Compounds > 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol

4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol and gamma-aminobutyric acid

4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol has been researched along with gamma-aminobutyric acid in 22 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (63.64)	18.7374
1990's	5 (22.73)	18.2507
2000's	3 (13.64)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Curtis, DR; Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Leah, JD; Mikkelsen, H; Peet, MJ	1
Emri, Z; Juhász, G; Kékesi, KA; Krogsgaard-Larsen, P; Schousboe, A; Ujszászi, J	1
Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N	1
Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A	1
Krogsgaard-Larsen, P; Schousboe, A; Wood, JD	1
Borsini, F; Evangelista, S; Meli, A	1
Engler, J; Hjeds, H; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD	1
Dingledine, R; Korn, SJ	1
Ben-Ari, Y; Cherubini, E; Rovira, C	1
Krogsgaard-Larsen, P	1
Cavagnini, F; Grandison, L; Guidotti, A; Invitti, SC; Schmid, R	1
Depaulis, A; Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM	1
Croucher, MJ; Krogsgaard-Larsen, P; Meldrum, BS	1
Magelund, G; Olianas, MC; Scheel-Krüger, J	1
Bergstrom, DA; Walters, JR; Waszczak, BL	1
Dobolyi, A; Juhász, G; Kékesi, KA; Krogsgaard-Larsen, P; Nyitrai, G; Schousboe, A	1
Nicklas, WJ; Zeevalk, GD	1
Parvini, S; Pirali, M; Rezayat, M; Tabarrai, E; Zarrindast, MR	1
Bolvig, T; Brehm, L; Buur, A; Falch, E; Frydenvang, K; FrŁlund, B; Hansen, LM; Krogsgaard-Larsen, P; Larsson, OM; Perregaard, J; Sanchez, C; Schousboe, A; SŁkilde, B; White, HS	1
Johnson, SW; Shen, KZ	1
Bolvig, T; Frølund, B; Kristensen, AS; Krogsgaard-Larsen, P; Larsson, OM; Nelson, N; Petersen, G; Pickering, DS; Sarup, A; Schousboe, A; White, HS	1
Frølund, B; Larsen, BB; Larsen, M; Nielsen, CU	1

Reviews

3 review(s) available for 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol and gamma-aminobutyric acid

Article	Year
GABA uptake inhibitors: relevance to antiepileptic drug research. Epilepsy research, 1987, Volume: 1, Issue:2 Topics: Animals; Anticonvulsants; Brain; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Neurotransmitter Uptake Inhibitors; Oxazoles	1987
Inhibitors of the GABA uptake systems. Molecular and cellular biochemistry, 1980, Jun-18, Volume: 31, Issue:2 Topics: Animals; Astrocytes; Biological Transport; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoxazoles; Muscimol; Neuroglia; Neurons; Nipecotic Acids; Receptors, Neurotransmitter; Structure-Activity Relationship; Synapses; Synaptosomes	1980
Role of GABA in the striatal output system: globus pallidus, nucleus entopeduncularis, substantia nigra and nucleus subthalamicus. Advances in biochemical psychopharmacology, 1981, Volume: 30 Topics: Animals; Basal Ganglia; Behavior, Animal; Corpus Striatum; Dopamine; Functional Laterality; gamma-Aminobutyric Acid; Globus Pallidus; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Substantia Nigra; Thalamus	1981

Other Studies

19 other study(ies) available for 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol and gamma-aminobutyric acid

Article	Year
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. Journal of medicinal chemistry, 1983, Volume: 26, Issue:6 Topics: Animals; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes	1983
Sleep promoting effect of a putative glial gamma-aminobutyric acid uptake blocker applied in the thalamus of cats. European journal of pharmacology, 1991, Dec-10, Volume: 209, Issue:1-2 Topics: Animals; Cats; Dialysis; Extracellular Space; gamma-Aminobutyric Acid; Isoxazoles; Neuroglia; Neurotransmitter Uptake Inhibitors; Perfusion; Sleep; Thalamus; Wakefulness	1991
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor. General pharmacology, 1985, Volume: 16, Issue:5 Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Seizures	1985
Amplification by glycine of the effect of the GABA transport inhibitor THPO on synaptosomal GABA level. Neurochemical research, 1988, Volume: 13, Issue:10 Topics: Amino Acids; Animals; Brain; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Oxazoles; Synaptosomes	1988
Effect of GABAergic drugs in the behavioral 'despair' test in rats. European journal of pharmacology, 1986, Feb-18, Volume: 121, Issue:2 Topics: Acetates; Aminooxyacetic Acid; Animals; Baclofen; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Muscimol; Oxazoles; Picrotoxin; Rats	1986
Tissue distribution, metabolism, anticonvulsant efficacy and effect on brain amino acid levels of the glia-selective gamma-aminobutyric acid transport inhibitor 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol in mice and chicks. Journal of neurochemistry, 1986, Volume: 47, Issue:3 Topics: Amino Acids; Animals; Anticonvulsants; Biological Transport; Brain; Chickens; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Liver; Male; Mice; Oxazoles; Tissue Distribution	1986
Prolongation of gamma-aminobutyric acid-mediated inhibitory postsynaptic potentials by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THPO). Neuroscience letters, 1986, Feb-14, Volume: 64, Issue:1 Topics: Animals; Drug Interactions; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Iontophoresis; Isoxazoles; Neural Inhibition; Nipecotic Acids; Oxazoles; Rats; Synapses	1986
Somatic and dendritic actions of gamma-aminobutyric acid agonists and uptake blockers in the hippocampus in vivo. Neuroscience, 1984, Volume: 12, Issue:2 Topics: Acetylcholine; Action Potentials; Animals; Dendrites; gamma-Aminobutyric Acid; Hippocampus; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Synaptic Transmission	1984
gamma-Aminobutyric acid- and benzodiazepine-binding sites in human anterior pituitary tissue. The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:3 Topics: Adult; Aged; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Middle Aged; Muscimol; Pituitary Gland, Anterior; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A	1982
Enhancement of spike and wave discharges by GABAmimetic drugs in rats with spontaneous petit-mal-like epilepsy. Neuroscience letters, 1984, Jan-27, Volume: 44, Issue:1 Topics: Action Potentials; Aminocaproates; Animals; Baclofen; Epilepsy, Absence; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Rats; Vigabatrin	1984
Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration. European journal of pharmacology, 1983, May-06, Volume: 89, Issue:3-4 Topics: Acoustic Stimulation; Animals; Anticonvulsants; Body Temperature; Female; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections, Intraventricular; Isoxazoles; Male; Mice; Mice, Inbred DBA; Motor Activity; Nipecotic Acids; Pentylenetetrazole; Seizures	1983
Single unit responses of substantia nigra and globus pallidus neurons to GABA agonist and antagonist drugs. Advances in biochemical psychopharmacology, 1981, Volume: 30 Topics: Animals; gamma-Aminobutyric Acid; Globus Pallidus; Iontophoresis; Isoxazoles; Kainic Acid; Male; Muscimol; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Substantia Nigra	1981
Differential effects of nipecotic acid and 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol on extracellular gamma-aminobutyrate levels in rat thalamus. European journal of pharmacology, 1997, Jul-23, Volume: 331, Issue:2-3 Topics: Animals; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Extracellular Space; gamma-Aminobutyric Acid; Isoxazoles; Microdialysis; Nipecotic Acids; Proline; Rats; Rats, Wistar; Thalamus	1997
Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina. Vision research, 1997, Volume: 37, Issue:24 Topics: Animals; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Chick Embryo; Culture Techniques; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycolysis; Iodoacetates; Ischemia; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nipecotic Acids; Organic Anion Transporters; Oximes; Proline; Retina	1997
Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 9, Issue:1-2 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Baclofen; Dose-Response Relationship, Drug; Formaldehyde; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Morphine; Pain; Pain Measurement; Receptors, Cholecystokinin	1999
Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues. Journal of medicinal chemistry, 1999, Dec-30, Volume: 42, Issue:26 Topics: Animals; Crystallography, X-Ray; gamma-Aminobutyric Acid; Hydrogen Bonding; Isoxazoles; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Neuroglia; Rats; Stereoisomerism	1999
Potentiation of GABA(A) receptor agonists by GABA uptake inhibitors in the rat ventral midbrain. European journal of pharmacology, 2001, Sep-28, Volume: 428, Issue:1 Topics: Animals; Carrier Proteins; Drug Synergism; Electrophysiology; GABA Agonists; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Mesencephalon; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Oximes; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium; Suprachiasmatic Nucleus	2001
Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkyla The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2 Topics: Alkylation; Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Biological Transport; Carrier Proteins; Cells, Cultured; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Neuroglia; Neurons; Organic Anion Transporters; Prefrontal Cortex; Structure-Activity Relationship	2002
Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008, Sep-02, Volume: 35, Issue:1-2 Topics: Algorithms; Amino Acid Transport Systems; Amino Acids; Biological Transport, Active; Caco-2 Cells; GABA Agonists; gamma-Aminobutyric Acid; Glycine; Humans; Hydrogen-Ion Concentration; Isoxazoles; Kinetics; Ligands; Muscimol; Neurotransmitter Uptake Inhibitors; Osmolar Concentration; Proline; Symporters	2008