydrofolate Dehydrogenase; Transcortin

1997
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
    Science (New York, N.Y.), 2011, Dec-09, Volume: 334, Issue:6061

    Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Humans; Imidazoles; Liver; Malaria; Mice; Mice, Inbred BALB C; Molecular Structure; Piperazines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Polymorphism, Single Nucleotide; Protozoan Proteins; Random Allocation; Small Molecule Libraries; Sporozoites

2011
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
    European journal of medicinal chemistry, 2017, Jul-28, Volume: 135

    Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines

2017