4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with dimethylnitrosamine in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (18.18) | 18.7374 |
| 1990's | 13 (59.09) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guengerich, FP; Inui, Y; Shimada, T; Yamazaki, H; Yun, CH | 1 |
| Briere, N; Castonguay, A; Pepin, P | 1 |
| Hecht, SS; Peterson, LA | 1 |
| Brady, JF; Hong, JY; Lee, MJ; Li, WS; Ma, BL; Ning, SM; Smith, T; Thomas, PE; Yang, CS | 1 |
| Crespi, CL; Gelboin, HV; Gonzalez, FJ; Penman, BW | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Maronpot, RR; Stoner, GD | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR | 1 |
| Castonguay, A; Hecht, SS; Rivenson, A; Trushin, N | 1 |
| Chung, FL; Hecht, SS; Wang, MY | 1 |
| Gradia, S; Hecht, SS; Peterson, LA; Ronai, ZA | 1 |
| Bäckbro, A; Beije, B; Diaz-Pohl, C; Jenssen, D; Romert, L; Swedmark, S | 1 |
| Bianchini, F; Wild, CP | 1 |
| Castonguay, A; Jorquera, R; Schuller, HM | 1 |
| Amin, S; Anderson, LM; Beebe, LE; Kim, YE; Kovatch, RM; Riggs, CW | 1 |
| Bombick, BR; Doolittle, DJ; Fulp, C; Lee, CK | 1 |
| Morse, MA; Stoner, GD | 1 |
| Liao, A; Philbert, MA; Smith, TJ; Starcic, S; Wang, LD; Yang, CS; Yang, GY | 1 |
| Crankshaw, DL; Donaldson, EE; Kenney, PJ; Peterson, LA; Thomson, NM | 1 |
| Jones, R; Shallop, A; Tretyakova, N; Upadhyaya, P; Ziegel, R | 1 |
| Augusto, LA; Bissonnette, EY; Castonguay, A; Gaudreault, M; Proulx, LI; Turmel, V | 1 |
| Cheng, G; Hecht, SS; Villalta, PW; Wang, M | 1 |
| Cheng, G; Hecht, SS; Upadhyaya, P; Villalta, PW; Wang, M | 1 |
22 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and dimethylnitrosamine
| Article | Year |
|---|---|
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.
Topics: Animals; Antibodies; Biotransformation; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Activation; Humans; Microsomes, Liver; Nicotiana; Nitrosamines; Oxidoreductases, N-Demethylating; Oxygenases; Plants, Toxic; Rabbits | 1992 |
Modulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone demethylation and denitrosation by rat liver microsomes.
Topics: Animals; Carcinogens; Catechin; Dimethylnitrosamine; Enzyme Induction; Formaldehyde; Kinetics; Male; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Nitrates; Nitrogen Dioxide; Nitrosamines; Nitrosation; Rats; Rats, Inbred F344 | 1991 |
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Female; Guanine; Hydroxylation; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1991 |
Metabolism of carcinogenic nitrosamines by rat nasal mucosa and the effect of diallyl sulfide.
Topics: Acetone; Age Factors; Allyl Compounds; Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Microsomes; Nasal Mucosa; Nitrosamines; Rats; Rats, Inbred Strains; Sex Factors; Sulfides | 1991 |
A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.
Topics: Biotransformation; Carcinogens; Cell Line; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Humans; Isoenzymes; Mixed Function Oxygenases; Mutagens; Nitrosamines; Transfection | 1991 |
Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines.
Topics: Adenocarcinoma; Animals; Blotting, Southern; Codon; Dimethylnitrosamine; DNA Mutational Analysis; Female; Gene Expression Regulation; Genes, ras; Lung Neoplasms; Mice; Mice, Inbred Strains; Mutation; Neoplasms, Experimental; Nitrosamines; Transfection | 1989 |
Factors regulating activation and DNA alkylation by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and nitrosodimethylamine in rat lung and isolated lung cells, and the relationship to carcinogenicity.
Topics: Alkylation; Animals; Antibodies; Benzoflavones; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Isoenzymes; Lung; Methylation; Nitrosamines; Rats | 1988 |
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA, Neoplasm; Guanine; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats | 1986 |
Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone alpha-hydroxylation and DNA methylation in rat liver.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Glucosinolates; Hydroxylation; In Vitro Techniques; Indoles; Male; Methylation; Microsomes, Liver; Nitrosamines; Rats; Rats, Inbred F344; Thiocyanates | 1985 |
G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents.
Topics: Adenine; Animals; Base Sequence; Carcinogens; Codon; Dimethylnitrosamine; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Point Mutation; Polymorphism, Restriction Fragment Length; Pyridines; Thymine | 1993 |
Comparison of co-cultivation of V79 cells with rat hepatocytes and rat H4IIE hepatoma cells for studying nitrosamine-induced hprt gene mutations.
Topics: Animals; Biotransformation; Cells, Cultured; Cricetinae; Cricetulus; Culture Techniques; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Fibroblasts; Genes; Hypoxanthine Phosphoribosyltransferase; Liver; Liver Neoplasms, Experimental; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Wistar; Tumor Cells, Cultured | 1994 |
Comparison of 7-medG formation in white blood cells, liver and target organs in rats treated with methylating carcinogens.
Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Carcinogens; Dimethylhydrazines; Dimethylnitrosamine; DNA; Guanine; Leukocytes; Liver; Male; Methylation; Nitrosamines; Rats | 1994 |
DNA single-strand breaks and toxicity induced by 4-(methyl-nitrosamino)-1-(3- pyridyl)-1-butanone or N-nitrosodimethylamine in hamster and rat liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA Damage; DNA Repair; DNA, Single-Stranded; L-Lactate Dehydrogenase; Liver; Male; Mesocricetus; Nitrosamines; Rats; Rats, Inbred F344 | 1994 |
Comparison of transplacental and neonatal initiation of mouse lung and liver tumors by N-nitrosodimethylamine (NDMA) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and promotability by a polychlorinated biphenyls mixture (Aroclor 1254).
Topics: Animals; Animals, Newborn; Aroclors; Carcinogens; Chlorodiphenyl (54% Chlorine); Cocarcinogenesis; Dimethylnitrosamine; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Maternal-Fetal Exchange; Mice; Nitrosamines; Pregnancy; Time Factors | 1993 |
Inhibition of mutagenicity of N-nitrosamines by tobacco smoke and its constituents.
Topics: Animals; Antimutagenic Agents; CHO Cells; Cotinine; Cricetinae; Dimethylnitrosamine; Dose-Response Relationship, Drug; Nicotine; Nitrosamines | 1996 |
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; DNA Methylation; Dose-Response Relationship, Drug; Ellagic Acid; Esophageal Neoplasms; Female; Guanine; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
Characterization of xenobiotic-metabolizing enzymes and nitrosamine metabolism in the human esophagus.
Topics: Adult; Dimethylnitrosamine; Enzyme Inhibitors; Enzymes; Esophagus; Female; Humans; Male; Microsomes; Middle Aged; Nitrosamines; Xenobiotics | 1998 |
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2001 |
Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: 5-Methylcytosine; Base Sequence; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; Dimethylnitrosamine; DNA Adducts; DNA Methylation; Genes, p53; Guanine; Hydrolysis; Nicotiana; Nitrosamines; Spectrometry, Mass, Electrospray Ionization | 2004 |
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a component of tobacco smoke, modulates mediator release from human bronchial and alveolar epithelial cells.
Topics: Bronchi; Carcinogens; Cell Line; Chemokine CCL2; Cytokines; Dimethylnitrosamine; Dinoprostone; Epithelial Cells; Humans; Hydroxylation; Interleukin-6; Interleukin-8; Nitrosamines; Pulmonary Alveoli; Pyridines | 2005 |
Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Adenosine Deaminase; Animals; Chromatography, High Pressure Liquid; Dimethylnitrosamine; DNA Adducts; Dose-Response Relationship, Drug; Formaldehyde; Hydrolysis; Male; Models, Chemical; Nitrosamines; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2007 |
Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA).
Topics: Acetates; Carcinogens; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Deoxyribonucleosides; Dimethylnitrosamine; DNA Adducts; Formaldehyde; Nitrosamines; Pyridines; Spectrometry, Mass, Electrospray Ionization | 2008 |