Page last updated: 2024-09-03

4'-hydroxydiclofenac and dextromethorphan

4'-hydroxydiclofenac has been researched along with dextromethorphan in 2 studies

Compound Research Comparison

Studies (4'-hydroxydiclofenac)	Trials (4'-hydroxydiclofenac)	Recent Studies (post-2010) (4'-hydroxydiclofenac)	Studies (dextromethorphan)	Trials (dextromethorphan)	Recent Studies (post-2010) (dextromethorphan)
43	0	25	2,020	342	593

Protein Interaction Comparison

Protein	Taxonomy	dextromethorphan (IC50)
Sodium channel protein type 1 subunit alpha	Rattus norvegicus (Norway rat)	1.3
Sodium channel protein type 2 subunit alpha	Rattus norvegicus (Norway rat)	1.3
Sodium channel protein type 3 subunit alpha	Rattus norvegicus (Norway rat)	1.3
Cytochrome P450 2D26	Rattus norvegicus (Norway rat)	5.6
Cytochrome P450 2D6	Homo sapiens (human)	2.1768
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.0027
Sigma non-opioid intracellular receptor 1	Cavia porcellus (domestic guinea pig)	0.1236

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dostalek, M; Hanesova, M; Jurica, J; Linhart, I; Pistovcakova, J; Sulcova, A; Tomandl, J	1
Bedwell, DW; Hall, SD; Mohutsky, MA; Rougée, LRA; Ruterbories, KJ	1

Other Studies

2 other study(ies) available for 4'-hydroxydiclofenac and dextromethorphan

Article	Year
Effect of methamphetamine on cytochrome P450 activity. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12 Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide	2007
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9 Topics: Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Drug Interactions; Female; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Midazolam; Plasma; Testosterone; Warfarin	2017

Article

Year

Effect of methamphetamine on cytochrome P450 activity.

Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12

Topics: Animals; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Diclofenac; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Liver; Male; Methamphetamine; Midazolam; Perfusion; Rats; Rats, Wistar; Steroid 21-Hydroxylase; Tolbutamide

2007

The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates.

Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9

Topics: Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Drug Interactions; Female; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Midazolam; Plasma; Testosterone; Warfarin

2017