Page last updated: 2024-09-03

4'-phosphopantetheine and pantetheine

4'-phosphopantetheine has been researched along with pantetheine in 129 studies

Compound Research Comparison

Studies
(4'-phosphopantetheine)
Trials
(4'-phosphopantetheine)
Recent Studies (post-2010)
(4'-phosphopantetheine)
Studies
(pantetheine)
Trials
(pantetheine)
Recent Studies (post-2010) (pantetheine)
1290294651887

Research

Studies (129)

TimeframeStudies, this research(%)All Research%
pre-199019 (14.73)18.7374
1990's24 (18.60)18.2507
2000's51 (39.53)29.6817
2010's27 (20.93)24.3611
2020's8 (6.20)2.80

Authors

AuthorsStudies
Cebe, M; Perahia, D1
Han, KK; Martinage, A1
Díez, B; Gutiérrez, S; Martín, JF; Montenegro, E1
Drueckhammer, D; Reichert, J; Rusnak, F; Sakaitani, M; Walsh, CT1
Fernandez, MD; Lamppa, GK2
Fearnley, IM; Runswick, MJ; Skehel, JM; Walker, JE1
Geiger, O; Kennedy, EP; Spaink, HP1
Dittmann, J; Kleinkauf, H; Lawen, A; Zocher, R1
Lawen, A; Zocher, R1
Jaworski, JG; Ohlrogge, JB; Post-Beittenmiller, MA1
Brody, S; Lakin-Thomas, PL1
Neely, JR; Tahiliani, AG1
Kennedy, EP; Therisod, H1
Gurinovich, VA; Moiseenok, AG; Sheibak, VM1
Knudsen, J; Randhawa, ZI; Smith, S; Stern, A1
Knudsen, J; Mikkelsen, J; Smith, S; Stern, A1
Azuma, I; Iida, J; Nishimura, K; Ukei, S1
Burton, DN; Yu, HL1
Jackowski, S; Rock, CO3
Gross, CJ; Henderson, LM; Shibata, K1
Kumagai, A; Matsuoka, N; Morisaki, N; Saito, Y1
Kumagai, A; Matsuoka, N; Morisaki, N; Saito, Y; Sasaki, N; Shirai, K1
Keller, U; Kleinkauf, H; Zocher, R1
Katiyar, SS; Pan, D; Porter, JW1
Abu-Elheiga, L; al-Feel, W; Chirala, SS; Hsu, M; Huang, WY; Jayakumar, A; Tai, MH; Wakil, SJ1
Franke, P; Kluge, B; Otto, A; Stein, T; Vater, J; Wittmann-Liebold, B1
Franke, P; Kruft, V; Mc Dowell, R; Morris, HR; Panico, M; Stein, T; Vater, J; Wittmann-Liebold, B1
Geiger, O; Ghose, R; Prestegard, JH1
Flint, DH1
Drueckhammer, DG; Gehring, AM; Lambalot, RH; Vogel, KW; Walsh, CT1
Bradley, KA; Gehring, AM; Walsh, CT1
Joshi, AK; Smith, S; Witkowski, A1
Quadri, LE; Walsh, CT; Weinreb, PH; Zuber, P1
Bucovaz, ET; Macleod, RM; Morrison, JC; Whybrew, WD1
Hoppensack, A; Rehm, BH; Steinbüchel, A1
Broadwater, JA; Fox, BG1
Belshaw, PJ; Stachelhaus, T; Walsh, CT1
Falick, AM; Joshi, AK; Rangan, VS; Smith, S; Witkowska, HE; Witkowski, A1
Hughes, C; Hyland, C; Koronakis, V; Stanley, P1
Cronan, JE; Flugel, RS; Hwangbo, Y; Lambalot, RH; Walsh, CT1
Kleinkauf, H1
Keating, TA; Miller, DA; Walsh, CT1
Stachelhaus, T; Walsh, CT1
Blaesse, M; Jung, G; Kupke, T; Schmid, D; Steinbacher, S; Uebele, M1
Bugg, CW; Huang, F; Yarus, M1
Suo, Z; Tseng, CC; Walsh, CT1
Ferber, D1
Culianez-Macia, FA; Hernandez-Acosta, P; Kupke, T; Steinbacher, S1
Luo, L; Walsh, CT1
Begley, TP; Strauss, E1
Finking, R; Marahiel, MA; Mootz, HD1
Bhattacharjee, JK; Evans, SA; Guo, S; Wilkes, MB1
Dunaway-Mariano, D; Luo, L; Taylor, KL; Wei, Y; Xiang, H; Zhang, W1
Izard, T1
Bruner, SD; Kohli, RM; Marahiel, MA; Schwarzer, D; Stubbs, MT; Walsh, CT; Weber, T1
Burkart, MD; Marshall, CG; Meray, RK; Walsh, CT1
Ferlan, JT; Gardner, MJ; Guszczynski, T; Kopydlowski, KM; Lee, PJ; Li, Z; Prigge, ST; Sellers, P; Shallom, S; Waters, NC; Wei, L; Woodard, CL1
Fox, BG; Haas, JA1
Khosla, C; Li, Q; Liu, CW; Puglisi, JD1
Chakrabarti, S; Sowdhamini, R1
Culiáñez-Macià, FA; Hernández-Acosta, P; Kupke, T1
Amara, AA; Rehm, BH1
ALBERTS, AW; MAJERUS, PW; VAGELOS, PR1
Arisaka, F; Fujimoto, Y; Inagaki, E; Kuramitsu, S; Kuroishi, C; Miyano, M; Nakamura, Y; Nodake, Y; Tahirov, TH; Takahashi, H; Yamamoto, M; Yokoyama, S; Yutani, K1
Begley, TP; Brand, LA; McLafferty, FW; Strauss, E; Zhai, H1
Burkart, MD; La Clair, JJ; Mandel, AL1
Cronan, JE; Thomas, J1
Kupke, T; Schwarz, W1
Liu, Q; Ma, Y; Zhang, Y; Zhou, L1
Herrmann, T; Johnson, MA; Peti, W; Wilson, IA; Wüthrich, K1
Bernhard, F; Blum, MM; Dötsch, V; Koglin, A; Löhr, F; Marahiel, MA; Mittag, T; Mofid, MR; Rogov, VV; Schäfer, B1
Fox, BG; Markley, JL; Zornetzer, GA1
Sarma, SP; Sharma, AK; Sharma, SK; Surolia, A; Surolia, N1
Cole, PA; Ganguly, S; Ho, AK; Hwang, Y; Klein, DC1
Modak, R; Sinha, S; Surolia, N1
Yen, M; Yin, J1
Case, H; de Dreu, P; Miller, JR; Mueller, WT; Ohren, J; Sarver, RW; Thanabal, V1
Donato, H; Krupenko, NI; Krupenko, SA; Tsybovsky, Y1
Dorrestein, PC; Hensler, M; Meluzzi, D; Nizet, V; Zheng, WH1
Crawford, JM; Ehrlich, KC; Townsend, CA; Udwary, DW; Vagstad, AL1
Burkart, MD; Cheng, Q; Hur, GH; Meier, JL; Moore, BS; Worthington, AS1
Bodner, MJ; Freeman, MF; Li, R; Moshos, KA; Townsend, CA1
Arthur, CJ; Burston, SG; Crosby, J; Crump, MP; Evans, SE; Simpson, TJ; Williams, C1
Ban, N; Jenni, S; Leibundgut, M; Maier, T1
Contreras-Martínez, S; Dávila-Martínez, Y; Encarnación, S; Geiger, O; López-Lara, IM; Ramos-Vega, AL; Sohlenkamp, C1
Rock, CO; Wu, BN; Zhang, YM; Zheng, JJ1
Burkart, MD; Foley, TL1
Da Silva, NA; Kealey, JT; Lee, KK1
Doyle, S; Frizzell, A; Stack, D; Tomkins, K1
Bumpus, SB; Evans, BS; Kelleher, NL; Ntai, I; Thomas, PM1
Contreras-Martínez, S; Dávila-Martínez, Y; Encarnación, S; Geiger, O; López-Lara, IM; Ramos-Vega, AL1
Sherman, DH1
Hoeferlin, LA; Krupenko, NI; Krupenko, SA; Oleinik, NV; Strickland, KC1
Bhagawati, M; Brunk, A; Paterok, D; Piehler, J; Podoplelova, Y; Reichel, A; Waichman, S1
Broadhurst, RW; Cavalli, A; Tosin, M; Tran, L; Weissman, KJ1
Arthur, CJ; Crosby, J; Crump, MP; Kanari, AL; Płoskoń, E; Simpson, TJ; Wattana-amorn, P; Williams, C; Willis, CL1
Mesecar, AD; Wubben, TJ1
Bafna, V; Burkart, MD; Cravatt, BF; Dorrestein, PC; Kersten, R; Meehan, M; Meier, JL; Niessen, S; Patel, AD; Rothmann, M; Yang, JY1
Acton, TB; Ciccosanti, C; Everett, JK; Hamilton, K; Kennedy, MA; Lee, HW; Montelione, GT; Prestegard, JH; Ramelot, TA; Smola, MJ; Xiao, R1
Borgaro, JG; Chang, A; Machutta, CA; Tonge, PJ; Zhang, X1
Amoroso, JW; Borketey, LS; Prasad, G; Schnarr, NA1
Chang, SY; Chen, T; Cheng, CS; Jia, KF; Lin, MS; Yin, HS1
Brock, J; Chen, B; de Jonge, BL; Gao, N; Gu, RF; Hajec, L; Holt, E; Hutchings, K; Huynh, H; Johnstone, M; Kutschke, A; Laganas, V; Lahiri, SD; Livchak, S; McKinney, D; Nash, TJ; Neckermann, G; Ni, H; San Martin, M; Thresher, J; Utley, L; Walkup, GK1
Bettencourt, C; Chiapparini, L; Demchenko, N; Dusi, S; Garavaglia, B; Goffrini, P; Gout, I; Gregory, A; Haack, TB; Hamada, J; Hayflick, S; Houlden, H; Invernizzi, F; Kurian, MA; Nardocci, N; Pasqualato, S; Prokisch, H; Sanford, L; Schwarzmayr, T; Strom, TM; Tigano, M; Tiranti, V; Tsuchiya, Y; Valletta, L; Venco, P; Wieland, T; Zorzi, G1
Axelrod, AJ; Detelich, ME; Keatinge-Clay, AT; Piasecki, SK; Zheng, J1
Atomi, H; Imanaka, T; Ishibashi, T; Kishimoto, A; Kita, A; Miki, K; Tomita, H; Yokooji, Y1
Cronan, JE1
Cao, R; Chen, C; Li, P; Maurmann, L; Zhang, W1
Baratashvili, M; Colombelli, C; Grzeschik, NA; Hayflick, S; Kanon, B; Kosec, G; Lambrechts, RA; Nollen, EA; Petković, H; Podgoršek, A; Reijngoud, DJ; Schaap, O; Sibon, OC; Srinivasan, B; Tiranti, V; van der Zwaag, M1
Aldrich, CC; Allen, CL; Drake, EJ; Gulick, AM; Miller, BR; Shi, C; Skiniotis, G; Sundlov, JA; Tarrasch, JT1
Aloise, MN; Harrison, PM; Reimer, JM; Schmeing, TM1
Sibon, OC; Strauss, E1
Degliesposti, G; Fiedorczuk, K; Kaszuba, K; Letts, JA; Sazanov, LA; Skehel, M1
Colombelli, C; Čusak, A; de Boer, T; de Villiers, M; Di Meo, I; Fox, R; Grzeschik, NA; Hamada, J; Harrs, CH; Hayflick, SJ; Jenko, B; Jeong, SY; Kosec, G; Lahaye, LL; Pahor, J; Rizzetto, E; Sibon, OCM; Srinivasan, B; Tepper, PG; Tiranti, V; van der Zwaag, M; Woltjer, RL1
Abe, T; Kawamura, S; Kobayashi, K; Kobayashi, M; Sakaguchi, T; Shiiba, K1
Basak, A; Biswas, R; Das, AK; Das, PK; Dutta, D; Maiti, MK; Singh, BK1
Bartholow, TG; Burkart, MD; McCammon, JA; Sztain, T1
Cobb, J; Duffy, M; Fox, R; Freed, A; Gray, N; Gregory, AM; Hamada, J; Hayflick, SJ; Hogarth, P; Jeong, SY; Jin, H; Lambrechts, R; Nilsen, A; Pham, T; Placzek, A; Rai, P; Ralle, M; Schwanemann, L; Sibon, OC; van der Zwaag, M; Wakeman, K; Woltjer, RL; Zhen, D1
Chen, N; Li, Y; Liu, Y; Wang, C1
Chen, N; Wang, C1
Arya, R; Dhembla, C; Kumar, A; Kundu, S; Sundd, M1
Bourland, R; Burns-Huang, K; d'Andrea, FB; Geiger, A; Gold, B; Hartman, TE; Jiang, X; Mosior, JW; Nathan, CF; Ouerfelli, O; Pandey, S; Rhee, K; Roberts, J; Sacchettini, JC; Singh, A; Tang, S; Yang, G1
Dhembla, C; Kundu, S; Sundd, M; Yadav, U1
Hu, Q; Li, X; Luo, W; Wang, H; Wang, S; Yang, J; Zeng, Z; Zheng, Y1
Cryle, MJ; Ho, YTC; Izoré, T; Jackson, CJ; Kaczmarski, JA; Schittenhelm, RB; Steer, DL; Tailhades, J; Tosin, M1
Liu, Y; Luo, T; Meng, X; Yu, G; Zhang, J; Zhang, R1

Reviews

4 review(s) available for 4'-phosphopantetheine and pantetheine

ArticleYear
Possible relationship between coding recognition amino acid sequence motif or residue(s) and post-translational chemical modification of proteins.
    The International journal of biochemistry, 1992, Volume: 24, Issue:9

    Topics: Acetylation; Acylation; Amino Acid Sequence; Animals; Glycosylation; Humans; Hydroxylation; Molecular Sequence Data; Pantetheine; Protein Kinases; Protein Processing, Post-Translational

1992
The multienzyme architecture of eukaryotic fatty acid synthases.
    Current opinion in structural biology, 2008, Volume: 18, Issue:6

    Topics: Animals; Eukaryotic Cells; Evolution, Molecular; Fatty Acid Desaturases; Fatty Acid Synthases; Fungal Proteins; Hydro-Lyases; Molecular Structure; Pantetheine; Protein Structure, Tertiary; Substrate Specificity; Transferases

2008
The chain-flipping mechanism of ACP (acyl carrier protein)-dependent enzymes appears universal.
    The Biochemical journal, 2014, Jun-01, Volume: 460, Issue:2

    Topics: Acyl Carrier Protein; Acyltransferases; Crystallization; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Hydro-Lyases; Models, Molecular; Pantetheine; Protein Structure, Secondary

2014
Chemical Labeling of Protein 4'-Phosphopantetheinylation.
    Chembiochem : a European journal of chemical biology, 2021, 04-16, Volume: 22, Issue:8

    Topics: Coenzyme A; Models, Molecular; Molecular Structure; Pantetheine; Protein Processing, Post-Translational

2021

Other Studies

125 other study(ies) available for 4'-phosphopantetheine and pantetheine

ArticleYear
Molecular orbital studies on the conformation of the phosphopantetheine moiety of coenzyme A.
    Biochimica et biophysica acta, 1977, Mar-15, Volume: 481, Issue:1

    Topics: Coenzyme A; Hydrogen Bonding; Molecular Conformation; Organophosphorus Compounds; Pantetheine; Quantum Theory; Sulfhydryl Compounds

1977
Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of mu
    Journal of bacteriology, 1991, Volume: 173, Issue:7

    Topics: Acremonium; Amino Acid Sequence; Base Sequence; Binding Sites; Blotting, Northern; Cephalosporins; Cloning, Molecular; Genes, Bacterial; Genetic Complementation Test; Genetic Linkage; Molecular Sequence Data; Multienzyme Complexes; Pantetheine; Peptide Synthases; Regulatory Sequences, Nucleic Acid; Restriction Mapping; RNA, Bacterial; RNA, Messenger; Thiolester Hydrolases; Transcription, Genetic

1991
Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine.
    Biochemistry, 1991, Mar-19, Volume: 30, Issue:11

    Topics: Amino Acid Isomerases; Amino Acid Sequence; Base Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Cloning, Molecular; DNA, Bacterial; Enterobactin; Escherichia coli; Genes, Bacterial; Molecular Sequence Data; Molecular Weight; Multienzyme Complexes; Pantetheine; Peptide Synthases; Plasmids; Restriction Mapping; Sequence Homology, Nucleic Acid

1991
Acyl carrier protein import into chloroplasts. Both the precursor and mature forms are substrates for phosphopantetheine attachment by a soluble chloroplast holo-acyl carrier protein synthase.
    The Journal of biological chemistry, 1991, Apr-15, Volume: 266, Issue:11

    Topics: Acyl Carrier Protein; Base Sequence; Chloroplasts; Kinetics; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Pantetheine; Phosphotransferases; Plants; Protein Precursors; Protein Processing, Post-Translational; Substrate Specificity; Transferases (Other Substituted Phosphate Groups)

1991
Presence of an acyl carrier protein in NADH:ubiquinone oxidoreductase from bovine heart mitochondria.
    FEBS letters, 1991, Jul-29, Volume: 286, Issue:1-2

    Topics: Acyl Carrier Protein; Amino Acid Sequence; Animals; Base Sequence; Cattle; DNA; Mitochondria, Heart; Molecular Sequence Data; NAD(P)H Dehydrogenase (Quinone); Pantetheine; Quinone Reductases; Sequence Alignment

1991
Acyl carrier protein (ACP) import into chloroplasts does not require the phosphopantetheine: evidence for a chloroplast holo-ACP synthase.
    The Plant cell, 1990, Volume: 2, Issue:3

    Topics: Acyl Carrier Protein; Amino Acid Sequence; Base Sequence; Chloroplasts; Escherichia coli; Molecular Sequence Data; Mutagenesis; Pantetheine; Phosphoric Diester Hydrolases; Phosphotransferases; Plants; Plasmids; Protein Precursors; Transferases (Other Substituted Phosphate Groups)

1990
Isolation of the Rhizobium leguminosarum NodF nodulation protein: NodF carries a 4'-phosphopantetheine prosthetic group.
    Journal of bacteriology, 1991, Volume: 173, Issue:9

    Topics: Amino Acid Sequence; Bacterial Proteins; Chromatography, Gel; Chromosome Mapping; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Pantetheine; Rhizobium; Sequence Homology, Nucleic Acid

1991
Isolation and partial characterization of cyclosporin synthetase from a cyclosporin non-producing mutant of Beauveria nivea.
    Biological chemistry Hoppe-Seyler, 1990, Volume: 371, Issue:9

    Topics: Amino Acid Sequence; Cyclosporins; Fungi; Methylation; Molecular Sequence Data; Multienzyme Complexes; Mutation; Pantetheine; Peptide Synthases

1990
Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described.
    The Journal of biological chemistry, 1990, Jul-05, Volume: 265, Issue:19

    Topics: Affinity Labels; Amino Acids; Carbohydrates; Centrifugation, Density Gradient; Cyclosporins; Immunoblotting; Methylation; Mitosporic Fungi; Molecular Weight; Multienzyme Complexes; Pantetheine; Peptide Synthases; Photochemistry; S-Adenosylmethionine; Trichoderma

1990
Site-directed mutagenesis of the spinach acyl carrier protein-I prosthetic group attachment site.
    European journal of biochemistry, 1989, Oct-01, Volume: 184, Issue:3

    Topics: Acyl Carrier Protein; Cross Reactions; Electrophoresis; Escherichia coli; Isoelectric Focusing; Mutation; Pantetheine; Phosphotransferases; Plants; Protein Conformation; Transferases (Other Substituted Phosphate Groups)

1989
Neurospora crassa mitochondria contain two forms of a 4'-phosphopantetheine-modified protein.
    The Journal of biological chemistry, 1986, Apr-15, Volume: 261, Issue:11

    Topics: Acyl Carrier Protein; Cell Membrane; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Fungal Proteins; Hydrogen-Ion Concentration; Hydroxylamine; Hydroxylamines; Isoelectric Point; Mercaptoethanol; Mitochondria; Molecular Weight; Neurospora; Neurospora crassa; Pantetheine; Sulfhydryl Compounds

1986
Mitochondrial synthesis of coenzyme A is on the external surface.
    Journal of molecular and cellular cardiology, 1987, Volume: 19, Issue:12

    Topics: Adenosine Triphosphate; Animals; Atractyloside; Coenzyme A; Dinitrophenols; In Vitro Techniques; Mitochondria, Heart; Pantetheine; Rats; Uncoupling Agents

1987
The function of acyl carrier protein in the synthesis of membrane-derived oligosaccharides does not require its phosphopantetheine prosthetic group.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:23

    Topics: Acyl Carrier Protein; Apoproteins; Ethylmaleimide; Glycoconjugates; Oligosaccharides; Palmitates; Pantetheine; Sulfhydryl Compounds

1987
Hepatic CoA, S-acyl-CoA, biosynthetic precursors of the coenzyme and pantothenate-protein complexes in dietary pantothenic acid deficiency.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1987, Volume: 57, Issue:1

    Topics: Acyl Coenzyme A; Animals; Body Weight; Coenzyme A; Liver; Male; Pantetheine; Pantothenic Acid; Proteins; Rats

1987
Mammalian fatty acid synthetase is a structurally and functionally symmetrical dimer.
    European journal of biochemistry, 1985, Nov-04, Volume: 152, Issue:3

    Topics: Acetone; Alkylation; Animals; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Fatty Acid Synthases; Female; Hydrolysis; Lactation; Liver; Mammary Glands, Animal; Molecular Weight; Pantetheine; Pregnancy; Rats; Trypsin

1985
Stoichiometry of substrate binding to rat liver fatty acid synthetase.
    The Biochemical journal, 1985, Sep-01, Volume: 230, Issue:2

    Topics: Acetates; Acetic Acid; Acetyl Coenzyme A; Animals; Binding Sites; Cysteamine; Cysteine; Fatty Acid Synthases; Iodoacetamide; Liver; Malonates; Malonyl Coenzyme A; Pantetheine; Rats

1985
Macrophage activation with pantethine and pantetheine-4'-phosphate.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1985, Volume: 55, Issue:4

    Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Female; Kinetics; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Pantetheine; Structure-Activity Relationship; Sulfhydryl Compounds

1985
Adaptive synthesis of rat liver fatty acid synthetase: evidence for in vitro formation of active enzyme from inactive protein precursors and 4'-phosphopantetheine.
    Biochemical and biophysical research communications, 1974, Nov-27, Volume: 61, Issue:2

    Topics: Animals; Carbon Radioisotopes; Coenzyme A; Dietary Fats; Enzyme Activation; Fatty Acid Synthases; Liver; Male; Organophosphorus Compounds; Pantetheine; Pantothenic Acid; Rats; Starvation; Sulfhydryl Compounds

1974
Turnover of the 4'-phosphopantetheine prosthetic group of acyl carrier protein.
    The Journal of biological chemistry, 1984, Feb-10, Volume: 259, Issue:3

    Topics: Acyl Carrier Protein; Alanine; Escherichia coli; Kinetics; Pantetheine; Species Specificity; Sulfhydryl Compounds

1984
Metabolism of 4'-phosphopantetheine in Escherichia coli.
    Journal of bacteriology, 1984, Volume: 158, Issue:1

    Topics: Acyl Carrier Protein; Alanine; Coenzyme A; Escherichia coli; Pantetheine; Pantothenic Acid; Sulfhydryl Compounds

1984
Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine.
    The Journal of nutrition, 1983, Volume: 113, Issue:10

    Topics: Absorption; Animals; Carbon Radioisotopes; Coenzyme A; Coenzymes; Hydrolysis; Intestine, Small; Male; Pantetheine; Pantothenic Acid; Rats; Rats, Inbred Strains

1983
Effects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria.
    The Tohoku journal of experimental medicine, 1983, Volume: 141, Issue:1

    Topics: Acyl Coenzyme A; Animals; Carnitine Acyltransferases; Coenzyme A Ligases; Fatty Acids; In Vitro Techniques; Male; Mitochondria, Liver; Oxidation-Reduction; Pantetheine; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sulfhydryl Compounds

1983
Effect of pantethine on fatty acid oxidation in microvessels of rat brain.
    The Tohoku journal of experimental medicine, 1983, Volume: 141, Issue:1

    Topics: Animals; Brain; Cerebral Hemorrhage; Fatty Acids; Hypertension; In Vitro Techniques; Microcirculation; Pantetheine; Rats; Sulfhydryl Compounds

1983
Regulation of coenzyme A biosynthesis.
    Journal of bacteriology, 1981, Volume: 148, Issue:3

    Topics: Acyl Carrier Protein; beta-Alanine; Coenzyme A; Escherichia coli; Organophosphorus Compounds; Pantetheine; Pantothenic Acid

1981
Enniatin synthetase, a novel type of multifunctional enzyme catalyzing depsipeptide synthesis in Fusarium oxysporum.
    Biochemistry, 1982, Jan-05, Volume: 21, Issue:1

    Topics: Amino Acids; Anti-Bacterial Agents; Fusarium; Iodoacetamide; Methylation; Molecular Weight; Organophosphorus Compounds; Pantetheine; Peptide Synthases; S-Adenosylmethionine; Substrate Specificity; Sulfhydryl Reagents

1982
Role of cysteine and 4'-phosphopantetheine in the inactivation of pigeon liver fatty acid synthetase by S-(4-bromo-2,3-dioxobutyl)-coenzyme A.
    Biochemical and biophysical research communications, 1982, Jan-29, Volume: 104, Issue:2

    Topics: Affinity Labels; Animals; Binding Sites; Coenzyme A; Columbidae; Cysteine; Fatty Acid Synthases; Kinetics; Liver; Organophosphorus Compounds; Pantetheine; Protein Binding; Sulfhydryl Compounds

1982
Human fatty acid synthase: properties and molecular cloning.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Sep-12, Volume: 92, Issue:19

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Carcinoma, Hepatocellular; Chickens; Cloning, Molecular; DNA, Complementary; Fatty Acid Synthases; Humans; Liver Neoplasms; Molecular Sequence Data; Pantetheine; Rats; Restriction Mapping; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Tumor Cells, Cultured

1995
Gramicidin S synthetase 1 (phenylalanine racemase), a prototype of amino acid racemases containing the cofactor 4'-phosphopantetheine.
    Biochemistry, 1995, Apr-11, Volume: 34, Issue:14

    Topics: Amino Acid Isomerases; Amino Acid Sequence; Binding Sites; Esters; Molecular Sequence Data; Pantetheine; Pantothenic Acid; Sequence Alignment

1995
Detection of 4'-phosphopantetheine at the thioester binding site for L-valine of gramicidinS synthetase 2.
    FEBS letters, 1994, Feb-28, Volume: 340, Issue:1-2

    Topics: Amino Acid Isomerases; Amino Acid Sequence; Amino Acids; Bacillus; Binding Sites; Esters; Molecular Sequence Data; Multienzyme Complexes; Pantetheine; Peptide Synthases; Spectrometry, Mass, Fast Atom Bombardment; Valine

1994
NMR investigations of the structural properties of the nodulation protein, NodF, from Rhizobium leguminosarum and its homology with Escherichia coli acyl carrier protein.
    FEBS letters, 1996, Jun-10, Volume: 388, Issue:1

    Topics: Acyl Carrier Protein; Amino Acid Sequence; Bacterial Proteins; Escherichia coli; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Pantetheine; Protein Folding; Protein Structure, Secondary; Rhizobium leguminosarum; Sequence Homology, Amino Acid

1996
Escherichia coli contains a protein that is homologous in function and N-terminal sequence to the protein encoded by the nifS gene of Azotobacter vinelandii and that can participate in the synthesis of the Fe-S cluster of dihydroxy-acid dehydratase.
    The Journal of biological chemistry, 1996, Jul-05, Volume: 271, Issue:27

    Topics: Alanine; Amino Acid Sequence; Azotobacter vinelandii; Bacterial Proteins; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Disulfides; Escherichia coli; Genes, Bacterial; Haemophilus influenzae; Hydro-Lyases; Iron-Sulfur Proteins; Kinetics; Macromolecular Substances; Molecular Sequence Data; Naphthalenesulfonates; Pantetheine; Peptide Fragments; Pyridoxal Phosphate; Sequence Homology, Amino Acid; Sulfhydryl Reagents

1996
Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase.
    Chemistry & biology, 1997, Volume: 4, Issue:1

    Topics: Acyl Carrier Protein; Anti-Bacterial Agents; Cloning, Molecular; Coenzyme A; DNA Primers; Escherichia coli; Molecular Structure; Multienzyme Complexes; Pantetheine; Polymerase Chain Reaction; Recombinant Proteins; Streptomyces; Substrate Specificity; Transferases (Other Substituted Phosphate Groups)

1997
Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate.
    Biochemistry, 1997, Jul-15, Volume: 36, Issue:28

    Topics: Acylation; Adenosine Triphosphate; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enterobactin; Escherichia coli; Escherichia coli Proteins; Hydrolases; Hydroxybenzoates; Kinetics; Ligases; Mass Spectrometry; Molecular Structure; Multienzyme Complexes; Pantetheine; Recombinant Proteins; Salicylates; Salicylic Acid; Sequence Homology, Amino Acid; Serine; Transferases

1997
Characterization of the interthiol acyltransferase reaction catalyzed by the beta-ketoacyl synthase domain of the animal fatty acid synthase.
    Biochemistry, 1997, Dec-23, Volume: 36, Issue:51

    Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acyl Carrier Protein; Acyl Coenzyme A; Acyltransferases; Animals; Binding Sites; Cysteine; Escherichia coli; Fatty Acid Synthases; Fatty Acids; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Pantetheine; Rats; Recombinant Proteins; Substrate Specificity; Sulfhydryl Compounds

1997
Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase.
    Biochemistry, 1998, Feb-10, Volume: 37, Issue:6

    Topics: Acylation; Adenosine Monophosphate; Aminoacyltransferases; Bacillus subtilis; Bacterial Proteins; Catalysis; Enzyme Stability; Escherichia coli; Genetic Vectors; Kinetics; Lipopeptides; Pantetheine; Peptide Synthases; Peptides, Cyclic; Protein Processing, Post-Translational; Recombinant Proteins; Substrate Specificity; Transferases (Other Substituted Phosphate Groups); Valine

1998
The coenzyme A-synthesizing protein complex and its proposed role in CoA biosynthesis in bakers' yeast.
    Biochimie, 1997, Volume: 79, Issue:12

    Topics: Catalysis; Coenzyme A; Feedback; Fungal Proteins; Molecular Weight; Multienzyme Complexes; Pantetheine; Peptide Synthases; Protein Binding; Saccharomyces cerevisiae

1997
Analysis of 4-phosphopantetheinylation of polyhydroxybutyrate synthase from Ralstonia eutropha: generation of beta-alanine auxotrophic Tn5 mutants and cloning of the panD gene region.
    Journal of bacteriology, 1999, Volume: 181, Issue:5

    Topics: Acyltransferases; Amino Acid Sequence; Bacterial Proteins; beta-Alanine; Cloning, Molecular; Consensus Sequence; Cupriavidus necator; Genes, Bacterial; Genetic Complementation Test; Molecular Sequence Data; Mutagenesis, Insertional; NADP Transhydrogenases; Open Reading Frames; Pantetheine; Plasmids; Protein Processing, Post-Translational; Recombinant Proteins; Restriction Mapping; Sequence Alignment; Sequence Homology, Amino Acid

1999
Spinach holo-acyl carrier protein: overproduction and phosphopantetheinylation in Escherichia coli BL21(DE3), in vitro acylation, and enzymatic desaturation of histidine-tagged isoform I.
    Protein expression and purification, 1999, Volume: 15, Issue:3

    Topics: Acyl Carrier Protein; Acylation; Amino Acid Sequence; Base Sequence; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Cloning, Molecular; Escherichia coli; Genes, Plant; Genes, Synthetic; Histidine; Molecular Sequence Data; Pantetheine; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Proteins; Restriction Mapping; Spinacia oleracea

1999
Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis.
    Science (New York, N.Y.), 1999, Apr-16, Volume: 284, Issue:5413

    Topics: Acyl Carrier Protein; Acyl Coenzyme A; Amino Acid Isomerases; Anti-Bacterial Agents; Bacterial Proteins; Dipeptides; Mass Spectrometry; Pantetheine; Peptide Biosynthesis; Peptide Synthases; Phenylalanine; Proline; Ribosomes

1999
Dibromopropanone cross-linking of the phosphopantetheine and active-site cysteine thiols of the animal fatty acid synthase can occur both inter- and intrasubunit. Reevaluation of the side-by-side, antiparallel subunit model.
    The Journal of biological chemistry, 1999, Apr-23, Volume: 274, Issue:17

    Topics: Acetone; Animals; Binding Sites; Chromatography, Gel; Cysteine; Electrophoresis, Polyacrylamide Gel; Evaluation Studies as Topic; Fatty Acid Synthases; Hydrogen-Ion Concentration; Models, Chemical; Molecular Weight; Pantetheine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfhydryl Compounds

1999
An ordered reaction mechanism for bacterial toxin acylation by the specialized acyltransferase HlyC: formation of a ternary complex with acylACP and protoxin substrates.
    Molecular microbiology, 1999, Volume: 34, Issue:5

    Topics: Acyl Carrier Protein; Acylation; Acyltransferases; Bacterial Proteins; Chromatography, Affinity; Cloning, Molecular; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Hemolysin Proteins; Immunoblotting; Kinetics; Lysine; Mutagenesis, Site-Directed; Pantetheine; Substrate Specificity

1999
Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli.
    The Journal of biological chemistry, 2000, Jan-14, Volume: 275, Issue:2

    Topics: Amino Acid Substitution; Cloning, Molecular; Concanavalin A; Escherichia coli; Genetic Complementation Test; Kinetics; Pantetheine; Plasmids; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; Tetracycline; Transferases (Other Substituted Phosphate Groups)

2000
The role of 4'-phosphopantetheine in t' biosynthesis of fatty acids, polyketides and peptides.
    BioFactors (Oxford, England), 2000, Volume: 11, Issue:1-2

    Topics: Carrier Proteins; Coenzyme A; Fatty Acids; Pantetheine; Peptides

2000
Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase.
    Biochemistry, 2000, Apr-25, Volume: 39, Issue:16

    Topics: Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Catalysis; Coenzyme A Ligases; Diphosphates; Genetic Complementation Test; Holoenzymes; Hydrolysis; Iron-Binding Proteins; Kinetics; Molecular Weight; Pantetheine; Peptide Synthases; Periplasmic Binding Proteins; Plasmids; Point Mutation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Salicylic Acid; Substrate Specificity; Yersinia pestis

2000
Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase.
    Biochemistry, 2000, May-16, Volume: 39, Issue:19

    Topics: Amino Acid Isomerases; Amino Acid Sequence; Bacillus; Carbohydrate Epimerases; Catalysis; Diketopiperazines; DNA Mutational Analysis; Electron Transport; Gramicidin; Hydrolysis; Molecular Sequence Data; Mutagenesis, Site-Directed; Pantetheine; Peptide Chain Initiation, Translational; Phenylalanine; Piperazines; Protein Structure, Tertiary; Sequence Homology, Amino Acid

2000
Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis.
    The Journal of biological chemistry, 2000, Oct-13, Volume: 275, Issue:41

    Topics: Amino Acid Motifs; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Carboxy-Lyases; Chromatography, Gel; Coenzyme A; Cysteine; Escherichia coli; Flavin Mononucleotide; Flavoproteins; Molecular Sequence Data; Mutation; Oxidoreductases; Pantetheine; Pantothenic Acid; Peptides; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; Sequence Homology, Amino Acid

2000
RNA-Catalyzed CoA, NAD, and FAD synthesis from phosphopantetheine, NMN, and FMN.
    Biochemistry, 2000, Dec-19, Volume: 39, Issue:50

    Topics: Coenzyme A; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Gene Library; NAD; Nicotinamide Mononucleotide; Pantetheine; RNA; Sequence Analysis, RNA

2000
Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Jan-02, Volume: 98, Issue:1

    Topics: Acyl Carrier Protein; Acylation; Acyltransferases; Apoproteins; Bacillus subtilis; Bacterial Outer Membrane Proteins; Bacterial Proteins; Cloning, Molecular; Cysteine; Escherichia coli; Holoenzymes; Iron-Binding Proteins; Kinetics; Malonyl Coenzyme A; Molecular Structure; Molecular Weight; Multienzyme Complexes; Pantetheine; Peptide Fragments; Peptide Synthases; Periplasmic Binding Proteins; Phenols; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Subunits; Recombinant Proteins; Siderophores; Thiazoles; Yersinia pestis

2001
Microbiology. Possible new route to polyketide synthesis.
    Science (New York, N.Y.), 2001, Mar-02, Volume: 291, Issue:5509

    Topics: Acyl Coenzyme A; Bacillus subtilis; Erythromycin; Escherichia coli; Genetic Engineering; Multienzyme Complexes; Pantetheine; Patents as Topic; Protein Engineering; Recombinant Proteins; Saccharopolyspora

2001
Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-Phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis.
    The Journal of biological chemistry, 2001, Jun-01, Volume: 276, Issue:22

    Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Binding Sites; Carboxy-Lyases; Catalysis; Chromatography, Gel; Coenzyme A; Crystallography, X-Ray; Cysteine; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Models, Chemical; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Oxidoreductases; Pantetheine; Pantothenic Acid; Peptide Synthases; Plant Proteins; Polymerase Chain Reaction; Protein Binding; Protein Conformation; Salts; Sequence Homology, Amino Acid; Signal Transduction; Time Factors

2001
Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase.
    Biochemistry, 2001, May-08, Volume: 40, Issue:18

    Topics: Adenosine Monophosphate; Alanine; Amino Acid Isomerases; Amino Acid Motifs; Aminoacylation; Apoenzymes; Bacillus; Carbon Radioisotopes; Catalysis; Gramicidin; Histidine; Holoenzymes; Kinetics; Mutagenesis, Site-Directed; Pantetheine; Peptide Chain Initiation, Translational; Phenylalanine; Protein Structure, Tertiary

2001
Mechanistic studies on phosphopantothenoylcysteine decarboxylase.
    Journal of the American Chemical Society, 2001, Jul-04, Volume: 123, Issue:26

    Topics: Carboxy-Lyases; Catalysis; Coenzyme A; Cysteine; Cytidine Monophosphate; Cytidine Triphosphate; Enzyme Activation; Escherichia coli; Molecular Structure; Pantetheine; Pantothenic Acid; Peptide Synthases; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity

2001
4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis.
    The Journal of biological chemistry, 2001, Oct-05, Volume: 276, Issue:40

    Topics: Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Calcium-Binding Proteins; Carrier Proteins; Escherichia coli; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Pantetheine; Plant Proteins; Sequence Homology, Amino Acid; Transferases (Other Substituted Phosphate Groups)

2001
Novel posttranslational activation of the LYS2-encoded alpha-aminoadipate reductase for biosynthesis of lysine and site-directed mutational analysis of conserved amino acid residues in the activation domain of Candida albicans.
    Journal of bacteriology, 2001, Volume: 183, Issue:24

    Topics: Aldehyde Oxidoreductases; Amino Acid Sequence; Apoenzymes; Candida albicans; Coenzyme A; Conserved Sequence; Enzyme Activation; Holoenzymes; L-Aminoadipate-Semialdehyde Dehydrogenase; Lysine; Pantetheine; Protein Processing, Post-Translational

2001
Role of active site binding interactions in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis.
    Biochemistry, 2001, Dec-25, Volume: 40, Issue:51

    Topics: Acyl Coenzyme A; Binding Sites; Binding, Competitive; Catalysis; Coenzyme A; Enzyme Stability; Hydrolases; Kinetics; Ligands; Mutagenesis, Site-Directed; Pantetheine; Substrate Specificity; Thermodynamics

2001
The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism.
    Journal of molecular biology, 2002, Jan-25, Volume: 315, Issue:4

    Topics: Adenosine Triphosphate; Binding Sites; Catalysis; Crystallography, X-Ray; Dimerization; Escherichia coli; Hydrogen Bonding; Ligands; Magnesium; Models, Molecular; Nucleotidyltransferases; Pantetheine; Protein Binding; Protein Structure, Quaternary; Protein Subunits; Structure-Activity Relationship

2002
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
    Structure (London, England : 1993), 2002, Volume: 10, Issue:3

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cyclization; Ligands; Lipopeptides; Models, Molecular; Molecular Sequence Data; Molecular Structure; Pantetheine; Peptide Synthases; Peptides, Cyclic; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment

2002
Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases.
    Biochemistry, 2002, Jul-02, Volume: 41, Issue:26

    Topics: Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Base Sequence; Binding Sites; Carrier Proteins; DNA Primers; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pantetheine; Peptide Synthases; Recombinant Proteins; Siderophores

2002
Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum.
    Molecular and biochemical parasitology, 2002, Aug-28, Volume: 123, Issue:2

    Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acyl Carrier Protein; Amino Acid Sequence; Amino Acid Substitution; Animals; Cloning, Molecular; Fatty Acid Synthases; Fatty Acids; Holoenzymes; Molecular Sequence Data; Mutation; Pantetheine; Plasmodium falciparum; Recombinant Proteins; Sequence Alignment

2002
Fluorescence anisotropy studies of enzyme-substrate complex formation in stearoyl-ACP desaturase.
    Biochemistry, 2002, Dec-10, Volume: 41, Issue:49

    Topics: Acyl Carrier Protein; Acylation; Apoproteins; Binding Sites; Dansyl Compounds; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Ferredoxins; Fluorescein-5-isothiocyanate; Fluorescence Polarization; Fluorescent Dyes; Kinetics; Macromolecular Substances; Mixed Function Oxygenases; Osmolar Concentration; Pantetheine; Protein Binding; Spectrometry, Fluorescence; Static Electricity; Substrate Specificity

2002
Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein.
    Biochemistry, 2003, Apr-29, Volume: 42, Issue:16

    Topics: Acyl Carrier Protein; Amino Acid Sequence; Models, Chemical; Models, Molecular; Molecular Sequence Data; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Protein Conformation; Sequence Alignment; Streptomyces

2003
Functional sites and evolutionary connections of acylhomoserine lactone synthases.
    Protein engineering, 2003, Volume: 16, Issue:4

    Topics: Acetyltransferases; Amino Acid Sequence; Binding Sites; Carboxylic Ester Hydrolases; Crystallography, X-Ray; Gram-Negative Bacteria; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Pantetheine; Sequence Alignment; Substrate Specificity

2003
4'-phosphopantetheine and coenzyme A biosynthesis in plants.
    The Journal of biological chemistry, 2003, Oct-03, Volume: 278, Issue:40

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Arabidopsis; Biochemical Phenomena; Biochemistry; Cell Line; Cloning, Molecular; Coenzyme A; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genome, Plant; Magnesium; Models, Chemical; Molecular Sequence Data; Nucleotidyltransferases; Osmosis; Pantetheine; Plants; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Time Factors

2003
Replacement of the catalytic nucleophile cysteine-296 by serine in class II polyhydroxyalkanoate synthase from Pseudomonas aeruginosa-mediated synthesis of a new polyester: identification of catalytic residues.
    The Biochemical journal, 2003, Sep-01, Volume: 374, Issue:Pt 2

    Topics: Acyltransferases; Amino Acid Sequence; Amino Acid Substitution; Animals; Catalytic Domain; Cysteine; Epoxide Hydrolases; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Pantetheine; Polyesters; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pseudomonas aeruginosa; Sequence Alignment; Serine; Substrate Specificity

2003
ACYL CARRIER PROTEIN. IV. THE IDENTIFICATION OF 4'-PHOSPHOPANTETHEINE AS THE PROSTHETIC GROUP OF THE ACYL CARRIER PROTEIN.
    Proceedings of the National Academy of Sciences of the United States of America, 1965, Volume: 53

    Topics: Acyl Carrier Protein; Alkaline Phosphatase; Amines; Carbon Isotopes; Chemistry Techniques, Analytical; Chromatography; Coenzyme A; Electrophoresis; Lactobacillus; Lactones; Metabolism; Pantetheine; Pantothenic Acid; Pepsin A; Peptide Hydrolases; Phosphates; Protein Hydrolysates; Proteins; Radiometry; Research

1965
Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus.
    Acta crystallographica. Section D, Biological crystallography, 2004, Volume: 60, Issue:Pt 1

    Topics: Crystallography, X-Ray; Enzyme Stability; Hot Temperature; Models, Molecular; Nucleotidyltransferases; Pantetheine; Thermus thermophilus; Ultracentrifugation

2004
Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent.
    Biochemistry, 2004, Dec-14, Volume: 43, Issue:49

    Topics: Binding Sites; Carboxy-Lyases; Catalysis; Cysteine; Decarboxylation; Enzyme Inhibitors; Enzyme Stability; Flavin Mononucleotide; Humans; Kinetics; Mutagenesis, Site-Directed; Pantetheine; Pantothenic Acid; Serine; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfhydryl Compounds

2004
Modular synthesis of pantetheine and phosphopantetheine.
    Organic letters, 2004, Dec-23, Volume: 6, Issue:26

    Topics: Molecular Structure; Pantetheine; Stereoisomerism

2004
The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization.
    The Journal of biological chemistry, 2005, Oct-14, Volume: 280, Issue:41

    Topics: Amino Acid Sequence; Carbon; Chromatography, Gel; Cloning, Molecular; Cosmids; DNA; Escherichia coli; Escherichia coli Proteins; Gene Library; Genome; Histidine; Lipids; Molecular Sequence Data; Mutation; Oligopeptides; Pantetheine; Phosphoric Diester Hydrolases; Plasmids; Sequence Homology, Amino Acid; Serine; Spectrometry, Mass, Electrospray Ionization; Time Factors; Transferases

2005
4'-phosphopantetheine biosynthesis in Archaea.
    The Journal of biological chemistry, 2006, Mar-03, Volume: 281, Issue:9

    Topics: Amino Acid Sequence; Archaeal Proteins; Base Sequence; Binding Sites; Carboxy-Lyases; Cloning, Molecular; Humans; Methanococcales; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Pantetheine; Peptide Synthases; Sequence Alignment

2006
Gene cloning, expression and functional characterization of an acyl carrier protein AcpV from Vibrio anguillarum.
    Archives of microbiology, 2006, Volume: 185, Issue:2

    Topics: Acyl Carrier Protein; Bacterial Proteins; Blotting, Western; Chromatography, High Pressure Liquid; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Pantetheine; Transferases (Other Substituted Phosphate Groups); Vibrio

2006
Solution structure of Asl1650, an acyl carrier protein from Anabaena sp. PCC 7120 with a variant phosphopantetheinylation-site sequence.
    Protein science : a publication of the Protein Society, 2006, Volume: 15, Issue:5

    Topics: Acyl Carrier Protein; Amino Acid Sequence; Anabaena; Base Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Pantetheine; Peptide Synthases; Polyketide Synthases; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Structure-Activity Relationship

2006
Conformational switches modulate protein interactions in peptide antibiotic synthetases.
    Science (New York, N.Y.), 2006, Apr-14, Volume: 312, Issue:5771

    Topics: Apoproteins; Bacterial Proteins; Binding Sites; Carrier Proteins; Crystallography, X-Ray; Fatty Acid Synthases; Holoenzymes; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Peptide Synthases; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Thiolester Hydrolases; Transferases

2006
Solution structures of spinach acyl carrier protein with decanoate and stearate.
    Biochemistry, 2006, Apr-25, Volume: 45, Issue:16

    Topics: Acyl Carrier Protein; Binding Sites; Decanoates; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Protein Structure, Quaternary; Serine; Solutions; Spinacia oleracea; Stearates

2006
Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs.
    Biochemistry, 2006, Jun-06, Volume: 45, Issue:22

    Topics: Acyl Carrier Protein; Amino Acid Sequence; Animals; Bacterial Proteins; Hydrogen Bonding; Molecular Sequence Data; Pantetheine; Plasmodium falciparum; Protein Conformation; Protozoan Proteins; Rats; Solutions

2006
Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug.
    Bioorganic & medicinal chemistry, 2007, Mar-01, Volume: 15, Issue:5

    Topics: Animals; Arylalkylamine N-Acetyltransferase; Cells, Cultured; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Pantetheine; Pineal Gland; Prodrugs; Rats; Spectrometry, Mass, Electrospray Ionization

2007
Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein. Role of the 4'-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein.
    The FEBS journal, 2007, Volume: 274, Issue:13

    Topics: Acyl Carrier Protein; Animals; Biophysics; Dose-Response Relationship, Drug; Hydrogen Bonding; Molecular Conformation; Pantetheine; Peptides; Plasmodium falciparum; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Protein Structure, Tertiary; Temperature; Thermodynamics

2007
High-throughput profiling of posttranslational modification enzymes by phage display.
    BioTechniques, 2007, Volume: 43, Issue:1

    Topics: Acyl Carrier Protein; Bacterial Proteins; Cloning, Molecular; Enzymes; Pantetheine; Peptide Library; Peptide Synthases; Polyketide Synthases; Protein Processing, Post-Translational; Transferases (Other Substituted Phosphate Groups)

2007
Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis.
    Journal of bacteriology, 2007, Volume: 189, Issue:22

    Topics: Calorimetry; Coenzyme A; Escherichia coli; Kinetics; Models, Molecular; Nucleotidyltransferases; Pantetheine; Protein Binding; Protein Conformation

2007
10-formyltetrahydrofolate dehydrogenase requires a 4'-phosphopantetheine prosthetic group for catalysis.
    The Journal of biological chemistry, 2007, Nov-23, Volume: 282, Issue:47

    Topics: Acyl Carrier Protein; Animals; Carbon Dioxide; Catalysis; Leucovorin; NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Pantetheine; Protein Structure, Tertiary; Rats; Recombinant Proteins; Tetrahydrofolates

2007
Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways.
    Bioorganic & medicinal chemistry letters, 2008, May-15, Volume: 18, Issue:10

    Topics: Acyl Carrier Protein; Bacterial Proteins; Macrolides; Mass Spectrometry; Models, Molecular; Molecular Structure; Pantetheine; Peptide Synthases; Signal Transduction; Streptococcus agalactiae; Transferases (Other Substituted Phosphate Groups)

2008
Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases.
    Chembiochem : a European journal of chemical biology, 2008, Jul-02, Volume: 9, Issue:10

    Topics: Acyl Carrier Protein; Anthraquinones; Bacterial Proteins; Base Sequence; Carrier Proteins; Conserved Sequence; Fatty Acid Synthase, Type II; Fungal Proteins; Models, Molecular; Molecular Sequence Data; Pantetheine; Protein Subunits; Substrate Specificity; Transferases (Other Substituted Phosphate Groups)

2008
Probing the compatibility of type II ketosynthase-carrier protein partners.
    Chembiochem : a European journal of chemical biology, 2008, Sep-01, Volume: 9, Issue:13

    Topics: Amino Acid Sequence; Cross-Linking Reagents; Cyperaceae; Drug Design; Escherichia coli; Fatty Acid Synthase, Type II; Molecular Sequence Data; Pantetheine; Polyketide Synthases; Protein Binding; Protein Structure, Tertiary; Substrate Specificity

2008
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Aug-12, Volume: 105, Issue:32

    Topics: Bacterial Proteins; Coenzyme A; Cysteamine; Cysteine; Genes, Bacterial; Multigene Family; Pantetheine; Streptomyces; Thienamycins

2008
An ACP structural switch: conformational differences between the apo and holo forms of the actinorhodin polyketide synthase acyl carrier protein.
    Chembiochem : a European journal of chemical biology, 2008, Oct-13, Volume: 9, Issue:15

    Topics: Acyl Carrier Protein; Bacillus subtilis; Crystallography, X-Ray; Holoenzymes; Models, Molecular; Mutation; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Polyketide Synthases; Protein Binding; Protein Structure, Tertiary; Streptomyces coelicolor

2008
SMb20651 is another acyl carrier protein from Sinorhizobium meliloti.
    Microbiology (Reading, England), 2009, Volume: 155, Issue:Pt 1

    Topics: Acyl Carrier Protein; Acyl-Carrier Protein S-Malonyltransferase; Animals; Antibodies, Bacterial; Bacterial Proteins; Ligases; Medicago sativa; Mutagenesis, Site-Directed; Operon; Pantetheine; Rabbits; Sinorhizobium meliloti

2009
Structural modification of acyl carrier protein by butyryl group.
    Protein science : a publication of the Protein Society, 2009, Volume: 18, Issue:1

    Topics: Acyl Carrier Protein; Apoproteins; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Protein Structure, Tertiary; Substrate Specificity

2009
A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase.
    Analytical biochemistry, 2009, Nov-01, Volume: 394, Issue:1

    Topics: Animals; Bacterial Proteins; Cattle; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Enzyme Inhibitors; Enzyme Stability; Escherichia coli Proteins; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Models, Molecular; Pantetheine; Peptides; Protein Conformation; Serum Albumin, Bovine; Transferases; Transferases (Other Substituted Phosphate Groups)

2009
Determination of the extent of phosphopantetheinylation of polyketide synthases expressed in Escherichia coli and Saccharomyces cerevisiae.
    Analytical biochemistry, 2009, Nov-01, Volume: 394, Issue:1

    Topics: Acyl Carrier Protein; Acyltransferases; Bacterial Proteins; Biocatalysis; Escherichia coli; Fluorescent Dyes; Gene Expression; Ligases; Lovastatin; Macrolides; Multienzyme Complexes; Oxidoreductases; Pantetheine; Polyketide Synthases; Protein Structure, Tertiary; Saccharomyces cerevisiae; Transferases (Other Substituted Phosphate Groups)

2009
Solid phase 4'-phosphopantetheinylation: fungal thiolation domains are targets for chemoenzymatic modification.
    Bioconjugate chemistry, 2009, Aug-19, Volume: 20, Issue:8

    Topics: Aspergillus fumigatus; Bacterial Proteins; Biocatalysis; Coenzyme A; Pantetheine; Recombinant Proteins; Transferases (Other Substituted Phosphate Groups)

2009
A proteomics approach to discovering natural products and their biosynthetic pathways.
    Nature biotechnology, 2009, Volume: 27, Issue:10

    Topics: Bacillus; Biological Products; Cluster Analysis; Gene Regulatory Networks; Lipopeptides; Mass Spectrometry; Metabolic Networks and Pathways; Pantetheine; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Fragments; Peptide Synthases; Polyketide Synthases; Proteomics; Streptomyces

2009
SMc01553 is the sixth acyl carrier protein in Sinorhizobium meliloti 1021.
    Microbiology (Reading, England), 2010, Volume: 156, Issue:Pt 1

    Topics: Acyl Carrier Protein; Bacterial Proteins; Escherichia coli; Pantetheine; Protein Structure, Secondary; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Bacterial; Sinorhizobium meliloti

2010
Biochemistry: Enzyme's black box cracked open.
    Nature, 2009, Oct-22, Volume: 461, Issue:7267

    Topics: Aflatoxin B1; Aspergillus; Catalytic Domain; Crystallography, X-Ray; Cyclization; Pantetheine; Polyketide Synthases; Protein Structure, Tertiary; Structure-Activity Relationship

2009
Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.
    The Journal of biological chemistry, 2010, Jan-15, Volume: 285, Issue:3

    Topics: Acyl Carrier Protein; Base Sequence; Biocatalysis; Cell Cycle; Cell Death; Cell Line; Cloning, Molecular; Enzyme Activation; Gene Silencing; Humans; Oxidoreductases Acting on CH-NH Group Donors; Pantetheine; RNA, Small Interfering; Serine; Substrate Specificity; Transferases (Other Substituted Phosphate Groups)

2010
Functional immobilization and patterning of proteins by an enzymatic transfer reaction.
    Analytical chemistry, 2010, Feb-15, Volume: 82, Issue:4

    Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Coenzyme A; Glass; Immobilized Proteins; Interferon-alpha; Models, Molecular; Oligopeptides; Pantetheine; Polyethylene Glycols; Protein Structure, Tertiary; Receptor, Interferon alpha-beta; Spectrum Analysis; Substrate Specificity; Surface Properties; Transferases (Other Substituted Phosphate Groups)

2010
Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases.
    Chemistry & biology, 2010, Jul-30, Volume: 17, Issue:7

    Topics: Acyl Carrier Protein; Amino Acid Sequence; Apoenzymes; Coenzymes; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Polyketide Synthases; Protein Binding; Protein Structure, Tertiary; Stereoisomerism; Substrate Specificity; Thiolester Hydrolases

2010
Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis.
    Chemistry & biology, 2010, Jul-30, Volume: 17, Issue:7

    Topics: Acyl Carrier Protein; Amino Acid Sequence; Bacterial Proteins; Fatty Acids; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Sequence Data; Pantetheine; Protein Conformation; Streptomyces coelicolor

2010
Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis.
    Journal of molecular biology, 2010, Nov-26, Volume: 404, Issue:2

    Topics: Adenosine Triphosphate; Calorimetry; Coenzyme A; Crystallography, X-Ray; Feedback, Physiological; Kinetics; Models, Biological; Models, Molecular; Mycobacterium tuberculosis; Nucleotidyltransferases; Pantetheine; Protein Conformation; Protein Structure, Quaternary; Recombinant Proteins; Thermodynamics

2010
Practical 4'-phosphopantetheine active site discovery from proteomic samples.
    Journal of proteome research, 2011, Jan-07, Volume: 10, Issue:1

    Topics: Algorithms; Artificial Intelligence; Bacillus subtilis; Bacterial Proteins; Catalytic Domain; Chromatography, Liquid; Pantetheine; Peptide Fragments; Peptide Synthases; Polyketide Synthases; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteome; Proteomics; Reproducibility of Results; ROC Curve; Tandem Mass Spectrometry

2011
Solution structure of 4'-phosphopantetheine - GmACP3 from Geobacter metallireducens: a specialized acyl carrier protein with atypical structural features and a putative role in lipopolysaccharide biosynthesis.
    Biochemistry, 2011, Mar-08, Volume: 50, Issue:9

    Topics: Amino Acid Sequence; Bacterial Proteins; Carrier Proteins; Escherichia coli; Gene Expression Regulation, Bacterial; Geobacter; Lipopolysaccharides; Models, Molecular; Molecular Sequence Data; Pantetheine; Protein Conformation

2011
Substrate recognition by β-ketoacyl-ACP synthases.
    Biochemistry, 2011, Dec-13, Volume: 50, Issue:49

    Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Coenzyme A; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Kinetics; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Palmitoyl Coenzyme A; Pantetheine; Phosphotransferases (Alcohol Group Acceptor); Substrate Specificity

2011
N-activated β-lactams as versatile reagents for acyl carrier protein labeling.
    Organic & biomolecular chemistry, 2012, Mar-14, Volume: 10, Issue:10

    Topics: Acyl Carrier Protein; Acylation; beta-Lactams; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Mass Spectrometry; Pantetheine; Sulfhydryl Compounds

2012
Experimentally validated novel inhibitors of Helicobacter pylori phosphopantetheine adenylyltransferase discovered by virtual high-throughput screening.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Adenosine Triphosphate; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Coenzyme A; Databases, Chemical; Drug Discovery; Enzyme Inhibitors; Helicobacter pylori; High-Throughput Screening Assays; Methotrexate; Microbial Sensitivity Tests; Molecular Docking Simulation; Nucleotidyltransferases; Pantetheine; Protein Binding

2013
Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Binding, Competitive; Crystallography, X-Ray; Drug Discovery; Enzyme Inhibitors; Female; Lung; Mice; Models, Molecular; Nucleotidyltransferases; Pantetheine; Pneumococcal Infections; Pneumonia, Bacterial; Small Molecule Libraries; Staphylococcus aureus; Streptococcus pneumoniae; Thigh

2013
Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation.
    American journal of human genetics, 2014, Jan-02, Volume: 94, Issue:1

    Topics: Brain; Cloning, Molecular; Coenzyme A; Escherichia coli; Exome; Female; Fibroblasts; Gene Expression Regulation; Humans; Iron; Male; Mitochondria; Mutation, Missense; Nerve Degeneration; Pantetheine; Pedigree; Phosphorylation; Saccharomyces cerevisiae; Transferases

2014
Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction.
    Proteins, 2014, Volume: 82, Issue:9

    Topics: Acyltransferases; Alcohol Oxidoreductases; Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Crystallography, X-Ray; Models, Molecular; Molecular Sequence Data; Pantetheine; Peptide Synthases; Polyenes; Polyketide Synthases; Polyketides

2014
Crystal structure of phosphopantothenate synthetase from Thermococcus kodakarensis.
    Proteins, 2014, Volume: 82, Issue:9

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Archaeal Proteins; Binding Sites; Coenzyme A; Crystallography, X-Ray; Multiprotein Complexes; Pantetheine; Peptide Synthases; Sequence Alignment; Thermococcus

2014
Inhibitors of polyhydroxyalkanoate (PHA) synthases: synthesis, molecular docking, and implications.
    Chembiochem : a European journal of chemical biology, 2015, Jan-02, Volume: 16, Issue:1

    Topics: Acyltransferases; Aldehydes; Animals; Bacterial Proteins; Biocatalysis; Biodegradation, Environmental; Coenzyme A; Cupriavidus necator; Dogs; Enzyme Assays; Enzyme Inhibitors; Esterases; Kinetics; Lipase; Molecular Docking Simulation; Pantetheine; Polyhydroxyalkanoates; Structural Homology, Protein; Substrate Specificity; Sulfolobus solfataricus

2015
Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.
    Nature chemical biology, 2015, Volume: 11, Issue:10

    Topics: Animals; Caenorhabditis elegans; Cell Line; Coenzyme A; Coenzyme A Ligases; Drosophila; Female; HEK293 Cells; Humans; Longevity; Male; Mice, Inbred C57BL; Pantetheine; Phosphotransferases (Alcohol Group Acceptor)

2015
Structures of two distinct conformations of holo-non-ribosomal peptide synthetases.
    Nature, 2016, Jan-14, Volume: 529, Issue:7585

    Topics: Acinetobacter baumannii; Biocatalysis; Carrier Proteins; Coenzymes; Crystallography, X-Ray; Escherichia coli; Holoenzymes; Models, Molecular; Pantetheine; Peptide Synthases; Protein Structure, Tertiary

2016
Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase.
    Nature, 2016, Jan-14, Volume: 529, Issue:7585

    Topics: Amino Acid Isomerases; Anti-Bacterial Agents; Binding Sites; Biocatalysis; Brevibacillus; Carbohydrate Metabolism; Carrier Proteins; Catalytic Domain; Coenzymes; Crystallography, X-Ray; Gramicidin; Hydroxymethyl and Formyl Transferases; Models, Molecular; Multienzyme Complexes; Pantetheine; Peptide Synthases; Protein Binding; Protein Structure, Tertiary; RNA, Transfer

2016
Coenzyme A: to make it or uptake it?
    Nature reviews. Molecular cell biology, 2016, Volume: 17, Issue:10

    Topics: Animals; Biological Transport; Biosynthetic Pathways; Cell Membrane Permeability; Coenzyme A; Humans; Pantetheine

2016
Atomic structure of the entire mammalian mitochondrial complex I.
    Nature, 2016, Oct-20, Volume: 538, Issue:7625

    Topics: Animals; Binding Sites; Cardiolipins; Cross-Linking Reagents; Cryoelectron Microscopy; Electron Transport; Electron Transport Complex I; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Mitochondria; Models, Molecular; NADP; Oxidation-Reduction; Pantetheine; Protein Stability; Protein Subunits; Sheep

2016
Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.
    Scientific reports, 2017, 09-12, Volume: 7, Issue:1

    Topics: Animals; Cell Line; Disease Models, Animal; Drosophila; Heredodegenerative Disorders, Nervous System; Humans; Mice; Pantetheine; Phosphotransferases (Alcohol Group Acceptor); Serum; Treatment Outcome

2017
Dipeptide synthesis by internal adenylation domains of a multidomain enzyme involved in nonribosomal peptide synthesis.
    The Journal of general and applied microbiology, 2019, Mar-08, Volume: 65, Issue:1

    Topics: Adenosine Monophosphate; Coenzyme A Ligases; Cysteine; Dipeptides; Escherichia coli; Multienzyme Complexes; Oligopeptides; Pantetheine; Peptide Synthases; Protein Domains; Recombinant Proteins; Substrate Specificity

2019
Decrypting the oscillating nature of the 4'-phosphopantetheine arm in acyl carrier protein AcpM of Mycobacterium tuberculosis.
    FEBS letters, 2019, Volume: 593, Issue:6

    Topics: Amino Acid Motifs; Azoles; Bacterial Proteins; Binding Sites; Carrier Proteins; Cloning, Molecular; Coenzyme A; Escherichia coli; Fluorescent Dyes; Gene Expression; Genetic Vectors; Molecular Docking Simulation; Molecular Dynamics Simulation; Mycobacterium tuberculosis; Mycolic Acids; Nitrobenzenes; Pantetheine; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity

2019
Shifting the Hydrolysis Equilibrium of Substrate Loaded Acyl Carrier Proteins.
    Biochemistry, 2019, 08-27, Volume: 58, Issue:34

    Topics: Acyl Carrier Protein; Escherichia coli; Hydrolysis; Pantetheine; Protein Conformation

2019
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.
    EMBO molecular medicine, 2019, Volume: 11, Issue:12

    Topics: Animals; Biomarkers; Coenzyme A; Dopamine; Genotype; Iron; Mice; Pantetheine; Pantothenate Kinase-Associated Neurodegeneration; Phosphotransferases (Alcohol Group Acceptor)

2019
Chemical Proteomic Profiling of Protein 4'-Phosphopantetheinylation in Mammalian Cells.
    Angewandte Chemie (International ed. in English), 2020, 09-07, Volume: 59, Issue:37

    Topics: Animals; Humans; Mass Spectrometry; Pantetheine; Protein Processing, Post-Translational; Proteomics

2020
L. major apo-acyl carrier protein forms ordered aggregates due to an exposed phenylalanine, while phosphopantetheine inhibits aggregation in the holo-form.
    International journal of biological macromolecules, 2021, May-15, Volume: 179

    Topics: Acyl Carrier Protein; Leishmania major; Pantetheine; Phenylalanine; Protein Aggregates; Protozoan Proteins

2021
Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis.
    Microbiology spectrum, 2021, 10-31, Volume: 9, Issue:2

    Topics: Animals; Bacterial Proteins; Cell Wall; Female; Humans; Lipids; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Pantetheine; Phosphoric Diester Hydrolases; Protein Processing, Post-Translational; Tuberculosis; Virulence

2021
Lipoate protein ligase B primarily recognizes the C
    The Journal of biological chemistry, 2022, Volume: 298, Issue:8

    Topics: Acyl Carrier Protein; Acyltransferases; Coenzyme A; Escherichia coli; Escherichia coli Proteins; Ligases; Pantetheine; Thioctic Acid

2022
Controlled co-immobilisation of proteins via 4'-phosphopantetheine-mediated site-selective covalent linkage.
    New biotechnology, 2022, Dec-25, Volume: 72

    Topics: Acyl Carrier Protein; alpha-Amylases; Escherichia coli; Immobilized Proteins; Kinetics; Pantetheine

2022
Not always an innocent bystander: the impact of stabilised phosphopantetheine moieties when studying nonribosomal peptide biosynthesis.
    Chemical communications (Cambridge, England), 2023, Jun-29, Volume: 59, Issue:53

    Topics: Catalytic Domain; Pantetheine; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Synthases; Peptides

2023
Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring.
    Chemosphere, 2023, Volume: 341

    Topics: Alanine; Animals; Aspartic Acid; Cytochrome P-450 Enzyme System; Female; Gene Expression Profiling; Glycine; Lactation; Lipid Metabolism; Metabolomics; Pantetheine; Phosphates; Pregnancy; Rats; Serine; Threonine; Transcriptome; Xenobiotics

2023