Page last updated: 2024-09-04

4'-demethyldesoxypodophyllotoxin and podophyllotoxin

4'-demethyldesoxypodophyllotoxin has been researched along with podophyllotoxin in 8 studies

Compound Research Comparison

Studies
(4'-demethyldesoxypodophyllotoxin)
Trials
(4'-demethyldesoxypodophyllotoxin)
Recent Studies (post-2010)
(4'-demethyldesoxypodophyllotoxin)
Studies
(podophyllotoxin)
Trials
(podophyllotoxin)
Recent Studies (post-2010) (podophyllotoxin)
16063,119226782

Protein Interaction Comparison

ProteinTaxonomy4'-demethyldesoxypodophyllotoxin (IC50)podophyllotoxin (IC50)
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)2.145
Tubulin alpha-1A chainSus scrofa (pig)0.6733
Tubulin beta chainSus scrofa (pig)0.622
Glucocorticoid receptorHomo sapiens (human)0.014
Tubulin beta-4A chainHomo sapiens (human)1.7233
Tubulin beta chainHomo sapiens (human)1.7233
Cytochrome P450 3A4Homo sapiens (human)0.6
Tubulin alpha-3C chainHomo sapiens (human)1.7233
Cytochrome P450 2C9 Homo sapiens (human)4
Cytochrome P450 2C19Homo sapiens (human)5
Tubulin alpha-1B chainHomo sapiens (human)1.7233
Tubulin alpha-4A chainHomo sapiens (human)1.7233
Tubulin beta-4B chainHomo sapiens (human)1.7233
Tubulin beta-3 chainHomo sapiens (human)1.7233
Tubulin beta-2A chainHomo sapiens (human)1.7233
Tubulin beta-8 chainHomo sapiens (human)1.7233
Calcium-activated potassium channel subunit alpha-1Rattus norvegicus (Norway rat)0.56
Tubulin beta-2B chainBos taurus (cattle)0.8685
Tubulin alpha-3E chainHomo sapiens (human)1.7233
Tubulin alpha-1A chainHomo sapiens (human)1.7233
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)0.907
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)0.7744
Tubulin alpha-1C chainHomo sapiens (human)1.7233
Tubulin beta-6 chainHomo sapiens (human)1.7233
Tubulin beta-2B chainHomo sapiens (human)1.7233
Tubulin beta-1 chainHomo sapiens (human)1.7233

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chai, H; Cruz, JG; Hernández, L; Mar, W; Novelo, M; Pereda-Miranda, R; Pezzuto, JM1
Castro, MA; Faircloth, GT; Gordaliza, M; López-Vázquez, ML; Miguel del Corral, JM; San Feliciano, A1
But, PP; Hon, PM; Jiang, RW; Li, LL; Li, SL; Shaw, PC; Xu, HX; Ye, WC; Zhou, JR; Zhou, Y1
Chen, H; Hua, HM; Li, ZL; Liu, XQ; Sun, YJ; Zhou, W1
Chen, SW; Ding, YL; Huang, WT; Hui, L; Liu, J; Liu, JF1
Bunyapraphatsara, N; Fong, HH; Jutiviboonsuk, A; Ma, C; Manh Cuong, N; Soejarto, DD; Tan, GT; Van Hung, N; Zhang, H1
Lv, M; Sun, H; Tian, X; Wang, J; Xu, H; Yao, X; Zhang, X1
Chen, SW; Gao, YY; Huang, WT; Hui, L; Jin, Y; Jin, YX; Liu, J; Zhou, NN1

Other Studies

8 other study(ies) available for 4'-demethyldesoxypodophyllotoxin and podophyllotoxin

ArticleYear
Cytotoxic constituents from Hyptis verticillata.
    Journal of natural products, 1993, Volume: 56, Issue:10

    Topics: Animals; Antineoplastic Agents, Phytogenic; Artemia; Candida albicans; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mexico; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Podophyllotoxin; Rats

1993
Immunosuppressive cyclolignans.
    Journal of medicinal chemistry, 1996, Jul-05, Volume: 39, Issue:14

    Topics: Animals; Cells, Cultured; Immunosuppressive Agents; Lignans; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Molecular Structure; Spleen; Structure-Activity Relationship; T-Lymphocytes

1996
Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines.
    Journal of natural products, 2007, Volume: 70, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Drug Screening Assays, Antitumor; Humans; Lignans; Male; Molecular Structure; Plant Roots; Plants, Medicinal; Podophyllotoxin; Prostatic Neoplasms; Rhizome; Tumor Cells, Cultured

2007
Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Cell Line, Tumor; Cell Survival; Glucosides; HeLa Cells; Humans; Inhibitory Concentration 50; Lignans; Magnetic Resonance Spectroscopy; Plant Roots; Podophyllotoxin

2011
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
    European journal of medicinal chemistry, 2012, Volume: 49

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Drugs, Chinese Herbal; Enzyme Activation; Fluorouracil; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Neoplasms; Podophyllotoxin

2012
Bioactive constituents from roots of Bursera tonkinensis.
    Phytochemistry, 2005, Volume: 66, Issue:23

    Topics: Antineoplastic Agents, Phytogenic; Bursera; Drug Screening Assays, Antitumor; Humans; Lignans; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Plant Roots; Podophyllotoxin; Tumor Cells, Cultured

2005
Semisynthesis and quantitative structure-activity relationship (QSAR) study of novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin as insecticidal agents.
    Journal of agricultural and food chemistry, 2009, Sep-09, Volume: 57, Issue:17

    Topics: Animals; Benzene; Esters; Insecticides; Larva; Moths; Podophyllotoxin; Quantitative Structure-Activity Relationship

2009
Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
    Bioorganic & medicinal chemistry letters, 2011, Dec-15, Volume: 21, Issue:24

    Topics: Antineoplastic Agents; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Hydrophobic and Hydrophilic Interactions; M Phase Cell Cycle Checkpoints; Podophyllotoxin

2011