4'-demethyldesoxypodophyllotoxin has been researched along with etoposide in 7 studies
| Studies (4'-demethyldesoxypodophyllotoxin) | Trials (4'-demethyldesoxypodophyllotoxin) | Recent Studies (post-2010) (4'-demethyldesoxypodophyllotoxin) | Studies (etoposide) | Trials (etoposide) | Recent Studies (post-2010) (etoposide) |
|---|---|---|---|---|---|
| 16 | 0 | 6 | 18,306 | 3,693 | 4,900 |
| Protein | Taxonomy | 4'-demethyldesoxypodophyllotoxin (IC50) | etoposide (IC50) |
|---|---|---|---|
| nuclear receptor coactivator 1 isoform 1 [Homo sapiens] | Homo sapiens (human) | 1.153 | |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 1.4284 | |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 3.187 | |
| Caspase-3 | Homo sapiens (human) | 1 | |
| DNA topoisomerase 2-beta | Homo sapiens (human) | 0.4299 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 4.18 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, BZ; Kim, Y; Nam, NH; You, YJ | 1 |
| Chen, SW; Hui, L; Tian, X; Zhang, JQ; Zhang, ZW | 1 |
| Chen, H; Hua, HM; Li, ZL; Liu, XQ; Sun, YJ; Zhou, W | 1 |
| Chen, SW; Huang, WT; Hui, L; Jin, Y; Liu, J | 1 |
| Chen, SW; Gao, YY; Huang, WT; Hui, L; Jin, Y; Jin, YX; Liu, J; Zhou, NN | 1 |
| Chen, SW; Ding, YL; Huang, WT; Hui, L; Liu, J; Liu, JF | 1 |
| Chen, SW; Feng, SL; Guan, XW; Hui, L; Tang, ZB; Xu, XH | 1 |
7 other study(ies) available for 4'-demethyldesoxypodophyllotoxin and etoposide
| Article | Year |
|---|---|
Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity.
Topics: Amino Acids; Antineoplastic Agents; Carbamates; Carbonates; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Hydrolysis; Lethal Dose 50; Podophyllotoxin; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
Topics: Animals; Antioxidants; Cell Line; Drugs, Chinese Herbal; Humans; Podophyllotoxin; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spin Labels | 2010 |
Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi.
Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Cell Line, Tumor; Cell Survival; Glucosides; HeLa Cells; Humans; Inhibitory Concentration 50; Lignans; Magnetic Resonance Spectroscopy; Plant Roots; Podophyllotoxin | 2011 |
Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Podophyllotoxin; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared | 2011 |
Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
Topics: Antineoplastic Agents; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Hydrophobic and Hydrophilic Interactions; M Phase Cell Cycle Checkpoints; Podophyllotoxin | 2011 |
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Drugs, Chinese Herbal; Enzyme Activation; Fluorouracil; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Neoplasms; Podophyllotoxin | 2012 |
Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Matrix Metalloproteinase 9; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Tissue Inhibitor of Metalloproteinase-1 | 2016 |