4-6-cholestadien-3-one and cholest-4-en-3-one

4-6-cholestadien-3-one has been researched along with cholest-4-en-3-one* in 1 studies

Other Studies

1 other study(ies) available for 4-6-cholestadien-3-one and cholest-4-en-3-one

ArticleYear
The cholesterol metabolite cholest-4-en-3-one and its 3-oxo derivatives suppress body weight gain, body fat accumulation and serum lipid concentration in mice.
    Bioorganic & medicinal chemistry letters, 1998, Aug-18, Volume: 8, Issue:16

    Based on the findings that cholest-4-en-3-one, an intestinal metabolite of cholesterol, has an anti-obesity effect on animals, the structure-effect relationship of its 3-oxo derivatives and related compounds were investigated. Cholesten-3-ones, which possesses an enone structure with a carbonyl group at C3, markedly inhibit body weight gain and body fat accumulation, as well as the levels of serum triglyceride and cholesterol in animals without any clinical abnormalities.

    Topics: Adipose Tissue; Animals; Cholestenones; Cholesterol; Drug Design; Lipids; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Molecular Structure; Organ Size; Structure-Activity Relationship; Weight Gain

1998
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