Compounds > 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone
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4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and methoxsalen

4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with methoxsalen in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (85.71)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ikeda, M; Imaida, K; Kamataki, T; Maeta, H; Miyazaki, M; Saoo, K; Takeuchi, H; Yamazaki, H; Yokohira, M1
Djordjevic, MV; Ramamoorthy, Y; Sellers, EM; Tyndale, RF; Zeman, MV1
Fujieda, M; Imaida, K; Kamataki, T; Matsuda, Y; Miyazaki, M; Saoo, K; Takeuchi, H; Yamakawa, K; Yokohira, M; Zeng, Y1
Funae, Y; Imaida, K; Kamataki, T; Masumura, K; Miyazaki, M; Nohmi, T; Saoo, K; Takeuchi, H; Yamazaki, H; Yokohira, M1
D'Agostino, J; Ding, X; Murphy, SE; von Weymarn, L; Wu, H; Zhang, QY; Zhang, X1
Hashimoto, N; Imaida, K; Kuno, T; Matsuda, Y; Saoo, K; Suzuki, S; Yamakawa, K; Yokohira, M1
Cao, B; Feng, M; Liu, S; Mao, J; Zhang, H; Zhang, Q1

Trials

1 trial(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and methoxsalen

ArticleYear
The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003, Volume: 5, Issue:6

    Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Female; Ganglionic Stimulants; Humans; Injections, Subcutaneous; Male; Methoxsalen; Mixed Function Oxygenases; Nicotine; Nitrosamines; Placebos; Smoking

2003

Other Studies

6 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and methoxsalen

ArticleYear
Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
    Cancer research, 2003, Nov-15, Volume: 63, Issue:22

    Topics: Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Female; Lung Neoplasms; Methoxsalen; Mice; Mice, Inbred A; Mixed Function Oxygenases; Nitrosamines

2003
Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.
    Cancer letters, 2006, Mar-28, Volume: 234, Issue:2

    Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Female; Gene Expression; Humans; Lung Neoplasms; Methoxsalen; Mice; Mixed Function Oxygenases; Nitrosamines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroid Hydroxylases

2006
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
    Carcinogenesis, 2005, Volume: 26, Issue:11

    Topics: Adenoma; Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Carcinogens; Chemoprevention; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Escherichia coli Proteins; Female; Humans; Lung Neoplasms; Methoxsalen; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microsomes; Mixed Function Oxygenases; Mutation; Nitrosamines; Pentosyltransferases; Proteins; Salmonella typhimurium; Steroid Hydroxylases

2005
CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cytochrome P-450 CYP2A6; Female; Humans; Hydroxylation; Lung; Male; Methoxsalen; Microsomes; Middle Aged; Mixed Function Oxygenases; NADP; Nitrosamines; RNA, Messenger

2007
Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice.
    Oncology reports, 2008, Volume: 20, Issue:4

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Disease Progression; Enzyme Inhibitors; Female; Lung Neoplasms; Methoxsalen; Mice; Neoplasm Staging; Nitrosamines

2008
Effects of 8-methoxypsoralen on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
    Drug metabolism and pharmacokinetics, 2015, Volume: 30, Issue:4

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogenesis; Carcinogens; Catalysis; Coumarins; Cytochrome P450 Family 2; Female; Hydroxylation; Imidazoles; Methoxsalen; Mice; Mice, Inbred C57BL; Nitrosamines

2015