4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and nicotine

4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with nicotine in 126 studies

Research

Studies (126)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (7.94)	18.7374
1990's	24 (19.05)	18.2507
2000's	38 (30.16)	29.6817
2010's	51 (40.48)	24.3611
2020's	3 (2.38)	2.80

Authors

Authors	Studies
Chen, CB; Hecht, SS; Hirota, N; Hoffmann, D; Ornaf, RM; Tso, TC	1
Gronowitz, JS; Hirsch, JM; Larsson, PA; Vahlne, A	1
Cherrick, HM; Dokko, H; Min, PS; Park, NH	1
Fischer, S; Preussmann, R; Spiegelhalder, B	1
Castonguay, A; Orloff, M; Rossignol, G; Schuller, HM	1
Heiblum, R; Murphy, SE	1
Castonguay, A; Fischer, S; Kaiserman, M; Preussmann, R; Spiegelhalder, B	1
Eisenbarth, J; Fischer, S; Preussmann, R; Spiegelhalder, B	1
Castonguay, A; Desnoyers, S; Talbot, B	1
Schuller, HM	1
Adams, JD; Hoffmann, D; LaVoie, EJ; Prokopczyk, G	1
Hecht, SS; Hoffmann, D; Lavoie, EJ	1
Andersen, RA; Kemp, TR	1
Adams, JD; Castonguay, A; Hoffmann, D; Lee, SJ; Vinchkoski, N	1
Adams, JD; Hoffmann, D	1
Chen, CB; Hecht, SS; Hoffmann, D; Lin, D; Young, R	1
Castonguay, A; Hecht, SS; Hoffmann, D; Rivenson, A	1
Chen, CB; Hecht, SS; Hoffmann, D; Ohmori, T	1
Chen, YP; Johnson, GK; Squier, CA	1
Andersson, G; Björnberg, G; Curvall, M	1
Richter, E; Tricker, AR	2
Belinsky, SA; Castonguay, A; Grafström, RC; Liu, Y; Sundqvist, K; Tjälve, H	1
Corvese, D; Weitberg, AB	1
Caldwell, WS; deBethizy, JD; Dobson, GP; Greene, JM	1
Bombick, BR; Doolittle, DJ; Fulp, C; Lee, CK	1
Hecht, SS; Hoffmann, D; Rivenson, A	1
Akerkar, SA; Borukhova, A; Carmella, SG; Hecht, SS	1
Borukhova, A; Carmella, SG; Desai, D; Hecht, SS	1
Hasséus, B; Hirsch, JM; Jontell, M; Osterdahl, BG; Wallström, M	1
Foth, H; Kahl, GF; Richter, E; Schrader, E; Schulze, J	1
Hecht, SS	1
Avadhani, NG; Bhagwat, SV; Mullick, J; Raza, H; Vijayasarathy, C	1
Carmella, SG; Chen, M; Dor Koch, JF; Hatsukami, DK; Hecht, SS; Jensen, JA; Miller, AT; Murphy, SE; Zimmerman, CL	1
Carmella, SG; Chen, M; Hecht, SS; Lackmann, GM; Salzberger, U; Töllner, U	1
Plummer, HK; Schuller, HM; Sheppard, BJ; Williams, M	1
Atawodi, SE; Meiser, H; Richter, E	1
Hecht, SS; Hochalter, JB; Murphy, SE; Villalta, PW	1
Hee, SS; Yim, SH	1
Andrews, R; Barnhill, M; Elgayyar, M; Schuller, HM; Tithof, PK	1
Jull, BA; Plummer, HK; Schuller, HM	1
Belinsky, S; Brognard, J; Clark, AS; Dennis, PA; Harris, C; Linnoila, IR; Swain, SM; West, KA; Yang, X	1
Collins, G; Keyler, D; Kuehl, G; Murphy, SE; Pentel, PR	1
Djordjevic, MV; Ramamoorthy, Y; Sellers, EM; Tyndale, RF; Zeman, MV	1
Djordjevic, MV; Leischow, SJ	1
Cho, CH; Liu, ES; Shin, VY; Wu, WK; Ye, YN	1
Carmella, SG; Hatsukami, DK; Hecht, SS; Le, C; Lemmonds, C; Murphy, SE; Zhang, Y	1
Goodsell, DS	1
Bao, Z; Ding, X; He, XY; Hong, JY; Prabhu, S	1
Barley, RD; Lam, EW; Peters, E; Pollock, S; Shallow, MC	1
He, XY; Hong, JY; Wang, SL	1
Gupta, PC; Hecht, SS; Ramakrishnan, S; Stepanov, I	1
Brognard, J; Castillo, SS; Dennis, PA; Gills, JJ; Granville, CA; Sayyah, J; Tsurutani, J; Zhang, C	1
Carmella, SG; Hatsukami, DK; Hecht, SS; Lemmonds, C; Murphy, S; Tulunay, OE; Zhang, Y	1
Dicke, KE; Murphy, SE; Skrlin, SM	1
An, L; Boettcher, AJ; Carmella, SG; Hecht, SS; Hennrikus, DJ; Koopmeiners, J; Le, C; Le, KA; Murphy, SE	1
Carmella, SG; Hatsukami, DK; Hecht, SS; Joseph, AM; Le, CT; Mooney, ME; Zhang, Y	1
Feuer, R; Hatsukami, D; Hecht, SS; Jensen, J; Stepanov, I	1
Benowitz, NL; Hecht, SS; Jacob, P; Lindgren, B; Stepanov, I; Wilson, M	1
Al-Wadei, HA; Majidi, M; Schuller, HM; Takahashi, T	1
Glantz, S; Schick, SF	1
Feng, S; Kapur, S; Mendes, P; Roethig, H; Wang, J	1
Cho, CH; Jin, HC; Leung, WK; Ng, EK; Shin, VY; Sung, JJ; Yu, J	1
Carmella, SG; Derby, KS; Hatsukami, D; Hecht, SS; Le Marchand, L; Murphy, SE; Tiirikainen, M; Wang, H	1
Feng, S; Frost-Pineda, K; Kapur, S; Liang, Q; Roethig, H; Sarkar, M; Wang, J	1
Breland, AB; Eissenberg, T; Gray, JN; Weaver, M	1
El-Bayoumy, K; Freeman, WM; Prokopczyk, B; Sinha, I; Trushin, N	1
Blake, DC; Freeman, WM; Herzog, CR; Mikse, OR	1
Frost-Pineda, K; Liang, Q; Mendes, P; Munjal, S; Roethig, HJ; Walk, RA	1
Spindel, ER	1
Dixon, M; Eldridge, AC; Errington, G; Mariner, DC; McEwan, M; Shepperd, CJ	1
Caberto, C; Carmella, S; Cuthrell, K; Derby, KS; Hecht, SS; Le Marchand, L; Murphy, SE	1
Gregg, EO; Lowe, FJ; McEwan, M	1
Chen, CY; Chen, L; Guo, J; Huppi, P; Nishioka, T; Yamamoto, D	1
Feng, S; Jin, Y; Koval, T; Liu, J; Newland, K; Roethig, HJ; Sarkar, M; Serafin, R; Wang, J; Xie, Y	1
Blank, MD; Eissenberg, T	1
Ashley, DL; Bernert, JT; Cummings, KM; Fong, GT; Giovino, GA; Hammond, D; Hatsukami, DK; Jain, RB; King, B; McCraw, JM; McNeill, A; O'Connor, RJ; Polzin, GM; Shahab, L; Watson, CH; Xia, Y; Yan, X; Zhang, L	1
Benowitz, NL; Gan, Q; Glantz, SA; Goniewicz, M; Li, X; Lu, W; Xu, J	1
Carmella, SG; Hatsukami, DK; Hecht, SS; Hertsgaard, LA; Jensen, JA; Kotlyar, M; Lindgren, BR; Murphy, SE; Stepanov, I	1
Ashley, DL; Bernert, JT; Jain, RB; Pirkle, JL; Xia, Y	1
Liang, Q; Mendes, P; Sarkar, M; Wang, J	1
Rehan, VK; Sakurai, R; Torday, JS	1
Asomaning, K; Carmella, SG; Chen, F; Christiani, DC; Hecht, SS; Lin, X; Su, L; Ter-Minassian, M; Zhao, Y	1
Leroy, CM; Lindner, D; Smith, S; Tricker, AR	1
Dixon, M; Eldridge, AC; Errington, G; Shepperd, CJ	1
Kassie, F; Modiano, JF; Murphy, SE; Schutten, MM; von Weymarn, LB	1
Dennis, PA; Dogan, I; Hobbs, EA; Hollander, MC; Linnoila, RI; Maier, CR	1
Carmella, SG; Chen, M; Davis, AB; Gao, YT; Han, S; Hecht, SS; Moy, KA; Murphy, SE; Nelson, HH; Tao, L; Wang, R; Yu, MC; Yuan, JM; Zhong, Y	1
Shields, PG	1
Lam, DC; Minna, JD	1
Brinkman, MC; Chuang, JC; Gordon, SM; Kim, H; Kroeger, RR; Polzin, GM; Richter, PA	1
DeVore, NM; Scott, EE	1
Cho, CH; Chu, KM; Shin, VY	1
Liang, Q; Sarkar, M; Wang, J	1
Ashley, DL; Ding, YS; Hearn, BA; Polzin, GM; Renner, CC; Stanfill, SB; Vaughan-Watson, C; Watson, CH; Zhang, L	1
Barker, T; Howell, AR; Lynes, MA; Marusov, GP; Richardson, SK; Rood, D; Silbart, LK; Wanczyk, H; Zapata, DI; Zinckgraf, J	1
Balmes, J; Farraro, KF; Hammond, SK; Jenkins, BM; Perrino, C; Schick, SF; Sleiman, M; Trinh, MP; van de Vossenberg, G	1
Chao, MR; Chen, JL; Hsu, YW; Hu, CW; Tam, LM	1
Gao, YT; Hecht, SS; Sebero, E; Stepanov, I; Wang, R; Yuan, JM	1
Butler, LM; Hecht, SS; Stepanov, I; Yuan, JM	1
Benowitz, NL; Carmella, SG; Chatfield, DA; Chen, M; Daffa, RM; Hecht, SS; Hovell, MF; Jackson, SR; Jacob, P; Kassem, NO; Liles, S; Matt, GE; Mehta, S; Younis, MA	1
Chen, SF; Chu, YH; Jao, SW; Lee, TY; Lin, YS; Liu, CL; Liu, TY; Nieh, S; Tseng, YH; Yang, CY	1
Printz, C	1
Chen, B; Hu, B; Li, XF; Qian, Y; Wu, M; Zhu, L	1
Lang, G; Vuarnoz, A	1
Camacho, OM; Cunningham, A; Prasad, K; Sisodiya, AS; Sommarström, J	1
Hwang, SH; Jeong, BY; Lee, DH; Lim, MK; Park, EY; Yang, W; Yun, EH	1
de la Monte, SM; Deochand, C; Silbermann, E; Tong, M; Yu, R; Zabala, V	1
de la Monte, SM; Deochand, C; Tong, M; Yu, R	1
Biddick, L; Kopelovich, L; Kumar, G; Lightfoot, S; Madka, V; Mohammed, A; Patlolla, JM; Qian, L; Rao, CV; Sadeghi, M; Zhang, Y	1
Haiman, CA; Hecht, SS; Kolonel, LN; Le Marchand, L; Murphy, SE; Park, SL; Stram, DO; Wang, H; Wilkens, LR	1
Benowitz, NL; Hoh, E; Hovell, MF; Jacob, P; Khan, AM; Matt, GE; Northrup, TF; Stotts, AL	1
Fernández, E; Fu, M; Martínez-Sánchez, JM; Pascual, JA; Pérez-Ortuño, R	1
Cabot, PJ; Moghbel, N; Ryu, B; Steadman, KJ	1
Adams-Haduch, J; Carmella, SG; Hecht, SS; Jin, A; Koh, WP; Kuriger-Laber, J; Murphy, SE; Nelson, HH; Wang, R; Yuan, JM	1
Lipowicz, PJ; Seeman, JI	1
Daniels, YC; Holman, MR; Johnson, TL; Lane, B; Lang, BE; Lee, GE; Lisko, JG; Phillips, T; Pritchett, JS; Sander, LC; Valentin-Blasini, L; Walters, MJ; Watson, C; Wise, SA; Wood, LJ; Yen, JH	1
Ji, M; Li, N; Wang, C; Wang, SL; Xia, R; Zhang, Y; Zhang, Z	1
da Costa, GG; Loukotková, L; Vanlandingham, M; VonTungeln, LS	1
Chen, H; Hou, H; Hu, Q; Liu, Y; Wang, A; Zhang, S	1
Chen, LC; Huang, WC; Lee, HW; Lepor, H; Park, SH; Tang, MS; Wang, HT; Weng, MW; Wu, XR	1
Akinbiyi, EO; Alahmari, AA; Alexandre, M; Ashat, M; Ceplenski, A; Gorelick, FS; Groblewski, GE; Kolodecik, TR; Messenger, SW; Patel, V; Shugrue, CA; Sreekumar, B; Tashkandi, N; Thrower, EC; Uduman, AK	1
Chang, HL; Chang, HW; Chen, LC; Cheng, TC; Fararjeh, AS; Ho, YS; Huang, CC; Hwang-Verslues, WW; Liu, YR; Tu, SH; Wang, HR; Wu, CH	1
Benowitz, NL; Chaffee, BW; Couch, ET; Jacob, P	1
Lee, DH; Lee, TS; Oh, JE; Park, MB	1
Bi, H; Cao, L; Chen, Y; Huang, Y; Song, J; Sun, G; Tang, Y; Wang, Q; Yao, M	1

Reviews

5 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and nicotine

Article	Year
The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung. Critical reviews in toxicology, 1996, Volume: 26, Issue:2 Topics: Adenocarcinoma; Animals; Black People; Carcinogenicity Tests; Carcinogens; Cricetinae; Female; Humans; Lung Neoplasms; Male; Mice; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Smoking; Tars; United States; White People	1996
Tobacco and cancer: approaches using carcinogen biomarkers and chemoprevention. Annals of the New York Academy of Sciences, 1997, Dec-29, Volume: 833 Topics: Adult; Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; Chemoprevention; Humans; Isothiocyanates; Lung Neoplasms; Male; Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Risk Factors; Smoke; Smoking; Smoking Cessation; Smoking Prevention; Substance-Related Disorders	1997
Receptor-mediated effects of nicotine and its nitrosated derivative NNK on pulmonary neuroendocrine cells. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, 2003, Volume: 270, Issue:1 Topics: Animals; Asthma; Carbon Dioxide; Carcinogens; Carcinoma, Small Cell; Epithelial Cells; Humans; Lung; Neurosecretory Systems; Nicotine; Nitrosamines; Receptors, Nicotinic; Serotonin	2003
Nicotine and gastrointestinal disorders: its role in ulceration and cancer development. Current pharmaceutical design, 2013, Volume: 19, Issue:1 Topics: Animals; Cyclooxygenase 2; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Humans; Inflammation; Nicotine; Nitrosamines; Peptic Ulcer; Risk Factors; Smoking; Stomach Ulcer; United States	2013
Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer. Cancer research, 2014, Jan-15, Volume: 74, Issue:2 Topics: Biomarkers; Carcinogens; Cotinine; Glucuronides; Humans; Lung Neoplasms; Mass Spectrometry; Multivariate Analysis; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Polycyclic Aromatic Hydrocarbons; Prospective Studies; Pyridines; Risk; Risk Assessment; Smoke	2014

Trials

10 trial(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and nicotine

Article	Year
The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003, Volume: 5, Issue:6 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Female; Ganglionic Stimulants; Humans; Injections, Subcutaneous; Male; Methoxsalen; Mixed Function Oxygenases; Nicotine; Nitrosamines; Placebos; Smoking	2003
Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products. Journal of the National Cancer Institute, 2004, Jun-02, Volume: 96, Issue:11 Topics: Administration, Cutaneous; Adult; Biomarkers; Carbon Monoxide; Carcinogens; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Nitrosamines; Pyrenes; Research Design; Smoking; Smoking Cessation; Tobacco, Smokeless	2004
A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes switching to Marlboro Lights or Marlboro Ultra Lights cigarettes. Regulatory toxicology and pharmacology : RTP, 2008, Volume: 51, Issue:3 Topics: Acrolein; Administration, Inhalation; Adult; Aged; Benzene; Biomarkers; Carbon Monoxide; Carboxyhemoglobin; Dose-Response Relationship, Drug; Female; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Nitrosamines; Pyrenes; Smoke; Smoking; Tars; Tobacco Smoke Pollution	2008
Evaluation of biomarkers of exposure to selected cigarette smoke constituents in adult smokers switched to carbon-filtered cigarettes in short-term and long-term clinical studies. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008, Volume: 10, Issue:12 Topics: Acrolein; Administration, Inhalation; Adult; Benzene; Biomarkers; Butadienes; Carbon Monoxide; Carboxyhemoglobin; Environmental Monitoring; Filtration; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Nitrosamines; Pyrenes; Smoke; Smoking	2008
Potential reduced exposure products (PREPs) for smokeless tobacco users: clinical evaluation methodology. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008, Volume: 10, Issue:9 Topics: Adult; Biomarkers; Carbon Monoxide; Carcinogens; Cotinine; Environmental Monitoring; Female; Harm Reduction; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Nitrosamines; Tobacco Use Cessation; Tobacco, Smokeless	2008
Evaluation of biomarkers of exposure in adult cigarette smokers using Marlboro snus. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2010, Volume: 12, Issue:2 Topics: Administration, Inhalation; Adult; Biomarkers; Butadienes; Carbon Monoxide; Environmental Monitoring; Female; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Nitrosamines; Pyrenes; Smoke; Smoking; Tobacco, Smokeless; Young Adult	2010
Evaluating oral noncombustible potential-reduced exposure products for smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2010, Volume: 12, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Carbon Monoxide; Female; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Smoking Cessation; Tobacco, Smokeless; Young Adult	2010
Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011, Volume: 20, Issue:1 Topics: Adolescent; Adult; Aged; Carbon Monoxide; Cotinine; Feasibility Studies; Humans; Middle Aged; Nicotine; Nitrosamines; Pyridines; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco, Smokeless; Young Adult	2011
A study to evaluate the effect on Mouth Level Exposure and biomarkers of exposure estimates of cigarette smoke exposure following a forced switch to a lower ISO tar yield cigarette. Regulatory toxicology and pharmacology : RTP, 2011, Dec-01, Volume: 61, Issue:3 Suppl Topics: Acrolein; Adult; Biomarkers; Cotinine; Female; Filtration; Germany; Humans; Inhalation Exposure; Male; Middle Aged; Mouth Mucosa; Nicotiana; Nicotine; Nitrosamines; Pyrenes; Saliva; Smoke; Smoking; Tars; Young Adult	2011
Exposure to and deposition of fine and ultrafine particles in smokers of menthol and nonmenthol cigarettes. Inhalation toxicology, 2012, Volume: 24, Issue:5 Topics: Adult; Biomarkers; Cross-Over Studies; Female; Humans; Inhalation Exposure; Male; Menthol; Nicotiana; Nicotine; Nitrosamines; Particle Size; Particulate Matter; Polycyclic Aromatic Hydrocarbons; Smoke; Smoking; Young Adult	2012

Other Studies

111 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and nicotine

Article	Year
Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice. Journal of the National Cancer Institute, 1978, Volume: 60, Issue:4 Topics: Adenoma; Animals; Female; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines	1978
Inhibition of herpes simplex virus replication and protein synthesis by non-smoked tobacco, tobacco alkaloids and nitrosamines. Archives of oral biology, 1992, Volume: 37, Issue:11 Topics: Alkaloids; Anabasine; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; DNA-Directed DNA Polymerase; Humans; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plants, Toxic; Simplexvirus; Thymidine Kinase; Tobacco, Smokeless; Tumor Cells, Cultured; Viral Proteins; Virus Replication	1992
Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus. Oral surgery, oral medicine, and oral pathology, 1991, Volume: 71, Issue:4 Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Chlorocebus aethiops; Kidney; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Simplexvirus; Tobacco, Smokeless; Ultraviolet Rays; Virus Activation	1991
Tobacco-specific nitrosamines in commercial cigarettes: possibilities for reducing exposure. IARC scientific publications, 1991, Issue:105 Topics: Carcinogens; Humans; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Smoke	1991
Modulation of the uptake and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by nicotine in hamster lung. Cancer research, 1991, Apr-15, Volume: 51, Issue:8 Topics: Animals; Binding, Competitive; Carcinogens; Cricetinae; Lung; Male; Mesocricetus; Nicotine; Nitrosamines; Receptors, Nicotinic	1991
Effect of nicotine and tobacco-specific nitrosamines on the metabolism of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by rat oral tissue. Carcinogenesis, 1990, Volume: 11, Issue:9 Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Mouth; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Radioisotope Dilution Technique; Rats; Rats, Inbred F344; Tritium	1990
Tobacco-specific nitrosamines in Canadian cigarettes. Journal of cancer research and clinical oncology, 1990, Volume: 116, Issue:6 Topics: Canada; Carcinogens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic	1990
Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes. Carcinogenesis, 1990, Volume: 11, Issue:5 Topics: Carcinogens; Nicotiana; Nicotine; Nitrates; Nitrosamines; Plants, Toxic; Smoke	1990
Immunoassays for proteins alkylated by nicotine-derived N-nitrosamines. Archives of toxicology, 1990, Volume: 64, Issue:5 Topics: Animals; Carcinogens; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Immunoassay; Immunoblotting; Isoelectric Focusing; Killer Cells, Natural; Nicotine; Nitrosamines; Proteins	1990
Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines. Biochemical pharmacology, 1989, Oct-15, Volume: 38, Issue:20 Topics: Adenocarcinoma; Carcinogens; Cell Division; Diethylnitrosamine; Hexamethonium; Hexamethonium Compounds; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Receptors, Nicotinic; Tumor Cells, Cultured	1989
Effect of snuff and nicotine on DNA methylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: Animals; DNA; Guanine; Liver; Lung; Male; Mathematics; Methylation; Mouth; Nasal Mucosa; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Tobacco, Smokeless	1987
Nicotine: a precursor for carcinogens. Cancer letters, 1985, Volume: 26, Issue:1 Topics: Animals; Biotransformation; Carcinogens; Cotinine; Humans; Lung Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Smoking	1985
Accumulation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in alkaloid genotypes of burley tobacco during postharvest processing: comparisons with N'-nitrosonornicotine and probable nitrosamine precursors. Cancer research, 1985, Volume: 45, Issue:11 Pt 1 Topics: Alkaloids; Carcinogens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Time Factors	1985
On the formation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone during smoking. Cancer letters, 1983, Volume: 17, Issue:3 Topics: Carbon Radioisotopes; Carcinogens; Humans; Nicotine; Nitrosamines; Smoke; Smoking	1983
Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers. Cancer research, 1981, Volume: 41, Issue:11 Pt 1 Topics: Adult; Alkaloids; Denmark; Germany, West; Humans; Male; Middle Aged; Mouth Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines; Saliva; Sweden; Tobacco, Smokeless; United States	1981
Metabolism of the tobacco specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. IARC scientific publications, 1980, Issue:31 Topics: Animals; Biotransformation; Hydroxylation; Liver; Microsomes; Nicotiana; Nicotine; Nitrosamines; Oxidation-Reduction; Plants, Toxic; Pyridines; Rats	1980
Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in Syrian golden hamsters. Cancer research, 1981, Volume: 41, Issue:6 Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cricetinae; Feces; Female; Injections, Subcutaneous; Lung Neoplasms; Male; Mesocricetus; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines	1981
Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer research, 1980, Volume: 40, Issue:2 Topics: Animals; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines; Rats; Rats, Inbred F344	1980
Effects of nicotine and tobacco-specific nitrosamines on hamster cheek pouch and gastric mucosa. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1994, Volume: 23, Issue:6 Topics: Animals; Carcinogens; Cheek; Cricetinae; Drug Synergism; Epithelium; Gastric Mucosa; Hyperplasia; Keratosis; Leukoplakia, Oral; Male; Mesocricetus; Mouth Mucosa; Nicotine; Nitrosamines; Papilloma; Plants, Toxic; Tobacco, Smokeless	1994
Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1994, Volume: 23, Issue:4 Topics: Adult; Cotinine; Glucuronates; Glucuronic Acid; Humans; Leukoedema, Oral; Male; Middle Aged; Mouth Diseases; Mouth Mucosa; Nicotine; Nitrosamines; Plants, Toxic; Saliva; Sweden; Tobacco, Smokeless	1994
Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats. Carcinogenesis, 1994, Volume: 15, Issue:5 Topics: Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Male; Nicotine; Nitrosamines; Rats; Rats, Wistar	1994
Metabolism and macromolecular interaction of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in cultured explants and epithelial cells of human buccal mucosa. Carcinogenesis, 1993, Volume: 14, Issue:11 Topics: Autoradiography; Biotransformation; Carcinogens; Cell Division; Cells, Cultured; DNA; Epithelial Cells; Epithelium; Humans; Methylation; Mouth Mucosa; Nicotine; Nitrosamines; Organ Culture Techniques; Protein Binding; Tritium	1993
Oxygen radicals potentiate the genetic toxicity of tobacco-specific nitrosamines. Clinical genetics, 1993, Volume: 43, Issue:2 Topics: Carcinogens; Cells, Cultured; DNA Damage; DNA, Single-Stranded; Drug Synergism; Fetus; Fibroblasts; Free Radical Scavengers; Free Radicals; Humans; Lung; Mutagens; Nicotiana; Nicotine; Nitrosamines; Nucleic Acid Denaturation; Plants, Toxic; Reactive Oxygen Species	1993
Intragastric nitrosation of nicotine is not a significant contributor to nitrosamine exposure. Annals of the New York Academy of Sciences, 1993, May-28, Volume: 686 Topics: Butanones; Carcinogens; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Models, Biological; Nicotine; Nitrosamines; Nitrosation; Sodium Nitrite; Stomach	1993
Inhibition of mutagenicity of N-nitrosamines by tobacco smoke and its constituents. Mutation research, 1996, Volume: 367, Issue:2 Topics: Animals; Antimutagenic Agents; CHO Cells; Cotinine; Cricetinae; Dimethylnitrosamine; Dose-Response Relationship, Drug; Nicotine; Nitrosamines	1996
Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Volume: 6, Issue:2 Topics: Anticarcinogenic Agents; Biomarkers; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cotinine; Creatinine; Enzyme Inhibitors; Glucuronates; Humans; Inactivation, Metabolic; Isothiocyanates; Lung Neoplasms; Mass Spectrometry; Nicotine; Nitrosamines; Proteus mirabilis; Pyridines	1997
Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. Carcinogenesis, 1997, Volume: 18, Issue:3 Topics: Alkaloids; Animals; Biotransformation; Drug Synergism; Glucuronates; Male; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plants, Toxic; Rats; Rats, Inbred F344; Sodium Nitrite	1997
Immunotoxic effects of smokeless tobacco on the accessory cell function of rat oral epithelium. European journal of oral sciences, 1997, Volume: 105, Issue:1 Topics: Alkaloids; Anabasine; Animals; Antigen-Presenting Cells; Carcinogens; Cell Division; Concanavalin A; Epithelial Cells; Epithelium; Immunosuppressive Agents; Langerhans Cells; Lymphocyte Activation; Mitogens; Mouth Mucosa; Nicotine; Nitrosamines; Nitroso Compounds; Plant Extracts; Plant Lectins; Plants, Toxic; Rats; Rats, Inbred Lew; Spleen; T-Lymphocytes; Tobacco, Smokeless	1997
Effect of nicotine or cotinine on metabolism of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in isolated rat lung and liver. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:3 Topics: Animals; Carcinogens; Cotinine; Liver; Lung; Male; Metabolic Clearance Rate; Nicotine; Nicotinic Agonists; Nitrosamines; Perfusion; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Starvation	1998
Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain. Biochemical pharmacology, 1998, Oct-01, Volume: 56, Issue:7 Topics: Animals; Brain; Enzyme Induction; Glutathione Transferase; Lung; Male; Mitochondria; Nicotine; Nitrosamines; Oxidative Stress; Rats; Rats, Sprague-Dawley	1998
Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation. Cancer research, 1999, Feb-01, Volume: 59, Issue:3 Topics: Adult; Animals; Carcinogens; Cotinine; Female; Glucuronates; Humans; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Rats; Rats, Inbred F344; Smoking Cessation	1999
Metabolites of a tobacco-specific carcinogen in urine from newborns. Journal of the National Cancer Institute, 1999, Mar-03, Volume: 91, Issue:5 Topics: Adult; Carcinogens; Cotinine; Female; Gas Chromatography-Mass Spectrometry; Glucuronates; Humans; Infant, Newborn; Nicotine; Nitrosamines; Pregnancy; Prenatal Exposure Delayed Effects; Smoking	1999
Activation of voltage-operated Ca2+-channels in human small cell lung carcinoma by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. International journal of oncology, 2000, Volume: 16, Issue:3 Topics: Calcium Channels; Carcinogens; Carcinoma, Small Cell; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Tumor Cells, Cultured	2000
Cotinine effects on bile flow and biliary NNK elimination. European journal of medical research, 2000, Jun-20, Volume: 5, Issue:6 Topics: Animals; Bile Ducts; Carcinogens; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Male; Nicotine; Nicotinic Agonists; Nitrosamines; Rats; Rats, Inbred F344	2000
2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor. Proceedings of the National Academy of Sciences of the United States of America, 2000, Nov-07, Volume: 97, Issue:23 Topics: Aryl Hydrocarbon Hydroxylases; Carcinogens; Cotinine; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Humans; Hydroxy Acids; Hydroxylation; Keto Acids; Lung; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; NADP; Nicotine; Nitrosamines; Prodrugs	2000
Bacterial mutagenicity of some tobacco aromatic nitrogen bases and their mixtures. Mutation research, 2001, May-31, Volume: 492, Issue:1-2 Topics: Animals; Carcinogens; Cotinine; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Vibrio	2001
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:5 Topics: Animals; Aorta; Apoptosis; Arachidonic Acid; Arteriosclerosis; Carcinogens; Endothelium, Vascular; In Situ Nick-End Labeling; Nicotine; Nitrosamines; Receptors, Adrenergic, beta; Smoking; Swine; Tritium	2001
Effect of nicotine, cotinine and phenethyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in the Syrian golden hamster. Toxicology, 2002, Sep-30, Volume: 179, Issue:1-2 Topics: Animals; Biotransformation; Cotinine; Cricetinae; DNA Damage; Female; Glucuronides; Isothiocyanates; Mesocricetus; Nicotiana; Nicotine; Nicotinic Agonists; Nitrosamines	2002
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. The Journal of clinical investigation, 2003, Volume: 111, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Bronchi; Carcinogens; Carrier Proteins; Cell Cycle Proteins; Cell Death; Cell Survival; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Forkhead Box Protein O1; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Humans; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Nicotiana; Nicotine; Nitrosamines; Phenotype; Phosphoproteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; Time Factors; Transcription Factors; Ultraviolet Rays	2003
Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats. Cancer letters, 2003, Dec-08, Volume: 202, Issue:1 Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Hydroxylation; Infusions, Intravenous; Injections, Subcutaneous; Male; Nicotine; Nicotinic Agonists; Nitrosamines; Rats; Rats, Sprague-Dawley	2003
Smoking reduction and tobacco-related cancers: the more things change, the more they stay the same. Journal of the National Cancer Institute, 2004, Jan-21, Volume: 96, Issue:2 Topics: Biomarkers, Tumor; Carcinogens; Global Health; Humans; International Agencies; Lung Neoplasms; Neoplasms; Nicotine; Nicotinic Agonists; Nitrosamines; Risk Factors; Smoking; Smoking Cessation; Tobacco Smoke Pollution; Tobacco Use Disorder; United States	2004
The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1 Topics: alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Carcinogens; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; DNA; Drug Interactions; Gene Expression; Humans; Isoenzymes; Lipoxygenase; Membrane Proteins; NF-kappa B; Nicotine; Nicotinic Antagonists; Nitrosamines; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Receptors, Nicotinic; RNA, Messenger; Tumor Cells, Cultured	2004
The molecular perspective: nicotine and nitrosamines. Stem cells (Dayton, Ohio), 2004, Volume: 22, Issue:4 Topics: Carcinogens; DNA; Humans; Neoplasms; Nicotine; Nitrosamines	2004
Metabolism of nicotine and cotinine by human cytochrome P450 2A13. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cotinine; Dose-Response Relationship, Drug; Humans; Insecta; Microsomes; Nicotine; Nitrosamines; Substrate Specificity	2005
Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch. Journal of dental research, 2004, Volume: 83, Issue:12 Topics: Animals; Carcinogens; Cell Survival; Cells, Cultured; Chromatin; Cricetinae; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Mesocricetus; Mouth Mucosa; Nicotine; Nitrosamines; Oxidative Stress; Peroxynitrous Acid; Tobacco, Smokeless; Tyrosine	2004
Human cytochrome p450 2s1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3 Topics: Animals; Baculoviridae; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Insecta; Nicotiana; Nicotine; Nitrosamines; Oxygenases; Smoke	2005
Tobacco-specific nitrosamines in smokeless tobacco products marketed in India. International journal of cancer, 2005, Aug-10, Volume: 116, Issue:1 Topics: Carcinogens; Humans; India; Nicotine; Nitrates; Nitrites; Nitrosamines; Tobacco, Smokeless	2005
Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. Carcinogenesis, 2005, Volume: 26, Issue:7 Topics: Carcinogens; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Proliferation; Cell Survival; Ganglionic Stimulants; Humans; Lung; Lung Neoplasms; NF-kappa B; Nicotine; Nitrosamines; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Smoking; Tumor Cells, Cultured	2005
Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005, Volume: 14, Issue:5 Topics: Adolescent; Adult; Air Pollutants, Occupational; Biomarkers; Carcinogens; Cotinine; Creatinine; Female; Glucuronates; Humans; Interviews as Topic; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Pyridines; Restaurants; Tobacco Smoke Pollution; Workforce	2005
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:12 Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2B6; Humans; Hydroxylation; Microsomes, Liver; Nicotine; Nitrosamines; Oxidoreductases, N-Demethylating	2005
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Volume: 15, Issue:5 Topics: Biomarkers; Chromatography, High Pressure Liquid; Cotinine; Creatinine; Female; Glucuronides; Humans; Infant; Male; Mothers; Nicotine; Nitrosamines; Statistics, Nonparametric; Tobacco Smoke Pollution	2006
Toxicant exposure in cigarette reducers versus light smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Volume: 15, Issue:12 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Chewing Gum; Environmental Exposure; Female; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Pyridines; Smoking; Smoking Cessation	2006
Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Volume: 15, Issue:12 Topics: Cotinine; Gas Chromatography-Mass Spectrometry; Humans; Nails; Nicotine; Nitrosamines; Sensitivity and Specificity	2006
Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urine. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:7 Topics: Adult; Aged; Biomarkers; Cotinine; Endpoint Determination; Environmental Exposure; Female; Ganglionic Stimulants; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Inhalation Exposure; Longitudinal Studies; Male; Middle Aged; Nails; Nicotine; Nitrosamines; Sensitivity and Specificity; Smoking	2007
Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. Cancer research, 2007, Jul-15, Volume: 67, Issue:14 Topics: Adenocarcinoma; Carcinogens; Epithelial Cells; Estrogen Receptor beta; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Nicotine; Nitrosamines; Receptors, Adrenergic, beta-1; Smoking; Trachea	2007
Concentrations of the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:8 Topics: Air Pollutants; Air Pollution, Indoor; Carcinogens; Humans; Humidity; Nicotine; Nitric Oxide; Nitrogen Dioxide; Nitrosamines; Nitrosation; Temperature; Time Factors; Tobacco Industry; Tobacco Smoke Pollution	2007
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. Toxicology and applied pharmacology, 2008, Dec-01, Volume: 233, Issue:2 Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclooxygenase 2; Dinoprostone; Gene Expression Regulation; Humans; Nicotine; Nitrosamines; p38 Mitogen-Activated Protein Kinases; Propranolol; Receptors, Adrenergic, beta; Receptors, Nicotinic; Signal Transduction; Stomach Neoplasms	2008
Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer research, 2008, Nov-15, Volume: 68, Issue:22 Topics: Adult; Aged; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nerve Tissue Proteins; Nicotine; Nitrosamines; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Smoking	2008
Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemico-biological interactions, 2009, Feb-12, Volume: 177, Issue:3 Topics: Alphapapillomavirus; Blotting, Western; Carcinogens; Cell Line, Transformed; Cell Transformation, Viral; Cervix Uteri; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Histones; Humans; Nicotine; Nitrosamines; Oligonucleotide Array Sequence Analysis; Phosphorylation; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction	2009
FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK). Lung cancer (Amsterdam, Netherlands), 2010, Volume: 67, Issue:1 Topics: Adenocarcinoma; Apoptosis; Carcinogens; Cell Line, Tumor; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Transcription, Genetic; Tumor Suppressor Proteins	2010
The relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the US. Regulatory toxicology and pharmacology : RTP, 2009, Volume: 55, Issue:1 Topics: Acrolein; Adult; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; Butadienes; Carbon Dioxide; Chemistry Techniques, Analytical; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Observation; Pyrenes; Reference Standards; Reproducibility of Results; Smoking; Tars; Young Adult	2009
Is nicotine the estrogen of lung cancer? American journal of respiratory and critical care medicine, 2009, Jun-15, Volume: 179, Issue:12 Topics: alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Nicotine; Nitrosamines; Prognosis; Receptors, Nicotinic; Risk Factors; Tobacco Smoke Pollution	2009
A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure. Regulatory toxicology and pharmacology : RTP, 2009, Volume: 55, Issue:1 Topics: Acrolein; Adult; Aged; Analysis of Variance; Biomarkers; Chemistry Techniques, Analytical; Environmental Exposure; Female; Filtration; Humans; Male; Middle Aged; Mouth Mucosa; Nicotiana; Nicotine; Nitrosamines; Pyrenes; Reference Values; Smoke; Smoking; Young Adult	2009
Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer. International journal of cancer, 2009, Nov-15, Volume: 125, Issue:10 Topics: Aged; Asian; Carcinogens; Cross-Sectional Studies; Ethnicity; Female; Follow-Up Studies; Glucuronates; Hawaii; Humans; Inactivation, Metabolic; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Prognosis; Pyridines; Risk Factors; Smoking; Survival Rate; White People	2009
Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers. Clinical chemistry and laboratory medicine, 2009, Volume: 47, Issue:3 Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Biomarkers; Cholesterol, LDL; Cross-Sectional Studies; Deoxyguanosine; Dinoprost; Female; Humans; Immunoglobulin G; Male; Middle Aged; Nicotine; Nitrosamines; Pyridines; Reproducibility of Results; Smoke; Smoking; Smoking Cessation; Thromboxane B2; Thymidine	2009
Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation. Journal of cellular biochemistry, 2010, Jan-01, Volume: 109, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cisplatin; DNA Fragmentation; Humans; Immunoblotting; Mice; Nicotine; Nicotinic Agonists; Nitrosamines; Rats; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Up-Regulation	2010
Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:6 Topics: Adolescent; Adult; Biomarkers; Cotinine; Female; Humans; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Pyridines; Saliva; Smoking; Young Adult	2010
Chinese 'low-tar' cigarettes do not deliver lower levels of nicotine and carcinogens. Tobacco control, 2010, Volume: 19, Issue:5 Topics: Adult; Carcinogens; China; Consumer Product Safety; Cotinine; Humans; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Smoking; Surveys and Questionnaires; Tars	2010
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in smokers in the United States: NHANES 2007-2008. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2011, Volume: 16, Issue:2 Topics: Adolescent; Adult; Aged; Biomarkers; Black People; Carcinogens; Cotinine; Creatinine; Female; Humans; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Nutrition Surveys; Pyridines; Smoking; Tars; United States; White People; Young Adult	2011
Is 24h nicotine equivalents a surrogate for smoke exposure based on its relationship with other biomarkers of exposure? Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2011, Volume: 16, Issue:2 Topics: Acrolein; Adult; Benzene; Biomarkers; Butadienes; Carbon Monoxide; Environmental Exposure; Female; Humans; Male; Nicotiana; Nicotine; Nitrosamines; Pyrenes; Pyridines; Randomized Controlled Trials as Topic; Smoke; Smoking; Time Factors	2011
Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung. American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:1 Topics: Aldehydes; Animals; Apoptosis; Bungarotoxins; Calcium-Binding Proteins; Calponins; Lung; Mecamylamine; Microfilament Proteins; Nicotine; Nitrosamines; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Smoking; Tobacco Smoke Pollution	2011
Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). International journal of cancer, 2012, Mar-15, Volume: 130, Issue:6 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adult; Aged; Case-Control Studies; Creatinine; Female; Humans; Individuality; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Oxidoreductases; Polymorphism, Single Nucleotide; Pyridines; Smoking; Tobacco Smoke Pollution	2012
Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011, Volume: 20, Issue:7 Topics: 2-Naphthylamine; Acrolein; Adult; Aged; Aged, 80 and over; Aminobiphenyl Compounds; Benzene; Butadienes; Carbon Monoxide; Chromatography, Liquid; Europe; Female; Humans; Male; Mass Spectrometry; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Pyrenes; Smoke; Smoking; Tars; Tobacco Smoke Pollution; Toluidines; Young Adult	2011
Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Adenoma; Animals; Carcinogens; Cells, Cultured; Drinking Water; Female; Guanine; Humans; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nicotine; Nitrosamines	2011
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Adenocarcinoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Drinking Water; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)	2011
Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers. Cancer research, 2011, Nov-01, Volume: 71, Issue:21 Topics: Aged; China; Cotinine; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Prospective Studies; Pyridines; Smoke; Smoking	2011
Long-term nicotine replacement therapy: cancer risk in context. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)	2011
How do we safely get people to stop smoking? Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)	2011
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes. The Journal of biological chemistry, 2012, Aug-03, Volume: 287, Issue:32 Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2A6; Humans; Models, Molecular; Mutagenesis, Site-Directed; Nicotine; Nitrosamines; Protein Binding	2012
Metabolism of nicotine and 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) in menthol and non-menthol cigarette smokers. Drug metabolism letters, 2012, Sep-01, Volume: 6, Issue:3 Topics: Adult; Black or African American; Cotinine; Cross-Sectional Studies; Female; Glucuronides; Humans; Male; Menthol; Middle Aged; Nicotine; Nitrosamines; Pyridines; Smoking; Tobacco Products; White People; Young Adult	2012
Chemical analysis of Alaskan Iq'mik smokeless tobacco. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:7 Topics: Alaska; Benzo(a)pyrene; Humans; Hydrogen-Ion Concentration; Inuit; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Tobacco, Smokeless	2013
Cloning and characterization of a hybridoma secreting a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-specific monoclonal antibody and recombinant F(ab). Toxins, 2013, Mar-19, Volume: 5, Issue:3 Topics: Animals; Antibodies, Monoclonal; Binding Sites, Antibody; Carrier Proteins; Cell Line, Tumor; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; HEK293 Cells; Humans; Hybridomas; Immunoglobulin Fab Fragments; Mice; Mice, Inbred BALB C; Nicotine; Nitrosamines; Spleen	2013
Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK. Tobacco control, 2014, Volume: 23, Issue:2 Topics: Administration, Inhalation; Carcinogens; Cotinine; Dust; Environmental Exposure; Humans; Nicotiana; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Skin Absorption; Smoking; Tobacco Smoke Pollution	2014
Direct analysis of tobacco-specific nitrosamine NNK and its metabolite NNAL in human urine by LC-MS/MS: evidence of linkage to methylated DNA lesions. Archives of toxicology, 2014, Volume: 88, Issue:2 Topics: Adenine; Adult; Biomarkers; Chromatography, Liquid; Cotinine; DNA Methylation; Guanine; Humans; Limit of Detection; Nicotine; Nitrosamines; Pyridines; Sensitivity and Specificity; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2014
Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites. International journal of cancer, 2014, May-15, Volume: 134, Issue:10 Topics: Animals; Asian People; Case-Control Studies; China; Cohort Studies; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Molecular Structure; Multivariate Analysis; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Rats; Risk Factors; Smoking	2014
Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014, Volume: 16, Issue:7 Topics: Acetylcysteine; Air; Biomarkers; Carcinogens; Child, Preschool; Cotinine; Cross-Sectional Studies; Environmental Exposure; Family Characteristics; Female; Housing; Humans; Male; Nicotine; Nitrosamines; Pyridines; Smoking; Tobacco Smoke Pollution	2014
Regulation of tumor progression via the Snail-RKIP signaling pathway by nicotine exposure in head and neck squamous cell carcinoma. Head & neck, 2015, Volume: 37, Issue:12 Topics: Aldehyde Dehydrogenase 1 Family; alpha7 Nicotinic Acetylcholine Receptor; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Disease Progression; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Isoenzymes; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Staging; Neoplastic Stem Cells; Nicotine; Nicotinic Agonists; Nitrosamines; Retinal Dehydrogenase; Signal Transduction; Snail Family Transcription Factors; Tongue Neoplasms; Transcription Factors; Up-Regulation	2015
The impact of water pipe and tobacco marketing on young people. Cancer, 2014, Oct-01, Volume: 120, Issue:19 Topics: Adolescent; Adult; Carcinogens; Female; Humans; Male; Marketing; Nicotine; Nitrosamines; Pyridines; Smoking; Tobacco Products; Young Adult	2014
Identification of precursors and mechanisms of tobacco-specific nitrosamine formation in water during chloramination. Environmental science & technology, 2015, Jan-06, Volume: 49, Issue:1 Topics: Alkaloids; Chloramines; Chromatography, Liquid; Drinking Water; Halogenation; Mass Spectrometry; Nicotiana; Nicotine; Nitrosamines; Pyridines; Solid Phase Extraction; Tandem Mass Spectrometry; Water Pollutants, Chemical	2015
Matrix-bound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in tobacco: quantification and evidence for an origin from lignin-incorporated alkaloids. Journal of natural products, 2015, Jan-23, Volume: 78, Issue:1 Topics: Alkaloids; Butanones; Lignin; Molecular Structure; Nicotiana; Nicotine; Nitrosamines; Plant Leaves; Smoke	2015
A longitudinal study of smokers' exposure to cigarette smoke and the effects of spontaneous product switching. Regulatory toxicology and pharmacology : RTP, 2015, Volume: 72, Issue:1 Topics: Adult; Biomarkers; Female; Germany; Humans; Inhalation Exposure; Longitudinal Studies; Male; Middle Aged; Mouth; Nicotiana; Nicotine; Nitrosamines; Smoke; Smoking; Tars; Tobacco Products; Young Adult	2015
Consequences of Incomplete Smoke-Free Legislation in the Republic of Korea: Results from Environmental and Biochemical Monitoring: Community Based Study. Cancer research and treatment, 2016, Volume: 48, Issue:1 Topics: Air; Air Pollution, Indoor; Cotinine; Environmental Exposure; Environmental Monitoring; Hair; Humans; Nicotine; Nitrosamines; Particulate Matter; Private Facilities; Public Facilities; Republic of Korea; Schools; Tobacco Smoke Pollution; Toilet Facilities	2016
Differential Contributions of Alcohol and Nicotine-Derived Nitrosamine Ketone (NNK) to White Matter Pathology in the Adolescent Rat Brain. Alcohol and alcoholism (Oxford, Oxfordshire), 2015, Volume: 50, Issue:6 Topics: Animals; Drug Synergism; Ethanol; Forkhead Transcription Factors; Gene Expression; Growth Cones; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Male; Myelin-Associated Glycoprotein; Nerve Degeneration; Nerve Tissue Proteins; Nicotine; Nitrosamines; Oligodendroglia; Rats; Synapses; Transcription Factors; White Matter; Zebrafish Proteins	2015
Differential Contributions of Alcohol and the Nicotine-Derived Nitrosamine Ketone (NNK) to Insulin and Insulin-Like Growth Factor Resistance in the Adolescent Rat Brain. Alcohol and alcoholism (Oxford, Oxfordshire), 2015, Volume: 50, Issue:6 Topics: Acetylcholinesterase; Animals; Atrophy; Dinoprost; Drug Synergism; Ethanol; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Insulin Resistance; Male; Maze Learning; Nicotine; Nitrosamines; Oxidative Stress; Phosphorylation; Protein Carbonylation; Rats; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Somatomedins; Spatial Learning; tau Proteins; Temporal Lobe; Tyrosine	2015
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice. Oncology reports, 2015, Volume: 34, Issue:6 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; bcl-X Protein; Carcinogens; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Nicotiana; Nicotine; Nitrosamines; Proliferating Cell Nuclear Antigen; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; TOR Serine-Threonine Kinases	2015
Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study. American journal of epidemiology, 2015, Dec-01, Volume: 182, Issue:11 Topics: Aged; Asian People; Biomarkers; Black or African American; Cohort Studies; Cotinine; Female; Humans; Indians, North American; Male; Middle Aged; Native Hawaiian or Other Pacific Islander; Nicotine; Nitrosamines; Racial Groups; Smoking; White People	2015
Thirdhand smoke contamination in hospital settings: assessing exposure risk for vulnerable paediatric patients. Tobacco control, 2016, Volume: 25, Issue:6 Topics: Carcinogens; Cotinine; Environmental Exposure; Environmental Monitoring; Female; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Nicotine; Nitrosamines; Pregnancy; Tobacco Smoke Pollution	2016
Evaluation of tobacco specific nitrosamines exposure by quantification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human hair of non-smokers. Scientific reports, 2016, 04-26, Volume: 6 Topics: Cotinine; Hair; Humans; Nicotine; Nitrosamines; Tobacco Smoke Pollution	2016
In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa. Toxicology letters, 2016, 07-08, Volume: 254 Topics: Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Lung; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plant Leaves; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Tobacco, Smokeless	2016
CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study. Carcinogenesis, 2017, 04-01, Volume: 38, Issue:4 Topics: Asian People; Biomarkers; Carcinogens; Case-Control Studies; Cytochrome P-450 CYP2A6; Female; Genotype; Humans; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Polymorphism, Genetic; Prospective Studies; Risk; Singapore; Smoke; Smoking	2017
A Model To Estimate the Sources of Tobacco-Specific Nitrosamines in Cigarette Smoke. Chemical research in toxicology, 2017, 08-21, Volume: 30, Issue:8 Topics: Carcinogenesis; Gases; Humans; Models, Chemical; Nicotiana; Nicotine; Nitrosamines; Smoking; Temperature	2017
Development of a Cigarette Tobacco Filler Standard Reference Material. Analytical chemistry, 2017, 10-03, Volume: 89, Issue:19 Topics: Chromatography, High Pressure Liquid; Freezing; Gas Chromatography-Mass Spectrometry; Nicotine; Nitrosamines; Phase Transition; Reference Standards; Tandem Mass Spectrometry; Tobacco Products; Volatile Organic Compounds	2017
Nicotine Component of Cigarette Smoke Extract (CSE) Decreases the Cytotoxicity of CSE in BEAS-2B Cells Stably Expressing Human Cytochrome P450 2A13. International journal of environmental research and public health, 2017, 10-13, Volume: 14, Issue:10 Topics: Apoptosis; Aryl Hydrocarbon Hydroxylases; bcl-2-Associated X Protein; Bronchi; Caspase 3; Cell Count; Cell Line; Cell Survival; Humans; Nicotine; Nitrosamines; Tandem Mass Spectrometry; Tobacco Smoke Pollution	2017
A simple and highly sensitive UPLC-ESI-MS/MS method for the simultaneous quantification of nicotine, cotinine, and the tobacco-specific carcinogens N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in serum samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Jan-01, Volume: 1072 Topics: Carcinogens; Chromatography, High Pressure Liquid; Cotinine; Drug Stability; Humans; Limit of Detection; Linear Models; Nicotine; Nitrosamines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2018
Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model. Environmental toxicology and pharmacology, 2018, Volume: 58 Topics: A549 Cells; Benzo(a)pyrene; Biological Assay; Cell Survival; Histones; Humans; Models, Biological; Nicotine; Nitrosamines; Smoke; Tobacco Products	2018
E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proceedings of the National Academy of Sciences of the United States of America, 2018, 02-13, Volume: 115, Issue:7 Topics: Animals; Carcinogenesis; Cell Line; DNA Damage; DNA Repair; Electronic Nicotine Delivery Systems; Heart; Humans; Lung; Male; Mice; Mutation; Nicotine; Nitrosamines; Smoke; Urinary Bladder	2018
Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice. PloS one, 2018, Volume: 13, Issue:6 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Carcinogens; Cell Proliferation; Gene Deletion; Humans; Mice; Mice, Knockout; Nicotiana; Nicotine; Nitrosamines; Pancreatitis	2018
Long-term exposure to extremely low-dose of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induce non-malignant breast epithelial cell transformation through activation of the a9-nicotinic acetylcholine receptor-mediated signaling pathw Environmental toxicology, 2019, Volume: 34, Issue:1 Topics: Acetylcholine; Breast Neoplasms; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells; Female; Humans; Mammary Glands, Human; Nicotine; Nitrosamines; Receptors, Nicotinic; Signal Transduction; Time Factors; Toxicity Tests, Chronic	2019
Exposure to a Tobacco-Specific Carcinogen Among Adolescent Smokeless Tobacco Users in Rural California, United States. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020, 10-08, Volume: 22, Issue:10 Topics: Adolescent; California; Carcinogens; Humans; Inhalation Exposure; Nicotine; Nitrosamines; Tobacco Use; Tobacco, Smokeless	2020
Does the implementation of smoke-free laws and smoking culture affect exposure to tobacco smoking? Results from 3 hospitality settings in South Korea. International journal of occupational medicine and environmental health, 2021, Jan-07, Volume: 34, Issue:1 Topics: Adult; Aged; Air Pollution, Indoor; Cotinine; Cross-Sectional Studies; Dust; Female; Hair; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Occupational Exposure; Republic of Korea; Restaurants; Smoke-Free Policy; Tobacco Smoke Pollution	2021
Nicotine-derived NNK induces the stemness enrichment of CRC cells through regulating the balance of DUSP4-ERK1/2 feedback loop. Ecotoxicology and environmental safety, 2021, Volume: 214 Topics: Carcinogens; Cell Line, Tumor; Colorectal Neoplasms; Dual-Specificity Phosphatases; Epithelial Cells; Feedback; Humans; Hyaluronan Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Phosphatases; Neoplastic Stem Cells; Nicotine; Nitrosamines	2021