Page last updated: 2024-09-03

4'-hydroxydiclofenac and diclofenac

4'-hydroxydiclofenac has been researched along with diclofenac in 40 studies

Compound Research Comparison

Studies (4'-hydroxydiclofenac)	Trials (4'-hydroxydiclofenac)	Recent Studies (post-2010) (4'-hydroxydiclofenac)	Studies (diclofenac)	Trials (diclofenac)	Recent Studies (post-2010) (diclofenac)
43	0	25	8,874	1,874	3,616

Protein Interaction Comparison

Protein	Taxonomy	diclofenac (IC50)
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	1.9
Prostaglandin G/H synthase 1	Bos taurus (cattle)	0.003
Prostaglandin G/H synthase 1	Ovis aries (sheep)	1.3376
Interleukin-8	Homo sapiens (human)	0.008
Prostaglandin G/H synthase 1	Homo sapiens (human)	0.0415
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	0.5
C-X-C chemokine receptor type 1	Homo sapiens (human)	0.012
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	0.5
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	0.5
Prostaglandin G/H synthase 2	Homo sapiens (human)	0.4165
Prostaglandin G/H synthase 2	Rattus norvegicus (Norway rat)	0.5
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	0.5
Prostaglandin G/H synthase 2	Ovis aries (sheep)	1.6867
Prostaglandin G/H synthase 2	Mus musculus (house mouse)	0.0502
Solute carrier family 22 member 6	Homo sapiens (human)	4
Prostaglandin G/H synthase 1	Rattus norvegicus (Norway rat)	0.5
P2Y purinoceptor 12	Rattus norvegicus (Norway rat)	0.02

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.50)	18.2507
2000's	13 (32.50)	29.6817
2010's	19 (47.50)	24.3611
2020's	7 (17.50)	2.80

Authors

Authors	Studies
Hashimoto, S; Kaneda, N; Kawai, S; Koshino, T; Matsuzaki, T; Mizushima, Y; Okamoto, R; Yamazaki, R; Yokokura, T	1
Chiba, K; Higuchi, S; Ieiri, I; Irie, S; Ishizaki, T; Kimura, M; Kubota, T; Otsubo, K; Shimamoto, J; Urae, A	1
Dalton, JT; Lu, Y; Steiner, MS; Zhou, D	1
Agúndez, JA; Benítez, J; García-Gamito, FJ; Gervasini, G; Martínez, C	1
Anderson, BJ; Jacqz-Aigrain, E; Rømsing, J; Tibboel, D; van der Marel, CD	1
Chaudhary, A; Di Marco, A; Laufer, R; Marcucci, I; Taliani, M	1
Hanna, I; Homann, MJ; Vail, RB; Zaks, A	1
Kanz, MF; Kaphalia, BS; Kaphalia, L; Kumar, S; Treinen-Moslen, M	1
Clarke, SE; Meng, X; Naisbitt, DJ; Park, BK; Sanderson, LS; Stachulski, AV	1
Huang, HH; Lin, LH; Zhang, P; Zhong, DF	1
Bateman, KP; Gaudreault, M; Hughes, CS; Letarte, S; Lévesque, JF; Nicoll-Griffith, DA; Picard, P; Wu, J	1
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J	1
Kang, W; Kim, EY	1
Aranda, E; Hammel, KE; Hofrichter, M; Kinne, M; Poraj-Kobielska, M; Scheibner, K; Ullrich, R	1
Caminal, G; Cruz-Morató, C; Marco-Urrea, E; Pérez-Trujillo, M; Vicent, T	1
Bouju, H; Corvini, PF; Hommes, G; Malpei, F; Wintgens, T	1
Di Nardo, G; Gilardi, G; Goyal, A; Sideri, A; Tsotsou, GE	1
Chang, HR; Kim, K; Kwon, JH; Lee, E; Lee, HJ; Yoon, SH	1
Ahn, B; Gwak, Hs; Kang, W; Kim, E; Noh, K	1
Atzrodt, J; Blankenstein, J; Brasseur, D; Calvo-Vicente, S; Denoux, M; Derdau, V; Lavisse, M; Perard, S; Roy, S; Sandvoss, M; Schofield, J; Zimmermann, J	1
Murayama, N; Ohyama, K; Shimizu, M; Yamazaki, H	1
Boerma, JS; Commandeur, JN; Dragovic, S; Vermeulen, NP	1
de Graaf, IA; Groothuis, GM; Horvatovich, P; Langelaar-Makkinje, M; Niu, X	1
Dinger, J; Maurer, HH; Meyer, MR	1
Abad, JL; Barceló, D; Imbert-Bouchard, M; Osorio, V; Pérez, S; Zonja, B	1
Iwaki, M; Kawase, A; Matsushima, Y; Uraki, M	1
Casey, E; Dempsey, R; Kane, A; Murphy, CD; Quinn, L	1
Beck, B; Bouju, H; Corvini, PF; Hollender, J; Nastold, P; Wintgens, T	1
Ihm, C; Kang, W; Kim, E	1
Bencsik, T; Boda, G; Kroon, PA; Lemli, B; Needs, PW; Poór, M	1
Bedwell, DW; Hall, SD; Mohutsky, MA; Rougée, LRA; Ruterbories, KJ	1
Klopčič, I; Markovič, T; Mlinarič-Raščan, I; Sollner Dolenc, M	1
Bharatam, PV; Ramesh, M	1
Miura, T; Murayama, N; Shimizu, M; Suemizu, H; Uehara, S; Utoh, M; Yamazaki, H	1
Dai, R; Dai, T; Ding, L; Huang, L; Jiang, W; Xie, S	1
Caban, M; Maculewicz, J; Michnowska, A; Smolarz, K; Świacka, K	1
Caban, M; Maculewicz, J; Smolarz, K; Świacka, K	1
Barker, J; Salhab, H	1
Caban, M; Maculewicz, J; Smolarz, K; Świacka, K; Świeżak, J	1
Fernández-Quintero, ML; Kammerer, S; Liedl, KR; Lochmann, F; Loeffler, JR; Mayhew, CA; Nikolajevic, A; Ruzsanyi, V; Stock, V; Troppmair, J	1

Other Studies

40 other study(ies) available for 4'-hydroxydiclofenac and diclofenac

Article	Year
Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors. European journal of pharmacology, 1997, Jun-25, Volume: 329, Issue:2-3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Chromatography, Thin Layer; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Monocytes; Neutrophils; Prostaglandin-Endoperoxide Synthases; Synovial Membrane	1997
Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C93 allele. European journal of clinical pharmacology, 2000, Volume: 56, Issue:1* Topics: Adult; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Polymorphism, Single Nucleotide; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	2000
Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:10 Topics: Antineoplastic Agents, Alkylating; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blotting, Western; Cell Survival; Cyclophosphamide; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Humans; Kinetics; Male; Prodrugs; Prostatic Neoplasms; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tumor Cells, Cultured	2000
Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline. Pharmacogenetics, 2001, Volume: 11, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Activation; Enzyme Inhibitors; Epinephrine; Humans; Hydroxylation; Microsomes, Liver; Serotonin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole	2001
Diclofenac and metabolite pharmacokinetics in children. Paediatric anaesthesia, 2004, Volume: 14, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Body Weight; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diclofenac; Female; Half-Life; Humans; Male; Pain, Postoperative; Rectum; Suppositories; Tablets, Enteric-Coated; Tonsillectomy	2004
Development and validation of a high-throughput radiometric cyp2c9 inhibition assay using tritiated diclofenac. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3 Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Automation; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Humans; Hydroxylation; Microsomes, Liver; Radiometry; Reproducibility of Results; Theophylline; Tritium; Water	2005
Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli. Journal of industrial microbiology & biotechnology, 2005, Volume: 32, Issue:2 Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cloning, Molecular; Culture Media; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Escherichia coli; Fermentation; Glycerol; Hydroxytestosterones; NADPH-Ferrihemoprotein Reductase; Oxygen; Pharmaceutical Preparations; Phenacetin; Recombinant Proteins; Temperature; Testosterone	2005
Efficient high performance liquid chromatograph/ultraviolet method for determination of diclofenac and 4'-hydroxydiclofenac in rat serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Jan-18, Volume: 830, Issue:2 Topics: Animals; Chromatography, High Pressure Liquid; Diclofenac; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrophotometry, Ultraviolet	2006
Investigation of the immunogenicity of diclofenac and diclofenac metabolites. Toxicology letters, 2007, Jan-10, Volume: 168, Issue:1 Topics: Animals; Antigens; Cell Proliferation; Diclofenac; Female; Glucuronides; Local Lymph Node Assay; Lymph Nodes; Mice; Mice, Inbred BALB C	2007
[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:10 Topics: Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Cunninghamella; Cytochrome P-450 CYP2C9; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Fungal Proteins; Indomethacin; Isoenzymes; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfaphenazole; Tolbutamide; Valproic Acid	2006
High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry. Analytical chemistry, 2007, Jun-15, Volume: 79, Issue:12 Topics: Acetaminophen; Atmospheric Pressure; Binding, Competitive; Biological Assay; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextrorphan; Diclofenac; Enzyme Inhibitors; Hydroxytestosterones; Lasers; Protein Isoforms; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors	2007
Effect of methamphetamine on cytochrome P450 activity. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12 Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide	2007
Simultaneous determination of aceclofenac and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2008, Feb-13, Volume: 46, Issue:3 Topics: Chromatography, Liquid; Diclofenac; Humans; Sensitivity and Specificity; Tandem Mass Spectrometry	2008
Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with a fungal peroxygenase. Bioorganic & medicinal chemistry letters, 2009, Jun-01, Volume: 19, Issue:11 Topics: Agrocybe; Biocatalysis; Cytochrome P-450 Enzyme System; Diclofenac; Hydrogen Peroxide; Mixed Function Oxygenases; Propranolol; Stereoisomerism	2009
Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR. Journal of hazardous materials, 2010, Apr-15, Volume: 176, Issue:1-3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Biodegradation, Environmental; Cytochrome P-450 Enzyme System; Diclofenac; Hydroxylation; Laccase; Magnetic Resonance Spectroscopy; Trametes	2010
The fate of 14C-radiolabelled diclofenac and 4'-hydroxydiclofenac in membrane bioreactor treatment of wastewater. Water science and technology : a journal of the International Association on Water Pollution Research, 2011, Volume: 63, Issue:12 Topics: Biodegradation, Environmental; Biomass; Bioreactors; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Diclofenac; Equipment Design; Mass Spectrometry; Membranes, Artificial; Sewage; Water Pollutants, Chemical; Water Purification	2011
Identification of mutant Asp251Gly/Gln307His of cytochrome P450 BM3 for the generation of metabolites of diclofenac, ibuprofen and tolbutamide. Chemistry (Weinheim an der Bergstrasse, Germany), 2012, Mar-19, Volume: 18, Issue:12 Topics: Asparagine; Bacillus megaterium; Catalysis; Cytochrome P-450 Enzyme System; Diclofenac; Drug Discovery; Escherichia coli; Glutamine; Glycine; Histidine; Humans; Hydroxylation; Ibuprofen; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Tolbutamide	2012
Enzymatic and microbial transformation assays for the evaluation of the environmental fate of diclofenac and its metabolites. Chemosphere, 2012, Volume: 87, Issue:8 Topics: Animals; Biotransformation; Diclofenac; Environmental Pollutants; Enzymes; Glucuronides; Humans; Kinetics; Liver; Microbiology; Rats; Risk Assessment	2012
Quantitative determination of aceclofenac and its three major metabolites in rat plasma by HPLC-MS/MS. Journal of separation science, 2012, Volume: 35, Issue:17 Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Diclofenac; Rats; Tandem Mass Spectrometry	2012
Synthesis of stable isotope labelled internal standards for drug-drug interaction (DDI) studies. Bioorganic & medicinal chemistry, 2012, Sep-15, Volume: 20, Issue:18 Topics: Cytochrome P-450 Enzyme System; Deuterium Exchange Measurement; Diclofenac; Isotope Labeling; Microwaves; Midazolam; Molecular Structure; Pharmaceutical Preparations; Reference Standards	2012
Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. Xenobiotica; the fate of foreign compounds in biological systems, 2014, Volume: 44, Issue:1 Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Diclofenac; Drug Interactions; Humans; Kinetics; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure	2014
Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac. Chemical research in toxicology, 2013, Nov-18, Volume: 26, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Biocatalysis; Cytochrome P-450 Enzyme System; Diclofenac; Glutathione; Glutathione Transferase; Humans; Microsomes, Liver; Mutation; Oxidation-Reduction; Recombinant Proteins; Tandem Mass Spectrometry	2013
Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites. Archives of toxicology, 2015, Volume: 89, Issue:1 Topics: Adenosine Triphosphate; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Diclofenac; Female; Glucuronides; Humans; Immunohistochemistry; In Vitro Techniques; Jejunum; L-Lactate Dehydrogenase; Male; Middle Aged	2015
Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP inhibition cocktail. Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:18 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Bupropion; Calibration; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Drug Evaluation, Preclinical; Humans; Substrate Specificity; Tandem Mass Spectrometry; Umbelliferones	2014
Simultaneous determination of diclofenac, its human metabolites and microbial nitration/nitrosation transformation products in wastewaters by liquid chromatography/quadrupole-linear ion trap mass spectrometry. Journal of chromatography. A, 2014, Jun-20, Volume: 1347 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diclofenac; Humans; Nitrosation; Reference Standards; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical	2014
Effects of dose, flow rate, and bile acid on diclofenac disposition in the perfused rat liver. European journal of drug metabolism and pharmacokinetics, 2016, Volume: 41, Issue:3 Topics: Animals; Bile; Bile Acids and Salts; Diclofenac; Female; Glucuronides; Liver; Perfusion; Rats; Rats, Sprague-Dawley	2016
Production of drug metabolites by immobilised Cunninghamella elegans: from screening to scale up. Journal of industrial microbiology & biotechnology, 2015, Volume: 42, Issue:5 Topics: Alginates; Biofilms; Bioreactors; Biotransformation; Cells, Immobilized; Cunninghamella; Diclofenac; Glucuronic Acid; Hexuronic Acids; Pharmaceutical Preparations; Time Factors	2015
Elucidation of biotransformation of diclofenac and 4'hydroxydiclofenac during biological wastewater treatment. Journal of hazardous materials, 2016, Jan-15, Volume: 301 Topics: Bioreactors; Biotransformation; Diclofenac; Membranes, Artificial; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical	2016
Modeling of aceclofenac metabolism to major metabolites in healthy volunteers. Drug metabolism and pharmacokinetics, 2016, Volume: 31, Issue:6 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Healthy Volunteers; Humans; Male; Models, Biological; Young Adult	2016
Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88 Topics: Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Diclofenac; Drug Interactions; Flavonoids; Humans; Metabolome; Quercetin; Serum Albumin; Spectrometry, Fluorescence; Ultrafiltration; Warfarin	2017
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9 Topics: Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Drug Interactions; Female; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Midazolam; Plasma; Testosterone; Warfarin	2017
Endocrine disrupting activities and immunomodulatory effects in lymphoblastoid cell lines of diclofenac, 4-hydroxydiclofenac and paracetamol. Toxicology letters, 2018, Sep-15, Volume: 294 Topics: Acetaminophen; Analgesics, Non-Narcotic; Androgen Receptor Antagonists; Androgens; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Cell Line; Cell Survival; Cells, Cultured; Cytokines; Diclofenac; Endocrine Disruptors; Estrogens; Genes, Reporter; Humans; Immunologic Factors; Lymphocytes; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Thyroid Hormone; Recombinant Fusion Proteins; Structure-Activity Relationship	2018
Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study. Drug metabolism letters, 2019, Volume: 13, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Computer Simulation; Cytochrome P-450 CYP2C9; Diclofenac; Drug Development; Humans; Microsomes, Liver; Models, Chemical; Oxidation-Reduction	2019
Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice. Chemical research in toxicology, 2020, 02-17, Volume: 33, Issue:2 Topics: Animals; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Diclofenac; Hepatocytes; Humans; Hydroxylation; Mice; Transplantation Chimera	2020
Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice. International immunopharmacology, 2020, Volume: 86 Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury; Cytokines; Diclofenac; Disease Models, Animal; Gene Expression Regulation; Glucuronides; Humans; Immunity; Injections, Intraperitoneal; Interleukin-17; Liver; Mice, Transgenic; Protein Interaction Maps; Signal Transduction; Tumor Necrosis Factor-alpha	2020
Exposure of Mytilus trossulus to diclofenac and 4'-hydroxydiclofenac: Uptake, bioconcentration and mass balance for the evaluation of their environmental fate. The Science of the total environment, 2021, Oct-15, Volume: 791 Topics: Animals; Bioaccumulation; Diclofenac; Mytilus; Water Pollutants, Chemical	2021
Long-term stability of diclofenac and 4-hydroxydiclofenac in the seawater and sediment microenvironments: Evaluation of biotic and abiotic factors. Environmental pollution (Barking, Essex : 1987), 2022, Jul-01, Volume: 304 Topics: Diclofenac; Ecosystem; Geologic Sediments; Pharmaceutical Preparations; Seawater; Water Pollutants, Chemical	2022
Development and Validation of an HPLC-UV Method for the Quantification of 4'-Hydroxydiclofenac Using Salicylic Acid: Future Applications for Measurement of In Vitro Drug-Drug Interaction in Rat Liver Microsomes. Molecules (Basel, Switzerland), 2022, Jun-02, Volume: 27, Issue:11 Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Diclofenac; Drug Interactions; Humans; Microsomes, Liver; Rats; Reproducibility of Results; Salicylic Acid	2022
A multi-biomarker approach to assess toxicity of diclofenac and 4-OH diclofenac in Mytilus trossulus mussels - First evidence of diclofenac metabolite impact on molluscs. Environmental pollution (Barking, Essex : 1987), 2022, Dec-15, Volume: 315 Topics: Animals; Aquatic Organisms; Biomarkers; Diclofenac; Mytilus; Pharmaceutical Preparations; Water Pollutants, Chemical	2022
Establishing a cell-based screening workflow for determining the efficiency of CYP2C9 metabolism: moving towards the use of breath volatiles in personalised medicine. Journal of breath research, 2023, 07-19, Volume: 17, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Breath Tests; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; HEK293 Cells; Humans; Limonene; Precision Medicine; Workflow	2023