4'-hydroxypropranolol sulfate ester and propranolol

4'-hydroxypropranolol sulfate ester has been researched along with propranolol in 4 studies

*Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs. [MeSH]

Compound Research Comparison

Studies (4'-hydroxypropranolol sulfate ester)	Trials (4'-hydroxypropranolol sulfate ester)	Recent Studies (post-2010) (4'-hydroxypropranolol sulfate ester)	Studies (propranolol)	Trials (propranolol)	Recent Studies (post-2010) (propranolol)
6	0	0	33,310	3,406	3,218

Protein Interaction Comparison

Protein	Taxonomy	propranolol (IC50)
Beta-1 adrenergic receptor	Cavia porcellus (domestic guinea pig)	0.0347
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	0.0288
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	2.294
Cytochrome P450 1A2	Homo sapiens (human)	4
Beta-2 adrenergic receptor	Homo sapiens (human)	0.0114
Beta-1 adrenergic receptor	Homo sapiens (human)	0.0575
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	3.9811
Beta-2 adrenergic receptor	Rattus norvegicus (Norway rat)	0.012
Cytochrome P450 2D6	Homo sapiens (human)	2.9706
Beta-3 adrenergic receptor	Homo sapiens (human)	0.0493
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	0.0288
Beta-1 adrenergic receptor	Rattus norvegicus (Norway rat)	0.012
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	0.0288
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	0.0288
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	0.0827
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	0.0288
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	0.0288
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	0.0288
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	0.0288
Beta-3 adrenergic receptor	Rattus norvegicus (Norway rat)	0.012
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	1.466
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	2.294
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	0.0288
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	0.0288
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	0.243
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	0.0288
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.38
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	0.342
5-hydroxytryptamine receptor 6	Homo sapiens (human)	3.065
Beta-2 adrenergic receptor	Canis lupus familiaris (dog)	0.017
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	0.0288
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	0.0288
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	0.0288
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	2.828
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	2.1
Sodium/bile acid cotransporter	Homo sapiens (human)	5.5
Beta-2 adrenergic receptor	Cavia porcellus (domestic guinea pig)	0.0288
GABA theta subunit	Rattus norvegicus (Norway rat)	0.0288
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	2.87
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	0.0288

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Belolipetskaja, VG; Metelitsa, VI; Pavlinov, SA; Piotrovskii, VK	1
Daniell, HB; Gaffney, TE; Knapp, DR; Oatis, JE; Walle, T	1
Christ, DD; Walle, T; Walle, UK; Wilson, MJ	1
Walle, T; Wingstrand, KH	1

Other Studies

4 other study(ies) available for 4'-hydroxypropranolol sulfate ester and propranolol

Article	Year
Ion-exchange high-performance liquid chromatography in drug assay in biological fluids. V. Propranolol and metabolites. Journal of chromatography, 1989, Jul-21, Volume: 491, Issue:2 Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Mass Spectrometry; Propranolol	1989
Synthesis of 4'-hydroxypropranolol sulfate, a major non-beta-blocking propranolol metabolite in man. Journal of medicinal chemistry, 1985, Volume: 28, Issue:6 Topics: Adrenergic beta-Antagonists; Animals; Dogs; Dose-Response Relationship, Drug; Propranolol	1985
Separation of the enantiomers of intact sulfate conjugates of adrenergic drugs by high-performance liquid chromatography after chiral derivatization. Journal of chromatography, 1985, May-31, Volume: 341, Issue:1 Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Hypertension; Propranolol; Spectrophotometry, Ultraviolet; Stereoisomerism; Sulfates; Sympathomimetics	1985
Isolation from urine of 4'-hydroxypropranolol sulfate, a major new propranolol metabolite, by ion-pair extraction. Journal of chromatography, 1984, Jan-13, Volume: 305, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Propranolol	1984