Page last updated: 2024-09-03

4'-hydroxydiclofenac and 5-hydroxydiclofenac

4'-hydroxydiclofenac has been researched along with 5-hydroxydiclofenac in 8 studies

Compound Research Comparison

Studies
(4'-hydroxydiclofenac)
Trials
(4'-hydroxydiclofenac)
Recent Studies (post-2010)
(4'-hydroxydiclofenac)
Studies
(5-hydroxydiclofenac)
Trials
(5-hydroxydiclofenac)
Recent Studies (post-2010) (5-hydroxydiclofenac)
430251507

Protein Interaction Comparison

ProteinTaxonomy4'-hydroxydiclofenac (IC50)5-hydroxydiclofenac (IC50)
Calcium/calmodulin-dependent protein kinase type II subunit alphaHomo sapiens (human)1.81

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Moser, P; Sallmann, A; Wiesenberg, I1
Anderson, BJ; Jacqz-Aigrain, E; Rømsing, J; Tibboel, D; van der Marel, CD1
Clarke, SE; Meng, X; Naisbitt, DJ; Park, BK; Sanderson, LS; Stachulski, AV1
Caminal, G; Cruz-Morató, C; Marco-Urrea, E; Pérez-Trujillo, M; Vicent, T1
Boerma, JS; Commandeur, JN; Dragovic, S; Vermeulen, NP1
de Graaf, IA; Groothuis, GM; Horvatovich, P; Langelaar-Makkinje, M; Niu, X1
Miura, T; Murayama, N; Shimizu, M; Suemizu, H; Uehara, S; Utoh, M; Yamazaki, H1
Dai, R; Dai, T; Ding, L; Huang, L; Jiang, W; Xie, S1

Other Studies

8 other study(ies) available for 4'-hydroxydiclofenac and 5-hydroxydiclofenac

ArticleYear
Synthesis and quantitative structure-activity relationships of diclofenac analogues.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Diclofenac; Male; Rats; Structure-Activity Relationship

1990
Diclofenac and metabolite pharmacokinetics in children.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Body Weight; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diclofenac; Female; Half-Life; Humans; Male; Pain, Postoperative; Rectum; Suppositories; Tablets, Enteric-Coated; Tonsillectomy

2004
Investigation of the immunogenicity of diclofenac and diclofenac metabolites.
    Toxicology letters, 2007, Jan-10, Volume: 168, Issue:1

    Topics: Animals; Antigens; Cell Proliferation; Diclofenac; Female; Glucuronides; Local Lymph Node Assay; Lymph Nodes; Mice; Mice, Inbred BALB C

2007
Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR.
    Journal of hazardous materials, 2010, Apr-15, Volume: 176, Issue:1-3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biodegradation, Environmental; Cytochrome P-450 Enzyme System; Diclofenac; Hydroxylation; Laccase; Magnetic Resonance Spectroscopy; Trametes

2010
Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
    Chemical research in toxicology, 2013, Nov-18, Volume: 26, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biocatalysis; Cytochrome P-450 Enzyme System; Diclofenac; Glutathione; Glutathione Transferase; Humans; Microsomes, Liver; Mutation; Oxidation-Reduction; Recombinant Proteins; Tandem Mass Spectrometry

2013
Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.
    Archives of toxicology, 2015, Volume: 89, Issue:1

    Topics: Adenosine Triphosphate; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Diclofenac; Female; Glucuronides; Humans; Immunohistochemistry; In Vitro Techniques; Jejunum; L-Lactate Dehydrogenase; Male; Middle Aged

2015
Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice.
    Chemical research in toxicology, 2020, 02-17, Volume: 33, Issue:2

    Topics: Animals; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Diclofenac; Hepatocytes; Humans; Hydroxylation; Mice; Transplantation Chimera

2020
Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice.
    International immunopharmacology, 2020, Volume: 86

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury; Cytokines; Diclofenac; Disease Models, Animal; Gene Expression Regulation; Glucuronides; Humans; Immunity; Injections, Intraperitoneal; Interleukin-17; Liver; Mice, Transgenic; Protein Interaction Maps; Signal Transduction; Tumor Necrosis Factor-alpha

2020