4'-phosphopantetheine has been researched along with pantetheine in 129 studies
| Studies (4'-phosphopantetheine) | Trials (4'-phosphopantetheine) | Recent Studies (post-2010) (4'-phosphopantetheine) | Studies (pantetheine) | Trials (pantetheine) | Recent Studies (post-2010) (pantetheine) |
|---|---|---|---|---|---|
| 129 | 0 | 29 | 465 | 18 | 87 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (14.73) | 18.7374 |
| 1990's | 24 (18.60) | 18.2507 |
| 2000's | 51 (39.53) | 29.6817 |
| 2010's | 27 (20.93) | 24.3611 |
| 2020's | 8 (6.20) | 2.80 |
| Authors | Studies |
|---|---|
| Cebe, M; Perahia, D | 1 |
| Han, KK; Martinage, A | 1 |
| Díez, B; Gutiérrez, S; Martín, JF; Montenegro, E | 1 |
| Drueckhammer, D; Reichert, J; Rusnak, F; Sakaitani, M; Walsh, CT | 1 |
| Fernandez, MD; Lamppa, GK | 2 |
| Fearnley, IM; Runswick, MJ; Skehel, JM; Walker, JE | 1 |
| Geiger, O; Kennedy, EP; Spaink, HP | 1 |
| Dittmann, J; Kleinkauf, H; Lawen, A; Zocher, R | 1 |
| Lawen, A; Zocher, R | 1 |
| Jaworski, JG; Ohlrogge, JB; Post-Beittenmiller, MA | 1 |
| Brody, S; Lakin-Thomas, PL | 1 |
| Neely, JR; Tahiliani, AG | 1 |
| Kennedy, EP; Therisod, H | 1 |
| Gurinovich, VA; Moiseenok, AG; Sheibak, VM | 1 |
| Knudsen, J; Randhawa, ZI; Smith, S; Stern, A | 1 |
| Knudsen, J; Mikkelsen, J; Smith, S; Stern, A | 1 |
| Azuma, I; Iida, J; Nishimura, K; Ukei, S | 1 |
| Burton, DN; Yu, HL | 1 |
| Jackowski, S; Rock, CO | 3 |
| Gross, CJ; Henderson, LM; Shibata, K | 1 |
| Kumagai, A; Matsuoka, N; Morisaki, N; Saito, Y | 1 |
| Kumagai, A; Matsuoka, N; Morisaki, N; Saito, Y; Sasaki, N; Shirai, K | 1 |
| Keller, U; Kleinkauf, H; Zocher, R | 1 |
| Katiyar, SS; Pan, D; Porter, JW | 1 |
| Abu-Elheiga, L; al-Feel, W; Chirala, SS; Hsu, M; Huang, WY; Jayakumar, A; Tai, MH; Wakil, SJ | 1 |
| Franke, P; Kluge, B; Otto, A; Stein, T; Vater, J; Wittmann-Liebold, B | 1 |
| Franke, P; Kruft, V; Mc Dowell, R; Morris, HR; Panico, M; Stein, T; Vater, J; Wittmann-Liebold, B | 1 |
| Geiger, O; Ghose, R; Prestegard, JH | 1 |
| Flint, DH | 1 |
| Drueckhammer, DG; Gehring, AM; Lambalot, RH; Vogel, KW; Walsh, CT | 1 |
| Bradley, KA; Gehring, AM; Walsh, CT | 1 |
| Joshi, AK; Smith, S; Witkowski, A | 1 |
| Quadri, LE; Walsh, CT; Weinreb, PH; Zuber, P | 1 |
| Bucovaz, ET; Macleod, RM; Morrison, JC; Whybrew, WD | 1 |
| Hoppensack, A; Rehm, BH; Steinbüchel, A | 1 |
| Broadwater, JA; Fox, BG | 1 |
| Belshaw, PJ; Stachelhaus, T; Walsh, CT | 1 |
| Falick, AM; Joshi, AK; Rangan, VS; Smith, S; Witkowska, HE; Witkowski, A | 1 |
| Hughes, C; Hyland, C; Koronakis, V; Stanley, P | 1 |
| Cronan, JE; Flugel, RS; Hwangbo, Y; Lambalot, RH; Walsh, CT | 1 |
| Kleinkauf, H | 1 |
| Keating, TA; Miller, DA; Walsh, CT | 1 |
| Stachelhaus, T; Walsh, CT | 1 |
| Blaesse, M; Jung, G; Kupke, T; Schmid, D; Steinbacher, S; Uebele, M | 1 |
| Bugg, CW; Huang, F; Yarus, M | 1 |
| Suo, Z; Tseng, CC; Walsh, CT | 1 |
| Ferber, D | 1 |
| Culianez-Macia, FA; Hernandez-Acosta, P; Kupke, T; Steinbacher, S | 1 |
| Luo, L; Walsh, CT | 1 |
| Begley, TP; Strauss, E | 1 |
| Finking, R; Marahiel, MA; Mootz, HD | 1 |
| Bhattacharjee, JK; Evans, SA; Guo, S; Wilkes, MB | 1 |
| Dunaway-Mariano, D; Luo, L; Taylor, KL; Wei, Y; Xiang, H; Zhang, W | 1 |
| Izard, T | 1 |
| Bruner, SD; Kohli, RM; Marahiel, MA; Schwarzer, D; Stubbs, MT; Walsh, CT; Weber, T | 1 |
| Burkart, MD; Marshall, CG; Meray, RK; Walsh, CT | 1 |
| Ferlan, JT; Gardner, MJ; Guszczynski, T; Kopydlowski, KM; Lee, PJ; Li, Z; Prigge, ST; Sellers, P; Shallom, S; Waters, NC; Wei, L; Woodard, CL | 1 |
| Fox, BG; Haas, JA | 1 |
| Khosla, C; Li, Q; Liu, CW; Puglisi, JD | 1 |
| Chakrabarti, S; Sowdhamini, R | 1 |
| Culiáñez-Macià, FA; Hernández-Acosta, P; Kupke, T | 1 |
| Amara, AA; Rehm, BH | 1 |
| ALBERTS, AW; MAJERUS, PW; VAGELOS, PR | 1 |
| Arisaka, F; Fujimoto, Y; Inagaki, E; Kuramitsu, S; Kuroishi, C; Miyano, M; Nakamura, Y; Nodake, Y; Tahirov, TH; Takahashi, H; Yamamoto, M; Yokoyama, S; Yutani, K | 1 |
| Begley, TP; Brand, LA; McLafferty, FW; Strauss, E; Zhai, H | 1 |
| Burkart, MD; La Clair, JJ; Mandel, AL | 1 |
| Cronan, JE; Thomas, J | 1 |
| Kupke, T; Schwarz, W | 1 |
| Liu, Q; Ma, Y; Zhang, Y; Zhou, L | 1 |
| Herrmann, T; Johnson, MA; Peti, W; Wilson, IA; Wüthrich, K | 1 |
| Bernhard, F; Blum, MM; Dötsch, V; Koglin, A; Löhr, F; Marahiel, MA; Mittag, T; Mofid, MR; Rogov, VV; Schäfer, B | 1 |
| Fox, BG; Markley, JL; Zornetzer, GA | 1 |
| Sarma, SP; Sharma, AK; Sharma, SK; Surolia, A; Surolia, N | 1 |
| Cole, PA; Ganguly, S; Ho, AK; Hwang, Y; Klein, DC | 1 |
| Modak, R; Sinha, S; Surolia, N | 1 |
| Yen, M; Yin, J | 1 |
| Case, H; de Dreu, P; Miller, JR; Mueller, WT; Ohren, J; Sarver, RW; Thanabal, V | 1 |
| Donato, H; Krupenko, NI; Krupenko, SA; Tsybovsky, Y | 1 |
| Dorrestein, PC; Hensler, M; Meluzzi, D; Nizet, V; Zheng, WH | 1 |
| Crawford, JM; Ehrlich, KC; Townsend, CA; Udwary, DW; Vagstad, AL | 1 |
| Burkart, MD; Cheng, Q; Hur, GH; Meier, JL; Moore, BS; Worthington, AS | 1 |
| Bodner, MJ; Freeman, MF; Li, R; Moshos, KA; Townsend, CA | 1 |
| Arthur, CJ; Burston, SG; Crosby, J; Crump, MP; Evans, SE; Simpson, TJ; Williams, C | 1 |
| Ban, N; Jenni, S; Leibundgut, M; Maier, T | 1 |
| Contreras-Martínez, S; Dávila-Martínez, Y; Encarnación, S; Geiger, O; López-Lara, IM; Ramos-Vega, AL; Sohlenkamp, C | 1 |
| Rock, CO; Wu, BN; Zhang, YM; Zheng, JJ | 1 |
| Burkart, MD; Foley, TL | 1 |
| Da Silva, NA; Kealey, JT; Lee, KK | 1 |
| Doyle, S; Frizzell, A; Stack, D; Tomkins, K | 1 |
| Bumpus, SB; Evans, BS; Kelleher, NL; Ntai, I; Thomas, PM | 1 |
| Contreras-Martínez, S; Dávila-Martínez, Y; Encarnación, S; Geiger, O; López-Lara, IM; Ramos-Vega, AL | 1 |
| Sherman, DH | 1 |
| Hoeferlin, LA; Krupenko, NI; Krupenko, SA; Oleinik, NV; Strickland, KC | 1 |
| Bhagawati, M; Brunk, A; Paterok, D; Piehler, J; Podoplelova, Y; Reichel, A; Waichman, S | 1 |
| Broadhurst, RW; Cavalli, A; Tosin, M; Tran, L; Weissman, KJ | 1 |
| Arthur, CJ; Crosby, J; Crump, MP; Kanari, AL; Płoskoń, E; Simpson, TJ; Wattana-amorn, P; Williams, C; Willis, CL | 1 |
| Mesecar, AD; Wubben, TJ | 1 |
| Bafna, V; Burkart, MD; Cravatt, BF; Dorrestein, PC; Kersten, R; Meehan, M; Meier, JL; Niessen, S; Patel, AD; Rothmann, M; Yang, JY | 1 |
| Acton, TB; Ciccosanti, C; Everett, JK; Hamilton, K; Kennedy, MA; Lee, HW; Montelione, GT; Prestegard, JH; Ramelot, TA; Smola, MJ; Xiao, R | 1 |
| Borgaro, JG; Chang, A; Machutta, CA; Tonge, PJ; Zhang, X | 1 |
| Amoroso, JW; Borketey, LS; Prasad, G; Schnarr, NA | 1 |
| Chang, SY; Chen, T; Cheng, CS; Jia, KF; Lin, MS; Yin, HS | 1 |
| Brock, J; Chen, B; de Jonge, BL; Gao, N; Gu, RF; Hajec, L; Holt, E; Hutchings, K; Huynh, H; Johnstone, M; Kutschke, A; Laganas, V; Lahiri, SD; Livchak, S; McKinney, D; Nash, TJ; Neckermann, G; Ni, H; San Martin, M; Thresher, J; Utley, L; Walkup, GK | 1 |
| Bettencourt, C; Chiapparini, L; Demchenko, N; Dusi, S; Garavaglia, B; Goffrini, P; Gout, I; Gregory, A; Haack, TB; Hamada, J; Hayflick, S; Houlden, H; Invernizzi, F; Kurian, MA; Nardocci, N; Pasqualato, S; Prokisch, H; Sanford, L; Schwarzmayr, T; Strom, TM; Tigano, M; Tiranti, V; Tsuchiya, Y; Valletta, L; Venco, P; Wieland, T; Zorzi, G | 1 |
| Axelrod, AJ; Detelich, ME; Keatinge-Clay, AT; Piasecki, SK; Zheng, J | 1 |
| Atomi, H; Imanaka, T; Ishibashi, T; Kishimoto, A; Kita, A; Miki, K; Tomita, H; Yokooji, Y | 1 |
| Cronan, JE | 1 |
| Cao, R; Chen, C; Li, P; Maurmann, L; Zhang, W | 1 |
| Baratashvili, M; Colombelli, C; Grzeschik, NA; Hayflick, S; Kanon, B; Kosec, G; Lambrechts, RA; Nollen, EA; Petković, H; Podgoršek, A; Reijngoud, DJ; Schaap, O; Sibon, OC; Srinivasan, B; Tiranti, V; van der Zwaag, M | 1 |
| Aldrich, CC; Allen, CL; Drake, EJ; Gulick, AM; Miller, BR; Shi, C; Skiniotis, G; Sundlov, JA; Tarrasch, JT | 1 |
| Aloise, MN; Harrison, PM; Reimer, JM; Schmeing, TM | 1 |
| Sibon, OC; Strauss, E | 1 |
| Degliesposti, G; Fiedorczuk, K; Kaszuba, K; Letts, JA; Sazanov, LA; Skehel, M | 1 |
| Colombelli, C; Čusak, A; de Boer, T; de Villiers, M; Di Meo, I; Fox, R; Grzeschik, NA; Hamada, J; Harrs, CH; Hayflick, SJ; Jenko, B; Jeong, SY; Kosec, G; Lahaye, LL; Pahor, J; Rizzetto, E; Sibon, OCM; Srinivasan, B; Tepper, PG; Tiranti, V; van der Zwaag, M; Woltjer, RL | 1 |
| Abe, T; Kawamura, S; Kobayashi, K; Kobayashi, M; Sakaguchi, T; Shiiba, K | 1 |
| Basak, A; Biswas, R; Das, AK; Das, PK; Dutta, D; Maiti, MK; Singh, BK | 1 |
| Bartholow, TG; Burkart, MD; McCammon, JA; Sztain, T | 1 |
| Cobb, J; Duffy, M; Fox, R; Freed, A; Gray, N; Gregory, AM; Hamada, J; Hayflick, SJ; Hogarth, P; Jeong, SY; Jin, H; Lambrechts, R; Nilsen, A; Pham, T; Placzek, A; Rai, P; Ralle, M; Schwanemann, L; Sibon, OC; van der Zwaag, M; Wakeman, K; Woltjer, RL; Zhen, D | 1 |
| Chen, N; Li, Y; Liu, Y; Wang, C | 1 |
| Chen, N; Wang, C | 1 |
| Arya, R; Dhembla, C; Kumar, A; Kundu, S; Sundd, M | 1 |
| Bourland, R; Burns-Huang, K; d'Andrea, FB; Geiger, A; Gold, B; Hartman, TE; Jiang, X; Mosior, JW; Nathan, CF; Ouerfelli, O; Pandey, S; Rhee, K; Roberts, J; Sacchettini, JC; Singh, A; Tang, S; Yang, G | 1 |
| Dhembla, C; Kundu, S; Sundd, M; Yadav, U | 1 |
| Hu, Q; Li, X; Luo, W; Wang, H; Wang, S; Yang, J; Zeng, Z; Zheng, Y | 1 |
| Cryle, MJ; Ho, YTC; Izoré, T; Jackson, CJ; Kaczmarski, JA; Schittenhelm, RB; Steer, DL; Tailhades, J; Tosin, M | 1 |
| Liu, Y; Luo, T; Meng, X; Yu, G; Zhang, J; Zhang, R | 1 |
4 review(s) available for 4'-phosphopantetheine and pantetheine
| Article | Year |
|---|---|
Possible relationship between coding recognition amino acid sequence motif or residue(s) and post-translational chemical modification of proteins.
Topics: Acetylation; Acylation; Amino Acid Sequence; Animals; Glycosylation; Humans; Hydroxylation; Molecular Sequence Data; Pantetheine; Protein Kinases; Protein Processing, Post-Translational | 1992 |
The multienzyme architecture of eukaryotic fatty acid synthases.
Topics: Animals; Eukaryotic Cells; Evolution, Molecular; Fatty Acid Desaturases; Fatty Acid Synthases; Fungal Proteins; Hydro-Lyases; Molecular Structure; Pantetheine; Protein Structure, Tertiary; Substrate Specificity; Transferases | 2008 |
The chain-flipping mechanism of ACP (acyl carrier protein)-dependent enzymes appears universal.
Topics: Acyl Carrier Protein; Acyltransferases; Crystallization; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Hydro-Lyases; Models, Molecular; Pantetheine; Protein Structure, Secondary | 2014 |
Chemical Labeling of Protein 4'-Phosphopantetheinylation.
Topics: Coenzyme A; Models, Molecular; Molecular Structure; Pantetheine; Protein Processing, Post-Translational | 2021 |
125 other study(ies) available for 4'-phosphopantetheine and pantetheine
| Article | Year |
|---|---|
Molecular orbital studies on the conformation of the phosphopantetheine moiety of coenzyme A.
Topics: Coenzyme A; Hydrogen Bonding; Molecular Conformation; Organophosphorus Compounds; Pantetheine; Quantum Theory; Sulfhydryl Compounds | 1977 |
Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of mu
Topics: Acremonium; Amino Acid Sequence; Base Sequence; Binding Sites; Blotting, Northern; Cephalosporins; Cloning, Molecular; Genes, Bacterial; Genetic Complementation Test; Genetic Linkage; Molecular Sequence Data; Multienzyme Complexes; Pantetheine; Peptide Synthases; Regulatory Sequences, Nucleic Acid; Restriction Mapping; RNA, Bacterial; RNA, Messenger; Thiolester Hydrolases; Transcription, Genetic | 1991 |
Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Base Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Cloning, Molecular; DNA, Bacterial; Enterobactin; Escherichia coli; Genes, Bacterial; Molecular Sequence Data; Molecular Weight; Multienzyme Complexes; Pantetheine; Peptide Synthases; Plasmids; Restriction Mapping; Sequence Homology, Nucleic Acid | 1991 |
Acyl carrier protein import into chloroplasts. Both the precursor and mature forms are substrates for phosphopantetheine attachment by a soluble chloroplast holo-acyl carrier protein synthase.
Topics: Acyl Carrier Protein; Base Sequence; Chloroplasts; Kinetics; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Pantetheine; Phosphotransferases; Plants; Protein Precursors; Protein Processing, Post-Translational; Substrate Specificity; Transferases (Other Substituted Phosphate Groups) | 1991 |
Presence of an acyl carrier protein in NADH:ubiquinone oxidoreductase from bovine heart mitochondria.
Topics: Acyl Carrier Protein; Amino Acid Sequence; Animals; Base Sequence; Cattle; DNA; Mitochondria, Heart; Molecular Sequence Data; NAD(P)H Dehydrogenase (Quinone); Pantetheine; Quinone Reductases; Sequence Alignment | 1991 |
Acyl carrier protein (ACP) import into chloroplasts does not require the phosphopantetheine: evidence for a chloroplast holo-ACP synthase.
Topics: Acyl Carrier Protein; Amino Acid Sequence; Base Sequence; Chloroplasts; Escherichia coli; Molecular Sequence Data; Mutagenesis; Pantetheine; Phosphoric Diester Hydrolases; Phosphotransferases; Plants; Plasmids; Protein Precursors; Transferases (Other Substituted Phosphate Groups) | 1990 |
Isolation of the Rhizobium leguminosarum NodF nodulation protein: NodF carries a 4'-phosphopantetheine prosthetic group.
Topics: Amino Acid Sequence; Bacterial Proteins; Chromatography, Gel; Chromosome Mapping; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Pantetheine; Rhizobium; Sequence Homology, Nucleic Acid | 1991 |
Isolation and partial characterization of cyclosporin synthetase from a cyclosporin non-producing mutant of Beauveria nivea.
Topics: Amino Acid Sequence; Cyclosporins; Fungi; Methylation; Molecular Sequence Data; Multienzyme Complexes; Mutation; Pantetheine; Peptide Synthases | 1990 |
Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described.
Topics: Affinity Labels; Amino Acids; Carbohydrates; Centrifugation, Density Gradient; Cyclosporins; Immunoblotting; Methylation; Mitosporic Fungi; Molecular Weight; Multienzyme Complexes; Pantetheine; Peptide Synthases; Photochemistry; S-Adenosylmethionine; Trichoderma | 1990 |
Site-directed mutagenesis of the spinach acyl carrier protein-I prosthetic group attachment site.
Topics: Acyl Carrier Protein; Cross Reactions; Electrophoresis; Escherichia coli; Isoelectric Focusing; Mutation; Pantetheine; Phosphotransferases; Plants; Protein Conformation; Transferases (Other Substituted Phosphate Groups) | 1989 |
Neurospora crassa mitochondria contain two forms of a 4'-phosphopantetheine-modified protein.
Topics: Acyl Carrier Protein; Cell Membrane; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Fungal Proteins; Hydrogen-Ion Concentration; Hydroxylamine; Hydroxylamines; Isoelectric Point; Mercaptoethanol; Mitochondria; Molecular Weight; Neurospora; Neurospora crassa; Pantetheine; Sulfhydryl Compounds | 1986 |
Mitochondrial synthesis of coenzyme A is on the external surface.
Topics: Adenosine Triphosphate; Animals; Atractyloside; Coenzyme A; Dinitrophenols; In Vitro Techniques; Mitochondria, Heart; Pantetheine; Rats; Uncoupling Agents | 1987 |
The function of acyl carrier protein in the synthesis of membrane-derived oligosaccharides does not require its phosphopantetheine prosthetic group.
Topics: Acyl Carrier Protein; Apoproteins; Ethylmaleimide; Glycoconjugates; Oligosaccharides; Palmitates; Pantetheine; Sulfhydryl Compounds | 1987 |
Hepatic CoA, S-acyl-CoA, biosynthetic precursors of the coenzyme and pantothenate-protein complexes in dietary pantothenic acid deficiency.
Topics: Acyl Coenzyme A; Animals; Body Weight; Coenzyme A; Liver; Male; Pantetheine; Pantothenic Acid; Proteins; Rats | 1987 |
Mammalian fatty acid synthetase is a structurally and functionally symmetrical dimer.
Topics: Acetone; Alkylation; Animals; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Fatty Acid Synthases; Female; Hydrolysis; Lactation; Liver; Mammary Glands, Animal; Molecular Weight; Pantetheine; Pregnancy; Rats; Trypsin | 1985 |
Stoichiometry of substrate binding to rat liver fatty acid synthetase.
Topics: Acetates; Acetic Acid; Acetyl Coenzyme A; Animals; Binding Sites; Cysteamine; Cysteine; Fatty Acid Synthases; Iodoacetamide; Liver; Malonates; Malonyl Coenzyme A; Pantetheine; Rats | 1985 |
Macrophage activation with pantethine and pantetheine-4'-phosphate.
Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Female; Kinetics; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Pantetheine; Structure-Activity Relationship; Sulfhydryl Compounds | 1985 |
Adaptive synthesis of rat liver fatty acid synthetase: evidence for in vitro formation of active enzyme from inactive protein precursors and 4'-phosphopantetheine.
Topics: Animals; Carbon Radioisotopes; Coenzyme A; Dietary Fats; Enzyme Activation; Fatty Acid Synthases; Liver; Male; Organophosphorus Compounds; Pantetheine; Pantothenic Acid; Rats; Starvation; Sulfhydryl Compounds | 1974 |
Turnover of the 4'-phosphopantetheine prosthetic group of acyl carrier protein.
Topics: Acyl Carrier Protein; Alanine; Escherichia coli; Kinetics; Pantetheine; Species Specificity; Sulfhydryl Compounds | 1984 |
Metabolism of 4'-phosphopantetheine in Escherichia coli.
Topics: Acyl Carrier Protein; Alanine; Coenzyme A; Escherichia coli; Pantetheine; Pantothenic Acid; Sulfhydryl Compounds | 1984 |
Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine.
Topics: Absorption; Animals; Carbon Radioisotopes; Coenzyme A; Coenzymes; Hydrolysis; Intestine, Small; Male; Pantetheine; Pantothenic Acid; Rats; Rats, Inbred Strains | 1983 |
Effects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria.
Topics: Acyl Coenzyme A; Animals; Carnitine Acyltransferases; Coenzyme A Ligases; Fatty Acids; In Vitro Techniques; Male; Mitochondria, Liver; Oxidation-Reduction; Pantetheine; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sulfhydryl Compounds | 1983 |
Effect of pantethine on fatty acid oxidation in microvessels of rat brain.
Topics: Animals; Brain; Cerebral Hemorrhage; Fatty Acids; Hypertension; In Vitro Techniques; Microcirculation; Pantetheine; Rats; Sulfhydryl Compounds | 1983 |
Regulation of coenzyme A biosynthesis.
Topics: Acyl Carrier Protein; beta-Alanine; Coenzyme A; Escherichia coli; Organophosphorus Compounds; Pantetheine; Pantothenic Acid | 1981 |
Enniatin synthetase, a novel type of multifunctional enzyme catalyzing depsipeptide synthesis in Fusarium oxysporum.
Topics: Amino Acids; Anti-Bacterial Agents; Fusarium; Iodoacetamide; Methylation; Molecular Weight; Organophosphorus Compounds; Pantetheine; Peptide Synthases; S-Adenosylmethionine; Substrate Specificity; Sulfhydryl Reagents | 1982 |
Role of cysteine and 4'-phosphopantetheine in the inactivation of pigeon liver fatty acid synthetase by S-(4-bromo-2,3-dioxobutyl)-coenzyme A.
Topics: Affinity Labels; Animals; Binding Sites; Coenzyme A; Columbidae; Cysteine; Fatty Acid Synthases; Kinetics; Liver; Organophosphorus Compounds; Pantetheine; Protein Binding; Sulfhydryl Compounds | 1982 |
Human fatty acid synthase: properties and molecular cloning.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Carcinoma, Hepatocellular; Chickens; Cloning, Molecular; DNA, Complementary; Fatty Acid Synthases; Humans; Liver Neoplasms; Molecular Sequence Data; Pantetheine; Rats; Restriction Mapping; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Tumor Cells, Cultured | 1995 |
Gramicidin S synthetase 1 (phenylalanine racemase), a prototype of amino acid racemases containing the cofactor 4'-phosphopantetheine.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Binding Sites; Esters; Molecular Sequence Data; Pantetheine; Pantothenic Acid; Sequence Alignment | 1995 |
Detection of 4'-phosphopantetheine at the thioester binding site for L-valine of gramicidinS synthetase 2.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Amino Acids; Bacillus; Binding Sites; Esters; Molecular Sequence Data; Multienzyme Complexes; Pantetheine; Peptide Synthases; Spectrometry, Mass, Fast Atom Bombardment; Valine | 1994 |
NMR investigations of the structural properties of the nodulation protein, NodF, from Rhizobium leguminosarum and its homology with Escherichia coli acyl carrier protein.
Topics: Acyl Carrier Protein; Amino Acid Sequence; Bacterial Proteins; Escherichia coli; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Pantetheine; Protein Folding; Protein Structure, Secondary; Rhizobium leguminosarum; Sequence Homology, Amino Acid | 1996 |
Escherichia coli contains a protein that is homologous in function and N-terminal sequence to the protein encoded by the nifS gene of Azotobacter vinelandii and that can participate in the synthesis of the Fe-S cluster of dihydroxy-acid dehydratase.
Topics: Alanine; Amino Acid Sequence; Azotobacter vinelandii; Bacterial Proteins; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Disulfides; Escherichia coli; Genes, Bacterial; Haemophilus influenzae; Hydro-Lyases; Iron-Sulfur Proteins; Kinetics; Macromolecular Substances; Molecular Sequence Data; Naphthalenesulfonates; Pantetheine; Peptide Fragments; Pyridoxal Phosphate; Sequence Homology, Amino Acid; Sulfhydryl Reagents | 1996 |
Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase.
Topics: Acyl Carrier Protein; Anti-Bacterial Agents; Cloning, Molecular; Coenzyme A; DNA Primers; Escherichia coli; Molecular Structure; Multienzyme Complexes; Pantetheine; Polymerase Chain Reaction; Recombinant Proteins; Streptomyces; Substrate Specificity; Transferases (Other Substituted Phosphate Groups) | 1997 |
Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate.
Topics: Acylation; Adenosine Triphosphate; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enterobactin; Escherichia coli; Escherichia coli Proteins; Hydrolases; Hydroxybenzoates; Kinetics; Ligases; Mass Spectrometry; Molecular Structure; Multienzyme Complexes; Pantetheine; Recombinant Proteins; Salicylates; Salicylic Acid; Sequence Homology, Amino Acid; Serine; Transferases | 1997 |
Characterization of the interthiol acyltransferase reaction catalyzed by the beta-ketoacyl synthase domain of the animal fatty acid synthase.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acyl Carrier Protein; Acyl Coenzyme A; Acyltransferases; Animals; Binding Sites; Cysteine; Escherichia coli; Fatty Acid Synthases; Fatty Acids; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Pantetheine; Rats; Recombinant Proteins; Substrate Specificity; Sulfhydryl Compounds | 1997 |
Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase.
Topics: Acylation; Adenosine Monophosphate; Aminoacyltransferases; Bacillus subtilis; Bacterial Proteins; Catalysis; Enzyme Stability; Escherichia coli; Genetic Vectors; Kinetics; Lipopeptides; Pantetheine; Peptide Synthases; Peptides, Cyclic; Protein Processing, Post-Translational; Recombinant Proteins; Substrate Specificity; Transferases (Other Substituted Phosphate Groups); Valine | 1998 |
The coenzyme A-synthesizing protein complex and its proposed role in CoA biosynthesis in bakers' yeast.
Topics: Catalysis; Coenzyme A; Feedback; Fungal Proteins; Molecular Weight; Multienzyme Complexes; Pantetheine; Peptide Synthases; Protein Binding; Saccharomyces cerevisiae | 1997 |
Analysis of 4-phosphopantetheinylation of polyhydroxybutyrate synthase from Ralstonia eutropha: generation of beta-alanine auxotrophic Tn5 mutants and cloning of the panD gene region.
Topics: Acyltransferases; Amino Acid Sequence; Bacterial Proteins; beta-Alanine; Cloning, Molecular; Consensus Sequence; Cupriavidus necator; Genes, Bacterial; Genetic Complementation Test; Molecular Sequence Data; Mutagenesis, Insertional; NADP Transhydrogenases; Open Reading Frames; Pantetheine; Plasmids; Protein Processing, Post-Translational; Recombinant Proteins; Restriction Mapping; Sequence Alignment; Sequence Homology, Amino Acid | 1999 |
Spinach holo-acyl carrier protein: overproduction and phosphopantetheinylation in Escherichia coli BL21(DE3), in vitro acylation, and enzymatic desaturation of histidine-tagged isoform I.
Topics: Acyl Carrier Protein; Acylation; Amino Acid Sequence; Base Sequence; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Cloning, Molecular; Escherichia coli; Genes, Plant; Genes, Synthetic; Histidine; Molecular Sequence Data; Pantetheine; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Proteins; Restriction Mapping; Spinacia oleracea | 1999 |
Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis.
Topics: Acyl Carrier Protein; Acyl Coenzyme A; Amino Acid Isomerases; Anti-Bacterial Agents; Bacterial Proteins; Dipeptides; Mass Spectrometry; Pantetheine; Peptide Biosynthesis; Peptide Synthases; Phenylalanine; Proline; Ribosomes | 1999 |
Dibromopropanone cross-linking of the phosphopantetheine and active-site cysteine thiols of the animal fatty acid synthase can occur both inter- and intrasubunit. Reevaluation of the side-by-side, antiparallel subunit model.
Topics: Acetone; Animals; Binding Sites; Chromatography, Gel; Cysteine; Electrophoresis, Polyacrylamide Gel; Evaluation Studies as Topic; Fatty Acid Synthases; Hydrogen-Ion Concentration; Models, Chemical; Molecular Weight; Pantetheine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfhydryl Compounds | 1999 |
An ordered reaction mechanism for bacterial toxin acylation by the specialized acyltransferase HlyC: formation of a ternary complex with acylACP and protoxin substrates.
Topics: Acyl Carrier Protein; Acylation; Acyltransferases; Bacterial Proteins; Chromatography, Affinity; Cloning, Molecular; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Hemolysin Proteins; Immunoblotting; Kinetics; Lysine; Mutagenesis, Site-Directed; Pantetheine; Substrate Specificity | 1999 |
Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli.
Topics: Amino Acid Substitution; Cloning, Molecular; Concanavalin A; Escherichia coli; Genetic Complementation Test; Kinetics; Pantetheine; Plasmids; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; Tetracycline; Transferases (Other Substituted Phosphate Groups) | 2000 |
The role of 4'-phosphopantetheine in t' biosynthesis of fatty acids, polyketides and peptides.
Topics: Carrier Proteins; Coenzyme A; Fatty Acids; Pantetheine; Peptides | 2000 |
Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase.
Topics: Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Catalysis; Coenzyme A Ligases; Diphosphates; Genetic Complementation Test; Holoenzymes; Hydrolysis; Iron-Binding Proteins; Kinetics; Molecular Weight; Pantetheine; Peptide Synthases; Periplasmic Binding Proteins; Plasmids; Point Mutation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Salicylic Acid; Substrate Specificity; Yersinia pestis | 2000 |
Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Bacillus; Carbohydrate Epimerases; Catalysis; Diketopiperazines; DNA Mutational Analysis; Electron Transport; Gramicidin; Hydrolysis; Molecular Sequence Data; Mutagenesis, Site-Directed; Pantetheine; Peptide Chain Initiation, Translational; Phenylalanine; Piperazines; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2000 |
Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis.
Topics: Amino Acid Motifs; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Carboxy-Lyases; Chromatography, Gel; Coenzyme A; Cysteine; Escherichia coli; Flavin Mononucleotide; Flavoproteins; Molecular Sequence Data; Mutation; Oxidoreductases; Pantetheine; Pantothenic Acid; Peptides; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; Sequence Homology, Amino Acid | 2000 |
RNA-Catalyzed CoA, NAD, and FAD synthesis from phosphopantetheine, NMN, and FMN.
Topics: Coenzyme A; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Gene Library; NAD; Nicotinamide Mononucleotide; Pantetheine; RNA; Sequence Analysis, RNA | 2000 |
Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase.
Topics: Acyl Carrier Protein; Acylation; Acyltransferases; Apoproteins; Bacillus subtilis; Bacterial Outer Membrane Proteins; Bacterial Proteins; Cloning, Molecular; Cysteine; Escherichia coli; Holoenzymes; Iron-Binding Proteins; Kinetics; Malonyl Coenzyme A; Molecular Structure; Molecular Weight; Multienzyme Complexes; Pantetheine; Peptide Fragments; Peptide Synthases; Periplasmic Binding Proteins; Phenols; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Subunits; Recombinant Proteins; Siderophores; Thiazoles; Yersinia pestis | 2001 |
Microbiology. Possible new route to polyketide synthesis.
Topics: Acyl Coenzyme A; Bacillus subtilis; Erythromycin; Escherichia coli; Genetic Engineering; Multienzyme Complexes; Pantetheine; Patents as Topic; Protein Engineering; Recombinant Proteins; Saccharopolyspora | 2001 |
Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-Phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Binding Sites; Carboxy-Lyases; Catalysis; Chromatography, Gel; Coenzyme A; Crystallography, X-Ray; Cysteine; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Models, Chemical; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Oxidoreductases; Pantetheine; Pantothenic Acid; Peptide Synthases; Plant Proteins; Polymerase Chain Reaction; Protein Binding; Protein Conformation; Salts; Sequence Homology, Amino Acid; Signal Transduction; Time Factors | 2001 |
Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Isomerases; Amino Acid Motifs; Aminoacylation; Apoenzymes; Bacillus; Carbon Radioisotopes; Catalysis; Gramicidin; Histidine; Holoenzymes; Kinetics; Mutagenesis, Site-Directed; Pantetheine; Peptide Chain Initiation, Translational; Phenylalanine; Protein Structure, Tertiary | 2001 |
Mechanistic studies on phosphopantothenoylcysteine decarboxylase.
Topics: Carboxy-Lyases; Catalysis; Coenzyme A; Cysteine; Cytidine Monophosphate; Cytidine Triphosphate; Enzyme Activation; Escherichia coli; Molecular Structure; Pantetheine; Pantothenic Acid; Peptide Synthases; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity | 2001 |
4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis.
Topics: Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Calcium-Binding Proteins; Carrier Proteins; Escherichia coli; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Pantetheine; Plant Proteins; Sequence Homology, Amino Acid; Transferases (Other Substituted Phosphate Groups) | 2001 |
Novel posttranslational activation of the LYS2-encoded alpha-aminoadipate reductase for biosynthesis of lysine and site-directed mutational analysis of conserved amino acid residues in the activation domain of Candida albicans.
Topics: Aldehyde Oxidoreductases; Amino Acid Sequence; Apoenzymes; Candida albicans; Coenzyme A; Conserved Sequence; Enzyme Activation; Holoenzymes; L-Aminoadipate-Semialdehyde Dehydrogenase; Lysine; Pantetheine; Protein Processing, Post-Translational | 2001 |
Role of active site binding interactions in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis.
Topics: Acyl Coenzyme A; Binding Sites; Binding, Competitive; Catalysis; Coenzyme A; Enzyme Stability; Hydrolases; Kinetics; Ligands; Mutagenesis, Site-Directed; Pantetheine; Substrate Specificity; Thermodynamics | 2001 |
The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism.
Topics: Adenosine Triphosphate; Binding Sites; Catalysis; Crystallography, X-Ray; Dimerization; Escherichia coli; Hydrogen Bonding; Ligands; Magnesium; Models, Molecular; Nucleotidyltransferases; Pantetheine; Protein Binding; Protein Structure, Quaternary; Protein Subunits; Structure-Activity Relationship | 2002 |
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cyclization; Ligands; Lipopeptides; Models, Molecular; Molecular Sequence Data; Molecular Structure; Pantetheine; Peptide Synthases; Peptides, Cyclic; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment | 2002 |
Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases.
Topics: Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Base Sequence; Binding Sites; Carrier Proteins; DNA Primers; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pantetheine; Peptide Synthases; Recombinant Proteins; Siderophores | 2002 |
Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acyl Carrier Protein; Amino Acid Sequence; Amino Acid Substitution; Animals; Cloning, Molecular; Fatty Acid Synthases; Fatty Acids; Holoenzymes; Molecular Sequence Data; Mutation; Pantetheine; Plasmodium falciparum; Recombinant Proteins; Sequence Alignment | 2002 |
Fluorescence anisotropy studies of enzyme-substrate complex formation in stearoyl-ACP desaturase.
Topics: Acyl Carrier Protein; Acylation; Apoproteins; Binding Sites; Dansyl Compounds; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Ferredoxins; Fluorescein-5-isothiocyanate; Fluorescence Polarization; Fluorescent Dyes; Kinetics; Macromolecular Substances; Mixed Function Oxygenases; Osmolar Concentration; Pantetheine; Protein Binding; Spectrometry, Fluorescence; Static Electricity; Substrate Specificity | 2002 |
Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein.
Topics: Acyl Carrier Protein; Amino Acid Sequence; Models, Chemical; Models, Molecular; Molecular Sequence Data; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Protein Conformation; Sequence Alignment; Streptomyces | 2003 |
Functional sites and evolutionary connections of acylhomoserine lactone synthases.
Topics: Acetyltransferases; Amino Acid Sequence; Binding Sites; Carboxylic Ester Hydrolases; Crystallography, X-Ray; Gram-Negative Bacteria; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Pantetheine; Sequence Alignment; Substrate Specificity | 2003 |
4'-phosphopantetheine and coenzyme A biosynthesis in plants.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Arabidopsis; Biochemical Phenomena; Biochemistry; Cell Line; Cloning, Molecular; Coenzyme A; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genome, Plant; Magnesium; Models, Chemical; Molecular Sequence Data; Nucleotidyltransferases; Osmosis; Pantetheine; Plants; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Time Factors | 2003 |
Replacement of the catalytic nucleophile cysteine-296 by serine in class II polyhydroxyalkanoate synthase from Pseudomonas aeruginosa-mediated synthesis of a new polyester: identification of catalytic residues.
Topics: Acyltransferases; Amino Acid Sequence; Amino Acid Substitution; Animals; Catalytic Domain; Cysteine; Epoxide Hydrolases; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Pantetheine; Polyesters; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pseudomonas aeruginosa; Sequence Alignment; Serine; Substrate Specificity | 2003 |
ACYL CARRIER PROTEIN. IV. THE IDENTIFICATION OF 4'-PHOSPHOPANTETHEINE AS THE PROSTHETIC GROUP OF THE ACYL CARRIER PROTEIN.
Topics: Acyl Carrier Protein; Alkaline Phosphatase; Amines; Carbon Isotopes; Chemistry Techniques, Analytical; Chromatography; Coenzyme A; Electrophoresis; Lactobacillus; Lactones; Metabolism; Pantetheine; Pantothenic Acid; Pepsin A; Peptide Hydrolases; Phosphates; Protein Hydrolysates; Proteins; Radiometry; Research | 1965 |
Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus.
Topics: Crystallography, X-Ray; Enzyme Stability; Hot Temperature; Models, Molecular; Nucleotidyltransferases; Pantetheine; Thermus thermophilus; Ultracentrifugation | 2004 |
Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent.
Topics: Binding Sites; Carboxy-Lyases; Catalysis; Cysteine; Decarboxylation; Enzyme Inhibitors; Enzyme Stability; Flavin Mononucleotide; Humans; Kinetics; Mutagenesis, Site-Directed; Pantetheine; Pantothenic Acid; Serine; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfhydryl Compounds | 2004 |
Modular synthesis of pantetheine and phosphopantetheine.
Topics: Molecular Structure; Pantetheine; Stereoisomerism | 2004 |
The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization.
Topics: Amino Acid Sequence; Carbon; Chromatography, Gel; Cloning, Molecular; Cosmids; DNA; Escherichia coli; Escherichia coli Proteins; Gene Library; Genome; Histidine; Lipids; Molecular Sequence Data; Mutation; Oligopeptides; Pantetheine; Phosphoric Diester Hydrolases; Plasmids; Sequence Homology, Amino Acid; Serine; Spectrometry, Mass, Electrospray Ionization; Time Factors; Transferases | 2005 |
4'-phosphopantetheine biosynthesis in Archaea.
Topics: Amino Acid Sequence; Archaeal Proteins; Base Sequence; Binding Sites; Carboxy-Lyases; Cloning, Molecular; Humans; Methanococcales; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Pantetheine; Peptide Synthases; Sequence Alignment | 2006 |
Gene cloning, expression and functional characterization of an acyl carrier protein AcpV from Vibrio anguillarum.
Topics: Acyl Carrier Protein; Bacterial Proteins; Blotting, Western; Chromatography, High Pressure Liquid; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Pantetheine; Transferases (Other Substituted Phosphate Groups); Vibrio | 2006 |
Solution structure of Asl1650, an acyl carrier protein from Anabaena sp. PCC 7120 with a variant phosphopantetheinylation-site sequence.
Topics: Acyl Carrier Protein; Amino Acid Sequence; Anabaena; Base Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Pantetheine; Peptide Synthases; Polyketide Synthases; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2006 |
Conformational switches modulate protein interactions in peptide antibiotic synthetases.
Topics: Apoproteins; Bacterial Proteins; Binding Sites; Carrier Proteins; Crystallography, X-Ray; Fatty Acid Synthases; Holoenzymes; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Peptide Synthases; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Thiolester Hydrolases; Transferases | 2006 |
Solution structures of spinach acyl carrier protein with decanoate and stearate.
Topics: Acyl Carrier Protein; Binding Sites; Decanoates; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Protein Structure, Quaternary; Serine; Solutions; Spinacia oleracea; Stearates | 2006 |
Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs.
Topics: Acyl Carrier Protein; Amino Acid Sequence; Animals; Bacterial Proteins; Hydrogen Bonding; Molecular Sequence Data; Pantetheine; Plasmodium falciparum; Protein Conformation; Protozoan Proteins; Rats; Solutions | 2006 |
Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug.
Topics: Animals; Arylalkylamine N-Acetyltransferase; Cells, Cultured; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Pantetheine; Pineal Gland; Prodrugs; Rats; Spectrometry, Mass, Electrospray Ionization | 2007 |
Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein. Role of the 4'-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein.
Topics: Acyl Carrier Protein; Animals; Biophysics; Dose-Response Relationship, Drug; Hydrogen Bonding; Molecular Conformation; Pantetheine; Peptides; Plasmodium falciparum; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Protein Structure, Tertiary; Temperature; Thermodynamics | 2007 |
High-throughput profiling of posttranslational modification enzymes by phage display.
Topics: Acyl Carrier Protein; Bacterial Proteins; Cloning, Molecular; Enzymes; Pantetheine; Peptide Library; Peptide Synthases; Polyketide Synthases; Protein Processing, Post-Translational; Transferases (Other Substituted Phosphate Groups) | 2007 |
Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis.
Topics: Calorimetry; Coenzyme A; Escherichia coli; Kinetics; Models, Molecular; Nucleotidyltransferases; Pantetheine; Protein Binding; Protein Conformation | 2007 |
10-formyltetrahydrofolate dehydrogenase requires a 4'-phosphopantetheine prosthetic group for catalysis.
Topics: Acyl Carrier Protein; Animals; Carbon Dioxide; Catalysis; Leucovorin; NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Pantetheine; Protein Structure, Tertiary; Rats; Recombinant Proteins; Tetrahydrofolates | 2007 |
Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways.
Topics: Acyl Carrier Protein; Bacterial Proteins; Macrolides; Mass Spectrometry; Models, Molecular; Molecular Structure; Pantetheine; Peptide Synthases; Signal Transduction; Streptococcus agalactiae; Transferases (Other Substituted Phosphate Groups) | 2008 |
Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases.
Topics: Acyl Carrier Protein; Anthraquinones; Bacterial Proteins; Base Sequence; Carrier Proteins; Conserved Sequence; Fatty Acid Synthase, Type II; Fungal Proteins; Models, Molecular; Molecular Sequence Data; Pantetheine; Protein Subunits; Substrate Specificity; Transferases (Other Substituted Phosphate Groups) | 2008 |
Probing the compatibility of type II ketosynthase-carrier protein partners.
Topics: Amino Acid Sequence; Cross-Linking Reagents; Cyperaceae; Drug Design; Escherichia coli; Fatty Acid Synthase, Type II; Molecular Sequence Data; Pantetheine; Polyketide Synthases; Protein Binding; Protein Structure, Tertiary; Substrate Specificity | 2008 |
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.
Topics: Bacterial Proteins; Coenzyme A; Cysteamine; Cysteine; Genes, Bacterial; Multigene Family; Pantetheine; Streptomyces; Thienamycins | 2008 |
An ACP structural switch: conformational differences between the apo and holo forms of the actinorhodin polyketide synthase acyl carrier protein.
Topics: Acyl Carrier Protein; Bacillus subtilis; Crystallography, X-Ray; Holoenzymes; Models, Molecular; Mutation; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Polyketide Synthases; Protein Binding; Protein Structure, Tertiary; Streptomyces coelicolor | 2008 |
SMb20651 is another acyl carrier protein from Sinorhizobium meliloti.
Topics: Acyl Carrier Protein; Acyl-Carrier Protein S-Malonyltransferase; Animals; Antibodies, Bacterial; Bacterial Proteins; Ligases; Medicago sativa; Mutagenesis, Site-Directed; Operon; Pantetheine; Rabbits; Sinorhizobium meliloti | 2009 |
Structural modification of acyl carrier protein by butyryl group.
Topics: Acyl Carrier Protein; Apoproteins; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Protein Structure, Tertiary; Substrate Specificity | 2009 |
A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase.
Topics: Animals; Bacterial Proteins; Cattle; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Enzyme Inhibitors; Enzyme Stability; Escherichia coli Proteins; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Models, Molecular; Pantetheine; Peptides; Protein Conformation; Serum Albumin, Bovine; Transferases; Transferases (Other Substituted Phosphate Groups) | 2009 |
Determination of the extent of phosphopantetheinylation of polyketide synthases expressed in Escherichia coli and Saccharomyces cerevisiae.
Topics: Acyl Carrier Protein; Acyltransferases; Bacterial Proteins; Biocatalysis; Escherichia coli; Fluorescent Dyes; Gene Expression; Ligases; Lovastatin; Macrolides; Multienzyme Complexes; Oxidoreductases; Pantetheine; Polyketide Synthases; Protein Structure, Tertiary; Saccharomyces cerevisiae; Transferases (Other Substituted Phosphate Groups) | 2009 |
Solid phase 4'-phosphopantetheinylation: fungal thiolation domains are targets for chemoenzymatic modification.
Topics: Aspergillus fumigatus; Bacterial Proteins; Biocatalysis; Coenzyme A; Pantetheine; Recombinant Proteins; Transferases (Other Substituted Phosphate Groups) | 2009 |
A proteomics approach to discovering natural products and their biosynthetic pathways.
Topics: Bacillus; Biological Products; Cluster Analysis; Gene Regulatory Networks; Lipopeptides; Mass Spectrometry; Metabolic Networks and Pathways; Pantetheine; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Fragments; Peptide Synthases; Polyketide Synthases; Proteomics; Streptomyces | 2009 |
SMc01553 is the sixth acyl carrier protein in Sinorhizobium meliloti 1021.
Topics: Acyl Carrier Protein; Bacterial Proteins; Escherichia coli; Pantetheine; Protein Structure, Secondary; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Bacterial; Sinorhizobium meliloti | 2010 |
Biochemistry: Enzyme's black box cracked open.
Topics: Aflatoxin B1; Aspergillus; Catalytic Domain; Crystallography, X-Ray; Cyclization; Pantetheine; Polyketide Synthases; Protein Structure, Tertiary; Structure-Activity Relationship | 2009 |
Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.
Topics: Acyl Carrier Protein; Base Sequence; Biocatalysis; Cell Cycle; Cell Death; Cell Line; Cloning, Molecular; Enzyme Activation; Gene Silencing; Humans; Oxidoreductases Acting on CH-NH Group Donors; Pantetheine; RNA, Small Interfering; Serine; Substrate Specificity; Transferases (Other Substituted Phosphate Groups) | 2010 |
Functional immobilization and patterning of proteins by an enzymatic transfer reaction.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Coenzyme A; Glass; Immobilized Proteins; Interferon-alpha; Models, Molecular; Oligopeptides; Pantetheine; Polyethylene Glycols; Protein Structure, Tertiary; Receptor, Interferon alpha-beta; Spectrum Analysis; Substrate Specificity; Surface Properties; Transferases (Other Substituted Phosphate Groups) | 2010 |
Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases.
Topics: Acyl Carrier Protein; Amino Acid Sequence; Apoenzymes; Coenzymes; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Pantetheine; Polyketide Synthases; Protein Binding; Protein Structure, Tertiary; Stereoisomerism; Substrate Specificity; Thiolester Hydrolases | 2010 |
Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis.
Topics: Acyl Carrier Protein; Amino Acid Sequence; Bacterial Proteins; Fatty Acids; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Sequence Data; Pantetheine; Protein Conformation; Streptomyces coelicolor | 2010 |
Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis.
Topics: Adenosine Triphosphate; Calorimetry; Coenzyme A; Crystallography, X-Ray; Feedback, Physiological; Kinetics; Models, Biological; Models, Molecular; Mycobacterium tuberculosis; Nucleotidyltransferases; Pantetheine; Protein Conformation; Protein Structure, Quaternary; Recombinant Proteins; Thermodynamics | 2010 |
Practical 4'-phosphopantetheine active site discovery from proteomic samples.
Topics: Algorithms; Artificial Intelligence; Bacillus subtilis; Bacterial Proteins; Catalytic Domain; Chromatography, Liquid; Pantetheine; Peptide Fragments; Peptide Synthases; Polyketide Synthases; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteome; Proteomics; Reproducibility of Results; ROC Curve; Tandem Mass Spectrometry | 2011 |
Solution structure of 4'-phosphopantetheine - GmACP3 from Geobacter metallireducens: a specialized acyl carrier protein with atypical structural features and a putative role in lipopolysaccharide biosynthesis.
Topics: Amino Acid Sequence; Bacterial Proteins; Carrier Proteins; Escherichia coli; Gene Expression Regulation, Bacterial; Geobacter; Lipopolysaccharides; Models, Molecular; Molecular Sequence Data; Pantetheine; Protein Conformation | 2011 |
Substrate recognition by β-ketoacyl-ACP synthases.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Coenzyme A; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Kinetics; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Palmitoyl Coenzyme A; Pantetheine; Phosphotransferases (Alcohol Group Acceptor); Substrate Specificity | 2011 |
N-activated β-lactams as versatile reagents for acyl carrier protein labeling.
Topics: Acyl Carrier Protein; Acylation; beta-Lactams; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Mass Spectrometry; Pantetheine; Sulfhydryl Compounds | 2012 |
Experimentally validated novel inhibitors of Helicobacter pylori phosphopantetheine adenylyltransferase discovered by virtual high-throughput screening.
Topics: Adenosine Triphosphate; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Coenzyme A; Databases, Chemical; Drug Discovery; Enzyme Inhibitors; Helicobacter pylori; High-Throughput Screening Assays; Methotrexate; Microbial Sensitivity Tests; Molecular Docking Simulation; Nucleotidyltransferases; Pantetheine; Protein Binding | 2013 |
Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Binding, Competitive; Crystallography, X-Ray; Drug Discovery; Enzyme Inhibitors; Female; Lung; Mice; Models, Molecular; Nucleotidyltransferases; Pantetheine; Pneumococcal Infections; Pneumonia, Bacterial; Small Molecule Libraries; Staphylococcus aureus; Streptococcus pneumoniae; Thigh | 2013 |
Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation.
Topics: Brain; Cloning, Molecular; Coenzyme A; Escherichia coli; Exome; Female; Fibroblasts; Gene Expression Regulation; Humans; Iron; Male; Mitochondria; Mutation, Missense; Nerve Degeneration; Pantetheine; Pedigree; Phosphorylation; Saccharomyces cerevisiae; Transferases | 2014 |
Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction.
Topics: Acyltransferases; Alcohol Oxidoreductases; Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Crystallography, X-Ray; Models, Molecular; Molecular Sequence Data; Pantetheine; Peptide Synthases; Polyenes; Polyketide Synthases; Polyketides | 2014 |
Crystal structure of phosphopantothenate synthetase from Thermococcus kodakarensis.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Archaeal Proteins; Binding Sites; Coenzyme A; Crystallography, X-Ray; Multiprotein Complexes; Pantetheine; Peptide Synthases; Sequence Alignment; Thermococcus | 2014 |
Inhibitors of polyhydroxyalkanoate (PHA) synthases: synthesis, molecular docking, and implications.
Topics: Acyltransferases; Aldehydes; Animals; Bacterial Proteins; Biocatalysis; Biodegradation, Environmental; Coenzyme A; Cupriavidus necator; Dogs; Enzyme Assays; Enzyme Inhibitors; Esterases; Kinetics; Lipase; Molecular Docking Simulation; Pantetheine; Polyhydroxyalkanoates; Structural Homology, Protein; Substrate Specificity; Sulfolobus solfataricus | 2015 |
Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.
Topics: Animals; Caenorhabditis elegans; Cell Line; Coenzyme A; Coenzyme A Ligases; Drosophila; Female; HEK293 Cells; Humans; Longevity; Male; Mice, Inbred C57BL; Pantetheine; Phosphotransferases (Alcohol Group Acceptor) | 2015 |
Structures of two distinct conformations of holo-non-ribosomal peptide synthetases.
Topics: Acinetobacter baumannii; Biocatalysis; Carrier Proteins; Coenzymes; Crystallography, X-Ray; Escherichia coli; Holoenzymes; Models, Molecular; Pantetheine; Peptide Synthases; Protein Structure, Tertiary | 2016 |
Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase.
Topics: Amino Acid Isomerases; Anti-Bacterial Agents; Binding Sites; Biocatalysis; Brevibacillus; Carbohydrate Metabolism; Carrier Proteins; Catalytic Domain; Coenzymes; Crystallography, X-Ray; Gramicidin; Hydroxymethyl and Formyl Transferases; Models, Molecular; Multienzyme Complexes; Pantetheine; Peptide Synthases; Protein Binding; Protein Structure, Tertiary; RNA, Transfer | 2016 |
Coenzyme A: to make it or uptake it?
Topics: Animals; Biological Transport; Biosynthetic Pathways; Cell Membrane Permeability; Coenzyme A; Humans; Pantetheine | 2016 |
Atomic structure of the entire mammalian mitochondrial complex I.
Topics: Animals; Binding Sites; Cardiolipins; Cross-Linking Reagents; Cryoelectron Microscopy; Electron Transport; Electron Transport Complex I; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Mitochondria; Models, Molecular; NADP; Oxidation-Reduction; Pantetheine; Protein Stability; Protein Subunits; Sheep | 2016 |
Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.
Topics: Animals; Cell Line; Disease Models, Animal; Drosophila; Heredodegenerative Disorders, Nervous System; Humans; Mice; Pantetheine; Phosphotransferases (Alcohol Group Acceptor); Serum; Treatment Outcome | 2017 |
Dipeptide synthesis by internal adenylation domains of a multidomain enzyme involved in nonribosomal peptide synthesis.
Topics: Adenosine Monophosphate; Coenzyme A Ligases; Cysteine; Dipeptides; Escherichia coli; Multienzyme Complexes; Oligopeptides; Pantetheine; Peptide Synthases; Protein Domains; Recombinant Proteins; Substrate Specificity | 2019 |
Decrypting the oscillating nature of the 4'-phosphopantetheine arm in acyl carrier protein AcpM of Mycobacterium tuberculosis.
Topics: Amino Acid Motifs; Azoles; Bacterial Proteins; Binding Sites; Carrier Proteins; Cloning, Molecular; Coenzyme A; Escherichia coli; Fluorescent Dyes; Gene Expression; Genetic Vectors; Molecular Docking Simulation; Molecular Dynamics Simulation; Mycobacterium tuberculosis; Mycolic Acids; Nitrobenzenes; Pantetheine; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity | 2019 |
Shifting the Hydrolysis Equilibrium of Substrate Loaded Acyl Carrier Proteins.
Topics: Acyl Carrier Protein; Escherichia coli; Hydrolysis; Pantetheine; Protein Conformation | 2019 |
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.
Topics: Animals; Biomarkers; Coenzyme A; Dopamine; Genotype; Iron; Mice; Pantetheine; Pantothenate Kinase-Associated Neurodegeneration; Phosphotransferases (Alcohol Group Acceptor) | 2019 |
Chemical Proteomic Profiling of Protein 4'-Phosphopantetheinylation in Mammalian Cells.
Topics: Animals; Humans; Mass Spectrometry; Pantetheine; Protein Processing, Post-Translational; Proteomics | 2020 |
L. major apo-acyl carrier protein forms ordered aggregates due to an exposed phenylalanine, while phosphopantetheine inhibits aggregation in the holo-form.
Topics: Acyl Carrier Protein; Leishmania major; Pantetheine; Phenylalanine; Protein Aggregates; Protozoan Proteins | 2021 |
Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis.
Topics: Animals; Bacterial Proteins; Cell Wall; Female; Humans; Lipids; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Pantetheine; Phosphoric Diester Hydrolases; Protein Processing, Post-Translational; Tuberculosis; Virulence | 2021 |
Lipoate protein ligase B primarily recognizes the C
Topics: Acyl Carrier Protein; Acyltransferases; Coenzyme A; Escherichia coli; Escherichia coli Proteins; Ligases; Pantetheine; Thioctic Acid | 2022 |
Controlled co-immobilisation of proteins via 4'-phosphopantetheine-mediated site-selective covalent linkage.
Topics: Acyl Carrier Protein; alpha-Amylases; Escherichia coli; Immobilized Proteins; Kinetics; Pantetheine | 2022 |
Not always an innocent bystander: the impact of stabilised phosphopantetheine moieties when studying nonribosomal peptide biosynthesis.
Topics: Catalytic Domain; Pantetheine; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Synthases; Peptides | 2023 |
Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring.
Topics: Alanine; Animals; Aspartic Acid; Cytochrome P-450 Enzyme System; Female; Gene Expression Profiling; Glycine; Lactation; Lipid Metabolism; Metabolomics; Pantetheine; Phosphates; Pregnancy; Rats; Serine; Threonine; Transcriptome; Xenobiotics | 2023 |