4-4--dihydroxychalcone and isoliquiritigenin

4-4--dihydroxychalcone has been researched along with isoliquiritigenin* in 1 studies

Other Studies

1 other study(ies) available for 4-4--dihydroxychalcone and isoliquiritigenin

Article	Year
Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives. Journal of natural products, 2016, Jan-22, Volume: 79, Issue:1 Five isoliquiritigenin analogues, including a new methylene-bridged bischalcone (1), were isolated from Spatholobus suberectus. Cytotoxicity screening of these isolates and several synthetic derivatives indicated that the introduction, removal, position modification, or glycosylation of hydroxy groups in isoliquiritigenin did not improve the resultant cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines. In addition, cyclization of OH-2' chalcones or reduction of the α,β-unsaturated carbonyl double bond decreased such cytotoxicity substantially. However, methylation of hydroxy groups resulted in a marked increase in such cytotoxic activity. Among these active isoliquiritigenin analogues, 3',4',5',4″-tetramethoxychalcone (3h) was obtained as a compound with promising cytotoxic activity. Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Proliferation; Chalcones; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Fabaceae; Female; Humans; Molecular Structure	2016

Article

Year

Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives.

Journal of natural products, 2016, Jan-22, Volume: 79, Issue:1

Five isoliquiritigenin analogues, including a new methylene-bridged bischalcone (1), were isolated from Spatholobus suberectus. Cytotoxicity screening of these isolates and several synthetic derivatives indicated that the introduction, removal, position modification, or glycosylation of hydroxy groups in isoliquiritigenin did not improve the resultant cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines. In addition, cyclization of OH-2' chalcones or reduction of the α,β-unsaturated carbonyl double bond decreased such cytotoxicity substantially. However, methylation of hydroxy groups resulted in a marked increase in such cytotoxic activity. Among these active isoliquiritigenin analogues, 3',4',5',4″-tetramethoxychalcone (3h) was obtained as a compound with promising cytotoxic activity.

Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Proliferation; Chalcones; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Fabaceae; Female; Humans; Molecular Structure

2016