4'-demethylepipodophyllotoxin has been researched along with podophyllotoxin in 27 studies
| Studies (4'-demethylepipodophyllotoxin) | Trials (4'-demethylepipodophyllotoxin) | Recent Studies (post-2010) (4'-demethylepipodophyllotoxin) | Studies (podophyllotoxin) | Trials (podophyllotoxin) | Recent Studies (post-2010) (podophyllotoxin) |
|---|---|---|---|---|---|
| 39 | 0 | 18 | 3,119 | 226 | 782 |
| Protein | Taxonomy | 4'-demethylepipodophyllotoxin (IC50) | podophyllotoxin (IC50) |
|---|---|---|---|
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | 2.145 | |
| Tubulin alpha-1A chain | Sus scrofa (pig) | 0.6733 | |
| Tubulin beta chain | Sus scrofa (pig) | 0.622 | |
| Glucocorticoid receptor | Homo sapiens (human) | 0.014 | |
| Tubulin beta-4A chain | Homo sapiens (human) | 1.7233 | |
| Tubulin beta chain | Homo sapiens (human) | 1.7233 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.6 | |
| Tubulin alpha-3C chain | Homo sapiens (human) | 1.7233 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 4 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 5 | |
| Tubulin alpha-1B chain | Homo sapiens (human) | 1.7233 | |
| Tubulin alpha-4A chain | Homo sapiens (human) | 1.7233 | |
| Tubulin beta-4B chain | Homo sapiens (human) | 1.7233 | |
| Tubulin beta-3 chain | Homo sapiens (human) | 1.7233 | |
| Tubulin beta-2A chain | Homo sapiens (human) | 1.7233 | |
| Tubulin beta-8 chain | Homo sapiens (human) | 1.7233 | |
| Calcium-activated potassium channel subunit alpha-1 | Rattus norvegicus (Norway rat) | 0.56 | |
| Tubulin beta-2B chain | Bos taurus (cattle) | 0.8685 | |
| Tubulin alpha-3E chain | Homo sapiens (human) | 1.7233 | |
| Tubulin alpha-1A chain | Homo sapiens (human) | 1.7233 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 0.907 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 0.7744 | |
| Tubulin alpha-1C chain | Homo sapiens (human) | 1.7233 | |
| Tubulin beta-6 chain | Homo sapiens (human) | 1.7233 | |
| Tubulin beta-2B chain | Homo sapiens (human) | 1.7233 | |
| Tubulin beta-1 chain | Homo sapiens (human) | 1.7233 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 11 (40.74) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, YC; Han, FS; Irie, H; Lee, KH; Liu, ZC; Tani, S; Thurston, LS | 1 |
| Charlton, JL | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Imakura, Y; Lee, KH; Miki, T; Sakurai, H; Shibuya, M | 1 |
| al-Said, NH; Gupta, R; Lown, JW; Oreski, B | 1 |
| Cheng, YC; Cho, SJ; Lee, KH; Suffness, M; Tropsha, A | 1 |
| Amonkar, AJ; Balasubramanian, S; Dhawan, D; Singh, N | 1 |
| Bastow, KF; Chang, JY; Chen, HX; Cheng, YC; Fu, Q; Guan, J; Guo, X; Jiang, Z; Lee, KH; Wang, HK; Zhu, XK | 1 |
| Bastow, KF; Lee, KH; Vance, JR; Xiao, Z | 1 |
| Chen, SW; Tian, X; Tu, YQ | 1 |
| Arimondo, PB; Bertounesque, E; Dauzonne, D; Duca, M; Guianvarc'h, D; Kraus-Berthier, L; Léonce, S; Meresse, P; Monneret, C; Pfeiffer, B; Pierré, A; Renard, P; Thirot, S | 1 |
| Li, WG; Tian, X; Wu, YJ; Zhang, XY | 1 |
| Ge, T; Li, Q; Yan, G | 1 |
| Anklin, C; Bender, RP; Dunlap, N; Graves, DE; Jablonksy, MJ; Osheroff, N; Romaine, I; Shadid, M | 1 |
| Tang, YJ; Xu, XL; Zhong, JJ | 1 |
| Li, HM; Tang, YJ; Wan, DJ; Zhao, W | 1 |
| Chen, T; Li, DS; Li, HM; Tang, YJ; Wan, DJ; Xiao, L; Zhao, W | 1 |
| Chen, T; Li, HM; Li, JL; Liang, XH; Tang, YJ; Tang, YL; Zhang, YX; Zhao, W; Zhou, C | 1 |
| Fu, Y; Guo, L; He, Q; Li, C; Li, J; Wang, X; Zhang, Z; Zhou, M | 1 |
| Jing, YX; Qi, SN; Shi, RY; Wang, LS; Yang, YJ; Yao, J; Yuan, HQ | 1 |
| Chen, DW; Chen, RD; Dai, JG; Xie, KB; Zhang, YJ | 1 |
| Chen, Q; Jiang, X; Ma, L; Niu, L; Wang, C; Wang, Y; Wu, C; Yu, Y | 1 |
| Tang, YJ; Zhang, QY; Zhao, W | 1 |
| Sun, LY; Tang, YJ; Zhu, LW | 1 |
| Cai, R; Li, Y; Lu, Y; Zhao, Y; Zhu, L | 1 |
| Duan, Y; Li, HM; Li, S; Li, YZ; Shen, Y; Tang, YJ; Zhang, Y; Zhao, W | 1 |
| Chen, Y; Guo, S; Tian, M; Zhu, Y | 1 |
1 review(s) available for 4'-demethylepipodophyllotoxin and podophyllotoxin
| Article | Year |
|---|---|
Antiviral activity of lignans.
Topics: Animals; Antiviral Agents; Humans; Lignans; Plants, Medicinal; Viruses | 1998 |
26 other study(ies) available for 4'-demethylepipodophyllotoxin and podophyllotoxin
| Article | Year |
|---|---|
Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and alpha-peltatin analogues.
Topics: Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Humans; Leukemia, Lymphoid; Molecular Weight; Plants; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1986 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds.
Topics: DNA; DNA Damage; DNA, Superhelical; Etoposide; Gallic Acid; Metals; Oxygen; Podophyllotoxin; Ultraviolet Rays | 1991 |
Design, synthesis and topoisomerase II inhibition activity of 4'-demethylepipodophyllotoxin-lexitropsin conjugates.
Topics: Antineoplastic Agents; Base Sequence; Catalysis; Cell Survival; DNA Topoisomerases, Type II; DNA, Recombinant; Drug Design; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Netropsin; Podophyllotoxin; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1996 |
Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4'-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach.
Topics: Antineoplastic Agents; Computer Graphics; DNA; DNA Topoisomerases, Type I; Models, Molecular; Molecular Conformation; Molecular Structure; Nucleic Acid Conformation; Podophyllotoxin; Structure-Activity Relationship | 1996 |
Chemopreventive effect of 4'-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Catalase; Glutathione; Liver; Male; Malondialdehyde; Mice; Podophyllotoxin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1999 |
Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4beta-amino-4'-O-demethylepipodophyllotoxin conjugates.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Disease Models, Animal; DNA; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2000 |
Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; DNA; DNA Damage; DNA Topoisomerases, Type II; Humans; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Substrate Specificity; Topoisomerase II Inhibitors | 2004 |
Synthesis and cytotoxic activity of novel derivatives of 4'-demethylepipodophyllotoxin.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Etoposide; Fluorouracil; Humans; Podophyllotoxin; Structure-Activity Relationship | 2004 |
Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.
Topics: Animals; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia P388; Mice; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors; Transplantation, Heterologous | 2005 |
Antioxidative and antitumor activity of derivatives of 4-beta-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Proliferation; Erythrocytes; Female; Hemolysis; Humans; Hydrogen Peroxide; Indicators and Reagents; K562 Cells; Liver; Male; Malondialdehyde; Neutrophils; Podophyllotoxin; Rats; Structure-Activity Relationship; Superoxides; Tetrazolium Salts; Thiazoles | 2007 |
A fragmentation study of two compounds related to 4'-demethylepipodophyllotoxin in negative ion electrospray ionization by MSn ion-trap time-of-flight mass spectrometry.
Topics: Podophyllotoxin; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2008 |
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.
Topics: Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Etoposide; Humans; Podophyllotoxin; Protein Binding | 2008 |
A novel biotransformation process of 4'-demethylepipodophyllotoxin to 4'-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463, Part II: process optimization.
Topics: Bacillus; Bioreactors; Biotechnology; Biotransformation; Hydrogen-Ion Concentration; Industrial Microbiology; Kinetics; Models, Chemical; Models, Statistical; Nitrogen; Podophyllotoxin; Sodium Chloride; Sucrose; Surface Properties | 2010 |
Manipulation of heterogeneity product in 4'-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source.
Topics: Alternaria; Biotransformation; Culture Media; Nitrogen; Podophyllotoxin | 2012 |
Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways.
Topics: Amination; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Catalytic Domain; Cell Line, Tumor; DNA Topoisomerases, Type II; Drug Design; Humans; Molecular Docking Simulation; Podophyllotoxin; Signal Transduction; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2014 |
Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity.
Topics: Amines; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Transport; Carbon; Cell Cycle; Cell Line; Cell Line, Tumor; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; HeLa Cells; Hepatocytes; Humans; Microtubules; Mitochondria; Plant Extracts; Podophyllotoxin; Podophyllum; Quantitative Structure-Activity Relationship; Reactive Oxygen Species; Sulfur; Tubulin | 2015 |
Tertiary amine mediated targeted therapy against metastatic lung cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoates; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice, Inbred Strains; Molecular Structure; Molecular Targeted Therapy; Piperazines; Podophyllotoxin; Propylamines; Structure-Activity Relationship; Tissue Distribution; Xenograft Model Antitumor Assays | 2016 |
Induction of apoptotic DNA fragmentation mediated by mitochondrial pathway with caspase-3-dependent BID cleavage in human gastric cancer cells by a new nitroxyl spin-labeled derivative of podophyllotoxin.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Etoposide; Fluorouracil; Humans; Mitochondria; Podophyllotoxin; Spin Labels; Stomach Neoplasms | 2017 |
[Enzymatic glycosylation of 4'-demethylepipodophyllotoxin].
Topics: Aloe; Glucosides; Glycosides; Glycosylation; Glycosyltransferases; Podophyllotoxin | 2017 |
Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design.
Topics: Binding Sites; Drug Design; Molecular Docking Simulation; Podophyllotoxin; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2017 |
Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4'-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of 4'-demethylepipodophyllotoxin.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Drug Design; Halogenation; Hep G2 Cells; Humans; Models, Molecular; Neoplasms; Oxazoles; Podophyllotoxin | 2018 |
Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4β-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin.
Topics: Antineoplastic Agents; Benzimidazoles; DNA; DNA Topoisomerases, Type II; Humans; Models, Molecular; Podophyllotoxin; Poly-ADP-Ribose Binding Proteins; Protein Conformation; Protein Multimerization; Sulfur Compounds; Topoisomerase II Inhibitors | 2018 |
2, 4, 5-Trideoxyhexopyranosides Derivatives of 4'-Demethylepipodophyllotoxin:
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; HeLa Cells; Humans; Podophyllotoxin; Structure-Activity Relationship | 2022 |
Triazole/thiadiazole substituted 4'-demethylepipodophyllotoxin derivatives induced apoptosis in HeLa cells by up-regulating TMEM133.
Topics: Animals; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Checkpoints; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Etoposide; Female; Gene Expression Regulation; Gene Knockout Techniques; HeLa Cells; Histones; Humans; Male; Mice, Inbred C57BL; Podophyllotoxin; Thiadiazoles; Triazoles; Up-Regulation | 2021 |
Transcriptome analysis reveals differentially expressed genes involved in somatic embryogenesis and podophyllotoxin biosynthesis of Sinopodophyllum hexandrum (Royle) T. S. Ying.
Topics: Berberidaceae; Gene Expression Profiling; Plant Growth Regulators; Plant Somatic Embryogenesis Techniques; Podophyllotoxin; Transcriptome | 2023 |