Compounds > 4'-hydroxydiclofenac
Page last updated: 2024-09-03

4'-hydroxydiclofenac and tolbutamide

4'-hydroxydiclofenac has been researched along with tolbutamide in 3 studies

Compound Research Comparison

Studies
(4'-hydroxydiclofenac)		Trials
(4'-hydroxydiclofenac)		Recent Studies (post-2010)
(4'-hydroxydiclofenac)		Studies
(tolbutamide)		Trials
(tolbutamide)		Recent Studies (post-2010) (tolbutamide)
430255,368238265

Protein Interaction Comparison

ProteinTaxonomy4'-hydroxydiclofenac (IC50)tolbutamide (IC50)
Cytochrome P450 2C9 Homo sapiens (human)0.392

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, HH; Lin, LH; Zhang, P; Zhong, DF1
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J1
Di Nardo, G; Gilardi, G; Goyal, A; Sideri, A; Tsotsou, GE1

Other Studies

3 other study(ies) available for 4'-hydroxydiclofenac and tolbutamide

ArticleYear
[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:10

    Topics: Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Cunninghamella; Cytochrome P-450 CYP2C9; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Fungal Proteins; Indomethacin; Isoenzymes; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfaphenazole; Tolbutamide; Valproic Acid

2006
Effect of methamphetamine on cytochrome P450 activity.
    Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12

    Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide

2007
Identification of mutant Asp251Gly/Gln307His of cytochrome P450 BM3 for the generation of metabolites of diclofenac, ibuprofen and tolbutamide.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2012, Mar-19, Volume: 18, Issue:12

    Topics: Asparagine; Bacillus megaterium; Catalysis; Cytochrome P-450 Enzyme System; Diclofenac; Drug Discovery; Escherichia coli; Glutamine; Glycine; Histidine; Humans; Hydroxylation; Ibuprofen; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Tolbutamide

2012