4--hydroxyflavone and 4--methoxyflavone

4--hydroxyflavone has been researched along with 4--methoxyflavone* in 1 studies

Other Studies

1 other study(ies) available for 4--hydroxyflavone and 4--methoxyflavone

Article	Year
Preference for Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:10 2'-, 3'-, and 4'-Methoxyflavones (MeFs) were incubated with nine forms of recombinant human cytochrome P450 (P450 or CYP) enzymes in the presence of an NADPH-generating system and the products formed were analyzed with LC-MS/MS methods.CYP1B1.1 and 1B1.3 were highly active in demethylating 4'MeF to form 4'-hydroxyflavone (rate of 5.0 nmol/min/nmol P450) and further to 3',4'-dihydroxyflavone (rates of 2.1 and 0.66 nmol/min/nmol P450, respectively). 3'MeF was found to be oxidized by P450s to Topics: Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Demethylation; Flavonoids; Hydroxylation; Kinetics; Microsomes, Liver; Molecular Docking Simulation; Tandem Mass Spectrometry	2020

Article

Year

Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:10

2'-, 3'-, and 4'-Methoxyflavones (MeFs) were incubated with nine forms of recombinant human cytochrome P450 (P450 or CYP) enzymes in the presence of an NADPH-generating system and the products formed were analyzed with LC-MS/MS methods.CYP1B1.1 and 1B1.3 were highly active in demethylating 4'MeF to form 4'-hydroxyflavone (rate of 5.0 nmol/min/nmol P450) and further to 3',4'-dihydroxyflavone (rates of 2.1 and 0.66 nmol/min/nmol P450, respectively). 3'MeF was found to be oxidized by P450s to

Topics: Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Demethylation; Flavonoids; Hydroxylation; Kinetics; Microsomes, Liver; Molecular Docking Simulation; Tandem Mass Spectrometry

2020