4-4-difluoro-4-bora-3a-4a-diaza-s-indacene and phosphoric-acid

4-4-difluoro-4-bora-3a-4a-diaza-s-indacene has been researched along with phosphoric-acid* in 1 studies

Other Studies

1 other study(ies) available for 4-4-difluoro-4-bora-3a-4a-diaza-s-indacene and phosphoric-acid

Article	Year
The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway. Angewandte Chemie (International ed. in English), 2016, 06-27, Volume: 55, Issue:27 A divergent approach to enantioenriched 2H- and 3H-pyrroles catalyzed by a spirocyclic phosphoric acid is reported that makes use of a Fischer-type indolization and a [1,5]-alkyl shift. Catalyzed by the chiral phosphoric acid STRIP, good to excellent yields and enantioselectivities could be obtained. Remarkably, biological evaluation reveals one of these novel 2H-pyrroles to be a potent but nontoxic inhibitor of the Hedgehog signaling pathway by binding to the Smoothened protein. Topics: Boron Compounds; Catalysis; Crystallography, X-Ray; Hedgehog Proteins; HEK293 Cells; Humans; Microscopy, Fluorescence; Molecular Conformation; Phosphoric Acids; Pyrroles; Signal Transduction; Stereoisomerism	2016

Article

Year

The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway.

Angewandte Chemie (International ed. in English), 2016, 06-27, Volume: 55, Issue:27

A divergent approach to enantioenriched 2H- and 3H-pyrroles catalyzed by a spirocyclic phosphoric acid is reported that makes use of a Fischer-type indolization and a [1,5]-alkyl shift. Catalyzed by the chiral phosphoric acid STRIP, good to excellent yields and enantioselectivities could be obtained. Remarkably, biological evaluation reveals one of these novel 2H-pyrroles to be a potent but nontoxic inhibitor of the Hedgehog signaling pathway by binding to the Smoothened protein.

Topics: Boron Compounds; Catalysis; Crystallography, X-Ray; Hedgehog Proteins; HEK293 Cells; Humans; Microscopy, Fluorescence; Molecular Conformation; Phosphoric Acids; Pyrroles; Signal Transduction; Stereoisomerism

2016