4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with guanine in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (23.53) | 18.7374 |
| 1990's | 15 (29.41) | 18.2507 |
| 2000's | 15 (29.41) | 29.6817 |
| 2010's | 9 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castonguay, A; Gerson, SL; Liu, L | 1 |
| Amin, SG; Chung, FL; Han, C; Ho, CT; Xu, Y | 1 |
| Chung, FL; Eklind, KI; Hecht, SS; Morse, MA | 1 |
| Hecht, SS; Peterson, LA | 1 |
| Anderson, MW; Belinsky, SA; Foley, JF; Maronpot, RR; White, CM | 1 |
| Choi, CI; Hecht, SS; Jordan, KG; Trushin, N | 1 |
| Murphy, SE | 1 |
| Alaoui-Jamali, MA; Castonguay, A; Rossignol, G; Schuller, HM | 1 |
| Anderson, MW; Belinsky, SA; Dolan, ME; Maronpot, RR; Pegg, AE; White, CM | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR | 1 |
| Hecht, SS; Trushin, N | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; White, CM | 1 |
| Adams, JD; Hoffmann, D; LaVoie, EJ; Prokopczyk, G | 1 |
| Carmella, SG; Chung, FL; Foiles, PG; Hecht, SS; Lin, D; Rubin, JM; Trushin, N | 1 |
| Anderson, MW; Belinsky, SA; Swenberg, JA | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Swenberg, JA; White, CM | 1 |
| Castonguay, A; Hecht, SS; Rivenson, A; Trushin, N | 1 |
| Anderson, M; Belinsky, SA; Boucheron, JA; Richardson, FC; Swenberg, JA; White, CM | 1 |
| den Engelse, L; Feron, VJ; Leeman, WR; Scherer, E; Van Benthem, J; Vermeulen, E; Wilmer, JW | 1 |
| Gradia, S; Hecht, SS; Peterson, LA; Ronai, ZA | 1 |
| Bianchini, F; Wild, CP | 1 |
| Hecht, SS; Rivenson, A; Trushin, N | 1 |
| Hemminki, K; Mustonen, R; Schoket, B | 1 |
| Hecht, SS; Liu, XK; Peterson, LA | 1 |
| Morse, MA; Stoner, GD | 1 |
| Horikawa, S; Ichikawa, T; Kishimoto, M; Nakamura, T; Yajima, S; Yano, T | 1 |
| Ayres, PH; Brown, BG; Chang, CJ; Doolittle, DJ; Lee, CK | 1 |
| Ichikawa, T; Kishimoto, M; Kumagai, H; Otani, S; Sakurai, H; Virgona, N; Yajima, S; Yano, T; Yano, Y | 1 |
| Amin, S; Anderson, LM; Chhabra, SK; Desai, D; Kyrtopoulos, SA; Perella, C; Souliotis, VL | 1 |
| Crankshaw, DL; Donaldson, EE; Kenney, PJ; Peterson, LA; Thomson, NM | 1 |
| Ayres, PH; Brown, BG; Doolittle, DJ; Richter, E; Tricker, AR | 1 |
| Kenney, PM; Peterson, LA; Thomson, NM | 1 |
| Jones, R; Shallop, A; Tretyakova, N; Ziegel, R | 1 |
| Hecht, SS; Jalas, JR; Kenney, PM; McIntee, EJ; Peterson, LA; Upadhyaya, P | 1 |
| Jones, R; Shallop, A; Tretyakova, N; Upadhyaya, P; Ziegel, R | 1 |
| Fang, Q; Fleischer, NL; Kanugula, S; Mijal, RS; Moschel, RC; Pauly, GT; Pegg, AE; Peterson, LA; Thomson, NM | 1 |
| Jones, R; Rajesh, M; Tretyakova, N; Wang, G | 1 |
| Hu, ML; Huang, CS; Wang, WY; Yeh, SL | 1 |
| Angel, KC; Choi, JY; Chowdhury, G; Guengerich, FP; Peterson, LA; Vu, CC; Zang, H | 1 |
| Behr, M; Ding, X; Fang, C; Kaminsky, LS; Turesky, RJ; Weng, Y | 1 |
| Chang, LW; Chung, CJ; Hsieh, DP; Hsueh, YM; Lee, HL; Lin, P; Liou, SH; Pu, YS | 1 |
| Hecht, SS; Lindgren, BR; Upadhyaya, P | 1 |
| Kassie, F; Modiano, JF; Murphy, SE; Schutten, MM; von Weymarn, LB | 1 |
| Cao, Q; Peterson, LA; Upadhyaya, P; Urban, AM | 1 |
| Kanugula, S; Kassie, F; Koopmeiners, JS; Kotandeniya, D; Murphy, D; Park, S; Pegg, A; Seneviratne, U; Tretyakova, N; Yan, S | 1 |
| Ding, X; Liu, Z; Megaraj, V; Xie, F; Yang, W; Zhou, X | 1 |
| Chao, MR; Chen, JL; Hsu, YW; Hu, CW; Tam, LM | 1 |
| Balbo, S; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Balbo, S; Grill, AE; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Peterson, LA; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Hecht, SS; Leitzman, P; Narayanapillai, SC; O'Sullivan, MG; Puppala, M; Sun, H; Upadhyaya, P; Xing, C | 1 |
| Garden, JL; Wetmore, NT; Wetmore, SD; Wilson, KA | 1 |
51 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and guanine
| Article | Year |
|---|---|
Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; Cells, Cultured; Cricetinae; DNA; Guanine; Liver; Liver Neoplasms; Male; Mesocricetus; Methylation; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344 | 1992 |
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Caffeine; Carcinogens; Catechin; Deoxyguanosine; DNA; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Tea | 1992 |
Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates.
Topics: Animals; Carcinogens; DNA; Guanine; Isothiocyanates; Mice; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiocyanates | 1991 |
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Female; Guanine; Hydroxylation; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1991 |
Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cell Line; DNA; Dose-Response Relationship, Drug; Guanine; Hyperplasia; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Metaplasia; Methylation; Microscopy, Electron; Nitrosamines; Nose Neoplasms; Olfactory Mucosa; Rats; Rats, Inbred F344 | 1990 |
Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice.
Topics: Adenoma; Animals; Carcinogens; Deuterium; DNA; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Structure-Activity Relationship | 1990 |
DNA isolation from small tissue samples using anion-exchange HPLC.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA; Guanine; Indicators and Reagents; Lymphocytes; Male; Methylation; Microchemistry; Nitrosamines; Organ Specificity; Rats; Rats, Inbred F344 | 1989 |
Metabolism and DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in fetal tissues of the Syrian golden hamster.
Topics: Alkylating Agents; Animals; Chromosome Aberrations; Cricetinae; Culture Techniques; DNA Damage; Female; Fetus; Guanine; Lung; Maternal-Fetal Exchange; Methylation; Nitrosamines; Placenta; Pregnancy; Trachea | 1989 |
Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells.
Topics: Animals; DNA Repair; Guanine; Kinetics; Lung; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1988 |
Factors regulating activation and DNA alkylation by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and nitrosodimethylamine in rat lung and isolated lung cells, and the relationship to carcinogenicity.
Topics: Alkylation; Animals; Antibodies; Benzoflavones; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Isoenzymes; Lung; Methylation; Nitrosamines; Rats | 1988 |
DNA and hemoglobin alkylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.
Topics: Alkylating Agents; Animals; Biotransformation; Chromatography, High Pressure Liquid; DNA; DNA Damage; Guanine; Hemoglobins; Hydroxylation; Liver; Lung; Nasal Mucosa; Nitrosamines; Rats; Rats, Inbred F344; Time Factors | 1988 |
DNA adducts as a dosimeter for risk estimation.
Topics: Alkylation; Animals; Carcinogens; DNA; DNA Damage; Dose-Response Relationship, Drug; Guanine; Lung; Nasal Mucosa; Nitrosamines; Rats; Rats, Inbred F344; Respiratory Tract Neoplasms; Risk | 1987 |
Effect of snuff and nicotine on DNA methylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; DNA; Guanine; Liver; Lung; Male; Mathematics; Methylation; Mouth; Nasal Mucosa; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Tobacco, Smokeless | 1987 |
Investigations on the molecular dosimetry of tobacco-specific N-nitrosamines.
Topics: Animals; DNA; Guanine; Hemoglobins; Humans; Liver; Lung; Mutagenicity Tests; Nasal Mucosa; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Tobacco, Smokeless | 1987 |
Molecular dosimetry of O6-methylguanine formation and cell toxicity in lung and nasal mucosa by 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Guanine; Lung; Nasal Mucosa; Nitrosamines; Rats; Rats, Inbred F344 | 1987 |
Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Alkylation; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Lung; Lung Neoplasms; Methyltransferases; Nicotiana; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Plants, Toxic; Rats; Rats, Inbred F344 | 1987 |
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA, Neoplasm; Guanine; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats | 1986 |
Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; DNA; Guanine; Liver; Lung; Male; Methyltransferases; Nasal Mucosa; Nicotiana; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Plants, Toxic; Rats; Rats, Inbred F344; Respiratory System; Thymidine | 1986 |
Immunocytochemical identification of DNA adducts, O6-methylguanine and 7-methylguanine, in respiratory and other tissues of rat, mouse and Syrian hamster exposed to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Biotransformation; Carcinogens; Cell Nucleus; Cricetinae; DNA; DNA Adducts; DNA Damage; Guanine; Immunohistochemistry; Liver; Lung; Male; Mesocricetus; Methylation; Mice; Nasal Cavity; Nitrosamines; Rats; Rats, Sprague-Dawley; Respiratory System; Staining and Labeling; Trachea | 1994 |
G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents.
Topics: Adenine; Animals; Base Sequence; Carcinogens; Codon; Dimethylnitrosamine; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Point Mutation; Polymorphism, Restriction Fragment Length; Pyridines; Thymine | 1993 |
Comparison of 7-medG formation in white blood cells, liver and target organs in rats treated with methylating carcinogens.
Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Carcinogens; Dimethylhydrazines; Dimethylnitrosamine; DNA; Guanine; Leukocytes; Liver; Male; Methylation; Nitrosamines; Rats | 1994 |
Evidence supporting the role of DNA pyridyloxobutylation in rat nasal carcinogenesis by tobacco-specific nitrosamines.
Topics: Alkylation; Animals; Butanones; Carcinogens; Deuterium; DNA Damage; DNA, Neoplasm; Guanine; Male; Nasal Cavity; Nitrosamines; Nose Neoplasms; Olfactory Mucosa; Oxidation-Reduction; Pyridines; Rats; Rats, Inbred F344 | 1994 |
Smoking-related DNA adducts: 32P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA.
Topics: Adult; Aged; Bronchi; Carcinogens; DNA; DNA Damage; Female; Guanine; Humans; Lymphocytes; Male; Middle Aged; Nitrosamines; Phosphorus Radioisotopes; Smoking | 1993 |
Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.
Topics: Alkylation; Animals; Cattle; DNA; DNA Repair; Guanine; Liver; Methylation; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines; Rats | 1993 |
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; DNA Methylation; Dose-Response Relationship, Drug; Ellagic Acid; Esophageal Neoplasms; Female; Guanine; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA injury and the fixation of the DNA injury in mouse lungs.
Topics: Animals; Carcinogens; DNA Damage; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Rabbits; Specific Pathogen-Free Organisms; Vitamin E | 1998 |
The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Topics: Animals; Chromatography, High Pressure Liquid; Cotinine; DNA Adducts; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanine; Liver; Lung; Mice; Mutagens; Nitrosamines; Tobacco Smoke Pollution | 1999 |
The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica (wasabi) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-buatnone-induced lung tumorigenesis in mice.
Topics: Animals; Body Weight; Carcinogens; Female; Guanine; Immunoblotting; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Ornithine Decarboxylase; Plant Extracts; Proliferating Cell Nuclear Antigen; Spices | 2000 |
Coexposure to ethanol with N-nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone during lactation of rats: marked increase in O(6)-methylguanine-DNA adducts in maternal mammary gland and in suckling lung and kidney.
Topics: Animals; Animals, Newborn; Animals, Suckling; Carcinogens; DNA Adducts; Ethanol; Female; Guanine; Kidney; Lactation; Lung; Mammary Glands, Animal; Nitrosamines; Nitroso Compounds; Rats; Rats, Sprague-Dawley | 2000 |
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2001 |
The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Drug Interactions; Female; Guanine; Hydroxylation; Injections, Intraperitoneal; Liver; Lung; Mice; Mice, Inbred Strains; Nitrosamines; Tobacco Smoke Pollution | 2001 |
The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice.
Topics: Animals; Carcinogens; DNA; DNA Adducts; Female; Guanine; Liver; Lung; Mice; Mice, Inbred A; Nitrosamines; Pyridines | 2003 |
K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts.
Topics: Base Sequence; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Genes, ras; Guanine; Humans; Nitrosamines; Smoking; Time Factors | 2003 |
Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Deuterium; DNA; DNA Adducts; Dose-Response Relationship, Drug; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes; Mixed Function Oxygenases; Molecular Structure; Nitrosamines; Stereoisomerism; Structure-Activity Relationship | 2003 |
Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: 5-Methylcytosine; Base Sequence; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; Dimethylnitrosamine; DNA Adducts; DNA Methylation; Genes, p53; Guanine; Hydrolysis; Nicotiana; Nitrosamines; Spectrometry, Mass, Electrospray Ionization | 2004 |
The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.
Topics: Animals; Carcinogens; Cattle; DNA Adducts; DNA Repair; Guanine; Humans; Kinetics; Mice; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Rats; Species Specificity | 2004 |
Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-derived DNA sequences.
Topics: Base Sequence; Biotransformation; Carbon Isotopes; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; DNA Mutational Analysis; Exons; Genes, p53; Guanine; Guanosine; Nicotiana; Nitrogen Isotopes; Nitrosamines; Spectrometry, Mass, Electrospray Ionization | 2005 |
Flavonoids suppresses the enhancing effect of beta-carotene on DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A549 cells.
Topics: beta Carotene; DNA Damage; Drug Antagonism; Drug Combinations; Epithelial Cells; Flavanones; Flavonoids; Guanine; Humans; Nitrosamines; Quercetin; Reactive Oxygen Species; Respiratory Mucosa; Rutin | 2006 |
Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases.
Topics: Base Sequence; Biotransformation; Chromatography, Liquid; DNA Adducts; DNA Primers; DNA Repair; DNA-Directed DNA Polymerase; Guanine; Humans; Kinetics; Mass Spectrometry; Nitrosamines; Recombinant Proteins | 2006 |
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Topics: Animals; Carcinogens; Doxycycline; Female; Guanine; Inbreeding; Liver; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Transgenic; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Pyridines | 2007 |
Correlation between the urine profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolites and N7-methylguanine in urothelial carcinoma patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Carcinogens; Female; Guanine; Humans; Male; Middle Aged; Nitrosamines; Pyridines; Smoking; Surveys and Questionnaires; Urinary Bladder Neoplasms | 2008 |
Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Guanine; Liver; Lung; Lung Neoplasms; Nicotiana; Nitrosamines; Prohibitins; Rats; Rats, Inbred F344 | 2009 |
Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Adenoma; Animals; Carcinogens; Cells, Cultured; Drinking Water; Female; Guanine; Humans; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nicotine; Nitrosamines | 2011 |
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.
Topics: Animals; Carcinogens; Deoxyguanosine; DNA Adducts; Enzyme Inhibitors; Female; Guanine; Lung; Lung Neoplasms; Mice; Mutagens; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2012 |
Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase.
Topics: Base Sequence; Bronchi; Carcinogens; Cells, Cultured; Deoxyguanosine; DNA Adducts; DNA Methylation; DNA Repair; Electrophoretic Mobility Shift Assay; Epithelial Cells; Guanine; Humans; Kinetics; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Polynucleotides; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyridines; ras Proteins; Respiratory Mucosa; Transition Temperature | 2013 |
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; DNA Adducts; Guanine; Humans; Lung Neoplasms; Mice, Transgenic; Microsomes; Nicotiana; Nitrosamines; Pyridines | 2014 |
Direct analysis of tobacco-specific nitrosamine NNK and its metabolite NNAL in human urine by LC-MS/MS: evidence of linkage to methylated DNA lesions.
Topics: Adenine; Adult; Biomarkers; Chromatography, Liquid; Cotinine; DNA Methylation; Guanine; Humans; Limit of Detection; Nicotine; Nitrosamines; Pyridines; Sensitivity and Specificity; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.
Topics: Adenoma; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; Female; Guanine; Kava; Lung; Lung Neoplasms; Mice; Nitrosamines | 2014 |
Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.
Topics: Animals; Carcinogens; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Female; Guanine; Kava; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Pyrones; Structure-Activity Relationship | 2014 |
Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Female; Guanine; Lung; Lung Neoplasms; Mice; Nitrosamines; Pyrones; Structure-Activity Relationship | 2017 |
Computational insights into the mutagenicity of two tobacco-derived carcinogenic DNA lesions.
Topics: Base Pairing; Carcinogens; Catalytic Domain; DNA; DNA-Directed DNA Polymerase; Guanine; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Mutation; Nitrosamines; Nucleic Acid Conformation; Prohibitins; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Tobacco Products | 2018 |