4'-demethylepipodophyllotoxin has been researched along with etoposide in 15 studies
| Studies (4'-demethylepipodophyllotoxin) | Trials (4'-demethylepipodophyllotoxin) | Recent Studies (post-2010) (4'-demethylepipodophyllotoxin) | Studies (etoposide) | Trials (etoposide) | Recent Studies (post-2010) (etoposide) |
|---|---|---|---|---|---|
| 39 | 0 | 18 | 18,306 | 3,693 | 4,900 |
| Protein | Taxonomy | 4'-demethylepipodophyllotoxin (IC50) | etoposide (IC50) |
|---|---|---|---|
| nuclear receptor coactivator 1 isoform 1 [Homo sapiens] | Homo sapiens (human) | 1.153 | |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 1.4284 | |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 3.187 | |
| Caspase-3 | Homo sapiens (human) | 1 | |
| DNA topoisomerase 2-beta | Homo sapiens (human) | 0.4299 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 4.18 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, HX; Cheng, YC; Guo, X; Lee, KH; Shen, YC; Wang, ZQ; Zhang, YL | 1 |
| Cheng, YC; Haruna, M; Imakura, Y; Lee, KH; Li, DH; Liu, SY; Liu, ZC; Thurston, LS | 1 |
| Cheng, YC; Han, FS; Irie, H; Lee, KH; Liu, ZC; Tani, S; Thurston, LS | 1 |
| Cheng, YC; Cho, SJ; Lee, KH; Suffness, M; Tropsha, A | 1 |
| Charlton, JL | 1 |
| Feng, J; Golbraikh, A; Lee, KH; Tropsha, A; Xiao, YD; Xiao, Z | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Chen, L; Chen, T; Li, DS; Li, HM; Tang, YJ; Wang, DJ; Yuan, ZP; Zhao, W | 1 |
| Tang, YJ; Zhang, QY; Zhao, W | 1 |
| Bouchard, M; Fortin, S; Gagné-Boulet, M; Giguère, D; Paré-Lacroix, MP; Tremblay, T | 1 |
| Imakura, Y; Lee, KH; Miki, T; Sakurai, H; Shibuya, M | 1 |
| Chen, SW; Tian, X; Tu, YQ | 1 |
| Anklin, C; Bender, RP; Dunlap, N; Graves, DE; Jablonksy, MJ; Osheroff, N; Romaine, I; Shadid, M | 1 |
| Jing, YX; Qi, SN; Shi, RY; Wang, LS; Yang, YJ; Yao, J; Yuan, HQ | 1 |
| Duan, Y; Li, HM; Li, S; Li, YZ; Shen, Y; Tang, YJ; Zhang, Y; Zhao, W | 1 |
1 review(s) available for 4'-demethylepipodophyllotoxin and etoposide
| Article | Year |
|---|---|
Antiviral activity of lignans.
Topics: Animals; Antiviral Agents; Humans; Lignans; Plants, Medicinal; Viruses | 1998 |
14 other study(ies) available for 4'-demethylepipodophyllotoxin and etoposide
| Article | Year |
|---|---|
Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Topics: Antineoplastic Agents, Phytogenic; DNA; DNA Damage; DNA, Neoplasm; Humans; KB Cells; Podophyllotoxin; Topoisomerase II Inhibitors | 1992 |
Antitumor agents. 100. Inhibition of human DNA topoisomerase II by cytotoxic ether and ester derivatives of podophyllotoxin and alpha-peltatin.
Topics: Antineoplastic Agents, Phytogenic; Chemical Phenomena; Chemistry; Esters; Ethers; Humans; In Vitro Techniques; KB Cells; Leukemia, Lymphoid; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1989 |
Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and alpha-peltatin analogues.
Topics: Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Humans; Leukemia, Lymphoid; Molecular Weight; Plants; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1986 |
Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4'-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach.
Topics: Antineoplastic Agents; Computer Graphics; DNA; DNA Topoisomerases, Type I; Models, Molecular; Molecular Conformation; Molecular Structure; Nucleic Acid Conformation; Podophyllotoxin; Structure-Activity Relationship | 1996 |
Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.
Topics: Antineoplastic Agents; Models, Molecular; Podophyllotoxin; Quantitative Structure-Activity Relationship | 2002 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; Models, Molecular; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2014 |
Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4'-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of 4'-demethylepipodophyllotoxin.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Drug Design; Halogenation; Hep G2 Cells; Humans; Models, Molecular; Neoplasms; Oxazoles; Podophyllotoxin | 2018 |
Synthetic development of sugar amino acid oligomers towards novel podophyllotoxin analogues.
Topics: Amino Acids; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Development; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Sugars | 2021 |
Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds.
Topics: DNA; DNA Damage; DNA, Superhelical; Etoposide; Gallic Acid; Metals; Oxygen; Podophyllotoxin; Ultraviolet Rays | 1991 |
Synthesis and cytotoxic activity of novel derivatives of 4'-demethylepipodophyllotoxin.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Etoposide; Fluorouracil; Humans; Podophyllotoxin; Structure-Activity Relationship | 2004 |
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.
Topics: Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Etoposide; Humans; Podophyllotoxin; Protein Binding | 2008 |
Induction of apoptotic DNA fragmentation mediated by mitochondrial pathway with caspase-3-dependent BID cleavage in human gastric cancer cells by a new nitroxyl spin-labeled derivative of podophyllotoxin.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Etoposide; Fluorouracil; Humans; Mitochondria; Podophyllotoxin; Spin Labels; Stomach Neoplasms | 2017 |
Triazole/thiadiazole substituted 4'-demethylepipodophyllotoxin derivatives induced apoptosis in HeLa cells by up-regulating TMEM133.
Topics: Animals; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Checkpoints; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Etoposide; Female; Gene Expression Regulation; Gene Knockout Techniques; HeLa Cells; Histones; Humans; Male; Mice, Inbred C57BL; Podophyllotoxin; Thiadiazoles; Triazoles; Up-Regulation | 2021 |