Page last updated: 2024-09-04

4'-hydroxydiazepam and diazepam

4'-hydroxydiazepam has been researched along with diazepam in 6 studies

Compound Research Comparison

Studies
(4'-hydroxydiazepam)
Trials
(4'-hydroxydiazepam)
Recent Studies (post-2010)
(4'-hydroxydiazepam)
Studies
(diazepam)
Trials
(diazepam)
Recent Studies (post-2010) (diazepam)
60118,3772,3291,790

Protein Interaction Comparison

ProteinTaxonomy4'-hydroxydiazepam (IC50)diazepam (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0108
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0227
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0106
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)0.0101
GABA theta subunitRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)0.0101

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blatt, NB; Boitano, A; Dineen, TA; Ellman, JA; Emal, CD; Glick, GD; Leonetti, F; Opipari, AW; Roush, WR1
Fisher, PB; Fryer, RI; Pestka, S; Solowey, WE; Spector, S1
Brase, DA; Dewey, WL; Glennon, RA; Young, R1
Herschman, HR; Kujubu, DA; Lim, RW; Varnum, BC1
Fujita, S; Ishizuka, M; Kazusaka, A; Kim, HS; Saito, K; Sakai, N1
Darwish, WS; Hayami, A; Ikenaka, Y; Ishizuka, M; Kawai, YK; Mizukawa, H; Nakayama, SM; Watanabe, KP1

Other Studies

6 other study(ies) available for 4'-hydroxydiazepam and diazepam

ArticleYear
Structure activity studies of a novel cytotoxic benzodiazepine.
    Bioorganic & medicinal chemistry letters, 2003, Oct-06, Volume: 13, Issue:19

    Topics: Animals; Arthritis; Benzodiazepines; Cell Death; Lupus Vulgaris; Structure-Activity Relationship

2003
Peripheral-acting benzodiazepines inhibit the growth of human melanoma cells and potentiate the antiproliferative activity of recombinant human interferons.
    Journal of interferon research, 1990, Volume: 10, Issue:3

    Topics: Antineoplastic Agents; Benzodiazepines; Cell Division; Diazepam; Drug Synergism; Humans; Interferon Type I; Interferon-gamma; Interferons; Melanoma; Recombinant Proteins; Structure-Activity Relationship; Temazepam; Tumor Cells, Cultured

1990
Potencies of diazepam metabolites in rats trained to discriminate diazepam.
    Life sciences, 1986, Jul-07, Volume: 39, Issue:1

    Topics: Animals; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Nordazepam; Oxazepam; Rats; Rats, Inbred Strains; Temazepam

1986
Induction of transiently expressed genes in PC-12 pheochromocytoma cells.
    Oncogene, 1987, Volume: 1, Issue:3

    Topics: Animals; Benzodiazepines; Cell Differentiation; Cell Division; Cell Line; Cycloheximide; Dexamethasone; Diazepam; Epidermal Growth Factor; Gene Expression Regulation; Nerve Growth Factors; Pheochromocytoma; Potassium; Rats; RNA, Messenger; Temazepam; Tetradecanoylphorbol Acetate

1987
Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9

    Topics: Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Diazepam; Hydroxylation; Immune Sera; Kinetics; Male; Membrane Proteins; Microsomes, Liver; NADP; Polymorphism, Genetic; Rats; Rats, Inbred BN; Rats, Inbred Strains; Rats, Mutant Strains; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Steroid 16-alpha-Hydroxylase; Temazepam

2004
Characterization of equine cytochrome P450: role of CYP3A in the metabolism of diazepam.
    Journal of veterinary pharmacology and therapeutics, 2016, Volume: 39, Issue:5

    Topics: Animals; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP3A; Diazepam; Horses; Hypnotics and Sedatives; Male; Microsomes, Liver; Nordazepam; Oxazepam; Phylogeny; Protein Isoforms; Rats; Rats, Sprague-Dawley; Species Specificity; Temazepam

2016