Compounds > 4'-hydroxydiclofenac
Page last updated: 2024-09-03

4'-hydroxydiclofenac and midazolam

4'-hydroxydiclofenac has been researched along with midazolam in 3 studies

Compound Research Comparison

Studies
(4'-hydroxydiclofenac)		Trials
(4'-hydroxydiclofenac)		Recent Studies (post-2010)
(4'-hydroxydiclofenac)		Studies
(midazolam)		Trials
(midazolam)		Recent Studies (post-2010) (midazolam)
430259,8343,1913,301

Protein Interaction Comparison

ProteinTaxonomy4'-hydroxydiclofenac (IC50)midazolam (IC50)
Cytochrome P450 3A4Homo sapiens (human)2.7427

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J1
Atzrodt, J; Blankenstein, J; Brasseur, D; Calvo-Vicente, S; Denoux, M; Derdau, V; Lavisse, M; Perard, S; Roy, S; Sandvoss, M; Schofield, J; Zimmermann, J1
Bedwell, DW; Hall, SD; Mohutsky, MA; Rougée, LRA; Ruterbories, KJ1

Other Studies

3 other study(ies) available for 4'-hydroxydiclofenac and midazolam

ArticleYear
Effect of methamphetamine on cytochrome P450 activity.
    Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12

    Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide

2007
Synthesis of stable isotope labelled internal standards for drug-drug interaction (DDI) studies.
    Bioorganic & medicinal chemistry, 2012, Sep-15, Volume: 20, Issue:18

    Topics: Cytochrome P-450 Enzyme System; Deuterium Exchange Measurement; Diclofenac; Isotope Labeling; Microwaves; Midazolam; Molecular Structure; Pharmaceutical Preparations; Reference Standards

2012
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9

    Topics: Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Drug Interactions; Female; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Midazolam; Plasma; Testosterone; Warfarin

2017