Compounds > 4'-demethylepipodophyllotoxin
Page last updated: 2024-09-03

4'-demethylepipodophyllotoxin and shikonin

4'-demethylepipodophyllotoxin has been researched along with shikonin in 2 studies

Compound Research Comparison

Studies
(4'-demethylepipodophyllotoxin)		Trials
(4'-demethylepipodophyllotoxin)		Recent Studies (post-2010)
(4'-demethylepipodophyllotoxin)		Studies
(shikonin)		Trials
(shikonin)		Recent Studies (post-2010) (shikonin)
390186602505

Protein Interaction Comparison

ProteinTaxonomy4'-demethylepipodophyllotoxin (IC50)shikonin (IC50)
Epidermal growth factor receptorHomo sapiens (human)0.1392
DNA topoisomerase 2-alphaHomo sapiens (human)6.6
Pyruvate kinase PKMHomo sapiens (human)6.2933
M-phase inducer phosphatase 1Homo sapiens (human)0.22
M-phase inducer phosphatase 2Homo sapiens (human)0.4
DNA topoisomerase 2-betaHomo sapiens (human)6.6
Class A sortase SrtA Staphylococcus aureus2.65

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dai, M; Ding, J; Duan, W; Lin, L; Wang, W; Zhang, J; Zhu, C1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1

Other Studies

2 other study(ies) available for 4'-demethylepipodophyllotoxin and shikonin

ArticleYear
Synthesis and biological activity of novel shikonin analogues.
    Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; HL-60 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concentration 50; Models, Chemical; Naphthoquinones

2009
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012