4'-hydroxydiclofenac has been researched along with 5-hydroxydiclofenac in 8 studies
| Studies (4'-hydroxydiclofenac) | Trials (4'-hydroxydiclofenac) | Recent Studies (post-2010) (4'-hydroxydiclofenac) | Studies (5-hydroxydiclofenac) | Trials (5-hydroxydiclofenac) | Recent Studies (post-2010) (5-hydroxydiclofenac) |
|---|---|---|---|---|---|
| 43 | 0 | 25 | 15 | 0 | 7 |
| Protein | Taxonomy | 4'-hydroxydiclofenac (IC50) | 5-hydroxydiclofenac (IC50) |
|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (human) | 1.81 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moser, P; Sallmann, A; Wiesenberg, I | 1 |
| Anderson, BJ; Jacqz-Aigrain, E; Rømsing, J; Tibboel, D; van der Marel, CD | 1 |
| Clarke, SE; Meng, X; Naisbitt, DJ; Park, BK; Sanderson, LS; Stachulski, AV | 1 |
| Caminal, G; Cruz-Morató, C; Marco-Urrea, E; Pérez-Trujillo, M; Vicent, T | 1 |
| Boerma, JS; Commandeur, JN; Dragovic, S; Vermeulen, NP | 1 |
| de Graaf, IA; Groothuis, GM; Horvatovich, P; Langelaar-Makkinje, M; Niu, X | 1 |
| Miura, T; Murayama, N; Shimizu, M; Suemizu, H; Uehara, S; Utoh, M; Yamazaki, H | 1 |
| Dai, R; Dai, T; Ding, L; Huang, L; Jiang, W; Xie, S | 1 |
8 other study(ies) available for 4'-hydroxydiclofenac and 5-hydroxydiclofenac
| Article | Year |
|---|---|
Synthesis and quantitative structure-activity relationships of diclofenac analogues.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Diclofenac; Male; Rats; Structure-Activity Relationship | 1990 |
Diclofenac and metabolite pharmacokinetics in children.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Body Weight; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diclofenac; Female; Half-Life; Humans; Male; Pain, Postoperative; Rectum; Suppositories; Tablets, Enteric-Coated; Tonsillectomy | 2004 |
Investigation of the immunogenicity of diclofenac and diclofenac metabolites.
Topics: Animals; Antigens; Cell Proliferation; Diclofenac; Female; Glucuronides; Local Lymph Node Assay; Lymph Nodes; Mice; Mice, Inbred BALB C | 2007 |
Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biodegradation, Environmental; Cytochrome P-450 Enzyme System; Diclofenac; Hydroxylation; Laccase; Magnetic Resonance Spectroscopy; Trametes | 2010 |
Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biocatalysis; Cytochrome P-450 Enzyme System; Diclofenac; Glutathione; Glutathione Transferase; Humans; Microsomes, Liver; Mutation; Oxidation-Reduction; Recombinant Proteins; Tandem Mass Spectrometry | 2013 |
Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.
Topics: Adenosine Triphosphate; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Diclofenac; Female; Glucuronides; Humans; Immunohistochemistry; In Vitro Techniques; Jejunum; L-Lactate Dehydrogenase; Male; Middle Aged | 2015 |
Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice.
Topics: Animals; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Diclofenac; Hepatocytes; Humans; Hydroxylation; Mice; Transplantation Chimera | 2020 |
Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury; Cytokines; Diclofenac; Disease Models, Animal; Gene Expression Regulation; Glucuronides; Humans; Immunity; Injections, Intraperitoneal; Interleukin-17; Liver; Mice, Transgenic; Protein Interaction Maps; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |