4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with n'-nitrosonornicotine in 129 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (26.36) | 18.7374 |
| 1990's | 53 (41.09) | 18.2507 |
| 2000's | 21 (16.28) | 29.6817 |
| 2010's | 21 (16.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CB; Hecht, SS; Hirota, N; Hoffmann, D; Ornaf, RM; Tso, TC | 1 |
| Gronowitz, JS; Hirsch, JM; Larsson, PA; Vahlne, A | 1 |
| Guengerich, FP; Inui, Y; Shimada, T; Yamazaki, H; Yun, CH | 1 |
| Brunnemann, KD; Cox, JE; Hoffmann, D | 1 |
| Carmella, SG; Foiles, PG; Hecht, SS; Murphy, SE; Peterson, LA | 2 |
| Bartsch, H; Brouet, I; Faustman, EM; Friesen, M; Idris, AM; Nair, J; Ohshima, H | 2 |
| Cherrick, HM; Dokko, H; Min, PS; Park, NH | 1 |
| Cherrick, HM; Dokko, H; Li, SL; Park, NH | 1 |
| Carmella, SG; Hecht, SS; Kagan, M; Kagan, SS | 1 |
| Fischer, S; Preussmann, R; Spiegelhalder, B | 1 |
| Hecht, SS; Hoffmann, D | 2 |
| Amonkar, AJ; Bhide, SV; Padma, PR | 3 |
| Carmella, SG; Hecht, SS; Murphy, SE | 2 |
| Bowman, D; Davis, WJ; Heiblum, R; King, PG; Murphy, SE; Stoner, GD | 1 |
| Crespi, CL; Gelboin, HV; Gonzalez, FJ; Penman, BW | 1 |
| Becher, R; Dahl, JE; Dybing, E; Låg, M; Schuller, HM | 1 |
| Heiblum, R; Murphy, SE | 1 |
| Castonguay, A; Fischer, S; Kaiserman, M; Preussmann, R; Spiegelhalder, B | 1 |
| Eisenbarth, J; Fischer, S; Preussmann, R; Spiegelhalder, B | 1 |
| Heiblum, R; Murphy, SE; Trushin, N | 1 |
| Carmella, SG; Foiles, PG; Hecht, SS; Kagan, M; Kagan, SS; Palladino, G; Quart, AM; Quart, E | 1 |
| Castonguay, A; Desnoyers, S; Talbot, B | 1 |
| Bhide, SV; Gijare, PS; Rao, KV | 1 |
| Amonkar, AJ; Bhide, SV; Lalitha, VS; Padma, PR | 2 |
| Carmella, SG; Foiles, PG; Hecht, SS; Hoffmann, D; Spratt, TE; Trushin, N | 1 |
| Haubner, R; Preussmann, R; Spiegelhalder, B; Tricker, AR | 1 |
| Hecht, SS; Spratt, TE; Trushin, N | 1 |
| Carmella, SG; Hecht, SS | 2 |
| Adams, JD; Hoffmann, D; LaVoie, EJ; Prokopczyk, G | 1 |
| Carmella, SG; Chung, FL; Foiles, PG; Hecht, SS; Lin, D; Rubin, JM; Trushin, N | 1 |
| Preston-Martin, S | 1 |
| Adams, JD; Braley, J; DiBello, J; Hecht, SS; Hoffmann, D; Rivenson, A | 1 |
| Adams, JD; Choi, CI; LaVoie, EJ; Reinhardt, J; Stern, SL | 1 |
| Hecht, SS; Hoffmann, D; Lavoie, EJ | 1 |
| Adams, JD; Brunnemann, KD; Haley, NJ; Hoffmann, D; Melikian, A | 1 |
| Adams, JD; Hoffmann, D; LaVoie, EJ | 1 |
| Adams, JD; Carey, KD; Hoffmann, D; Lavoie, EJ; Marshall, MV; O'Mara-Adams, KJ | 1 |
| Andersen, RA; Kemp, TR | 1 |
| Castonguay, A; d'Argy, R; Sperber, G; Tjälve, H; Trushin, N | 1 |
| Bhide, SV; Nagarajrao, D; Nair, J; Shah, AS | 1 |
| Adams, JD; Hoffmann, D; Lavoie, EJ; O'Donnell, M | 1 |
| Bhide, SV; Brunnemann, KD; Hoffmann, D; Rivenson, A; Wenke, G | 1 |
| Castonguay, A; Hecht, SS; Schut, HA; Stoner, GD | 1 |
| Amin, S; Hecht, SS; Hoffmann, D; Rivenson, A | 1 |
| Castonguay, A; Furuya, K; Hecht, SS; Klaunig, JE; Lin, D; Radok, P; Schut, HA; Stoner, GD | 1 |
| Brittebo, EB; Castonguay, A; Furuya, K; Hecht, SS | 1 |
| Adams, JD; Hoffmann, D | 1 |
| Chen, CB; Hecht, SS; Hoffmann, D; Lin, D; Young, R | 1 |
| Castonguay, A; Hecht, SS; Hoffmann, D; Rivenson, A | 1 |
| Chen, CB; Hecht, SS; Hoffmann, D; Ohmori, T | 1 |
| Benitez, L; Espinosa-Aguirre, JJ; Lares, I; Ostrosky-Wegman, P; Rubio, J; Vilchis, C | 1 |
| Hecht, SS; Peterson, LA; Spratt, TE | 1 |
| Chakravarti, A; Eskelson, CD; Mufti, SI; Nachiappan, V; Rajasekharan, R | 1 |
| Chen, YP; Johnson, GK; Squier, CA | 1 |
| Bäckbro, A; Beije, B; Diaz-Pohl, C; Jenssen, D; Romert, L; Swedmark, S | 1 |
| Andersson, G; Björnberg, G; Curvall, M | 1 |
| Hecht, SS | 2 |
| Falter, B; Kutzer, C; Richter, E | 1 |
| Hecht, SS; Rivenson, A; Trushin, N | 1 |
| Kassie, F; Knasmüller, S; Kundi, M; McCoy, DG; Schulte-Hermann, R; Zöhrer, E | 1 |
| Amin, S; Desai, D; Djordjevic, MV; Hoffmann, D; Rivenson, A; Zang, E | 1 |
| Hemminki, K; Mustonen, R; Schoket, B | 1 |
| Corvese, D; Weitberg, AB | 1 |
| Gilchrist, EP; Moyer, MP; Murrah, VA | 1 |
| Caldwell, WS; deBethizy, JD; Dobson, GP; Greene, JM | 1 |
| Guengerich, FP; Guo, Z; Smith, TJ; Yang, CS | 1 |
| Bombick, BR; Doolittle, DJ; Fulp, C; Lee, CK | 1 |
| Calcagnotto, A; Hoffmann, D; Idris, AM; Kim, J; Lazarus, P | 1 |
| Dahle, HK; Hoffmann, D; Koppang, N; Rivenson, A | 1 |
| Amin, S; Guengerich, FP; Hecht, SS; Koehl, W; Koenig, LA; Murphy, SE; Nunes, MG; Patten, CJ; Staretz, ME | 1 |
| Borukhova, A; Carmella, SG; Desai, D; Hecht, SS | 1 |
| Hasséus, B; Hirsch, JM; Jontell, M; Osterdahl, BG; Wallström, M | 1 |
| Espiritu, I; Jones, AD; Maronpot, RR; Pinkerton, KE; Witschi, H | 1 |
| Djordjevic, MV; Hoffmann, D | 1 |
| Castonguay, A; Cloutier, JF | 1 |
| Liao, A; Philbert, MA; Smith, TJ; Starcic, S; Wang, LD; Yang, CS; Yang, GY | 1 |
| Orloff, M; Schuller, HM | 1 |
| Heard, P; Jenson, HB; Moyer, MP | 1 |
| Chen, M; Guttenplan, JB; von Pressentin , MM | 1 |
| Boyle, P; Gray, N | 1 |
| Hecht, SS; McIntee, EJ; Upadhyaya, P | 1 |
| Hee, SS; Yim, SH | 1 |
| Carmella, SG; Duca, G; Hecht, SS; Stepanov, I | 1 |
| Maier, H; Pfaue, D; Tisch, M | 1 |
| Barley, RD; Lam, EW; Peters, E; Pollock, S; Shallow, MC | 1 |
| Gupta, PC; Hecht, SS; Ramakrishnan, S; Stepanov, I | 1 |
| Talamini, G | 1 |
| Arredondo, J; Chernyavsky, AI; Grando, SA | 3 |
| Counts, ME; Hsu, FS; Tewes, FJ | 1 |
| Feng, S; Jin, Y; Kapur, S; Kinser, R; Lam, K; Mendes, P; Muhammad, R; Plunkett, SE; Roethig, HJ; Zimmermann, M | 1 |
| Schuller, HM | 1 |
| Michno, N; Murphy, SE; Schlicht, KE; Scott, EE; Smith, BD | 1 |
| Grando, SA | 1 |
| Abdel-Rahman, SZ; Havla, JB; Hill, CE; Richter, E | 1 |
| Berg, JZ; Murphy, SE; Schlicht, KE | 1 |
| Austin, DF; Djordjevic, MV; Pankow, JF; Stellman, SD; Toccalino, PL; Watanabe, KH | 1 |
| Cheung, F; Errington, G; Kavvadias, D; McEwan, M; Scherer, G; Shepperd, J | 1 |
| Hatsukami, DK; Hecht, SS; Stepanov, I | 1 |
| Hu, Q; Ou, H; Tang, G; Xiong, W | 1 |
| Ashley, DL; Ding, YS; Hearn, BA; Polzin, GM; Renner, CC; Stanfill, SB; Vaughan-Watson, C; Watson, CH; Zhang, L | 1 |
| Appleton, S; Lipowicz, PJ; Olegario, RM | 1 |
| Balmes, J; Farraro, KF; Hammond, SK; Jenkins, BM; Perrino, C; Schick, SF; Sleiman, M; Trinh, MP; van de Vossenberg, G | 1 |
| Anadon, A; Garcia-Canton, C; Meredith, C | 1 |
| Gao, YT; Hecht, SS; Sebero, E; Stepanov, I; Wang, R; Yuan, JM | 1 |
| Nachiappan, V; Sarkar, M; Sivaprakasam, C; Varthini, LV; Vijayaraj, P | 1 |
| Chen, B; Hu, B; Li, XF; Qian, Y; Wu, M; Zhu, L | 1 |
| Benowitz, NL; Havel, C; Jacob, P; Metayer, C; Whitehead, TP | 1 |
| Li, L; Li, MT; Wang, WN; Yin, YG; Zhu, QH; Zhu, YY | 1 |
| Hyodo, T; Mikita, A; Minagawa, K | 1 |
| Carmella, SG; Hecht, SS; Stepanov, I | 1 |
| Gadani, F; Gunduz, I; Hofer, R; Jaccard, G; Kondylis, A; Renaud, JM; Ruffieux, L | 1 |
| Cabot, PJ; Moghbel, N; Ryu, B; Steadman, KJ | 1 |
| Lipowicz, PJ; Seeman, JI | 1 |
| Daniels, YC; Holman, MR; Johnson, TL; Lane, B; Lang, BE; Lee, GE; Lisko, JG; Phillips, T; Pritchett, JS; Sander, LC; Valentin-Blasini, L; Walters, MJ; Watson, C; Wise, SA; Wood, LJ; Yen, JH | 1 |
| da Costa, GG; Loukotková, L; Vanlandingham, M; VonTungeln, LS | 1 |
| Chen, H; Hou, H; Hu, Q; Liu, Y; Wang, A; Zhang, S | 1 |
| Bharadwaj, M; Gupta, AK; Mehrotra, R; Tulsyan, S | 1 |
| Bian, Z; Deng, H; Fan, Z; Li, Z; Liu, S; Shen, W; Tang, G; Tang, S; Wang, Y; Yang, F | 1 |
9 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and n'-nitrosonornicotine
| Article | Year |
|---|---|
DNA and hemoglobin adducts as markers of metabolic activation of tobacco-specific carcinogens.
Topics: Animals; Biotransformation; Butanones; Carcinogens; DNA, Neoplasm; Hemoglobins; Humans; Lung Neoplasms; Nitrosamines; Pyridines; Risk Factors | 1992 |
Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions.
Topics: Animals; Biotransformation; Carcinogens; Humans; Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic; Smoking | 1985 |
Tobacco-specific nitrosamines.
Topics: Animals; Carcinogens; DNA; DNA Adducts; Humans; Nicotiana; Nitrosamines; Plants, Toxic | 1994 |
Metabolic activation and detoxification of tobacco-specific nitrosamines--a model for cancer prevention strategies.
Topics: Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Humans; Inactivation, Metabolic; Male; Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic | 1994 |
Chemical composition and carcinogenicity of smokeless tobacco.
Topics: Animals; Biotransformation; Carcinogenicity Tests; Carcinogens; Cricetinae; Humans; Mouth Neoplasms; Nitrosamines; Plants, Toxic; Rats; Tobacco, Smokeless; United States | 1997 |
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.
Topics: Animals; Carcinogens; DNA Adducts; DNA Damage; Genes, p53; Genes, ras; Hemoglobins; Humans; Lung Neoplasms; Mutation; Nitrosamines | 1998 |
Nitrosamines as nicotinic receptor ligands.
Topics: Animals; Binding, Competitive; Humans; Molecular Structure; Nicotinic Agonists; Nitrosamines; Receptors, Nicotinic | 2007 |
Basic and clinical aspects of non-neuronal acetylcholine: biological and clinical significance of non-canonical ligands of epithelial nicotinic acetylcholine receptors.
Topics: Acetylcholine; Adaptor Proteins, Signal Transducing; Animals; Antigens, Ly; Carcinogens; Epithelial Cells; GPI-Linked Proteins; Humans; Ligands; Membrane Glycoproteins; Neoplasms; Neurons; Nicotiana; Nitrosamines; Receptors, Nicotinic; Urokinase-Type Plasminogen Activator | 2008 |
Grass roots approach to control levels of carcinogenic nitrosamines, NNN and NNK in smokeless tobacco products.
Topics: Carcinogens; Humans; Neoplasms; Nitrosamines; Tobacco Industry; Tobacco, Smokeless | 2019 |
120 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and n'-nitrosonornicotine
| Article | Year |
|---|---|
Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice.
Topics: Adenoma; Animals; Female; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines | 1978 |
Inhibition of herpes simplex virus replication and protein synthesis by non-smoked tobacco, tobacco alkaloids and nitrosamines.
Topics: Alkaloids; Anabasine; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; DNA-Directed DNA Polymerase; Humans; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plants, Toxic; Simplexvirus; Thymidine Kinase; Tobacco, Smokeless; Tumor Cells, Cultured; Viral Proteins; Virus Replication | 1992 |
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.
Topics: Animals; Antibodies; Biotransformation; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Activation; Humans; Microsomes, Liver; Nicotiana; Nitrosamines; Oxidoreductases, N-Demethylating; Oxygenases; Plants, Toxic; Rabbits | 1992 |
Analysis of tobacco-specific N-nitrosamines in indoor air.
Topics: Air Pollution, Indoor; Carcinogens; Chromatography, Gas; Nicotiana; Nitrosamines; Plants, Toxic | 1992 |
Carcinogenic tobacco-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan.
Topics: Adolescent; Adult; Aged; Humans; Middle Aged; Nitrosamines; Plants, Toxic; Saliva; Sudan; Tobacco, Smokeless | 1992 |
Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Chlorocebus aethiops; Kidney; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Simplexvirus; Tobacco, Smokeless; Ultraviolet Rays; Virus Activation | 1991 |
Synergism of herpes simplex virus and tobacco-specific N'-nitrosamines in cell transformation.
Topics: Animals; Carcinogens; Cell Count; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Nicotiana; Nitrosamines; Plants, Toxic; Simplexvirus; Ultraviolet Rays; Vero Cells | 1991 |
Quantification of 4-hydroxy-1-(3-pyridyl)-1-butanone released from human haemoglobin as a dosimeter for exposure to tobacco-specific nitrosamines.
Topics: Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Nitrosamines; Plants, Toxic; Smoking; Tobacco, Smokeless | 1991 |
Tobacco-specific nitrosamines in commercial cigarettes: possibilities for reducing exposure.
Topics: Carcinogens; Humans; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Smoke | 1991 |
N-nitroso compounds and tobacco-induced cancers in man.
Topics: Carcinogens; Esophageal Neoplasms; Humans; Lung Neoplasms; Mouth Neoplasms; Nitrosamines; Pancreatic Neoplasms; Smoking | 1991 |
Effect of long-term treatment of two tobacco-specific N-nitrosamines on the vitamin A status of mice.
Topics: Animals; Carcinogens; Liver; Male; Mice; Mice, Inbred BALB C; Nicotiana; Nitrosamines; Plants, Toxic; Time Factors; Vitamin A | 1991 |
Hemoglobin adducts as biomarkers of exposure to and metabolic activation of carcinogenic tobacco-specific nitrosamines.
Topics: Animals; Biomarkers; Biotransformation; Carcinogens; DNA Damage; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Nicotiana; Nitrosamines; Plants, Toxic; Rats | 1991 |
Unusually high levels of carcinogenic tobacco-specific nitrosamines in Sudan snuff (toombak).
Topics: Carcinogens; Chromatography, Gas; Nitrosamines; Plants, Toxic; Sudan; Tobacco, Smokeless | 1991 |
Effect of phenethyl isothiocyanate on the metabolism of tobacco-specific nitrosamines by cultured rat oral tissue.
Topics: Animals; Carcinogens; Culture Techniques; Hydroxylation; Isothiocyanates; Male; Mouth Mucosa; Mouth Neoplasms; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Thiocyanates; Tobacco, Smokeless | 1991 |
A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.
Topics: Biotransformation; Carcinogens; Cell Line; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Humans; Isoenzymes; Mixed Function Oxygenases; Mutagens; Nitrosamines; Transfection | 1991 |
Formation of genotoxic products from N-nitrosoheptamethyleneimine (NHMI), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) by isolated rabbit lung cells.
Topics: Animals; Biotransformation; DNA Repair; In Vitro Techniques; Lung; Male; Mutagens; Nitrosamines; Nitroso Compounds; Rabbits | 1990 |
Effect of nicotine and tobacco-specific nitrosamines on the metabolism of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by rat oral tissue.
Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Mouth; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Radioisotope Dilution Technique; Rats; Rats, Inbred F344; Tritium | 1990 |
Tobacco-specific nitrosamines in Canadian cigarettes.
Topics: Canada; Carcinogens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic | 1990 |
Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes.
Topics: Carcinogens; Nicotiana; Nicotine; Nitrates; Nitrosamines; Plants, Toxic; Smoke | 1990 |
Comparative metabolism of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured F344 rat oral tissue and esophagus.
Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Esophagus; Kinetics; Male; Mouth; Nitrosamines; Rats; Rats, Inbred F344; Tritium | 1990 |
Mass spectrometric analysis of tobacco-specific nitrosamine hemoglobin adducts in snuff dippers, smokers, and nonsmokers.
Topics: Adult; Carcinogens; Cotinine; Female; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Male; Nicotiana; Nitrosamines; Plants, Toxic; Smoking; Tobacco, Smokeless | 1990 |
Immunoassays for proteins alkylated by nicotine-derived N-nitrosamines.
Topics: Animals; Carcinogens; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Immunoassay; Immunoblotting; Isoelectric Focusing; Killer Cells, Natural; Nicotine; Nitrosamines; Proteins | 1990 |
Effects of tobacco-specific nitrosamines and snuff extract on cell proliferation and activities of ornithine decarboxylase and aryl hydrocarbon hydroxylase in mouse tongue primary epithelial cell cultures.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cell Division; Cells, Cultured; Epithelium; Mice; Mice, Inbred BALB C; Mouth Neoplasms; Nicotiana; Nitrosamines; Ornithine Decarboxylase; Plants, Toxic; Tobacco, Smokeless; Tongue | 1989 |
Antimutagenic effects of betel leaf extract against the mutagenicity of two tobacco-specific N-nitrosamines.
Topics: Animals; Areca; Male; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Mutation; Nitrosamines; Plant Extracts; Plants, Medicinal | 1989 |
Mutagenic and cytogenetic studies of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Adult; Animals; Bone Marrow; Chromosome Aberrations; Female; Humans; Lymphocytes; Male; Micronucleus Tests; Mutagenicity Tests; Nitrosamines; Salmonella typhimurium; Sister Chromatid Exchange | 1989 |
Carcinogenicity studies on the two tobacco-specific N-nitrosamines, N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Body Weight; Carcinogens; Cricetinae; Diet; Hydrogen Peroxide; Mesocricetus; Mice; Mice, Inbred Strains; Mouth Neoplasms; Nitrosamines; Survival Analysis; Vitamin A Deficiency | 1989 |
Anticarcinogenic effect of betel leaf extract against tobacco carcinogens.
Topics: Animals; Areca; Ascorbic Acid; Benzo(a)pyrene; Carcinogens; Drug Interactions; Liver; Male; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Plant Extracts; Plants, Medicinal; Plants, Toxic; Stomach Neoplasms; Tobacco, Smokeless; Vitamin A | 1989 |
Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA.
Topics: Animals; Carcinogens; DNA; Environmental Monitoring; Hemoglobins; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Smoke | 1988 |
The occurrence of tobacco-specific nitrosamines in oral tobacco products and their potential formation under simulated gastric conditions.
Topics: Carcinogens; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Nicotiana; Nitrosamines; Plants, Toxic | 1988 |
Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; DNA; Hydrogen-Ion Concentration; Hydroxylation; Liver; Lung; Male; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344 | 1988 |
Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.
Topics: Animals; Gas Chromatography-Mass Spectrometry; Hemoglobins; Male; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Tritium | 1987 |
Effect of snuff and nicotine on DNA methylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; DNA; Guanine; Liver; Lung; Male; Mathematics; Methylation; Mouth; Nasal Mucosa; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Tobacco, Smokeless | 1987 |
Investigations on the molecular dosimetry of tobacco-specific N-nitrosamines.
Topics: Animals; DNA; Guanine; Hemoglobins; Humans; Liver; Lung; Mutagenicity Tests; Nasal Mucosa; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Tobacco, Smokeless | 1987 |
N-nitroso compounds as a cause of human cancer.
Topics: Adult; China; Epidemiologic Methods; Esophageal Neoplasms; Female; Humans; Nasopharyngeal Neoplasms; Neoplasms; Nicotiana; Nitrosamines; Nitroso Compounds; Plants, Toxic; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Tobacco Smoke Pollution; Tobacco, Smokeless | 1987 |
Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff.
Topics: Animals; Carcinogens; Herpes Simplex; Male; Mouth Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Tobacco, Smokeless | 1986 |
Transfer of the tobacco-specific carcinogens N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene into the milk of lactating rats.
Topics: Animals; Benzo(a)pyrene; Carbon Radioisotopes; Carcinogens; Female; Lactation; Milk; Nicotiana; Nitrosamines; Plants, Toxic; Pregnancy; Rats; Rats, Inbred Strains; Smoking | 1987 |
Nicotine: a precursor for carcinogens.
Topics: Animals; Biotransformation; Carcinogens; Cotinine; Humans; Lung Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Smoking | 1985 |
New aspects of tobacco carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Catechols; Humans; Lung Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic; Smoking; Tobacco Smoke Pollution; Tritium | 1985 |
On the pharmacokinetics of tobacco-specific N-nitrosamines in Fischer rats.
Topics: Animals; Half-Life; Kinetics; Male; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344 | 1985 |
High-performance liquid chromatographic analysis of metabolites of the nicotine-derived nitrosamines, N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Culture Techniques; Esophagus; Hydrogen-Ion Concentration; Liver; Nitrosamines; Rats; Solvents; Spectrophotometry, Ultraviolet | 1985 |
Pharmacokinetics of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in laboratory animals.
Topics: Animals; Carcinogens; Cricetinae; Half-Life; Kinetics; Male; Mesocricetus; Mice; Mice, Inbred Strains; Nitrosamines; Papio; Rats; Rats, Inbred F344; Species Specificity | 1985 |
Accumulation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in alkaloid genotypes of burley tobacco during postharvest processing: comparisons with N'-nitrosonornicotine and probable nitrosamine precursors.
Topics: Alkaloids; Carcinogens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Time Factors | 1985 |
Metabolism and tissue distribution of tobacco-specific N-nitrosamines in the marmoset monkey (Callithrix jacchus).
Topics: Animals; Autoradiography; Callithrix; Carbon Radioisotopes; Carcinogens; Computers; Densitometry; DNA; Lung Neoplasms; Male; Methylation; Nitrosamines; Species Specificity; Tissue Distribution | 1985 |
Epidemiological and experimental studies on tobacco-related oral cancer in India.
Topics: Animals; Carcinogens; Female; Humans; India; Male; Mice; Mice, Inbred Strains; Mouth Neoplasms; Mutagenicity Tests; Mutagens; Nicotiana; Nitrosamines; Pharyngeal Neoplasms; Plants, Toxic; Salmonella typhimurium; Smoking | 1984 |
Pharmacokinetics of tobacco-specific N-nitrosamines.
Topics: Animals; Carcinogens; Cricetinae; Kinetics; Male; Mesocricetus; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344 | 1984 |
A study of betel quid carcinogenesis. II. Formation of N-nitrosamines during betel quid chewing.
Topics: Animals; Areca; Arecoline; Biological Assay; Carcinogens; Humans; Mastication; Nitrosamines; Nitroso Compounds; Plants, Medicinal; Rats; Rats, Inbred F344; Saliva | 1984 |
Metabolism of tobacco-specific N-nitrosamines by cultured human tissues.
Topics: Biotransformation; Cells, Cultured; Humans; Nicotiana; Nitrosamines; Plants, Toxic; Tissue Distribution | 1983 |
Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Male; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344 | 1984 |
Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues.
Topics: Animals; Autoradiography; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Lung; Male; Mice; Nitrosamines | 1983 |
Metabolism of tobacco-specific nitrosamines by cultured rat nasal mucosa.
Topics: Animals; Carbon Radioisotopes; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Kinetics; Male; Nasal Mucosa; Nicotiana; Nitrosamines; Organ Culture Techniques; Plants, Toxic; Rats; Rats, Inbred F344 | 1983 |
Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers.
Topics: Adult; Alkaloids; Denmark; Germany, West; Humans; Male; Middle Aged; Mouth Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines; Saliva; Sweden; Tobacco, Smokeless; United States | 1981 |
Metabolism of the tobacco specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Biotransformation; Hydroxylation; Liver; Microsomes; Nicotiana; Nicotine; Nitrosamines; Oxidation-Reduction; Plants, Toxic; Pyridines; Rats | 1980 |
Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in Syrian golden hamsters.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cricetinae; Feces; Female; Injections, Subcutaneous; Lung Neoplasms; Male; Mesocricetus; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines | 1981 |
Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines; Rats; Rats, Inbred F344 | 1980 |
Antimutagenicity of cyclohexanol towards 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone and N-nitrosodiethylamine in Salmonella typhimurium strain TA100.
Topics: Antimutagenic Agents; Cyclohexanols; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Induction; Liver Extracts; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nitrosamines; Salmonella typhimurium; Suppression, Genetic | 1993 |
Lipid peroxidation and ethanol-related tumor promotion in Fischer-344 rats treated with tobacco-specific nitrosamines.
Topics: Alcoholism; Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Esophagus; Glutathione; Lipid Metabolism; Lipid Peroxidation; Liver; Lung; Male; Malondialdehyde; Neoplasms, Experimental; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Vitamin E | 1994 |
Effects of nicotine and tobacco-specific nitrosamines on hamster cheek pouch and gastric mucosa.
Topics: Animals; Carcinogens; Cheek; Cricetinae; Drug Synergism; Epithelium; Gastric Mucosa; Hyperplasia; Keratosis; Leukoplakia, Oral; Male; Mesocricetus; Mouth Mucosa; Nicotine; Nitrosamines; Papilloma; Plants, Toxic; Tobacco, Smokeless | 1994 |
Comparison of co-cultivation of V79 cells with rat hepatocytes and rat H4IIE hepatoma cells for studying nitrosamine-induced hprt gene mutations.
Topics: Animals; Biotransformation; Cells, Cultured; Cricetinae; Cricetulus; Culture Techniques; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Fibroblasts; Genes; Hypoxanthine Phosphoribosyltransferase; Liver; Liver Neoplasms, Experimental; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Wistar; Tumor Cells, Cultured | 1994 |
Tobacco-specific nitrosamine-hemoglobin adducts.
Topics: Animals; Butanones; Carcinogens; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Nicotiana; Nitrosamines; Plants, Toxic; Pyridines | 1994 |
Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study.
Topics: Adult; Cotinine; Glucuronates; Glucuronic Acid; Humans; Leukoedema, Oral; Male; Middle Aged; Mouth Diseases; Mouth Mucosa; Nicotine; Nitrosamines; Plants, Toxic; Saliva; Sweden; Tobacco, Smokeless | 1994 |
Biomonitoring of hemoglobin adducts: aromatic amines and tobacco-specific nitrosamines.
Topics: Aminobiphenyl Compounds; Animals; Butanones; Cotinine; Hemoglobinometry; Hemoglobins; Humans; Nicotiana; Nitrosamines; Plants, Toxic; Pyridines; Rats; Smoking; Tobacco, Smokeless | 1994 |
Evidence supporting the role of DNA pyridyloxobutylation in rat nasal carcinogenesis by tobacco-specific nitrosamines.
Topics: Alkylation; Animals; Butanones; Carcinogens; Deuterium; DNA Damage; DNA, Neoplasm; Guanine; Male; Nasal Cavity; Nitrosamines; Nose Neoplasms; Olfactory Mucosa; Oxidation-Reduction; Pyridines; Rats; Rats, Inbred F344 | 1994 |
Effects of ethanol treatment on DNA damage induced in Escherichia coli K-12 in various organs of mice by N-nitro-sonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosopyrrolidine.
Topics: Animals; Biotransformation; Blood; DNA Damage; DNA Repair; Escherichia coli; Ethanol; Kidney; Liver; Lung; Male; Mice; Mutagenicity Tests; N-Nitrosopyrrolidine; Nitrosamines; Spleen | 1994 |
Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans.
Topics: Animals; Biomarkers; Carcinogens; DNA; DNA Damage; Hemoglobins; Humans; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Smoking; Tobacco, Smokeless | 1993 |
A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumours in A/J mice.
Topics: Adenoma; Animals; Female; Lung Neoplasms; Mice; N-Nitrosopyrrolidine; Nicotiana; Nitrosamines; Nitroso Compounds; Plants, Toxic; Smoke; Structure-Activity Relationship | 1993 |
Smoking-related DNA adducts: 32P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA.
Topics: Adult; Aged; Bronchi; Carcinogens; DNA; DNA Damage; Female; Guanine; Humans; Lymphocytes; Male; Middle Aged; Nitrosamines; Phosphorus Radioisotopes; Smoking | 1993 |
Oxygen radicals potentiate the genetic toxicity of tobacco-specific nitrosamines.
Topics: Carcinogens; Cells, Cultured; DNA Damage; DNA, Single-Stranded; Drug Synergism; Fetus; Fibroblasts; Free Radical Scavengers; Free Radicals; Humans; Lung; Mutagens; Nicotiana; Nicotine; Nitrosamines; Nucleic Acid Denaturation; Plants, Toxic; Reactive Oxygen Species | 1993 |
Morphologic and growth effects of tobacco-associated chemical carcinogens and smokeless tobacco extracts on human oral epithelial cells in culture.
Topics: Analysis of Variance; Carcinogens; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Humans; Immunophenotyping; Mouth Mucosa; Nitrosamines; Plants, Toxic; Tobacco, Smokeless | 1993 |
Intragastric nitrosation of nicotine is not a significant contributor to nitrosamine exposure.
Topics: Butanones; Carcinogens; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Models, Biological; Nicotine; Nitrosamines; Nitrosation; Sodium Nitrite; Stomach | 1993 |
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.
Topics: Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isothiocyanates; Microsomes, Liver; Nitrosamines; Oxidoreductases; Substrate Specificity | 1996 |
Inhibition of mutagenicity of N-nitrosamines by tobacco smoke and its constituents.
Topics: Animals; Antimutagenic Agents; CHO Cells; Cotinine; Cricetinae; Dimethylnitrosamine; Dose-Response Relationship, Drug; Nicotine; Nitrosamines | 1996 |
p53 mutations in head and neck squamous cell carcinomas from Sudanese snuff (toombak) users.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Genes, p53; Genes, ras; Head and Neck Neoplasms; Humans; Mice; Mutation; Nitrosamines; Plants, Toxic; Polymorphism, Single-Stranded Conformational; Tobacco, Smokeless | 1996 |
A study of tobacco carcinogenesis, LIII: carcinogenicity of N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mink (Mustela vison).
Topics: Age Factors; Animals; Body Weight; Carcinogens; Female; Lethal Dose 50; Male; Mink; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms | 1997 |
Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
Topics: Benzo(a)pyrene; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Nicotiana; Nitrosamines; Plants, Toxic | 1997 |
Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite.
Topics: Alkaloids; Animals; Biotransformation; Drug Synergism; Glucuronates; Male; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plants, Toxic; Rats; Rats, Inbred F344; Sodium Nitrite | 1997 |
Immunotoxic effects of smokeless tobacco on the accessory cell function of rat oral epithelium.
Topics: Alkaloids; Anabasine; Animals; Antigen-Presenting Cells; Carcinogens; Cell Division; Concanavalin A; Epithelial Cells; Epithelium; Immunosuppressive Agents; Langerhans Cells; Lymphocyte Activation; Mitogens; Mouth Mucosa; Nicotine; Nitrosamines; Nitroso Compounds; Plant Extracts; Plant Lectins; Plants, Toxic; Rats; Rats, Inbred Lew; Spleen; T-Lymphocytes; Tobacco, Smokeless | 1997 |
The carcinogenic potential of the gas phase of environmental tobacco smoke.
Topics: Animals; Benzo(a)pyrene; Carcinogens, Environmental; Female; Lung; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Plants, Toxic; Smoke | 1997 |
Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage.
Topics: Animals; Carcinogens; Cells, Cultured; DNA Damage; DNA Methylation; DNA Repair; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Nitrosamines; Nucleic Acid Synthesis Inhibitors; Pyridines; Rats; Rats, Inbred F344; Tobacco Smoke Pollution; Topoisomerase I Inhibitors | 1998 |
Characterization of xenobiotic-metabolizing enzymes and nitrosamine metabolism in the human esophagus.
Topics: Adult; Dimethylnitrosamine; Enzyme Inhibitors; Enzymes; Esophagus; Female; Humans; Male; Microsomes; Middle Aged; Nitrosamines; Xenobiotics | 1998 |
Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells.
Topics: Adenocarcinoma; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Carcinogens; Carcinoma, Small Cell; Cell Division; Humans; Kinetics; Ligands; Lung Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic; Pyridines; Receptors, Nicotinic; Tumor Cells, Cultured | 1998 |
Evaluation of the effect of smokeless tobacco purified products and extracts on latent Epstein-Barr virus.
Topics: Benzo(a)pyrene; Cell Line; Cell Survival; Flow Cytometry; Herpesvirus 4, Human; Humans; Nitrosamines; Plant Extracts; Plants, Toxic; Tetradecanoylphorbol Acetate; Tobacco, Smokeless; Virus Activation | 1999 |
Mutagenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosonornicotine in lacZ upper aerodigestive tissue and liver and inhibition by green tea.
Topics: Animals; Antimutagenic Agents; Carcinogens; Esophagus; Female; Lac Operon; Liver; Lung; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mouth; Mutagenesis; Nasal Cavity; Nitrosamines; Organ Specificity; Tea; Tongue | 2001 |
Tobacco industry must not dump its high nitrosamine tobacco on poor countries.
Topics: Adenocarcinoma; Carcinogens; Developing Countries; Humans; Lung Neoplasms; Nitrosamines; Smoking; Tobacco Industry; United States | 2001 |
Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines.
Topics: Chromatography, High Pressure Liquid; Glucuronides; Magnetic Resonance Spectroscopy; Nicotiana; Nitrosamines; Plants, Toxic; Pyridines | 2001 |
Bacterial mutagenicity of some tobacco aromatic nitrogen bases and their mixtures.
Topics: Animals; Carcinogens; Cotinine; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Vibrio | 2001 |
Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco.
Topics: Carcinogens; Chromatography, Gas; Moldova; Nicotiana; Nitrosamines; United States | 2002 |
[Cancer from snuff?].
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Europe; Humans; Nitrosamines; Otorhinolaryngologic Neoplasms; Risk; Tobacco, Smokeless | 2003 |
Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch.
Topics: Animals; Carcinogens; Cell Survival; Cells, Cultured; Chromatin; Cricetinae; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Mesocricetus; Mouth Mucosa; Nicotine; Nitrosamines; Oxidative Stress; Peroxynitrous Acid; Tobacco, Smokeless; Tyrosine | 2004 |
Tobacco-specific nitrosamines in smokeless tobacco products marketed in India.
Topics: Carcinogens; Humans; India; Nicotine; Nitrates; Nitrites; Nitrosamines; Tobacco, Smokeless | 2005 |
Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis.
Topics: Alcohol Drinking; Bicarbonates; Duodenum; Exocrine Pancreatic Insufficiency; Gastric Acid; Humans; Hydrogen-Ion Concentration; Inflammation; Nitrosamines; Pancreas; Pancreatic Neoplasms; Pancreatitis, Chronic; Postprandial Period; Proton Pump Inhibitors; Proton Pumps; Risk Factors; Secretin; Smoking; Water | 2005 |
Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells.
Topics: Apoptosis; Carcinogens; Cell Cycle; Cells, Cultured; Epithelial Cells; Esophagus; GATA3 Transcription Factor; Humans; NF-kappa B; Nicotiana; Nitrosamines; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor | 2006 |
The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells.
Topics: Anticarcinogenic Agents; Binding Sites; Bungarotoxins; Cell Proliferation; Cells, Cultured; GATA3 Transcription Factor; Humans; Lung; NF-kappa B; Nicotiana; Nicotinic Antagonists; Nitrosamines; Proliferating Cell Nuclear Antigen; Protein Subunits; Proto-Oncogene Proteins c-bcl-2; Receptors, Nicotinic; STAT1 Transcription Factor; Transcription, Genetic; Up-Regulation | 2006 |
Development of a commercial cigarette "market map" comparison methodology for evaluating new or non-conventional cigarettes.
Topics: Animals; Cell Line; Embryo, Mammalian; Lead; Marketing; Mice; Mutagenicity Tests; Nicotiana; Nitrosamines; Predictive Value of Tests; Reference Standards; Reference Values; Regression Analysis; Smoke; Tars; Toxicity Tests; United States | 2006 |
A new method for estimating the retention of selected smoke constituents in the respiratory tract of smokers during cigarette smoking.
Topics: Acetaldehyde; Adult; Breath Tests; Butadienes; Carbon Monoxide; Ethylenes; Hemiterpenes; Humans; Male; Nicotiana; Nitrosamines; Pentanes; Plants, Toxic; Respiratory Function Tests; Smoke; Smoking | 2007 |
SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes.
Topics: Adaptor Proteins, Signal Transducing; Antigens, Ly; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Gene Expression; GPI-Linked Proteins; Humans; Immunoblotting; Keratinocytes; Membrane Glycoproteins; Mouth Mucosa; Nitrosamines; Protein Isoforms; Receptors, Nicotinic; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Transfection; Urokinase-Type Plasminogen Activator | 2007 |
Functional characterization of CYP2A13 polymorphisms.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Carcinogens; Coumarins; Humans; Hydroxylation; Nitrosamines; Polymorphism, Genetic; Sequence Deletion | 2007 |
Evaluation of the mutagenic effects of myosmine in human lymphocytes using the HPRT gene mutation assay.
Topics: Alkaloids; DNA Damage; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Mutagenicity Tests; Mutation; Nitrosamines | 2009 |
Effect of CYP2A13 active site mutation N297A on metabolism of coumarin and tobacco-specific nitrosamines.
Topics: Aryl Hydrocarbon Hydroxylases; Catalytic Domain; Chromatography, High Pressure Liquid; Coumarins; Models, Molecular; Mutagenesis, Site-Directed; Nicotiana; Nitrosamines; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2009 |
Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data.
Topics: Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Humans; Inhalation Exposure; Lung Neoplasms; Male; Monte Carlo Method; Nitrosamines; Risk Assessment; Smoke; Smoking; United States | 2009 |
Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers.
Topics: Carcinogens; Humans; Nicotiana; Nitrosamines; Pyridines; Smoke; Smoking | 2009 |
Major tobacco companies have technology to reduce carcinogen levels but do not apply it to popular smokeless tobacco products.
Topics: Carcinogens; Humans; Nitrosamines; Tobacco Industry; Tobacco, Smokeless | 2011 |
[Determination of four carcinogens in mainstream cigarette smoke by liquid chromatography-tandem mass spectrometry].
Topics: Carcinogens; Chromatography, Liquid; Nicotiana; Nitrosamines; Smoke; Tandem Mass Spectrometry | 2010 |
Chemical analysis of Alaskan Iq'mik smokeless tobacco.
Topics: Alaska; Benzo(a)pyrene; Humans; Hydrogen-Ion Concentration; Inuit; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Tobacco, Smokeless | 2013 |
TSNA levels in machine-generated mainstream cigarette smoke: 35 years of data.
Topics: Nicotiana; Nitrosamines; Smoke; Tobacco Smoke Pollution | 2013 |
Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK.
Topics: Administration, Inhalation; Carcinogens; Cotinine; Dust; Environmental Exposure; Humans; Nicotiana; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Skin Absorption; Smoking; Tobacco Smoke Pollution | 2014 |
Genotoxicity evaluation of individual cigarette smoke toxicants using the in vitro γH2AX assay by high content screening.
Topics: Benzo(a)pyrene; Bronchi; Cadmium; Cell Line; Epithelial Cells; Histones; Humans; Mutagenicity Tests; Nicotiana; Nitrosamines; Smoke | 2013 |
Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites.
Topics: Animals; Asian People; Case-Control Studies; China; Cohort Studies; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Molecular Structure; Multivariate Analysis; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Rats; Risk Factors; Smoking | 2014 |
In vitro exposure of tobacco specific nitrosamines decreases the rat lung phospholipids by enhanced phospholipase A2 activity.
Topics: Animals; Lung; Male; Nicotiana; Nitrosamines; Phospholipases A2; Phospholipids; Rats, Wistar | 2014 |
Identification of precursors and mechanisms of tobacco-specific nitrosamine formation in water during chloramination.
Topics: Alkaloids; Chloramines; Chromatography, Liquid; Drinking Water; Halogenation; Mass Spectrometry; Nicotiana; Nicotine; Nitrosamines; Pyridines; Solid Phase Extraction; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2015 |
Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users.
Topics: Air Pollution, Indoor; Alkaloids; Carcinogens; Child; Chromatography, Liquid; Dust; Humans; Nicotiana; Nitrosamines; Tandem Mass Spectrometry; Tobacco Smoke Pollution; Tobacco, Smokeless | 2015 |
Molecularly imprinted polymers on a silica surface for the adsorption of tobacco-specific nitrosamines in mainstream cigarette smoke.
Topics: Adsorption; Carcinogens; Mass Spectrometry; Microscopy, Electron, Scanning; Nicotiana; Nitrosamines; Polymers; Reproducibility of Results; Silicon Dioxide; Smoke; Smoking; Spectroscopy, Fourier Transform Infrared; Tobacco Products | 2015 |
Five-year yield variation in N-nitrosonornicotine and (4-methylnitrosoamino)-1-(3-pyridyl)-1-butanone from the smoke of commercial cigarette brands on the Japanese market.
Topics: Japan; Nitrosamines; Quality Control; Smoke; Smoking; Time Factors; Tobacco Products | 2015 |
Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.
Topics: Activation, Metabolic; Animals; Biomarkers, Tumor; Carcinogens; Humans; Lung Neoplasms; Mouth Neoplasms; Nitrosamines; Rats; Smoking; Tobacco Products | 2016 |
Tobacco-specific N-nitrosamines NNN and NNK levels in cigarette brands between 2000 and 2014.
Topics: Agriculture; Commerce; Consumer Product Safety; Humans; Nicotiana; Nitrosamines; Risk Assessment; Smoke; Smoking; Time Factors; Tobacco Products; Tobacco Smoke Pollution | 2016 |
In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa.
Topics: Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Lung; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plant Leaves; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Tobacco, Smokeless | 2016 |
A Model To Estimate the Sources of Tobacco-Specific Nitrosamines in Cigarette Smoke.
Topics: Carcinogenesis; Gases; Humans; Models, Chemical; Nicotiana; Nicotine; Nitrosamines; Smoking; Temperature | 2017 |
Development of a Cigarette Tobacco Filler Standard Reference Material.
Topics: Chromatography, High Pressure Liquid; Freezing; Gas Chromatography-Mass Spectrometry; Nicotine; Nitrosamines; Phase Transition; Reference Standards; Tandem Mass Spectrometry; Tobacco Products; Volatile Organic Compounds | 2017 |
A simple and highly sensitive UPLC-ESI-MS/MS method for the simultaneous quantification of nicotine, cotinine, and the tobacco-specific carcinogens N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in serum samples.
Topics: Carcinogens; Chromatography, High Pressure Liquid; Cotinine; Drug Stability; Humans; Limit of Detection; Linear Models; Nicotine; Nitrosamines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2018 |
Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model.
Topics: A549 Cells; Benzo(a)pyrene; Biological Assay; Cell Survival; Histones; Humans; Models, Biological; Nicotine; Nitrosamines; Smoke; Tobacco Products | 2018 |
Use of autoclave extraction-supercritical fluid chromatography/tandem mass spectrometry to analyze 4-(methylintrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in tobacco.
Topics: Carcinogens; Chemistry Techniques, Analytical; Chromatography, Supercritical Fluid; Nicotiana; Nitrosamines; Tandem Mass Spectrometry | 2019 |