4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol has been researched along with isoxazoles in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (53.33) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Emri, Z; Juhász, G; Kékesi, KA; Krogsgaard-Larsen, P; Schousboe, A; Ujszászi, J | 1 |
| Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N | 1 |
| Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A | 1 |
| Krogsgaard-Larsen, P; Schousboe, A; Wood, JD | 1 |
| Borsini, F; Evangelista, S; Meli, A | 1 |
| Engler, J; Hjeds, H; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD | 1 |
| Dingledine, R; Korn, SJ | 1 |
| Ben-Ari, Y; Cherubini, E; Rovira, C | 1 |
| Krogsgaard-Larsen, P | 1 |
| Cavagnini, F; Grandison, L; Guidotti, A; Invitti, SC; Schmid, R | 1 |
| Curtis, DR; Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Leah, JD; Mikkelsen, H; Peet, MJ | 1 |
| Depaulis, A; Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM | 1 |
| Johnson, DD; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD | 1 |
| Croucher, MJ; Krogsgaard-Larsen, P; Meldrum, BS | 1 |
| Magelund, G; Olianas, MC; Scheel-Krüger, J | 1 |
| Hansen, SH; Schultz, B | 1 |
| Bergstrom, DA; Walters, JR; Waszczak, BL | 1 |
| Dobolyi, A; Juhász, G; Kékesi, KA; Krogsgaard-Larsen, P; Nyitrai, G; Schousboe, A | 1 |
| Nicklas, WJ; Zeevalk, GD | 1 |
| Ghanipoor, N; Parvini, S; Rezayat, M; Zarrindast, MR | 1 |
| Parvini, S; Pirali, M; Rezayat, M; Tabarrai, E; Zarrindast, MR | 1 |
| Bolvig, T; Brehm, L; Buur, A; Falch, E; Frydenvang, K; FrŁlund, B; Hansen, LM; Krogsgaard-Larsen, P; Larsson, OM; Perregaard, J; Sanchez, C; Schousboe, A; SŁkilde, B; White, HS | 1 |
| Borowski, T; Broclawik, E | 1 |
| Johnson, SW; Shen, KZ | 1 |
| Bolvig, T; Frølund, B; Kristensen, AS; Krogsgaard-Larsen, P; Larsson, OM; Nelson, N; Petersen, G; Pickering, DS; Sarup, A; Schousboe, A; White, HS | 1 |
| Galler, JR; Shultz, PL; Tonkiss, J | 1 |
| Frølund, B; Larsen, BB; Larsen, M; Nielsen, CU | 1 |
| Madsen, KK; Schousboe, A | 1 |
| Alibhai, D; Aungraheeta, MR; Burley, K; Collins, J; Cornish, N; Downes, K; FitzGibbon, L; Greene, D; Mumford, AD; Turro, E; Westbury, SK | 1 |
| Cui, J; Feng, L; James, TD; Li, L; Liu, T; Ma, X; Shao, B; Tian, X; Yao, D | 1 |
4 review(s) available for 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol and isoxazoles
| Article | Year |
|---|---|
GABA uptake inhibitors: relevance to antiepileptic drug research.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Neurotransmitter Uptake Inhibitors; Oxazoles | 1987 |
Inhibitors of the GABA uptake systems.
Topics: Animals; Astrocytes; Biological Transport; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoxazoles; Muscimol; Neuroglia; Neurons; Nipecotic Acids; Receptors, Neurotransmitter; Structure-Activity Relationship; Synapses; Synaptosomes | 1980 |
Role of GABA in the striatal output system: globus pallidus, nucleus entopeduncularis, substantia nigra and nucleus subthalamicus.
Topics: Animals; Basal Ganglia; Behavior, Animal; Corpus Striatum; Dopamine; Functional Laterality; gamma-Aminobutyric Acid; Globus Pallidus; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Substantia Nigra; Thalamus | 1981 |
Delineation of the Role of Astroglial GABA Transporters in Seizure Control.
Topics: Animals; Anticonvulsants; Astrocytes; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Humans; Isoxazoles; Seizures | 2017 |
26 other study(ies) available for 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol and isoxazoles
| Article | Year |
|---|---|
Sleep promoting effect of a putative glial gamma-aminobutyric acid uptake blocker applied in the thalamus of cats.
Topics: Animals; Cats; Dialysis; Extracellular Space; gamma-Aminobutyric Acid; Isoxazoles; Neuroglia; Neurotransmitter Uptake Inhibitors; Perfusion; Sleep; Thalamus; Wakefulness | 1991 |
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Seizures | 1985 |
Amplification by glycine of the effect of the GABA transport inhibitor THPO on synaptosomal GABA level.
Topics: Amino Acids; Animals; Brain; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Oxazoles; Synaptosomes | 1988 |
Effect of GABAergic drugs in the behavioral 'despair' test in rats.
Topics: Acetates; Aminooxyacetic Acid; Animals; Baclofen; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Muscimol; Oxazoles; Picrotoxin; Rats | 1986 |
Tissue distribution, metabolism, anticonvulsant efficacy and effect on brain amino acid levels of the glia-selective gamma-aminobutyric acid transport inhibitor 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol in mice and chicks.
Topics: Amino Acids; Animals; Anticonvulsants; Biological Transport; Brain; Chickens; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Liver; Male; Mice; Oxazoles; Tissue Distribution | 1986 |
Prolongation of gamma-aminobutyric acid-mediated inhibitory postsynaptic potentials by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THPO).
Topics: Animals; Drug Interactions; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Iontophoresis; Isoxazoles; Neural Inhibition; Nipecotic Acids; Oxazoles; Rats; Synapses | 1986 |
Somatic and dendritic actions of gamma-aminobutyric acid agonists and uptake blockers in the hippocampus in vivo.
Topics: Acetylcholine; Action Potentials; Animals; Dendrites; gamma-Aminobutyric Acid; Hippocampus; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Synaptic Transmission | 1984 |
gamma-Aminobutyric acid- and benzodiazepine-binding sites in human anterior pituitary tissue.
Topics: Adult; Aged; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Middle Aged; Muscimol; Pituitary Gland, Anterior; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1982 |
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
Topics: Animals; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes | 1983 |
Enhancement of spike and wave discharges by GABAmimetic drugs in rats with spontaneous petit-mal-like epilepsy.
Topics: Action Potentials; Aminocaproates; Animals; Baclofen; Epilepsy, Absence; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Rats; Vigabatrin | 1984 |
Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO.
Topics: 4-Aminobutyrate Transaminase; Animals; Animals, Newborn; Anticonvulsants; Chickens; Cyclohexanecarboxylic Acids; Isoniazid; Isoxazoles; Male; Mice; Oxazoles; Seizures; Transaminases | 1983 |
Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Body Temperature; Female; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections, Intraventricular; Isoxazoles; Male; Mice; Mice, Inbred DBA; Motor Activity; Nipecotic Acids; Pentylenetetrazole; Seizures | 1983 |
Determination of the gamma-aminobutyric acid agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol in urine by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Isoxazoles; Kinetics; Oxazoles; Rats | 1982 |
Single unit responses of substantia nigra and globus pallidus neurons to GABA agonist and antagonist drugs.
Topics: Animals; gamma-Aminobutyric Acid; Globus Pallidus; Iontophoresis; Isoxazoles; Kainic Acid; Male; Muscimol; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Substantia Nigra | 1981 |
Differential effects of nipecotic acid and 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol on extracellular gamma-aminobutyrate levels in rat thalamus.
Topics: Animals; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Extracellular Space; gamma-Aminobutyric Acid; Isoxazoles; Microdialysis; Nipecotic Acids; Proline; Rats; Rats, Wistar; Thalamus | 1997 |
Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Chick Embryo; Culture Techniques; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycolysis; Iodoacetates; Ischemia; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nipecotic Acids; Organic Anion Transporters; Oximes; Proline; Retina | 1997 |
Interactions between antinociception induced by cholecystokinin antagonists and GABA agonists in the tail-flick test.
Topics: Animals; Baclofen; Benzodiazepinones; Devazepide; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; Isoxazoles; Male; Mice; Motor Activity; Pain; Pain Measurement; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Tail | 1998 |
Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Baclofen; Dose-Response Relationship, Drug; Formaldehyde; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Morphine; Pain; Pain Measurement; Receptors, Cholecystokinin | 1999 |
Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues.
Topics: Animals; Crystallography, X-Ray; gamma-Aminobutyric Acid; Hydrogen Bonding; Isoxazoles; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Neuroglia; Rats; Stereoisomerism | 1999 |
Characteristics of the ligand-binding site interaction for a series of arecoline-derived muscarinic agonists: a quantum chemical study.
Topics: Arecoline; Binding Sites; Bridged Bicyclo Compounds; Computer Simulation; Electrochemistry; Electron Spin Resonance Spectroscopy; Electrons; Isoxazoles; Ligands; Molecular Conformation; Muscarinic Agonists; Quantum Theory; Receptors, Muscarinic | 2000 |
Potentiation of GABA(A) receptor agonists by GABA uptake inhibitors in the rat ventral midbrain.
Topics: Animals; Carrier Proteins; Drug Synergism; Electrophysiology; GABA Agonists; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Mesencephalon; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Oximes; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium; Suprachiasmatic Nucleus | 2001 |
Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkyla
Topics: Alkylation; Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Biological Transport; Carrier Proteins; Cells, Cultured; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Neuroglia; Neurons; Organic Anion Transporters; Prefrontal Cortex; Structure-Activity Relationship | 2002 |
Prenatal protein malnutrition enhances stimulus control by CDP, but not a CDP/THIP combination in rats.
Topics: Animals; Chlordiazepoxide; Dietary Proteins; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Combinations; Female; Isoxazoles; Male; Placental Insufficiency; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2002 |
Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells.
Topics: Algorithms; Amino Acid Transport Systems; Amino Acids; Biological Transport, Active; Caco-2 Cells; GABA Agonists; gamma-Aminobutyric Acid; Glycine; Humans; Hydrogen-Ion Concentration; Isoxazoles; Kinetics; Ligands; Muscimol; Neurotransmitter Uptake Inhibitors; Osmolar Concentration; Proline; Symporters | 2008 |
Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia.
Topics: Humans; Isoxazoles; Thrombocytopenia; Thrombopoietin | 2020 |
Visual High-Throughput Screening for Developing a Fatty Acid Amide Hydrolase Natural Inhibitor Based on an Enzyme-Activated Fluorescent Probe.
Topics: Amidohydrolases; Benzamides; Carbamates; Cell Line; Cell Survival; Fluorescent Dyes; High-Throughput Screening Assays; Humans; Isoxazoles; Psoralea; Recombinant Proteins | 2020 |