Page last updated: 2024-09-04

4'-demethyldesoxypodophyllotoxin and anthricin

4'-demethyldesoxypodophyllotoxin has been researched along with anthricin in 9 studies

Compound Research Comparison

Studies
(4'-demethyldesoxypodophyllotoxin)
Trials
(4'-demethyldesoxypodophyllotoxin)
Recent Studies (post-2010)
(4'-demethyldesoxypodophyllotoxin)
Studies
(anthricin)
Trials
(anthricin)
Recent Studies (post-2010) (anthricin)
1606129078

Protein Interaction Comparison

ProteinTaxonomy4'-demethyldesoxypodophyllotoxin (IC50)anthricin (IC50)
Tubulin beta-4A chainHomo sapiens (human)2.4
Tubulin beta chainHomo sapiens (human)2.4
Tubulin alpha-3C chainHomo sapiens (human)2.4
Tubulin alpha-1B chainHomo sapiens (human)2.4
Tubulin alpha-4A chainHomo sapiens (human)2.4
Tubulin beta-4B chainHomo sapiens (human)2.4
Tubulin beta-3 chainHomo sapiens (human)2.4
Tubulin beta-2A chainHomo sapiens (human)2.4
Tubulin beta-8 chainHomo sapiens (human)2.4
Tubulin alpha-3E chainHomo sapiens (human)2.4
Tubulin alpha-1A chainHomo sapiens (human)2.4
Tubulin alpha-1C chainHomo sapiens (human)2.4
Tubulin beta-6 chainHomo sapiens (human)2.4
Tubulin beta-2B chainHomo sapiens (human)2.4
Tubulin beta-1 chainHomo sapiens (human)2.4

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's3 (33.33)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chai, H; Cruz, JG; Hernández, L; Mar, W; Novelo, M; Pereda-Miranda, R; Pezzuto, JM1
Ahn, BZ; Kim, Y; Nam, NH; You, YJ2
But, PP; Hon, PM; Jiang, RW; Li, LL; Li, SL; Shaw, PC; Xu, HX; Ye, WC; Zhou, JR; Zhou, Y1
Wang, JJ; Xu, H1
Chen, H; Hua, HM; Li, ZL; Liu, XQ; Sun, YJ; Zhou, W1
Chen, SW; Huang, WT; Hui, L; Jin, Y; Liu, J1
Chen, SW; Gao, YY; Huang, WT; Hui, L; Jin, Y; Jin, YX; Liu, J; Zhou, NN1
Chen, SW; Ding, YL; Huang, WT; Hui, L; Liu, J; Liu, JF1

Other Studies

9 other study(ies) available for 4'-demethyldesoxypodophyllotoxin and anthricin

ArticleYear
Cytotoxic constituents from Hyptis verticillata.
    Journal of natural products, 1993, Volume: 56, Issue:10

    Topics: Animals; Antineoplastic Agents, Phytogenic; Artemia; Candida albicans; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mexico; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Podophyllotoxin; Rats

1993
Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity.
    Bioorganic & medicinal chemistry letters, 2002, Dec-02, Volume: 12, Issue:23

    Topics: Amino Acids; Antineoplastic Agents; Carbamates; Carbonates; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Hydrolysis; Lethal Dose 50; Podophyllotoxin; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cells, Cultured; Drug Carriers; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Esters; Fatty Acids, Unsaturated; Mice; Podophyllotoxin

2003
Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines.
    Journal of natural products, 2007, Volume: 70, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Drug Screening Assays, Antitumor; Humans; Lignans; Male; Molecular Structure; Plant Roots; Plants, Medicinal; Podophyllotoxin; Prostatic Neoplasms; Rhizome; Tumor Cells, Cultured

2007
Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
    Bioorganic & medicinal chemistry letters, 2010, Apr-15, Volume: 20, Issue:8

    Topics: Animals; Biological Products; Drug Design; Drugs, Chinese Herbal; Insecticides; Larva; Moths; Podophyllotoxin

2010
Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Cell Line, Tumor; Cell Survival; Glucosides; HeLa Cells; Humans; Inhibitory Concentration 50; Lignans; Magnetic Resonance Spectroscopy; Plant Roots; Podophyllotoxin

2011
Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:9

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Podophyllotoxin; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared

2011
Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
    Bioorganic & medicinal chemistry letters, 2011, Dec-15, Volume: 21, Issue:24

    Topics: Antineoplastic Agents; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Hydrophobic and Hydrophilic Interactions; M Phase Cell Cycle Checkpoints; Podophyllotoxin

2011
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
    European journal of medicinal chemistry, 2012, Volume: 49

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Drugs, Chinese Herbal; Enzyme Activation; Fluorouracil; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Neoplasms; Podophyllotoxin

2012