4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with phenethyl isothiocyanate in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.70) | 18.7374 |
| 1990's | 28 (75.68) | 18.2507 |
| 2000's | 6 (16.22) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, Z; Ma, Q; Sadrieh, N; Smith, TJ; Thomas, PE; Wang, E; Yang, CS | 1 |
| Amin, SG; Chung, FL; Eklind, KI; Morse, MA | 1 |
| Chung, FL; Eklind, KI; Morse, MA | 1 |
| Guo, Z; Ishizaki, H; Smith, TJ; Yang, CS | 1 |
| Chung, FL; Eklind, KI; Hecht, SS; Morse, MA | 1 |
| Guo, Z; Smith, TJ; Thomas, PE; Yang, CS | 1 |
| Doerr-O'Rourke, K; Hecht, SS; Stoner, GD; Trushin, N | 1 |
| Bowman, D; Davis, WJ; Heiblum, R; King, PG; Murphy, SE; Stoner, GD | 1 |
| Chung, FL; Elkind, K; Guo, ZY; Morse, MA; Smith, TJ; Thomas, PE; Yang, CS | 1 |
| Chung, FL; Hecht, SS; Morse, MA | 1 |
| Amin, SG; Chung, FL; Conran, PB; Hecht, SS; Mandal, S; Morse, MA; Stoner, GD; Wang, CX | 1 |
| Hecht, SS; Staretz, ME | 1 |
| Anderson, MW; Crist, KA; Kelloff, GJ; Lubet, RA; Matzinger, SA; Pereira, MA; Steele, VE; Stoner, GD; You, M | 1 |
| Malone, A; Richter, E; Schulze, J | 1 |
| Hecht, SS; Isaacs, S; Trushin, N | 1 |
| Hamilton, SM; Teel, RW; Zhang, Z | 1 |
| Guo, Z; Li, C; Ning, SM; Smith, TJ; Thomas, PE; Yang, CS | 1 |
| Chung, FL; Eklind, KI; Morse, MA; Xu, Y | 1 |
| Guengerich, FP; Guo, Z; Smith, TJ; Yang, CS | 1 |
| Choi, CI; Chung, FL; Jiao, D; Kelloff, G; Pittman, B; Rigotty, J; Rivenson, A; Steele, V; Zang, E | 1 |
| Akerkar, SA; Borukhova, A; Carmella, SG; Chung, FL; Hecht, SS; Richie, JP; Skowronski, L | 1 |
| Akerkar, S; Borukhova, A; Carmella, SG; Hecht, SS; Rigotty, J; Rivenson, A; Trushin, N | 1 |
| Hecht, SS | 3 |
| Foiles, PG; Hecht, SS; Miglietta, LM; Staretz, ME | 1 |
| Akerkar, SA; Borukhova, A; Carmella, SG; Hecht, SS | 1 |
| Anderson, LM; Jones, AB; Liao, AM; Liu, Y; Smith, TJ; Yang, CS | 1 |
| Hecht, SS; Koenig, LA; Staretz, ME | 1 |
| Hecht, SS; Kenney, PM; Trushin, N; Upadhyaya, P; Wang, M | 1 |
| Boysen, G; Hecht, SS; Kenney, PM; Liang, H; Sticha, KR; Su, X; Upadhyaya, P; Wang, M | 1 |
| Richter, E; Tricker, AR | 1 |
| Boysen, G; Hecht, SS; Kenney, PM; Upadhyaya, P; Wang, M | 1 |
| Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM | 1 |
| Chen, HL; Lai, BT; Liu, MQ; Xia, D; Yang, F; Ye, B; Zhang, YX | 1 |
| Hecht, SS; Maertens, LA; Upadhyaya, P; Zimmerman, CL | 1 |
| Adams-Haduch, J; Allen, S; Hatsukami, D; Hecht, SS; Jensen, J; Kurzer, MS; Le, C; Murphy, SE; Nelson, HH; Stepanov, I; Strayer, L; Upadhyaya, P; Wang, R; Yu, MC; Yuan, JM | 1 |
4 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate
| Article | Year |
|---|---|
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis by compounds derived from cruciferous vegetables and green tea.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catechin; DNA; DNA Damage; Indoles; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Rats; Rats, Inbred F344; Tea; Thiocyanates; Vegetables | 1993 |
Chemoprevention of lung cancer by isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Isothiocyanates; Lung Neoplasms; Nitrosamines | 1996 |
Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Humans; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Rats | 1997 |
Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Isothiocyanates; Lung Neoplasms; Neoplasms, Experimental; Nitrosamines; Vegetables | 1999 |
1 trial(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate
| Article | Year |
|---|---|
Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers.
Topics: Activation, Metabolic; Adult; Anticarcinogenic Agents; Carcinogens; Cross-Over Studies; Double-Blind Method; Female; Humans; Isothiocyanates; Male; Middle Aged; Nitrosamines; Smoking | 2016 |
32 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate
| Article | Year |
|---|---|
Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats.
Topics: Animals; Anticarcinogenic Agents; Enzymes; Isothiocyanates; Lung; Male; Microsomes; Microsomes, Liver; Nitrosamines; Olfactory Mucosa; Rats; Rats, Inbred F344; Thiocyanates | 1992 |
Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Drug Administration Schedule; Female; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Thiocyanates | 1992 |
New potential chemopreventive agents for lung carcinogenesis of tobacco-specific nitrosamine.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Humans; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Structure; Nitrosamines; Rats; Rats, Inbred F344; Thiocyanates | 1992 |
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450IIB1 in a reconstituted system.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Isothiocyanates; Kinetics; Methylation; Microsomes, Liver; Nitrosamines; Oxidoreductases; Rats; Thiocyanates; Thiourea | 1991 |
Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates.
Topics: Animals; Carcinogens; DNA; Guanine; Isothiocyanates; Mice; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiocyanates | 1991 |
Metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone as measured by DNA alkylation in vitro and its inhibition by isothiocyanates.
Topics: Alkylation; Animals; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme System; DNA; Female; Glutathione; Isoenzymes; Isothiocyanates; Lung; Male; Mice; Microsomes; Nasal Cavity; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred Strains; Thiocyanates | 1991 |
Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue.
Topics: Animals; Carcinogens; Culture Techniques; Cyclic N-Oxides; Hydroxylation; Isothiocyanates; Lung; Male; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Thiocyanates | 1991 |
Effect of phenethyl isothiocyanate on the metabolism of tobacco-specific nitrosamines by cultured rat oral tissue.
Topics: Animals; Carcinogens; Culture Techniques; Hydroxylation; Isothiocyanates; Male; Mouth Mucosa; Mouth Neoplasms; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Thiocyanates; Tobacco, Smokeless | 1991 |
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates.
Topics: Animals; Carcinogens; Female; Isothiocyanates; Kinetics; Lung; Mice; Mice, Inbred Strains; Microsomes; Nitrosamines; Substrate Specificity; Thiocyanates | 1990 |
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
Topics: Animals; DNA; Isothiocyanates; Liver Neoplasms, Experimental; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Nose Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Thiocyanates | 1990 |
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate.
Topics: Alkylation; Animals; Biological Assay; Diet; DNA; Isothiocyanates; Liver Neoplasms; Lung Neoplasms; Methylation; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Thiocyanates | 1989 |
Effects of phenethyl isothiocyanate on the tissue distribution of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and metabolites in F344 rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Isothiocyanates; Male; Nitrosamines; Rats; Rats, Inbred F344; Tissue Distribution | 1995 |
K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Base Sequence; Carcinogens; Codon; Crosses, Genetic; DNA Primers; Female; Genes, p53; Genes, ras; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred Strains; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Species Specificity | 1995 |
Intestinal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats: Sex difference, inducibility and inhibition by phenethylisothiocyanate.
Topics: Acetone; Animals; Carcinogens; Ethanol; Female; Intestinal Mucosa; Isothiocyanates; Male; Nitrosamines; Phenobarbital; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Sex Factors; Species Specificity | 1995 |
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Stomach Neoplasms | 1994 |
Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activity.
Topics: Animals; Cricetinae; Cytochrome P-450 Enzyme System; Isothiocyanates; Male; Mesocricetus; Mice; Microsomes, Liver; Mutagenicity Tests; Mutation; Nitrosamines; Oxidation-Reduction; Rats; Rats, Inbred F344; Testosterone; Thiocyanates | 1994 |
Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cytochrome P-450 Enzyme System; Eating; Female; Hydroxylation; Isothiocyanates; Lung; Mice; Microsomes; Microsomes, Liver; Nitrosamines; Thiocyanates | 1993 |
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.
Topics: Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isothiocyanates; Microsomes, Liver; Nitrosamines; Oxidoreductases; Substrate Specificity | 1996 |
Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats.
Topics: Acetylcysteine; Analysis of Variance; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chi-Square Distribution; Diet; Free Radical Scavengers; Incidence; Isothiocyanates; Leukemia, Experimental; Leydig Cell Tumor; Lung Neoplasms; Lymphoma; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Survival Rate; Testicular Neoplasms | 1996 |
Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers.
Topics: Adult; Anticarcinogenic Agents; Carcinogens; Female; Follow-Up Studies; Glucuronates; Humans; Isothiocyanates; Lung Neoplasms; Male; Nitrosamines; Prognosis; Smoking; Vegetables | 1995 |
Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; DNA Adducts; Isothiocyanates; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344 | 1996 |
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Isothiocyanates; Lung; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
Topics: Anticarcinogenic Agents; Biomarkers; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cotinine; Creatinine; Enzyme Inhibitors; Glucuronates; Humans; Inactivation, Metabolic; Isothiocyanates; Lung Neoplasms; Mass Spectrometry; Nicotine; Nitrosamines; Proteus mirabilis; Pyridines | 1997 |
Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.
Topics: Animals; Aspirin; Biotransformation; Carbon Monoxide; Coumarins; Cytochrome P-450 Enzyme System; Erythrocebus patas; Female; Isothiocyanates; Lipoxygenase; Lung; Masoprocol; Microsomes; Microsomes, Liver; Nitrosamines; Oxygenases; Prostaglandin-Endoperoxide Synthases | 1997 |
Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.
Topics: Animals; Anticarcinogenic Agents; Diet; Glucuronates; Isothiocyanates; Lung; Male; Microsomes; Microsomes, Liver; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; Drug Therapy, Combination; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines | 2000 |
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Topics: Animals; Benzo(a)pyrene; Carcinogens; DNA; DNA Adducts; Drug Interactions; Female; Isothiocyanates; Lung; Mice; Mice, Inbred A; Nitrosamines | 2002 |
Effect of nicotine, cotinine and phenethyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in the Syrian golden hamster.
Topics: Animals; Biotransformation; Cotinine; Cricetinae; DNA Damage; Female; Glucuronides; Isothiocyanates; Mesocricetus; Nicotiana; Nicotine; Nicotinic Agonists; Nitrosamines | 2002 |
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.
Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hemoglobins; Isothiocyanates; Male; Nitrosamines; Rats; Rats, Inbred F344 | 2003 |
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates | 2005 |
Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Isothiocyanates; Lung Neoplasms; Nicotiana; Nitrosamines; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar | 2007 |
Formation and distribution of NNK metabolites in an isolated perfused rat lung.
Topics: Animals; Cyclic N-Oxides; DNA Adducts; Enzyme Inhibitors; Isothiocyanates; Keto Acids; Lung; Male; Metabolism; Nitrosamines; Perfusion; Pyridines; Rats; Rats, Inbred F344 | 2010 |