4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and benzo(a)pyrene

4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with benzo(a)pyrene in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (5.00)	18.7374
1990's	16 (26.67)	18.2507
2000's	19 (31.67)	29.6817
2010's	21 (35.00)	24.3611
2020's	1 (1.67)	2.80

Authors

Authors	Studies
Cherrick, HM; Dokko, H; Min, PS; Park, NH	1
Castonguay, A; Goldblatt, PJ; Gunning, WT; Stoner, GD	1
Gao, Y	1
Amonkar, AJ; Bhide, SV; Lalitha, VS; Padma, PR	1
Adams, JD; Choi, CI; LaVoie, EJ; Reinhardt, J; Stern, SL	1
Adams, JD; Brunnemann, KD; Haley, NJ; Hoffmann, D; Melikian, A	1
Hecht, SS; Isaacs, S; Trushin, N	1
Fuchs, SY; Ronai, Z	1
Kim, PM; Wells, PG	1
Hecht, SS	3
Amin, S; Guengerich, FP; Hecht, SS; Koehl, W; Koenig, LA; Murphy, SE; Nunes, MG; Patten, CJ; Staretz, ME	1
Espiritu, I; Jones, AD; Maronpot, RR; Pinkerton, KE; Witschi, H	1
Kim, PM; Laposa, RR; Nicol, CJ; Parman, T; Wells, PG; Winn, LM	1
Gram, TE	1
Lazarus, P; Park, JY; Ren, Q; Richie, JP; Schantz, SP; Sheikh, SN; Stern, JC	1
Agarwal, S; Hecht, SS; Kenney, PM; Rao, AV; Trushin, N; Upadhyaya, P; Wang, M	1
Heard, P; Jenson, HB; Moyer, MP	1
Garganta, F; Krause, G; Scherer, G; Vrieling, H	1
Hecht, SS; Kenney, PM; Trushin, N; Upadhyaya, P; Wang, M	1
Carlton, PS; Kresty, LA; Stoner, GD	1
Amin, S; Desai, D; El-Bayoumy, K; Fiala, ES; Prokopczyk, B; Rosa, JG; Sohn, OS	1
Hecht, SS; Kenney, PM; Upadhyaya, P; Wang, M	1
Boysen, G; Hecht, SS; Kenney, PM; Liang, H; Sticha, KR; Su, X; Upadhyaya, P; Wang, M	1
Rom, WN; Tchou-Wong, KM	1
Boysen, G; Hecht, SS; Kenney, PM; Upadhyaya, P; Wang, M	1
He, XY; Hong, JY; Wang, SL	1
Azzi, C; Chapman, JM; Hebert, JR; Nitcheva, D; Purdon, CH; Smith, EW; Zhang, J	1
Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM	1
Cody, D; Hong, WK; Kim, WY; Lee, HY; Moriarty, RM; Oh, SH; Pezzuto, JM; Price, RE; Tran, H; Van Pelt, CS; Woo, JK	1
Eguchi, H; Nakachi, K	1
Hisamoto, A; Hosokawa, S; Kiura, K; Kondo, E; Mimoto, J; Okada, T; Tabata, M; Takigawa, N; Tanimoto, M	1
Anderson, LB; Hecht, SS; Kassie, F; Lahti, D; Scherber, R; Upadhyaya, P; Yu, N	1
Anderson, LB; Hecht, SS; Higgins, L; Kassie, F; Matise, I; Negia, M; Pan, Y; Upadhyaya, P; Wang, M	1
Hanson, TE; Hecht, SS; Johnson, TE; Kassie, F; Negia, M; O'Sullivan, MG; Ruvolo, PP; Upadhyaya, P; Xing, C	1
Hecht, SS; Kassie, F; Matise, I; Negia, M; Upadhyaya, P	1
Austin, DF; Djordjevic, MV; Pankow, JF; Stellman, SD; Toccalino, PL; Watanabe, KH	1
Chen, YK; Lee, MJ; Li, GX; Liu, A; Loy, S; Lu, G; Picinich, SC; Xiao, H; Yang, CS	1
Lin, D; Rathore, K; Siriwardhana, N; Song, X; Wang, HC	1
D'Agostino, J; Ding, X; Lamb, JG; Weems, JM; Yost, GS	1
Song, X; Wang, H	1
Hecht, SS; Hermanson, D; Johnson, TE; Kassie, F; Lu, J; O'Sullivan, MG; Upadhyaya, P; Wang, L; Xing, C	1
Rathore, K; Wang, HC	2
Choudhary, S; Odoi, A; Rathore, K; Wang, HC	1
Choudhary, S; Sood, S; Wang, HC	1
Ashley, DL; Ding, YS; Hearn, BA; Polzin, GM; Renner, CC; Stanfill, SB; Vaughan-Watson, C; Watson, CH; Zhang, L	1
Anadon, A; Garcia-Canton, C; Meredith, C	1
Balbo, S; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B	1
Pluchino, LA; Wang, HC	1
Dial, SL; Guo, X; Heflich, RH; Mei, N; Moore, MM; Richter, PA	1
Li, L; Liu, Y; Lv, Y; Wu, K; Yang, X; Ye, H; Zheng, X	1
Fritz, V; Fujioka, N; Hecht, SS; Kassie, F; Upadhyaya, P	1
Desai, S; Hudlikar, RR; Ingle, AD; Kannan, S; Kumar, R; Mahimkar, MB; Maru, GB; Thorat, RA; Venkadakrishnan, VB	1
Ambati, CR; Berg, S; Bhowmik, SK; Coarfa, C; Degener, S; Donepudi, SR; El-Zein, R; Gödde, D; Gu, F; Jin, F; Kaipparettu, BA; Karanam, B; Kavuri, SM; Kheradmand, F; Krishnapuram, R; Lerner, SP; Lotan, Y; Maity, S; Michailidis, G; Noldus, J; Piyarathna, DWB; Purwaha, P; Putluri, N; Putluri, V; Rajapakshe, K; Roghmann, F; Roth, S; Sreekumar, A; Störkel, S; Terris, MK; Thaiparambil, J; Vantaku, V; von Rundstedt, FC	1
Chikara, S; Chittem, K; Christofidou-Solomidou, M; Dyer, N; Mamidi, S; Moorthy, G; Pietrofesa, R; Reindl, KM; Sreedasyam, A; Zuppa, A	1
Chen, H; Hou, H; Hu, Q; Liu, Y; Wang, A; Zhang, S	1
Hudlikar, RR; Ingle, AD; Kannan, S; Kumar, R; Mahimkar, MB; Maru, GB; Pai, V; Thorat, RA	1
Hou, R; Ma, X; Qu, Z; Yu, J; Zhang, L; Zhang, W; Zhuang, C	1

Reviews

6 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and benzo(a)pyrene

Article	Year
Chemoprevention of lung cancer by isothiocyanates. Advances in experimental medicine and biology, 1996, Volume: 401 Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Isothiocyanates; Lung Neoplasms; Nitrosamines	1996
Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke. Environmental health perspectives, 1997, Volume: 105 Suppl 4 Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Humans; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Rats	1997
Oxidative damage in chemical teratogenesis. Mutation research, 1997, Dec-12, Volume: 396, Issue:1-2 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antioxidants; Benzo(a)pyrene; Biotransformation; DNA Damage; Embryonic and Fetal Development; Free Radicals; Mice; Nitrosamines; Oxidative Stress; Phenytoin; Proteins; Rabbits; Rats; Reactive Oxygen Species; Signal Transduction; Teratogens; Thalidomide; Xenobiotics	1997
Chemically reactive intermediates and pulmonary xenobiotic toxicity. Pharmacological reviews, 1997, Volume: 49, Issue:4 Topics: Animals; Anti-Infective Agents, Urinary; Antibiotics, Antineoplastic; Antineoplastic Agents; Antioxidants; Benzo(a)pyrene; Biotransformation; Bleomycin; Butylated Hydroxytoluene; Carcinogens; Cytochrome P-450 Enzyme System; Dichloroethylenes; DNA Adducts; Herbicides; Hyperoxia; Lung; Lung Neoplasms; Naphthalenes; Nitrofurantoin; Nitrosamines; Paraquat; Skatole; Terpenes; Xenobiotics	1997
[Smoking as a risk factor for pancreatic cancer]. Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 1 Topics: Benzo(a)pyrene; Carcinogens; Cohort Studies; Cytochrome P-450 CYP1A1; Glutathione Transferase; Humans; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Polymorphism, Genetic; Risk Factors; Smoking; Tobacco Smoke Pollution	2006
Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg. Molecular nutrition & food research, 2016, Volume: 60, Issue:6 Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers; Brassicaceae; Carcinogens; Cell Line, Tumor; Diet; Disease Models, Animal; Epigenesis, Genetic; Glucosinolates; Humans; Indoles; Lung; Neoplasms; Nitrosamines; Vegetables	2016

Other Studies

54 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and benzo(a)pyrene

Article	Year
Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus. Oral surgery, oral medicine, and oral pathology, 1991, Volume: 71, Issue:4 Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Chlorocebus aethiops; Kidney; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Simplexvirus; Tobacco, Smokeless; Ultraviolet Rays; Virus Activation	1991
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens. Toxicologic pathology, 1991, Volume: 19, Issue:2 Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylhydrazines; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines	1991
[In vitro transformation induced by carcinogens in rat tracheal epithelial cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1990, Volume: 12, Issue:5 Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Epithelial Cells; Methylnitronitrosoguanidine; Nitrosamines; Rats; Trachea	1990
Anticarcinogenic effect of betel leaf extract against tobacco carcinogens. Cancer letters, 1989, Volume: 45, Issue:3 Topics: Animals; Areca; Ascorbic Acid; Benzo(a)pyrene; Carcinogens; Drug Interactions; Liver; Male; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Plant Extracts; Plants, Medicinal; Plants, Toxic; Stomach Neoplasms; Tobacco, Smokeless; Vitamin A	1989
Transfer of the tobacco-specific carcinogens N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene into the milk of lactating rats. Carcinogenesis, 1987, Volume: 8, Issue:3 Topics: Animals; Benzo(a)pyrene; Carbon Radioisotopes; Carcinogens; Female; Lactation; Milk; Nicotiana; Nitrosamines; Plants, Toxic; Pregnancy; Rats; Rats, Inbred Strains; Smoking	1987
New aspects of tobacco carcinogenesis. Carcinogenesis; a comprehensive survey, 1985, Volume: 8 Topics: Animals; Benzo(a)pyrene; Carcinogens; Catechols; Humans; Lung Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic; Smoking; Tobacco Smoke Pollution; Tritium	1985
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. Carcinogenesis, 1994, Volume: 15, Issue:12 Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Stomach Neoplasms	1994
Elevated binding to URE/PEBP2 during the late stages of NNK and benzo[a]pyrene-induced carcinogenesis in A/J mice. Cancer letters, 1996, Apr-19, Volume: 102, Issue:1-2 Topics: Animals; Base Sequence; Benzo(a)pyrene; Carcinogens; DNA-Binding Proteins; Female; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Sequence Data; Nitrosamines; Protein Binding; Tissue Distribution; Transcription Factor AP-1; Transcription Factor AP-2; Transcription Factors	1996
Genoprotection by UDP-glucuronosyltransferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. Cancer research, 1996, Apr-01, Volume: 56, Issue:7 Topics: Animals; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Male; Micronuclei, Chromosome-Defective; Nitrosamines; Peroxidases; Polychlorinated Dibenzodioxins; Rats; Rats, Gunn; Reactive Oxygen Species; Superoxide Dismutase	1996
Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:2 Topics: Benzo(a)pyrene; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Nicotiana; Nitrosamines; Plants, Toxic	1997
The carcinogenic potential of the gas phase of environmental tobacco smoke. Carcinogenesis, 1997, Volume: 18, Issue:11 Topics: Animals; Benzo(a)pyrene; Carcinogens, Environmental; Female; Lung; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Plants, Toxic; Smoke	1997
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use. Carcinogenesis, 1998, Volume: 19, Issue:3 Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Cyclin-Dependent Kinase Inhibitor p16; Cytochrome P-450 CYP1A1; Exons; Genes, p53; Genotype; Glutathione Transferase; Humans; Mouth Neoplasms; Mutation; Nicotiana; Nitrosamines; Plants, Toxic; Polymorphism, Genetic; Smoking	1998
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer letters, 1999, Apr-01, Volume: 137, Issue:2 Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Butylated Hydroxyanisole; Carotenoids; Curcumin; Female; Inositol; Lung Neoplasms; Lycopene; Mice; Mice, Inbred A; Nitrosamines; Resveratrol; Stilbenes; Umbelliferones	1999
Evaluation of the effect of smokeless tobacco purified products and extracts on latent Epstein-Barr virus. Toxicology, 1999, Mar-01, Volume: 133, Issue:1 Topics: Benzo(a)pyrene; Cell Line; Cell Survival; Flow Cytometry; Herpesvirus 4, Human; Humans; Nitrosamines; Plant Extracts; Plants, Toxic; Tetradecanoylphorbol Acetate; Tobacco, Smokeless; Virus Activation	1999
Spontaneous and chemically induced point mutations in HPRT cDNA of the metabolically competent human lymphoblastoid cell line, MCL-5. Mutation research, 1999, Dec-17, Volume: 431, Issue:2 Topics: Benzo(a)pyrene; Cell Line; DNA, Complementary; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocyte Activation; Lymphocytes; Mutagens; Nicotiana; Nitrosamines; Plants, Toxic; Point Mutation; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Smoke	1999
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer letters, 2000, Mar-13, Volume: 150, Issue:1 Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; Drug Therapy, Combination; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines	2000
Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice. Cancer letters, 2000, Oct-31, Volume: 159, Issue:2 Topics: Adenoma; Animals; Antineoplastic Agents; Benzo(a)pyrene; Biological Assay; Carcinogens; Diet; Freeze Drying; Fruit; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines	2000
Chemoprevention of lung tumorigenesis induced by a mixture of benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate. Cancer letters, 2000, Dec-08, Volume: 161, Issue:1 Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; Drug Administration Schedule; Female; Glutathione Transferase; Inactivation, Metabolic; Isoenzymes; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Organoselenium Compounds; Stomach Neoplasms	2000
Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo. Cancer letters, 2001, Jun-10, Volume: 167, Issue:1 Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; Eating; Female; Inositol; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines	2001
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis, 2002, Volume: 23, Issue:9 Topics: Animals; Benzo(a)pyrene; Carcinogens; DNA; DNA Adducts; Drug Interactions; Female; Isothiocyanates; Lung; Mice; Mice, Inbred A; Nitrosamines	2002
Lung-specific expression of mutant p53 as mouse model for lung cancer. Methods in molecular medicine, 2003, Volume: 74 Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Genes, p53; Humans; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Nitrosamines; Proliferating Cell Nuclear Antigen; Promoter Regions, Genetic; Proteins; Uteroglobin	2003
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. Carcinogenesis, 2003, Volume: 24, Issue:3 Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hemoglobins; Isothiocyanates; Male; Nitrosamines; Rats; Rats, Inbred F344	2003
Human cytochrome p450 2s1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3 Topics: Animals; Baculoviridae; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Insecta; Nicotiana; Nicotine; Nitrosamines; Oxygenases; Smoke	2005
Permeation and reservoir formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P) across porcine esophageal tissue in the presence of ethanol and menthol. Carcinogenesis, 2006, Volume: 27, Issue:1 Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Membrane; Cell Membrane Permeability; Drug Synergism; Esophagus; Ethanol; Menthol; Nicotiana; Nitrosamines; Swine	2006
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer research, 2005, Sep-15, Volume: 65, Issue:18 Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates	2005
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens. Journal of the National Cancer Institute, 2005, Nov-16, Volume: 97, Issue:22 Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution	2005
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. Journal of the National Cancer Institute, 2005, Nov-16, Volume: 97, Issue:22 Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Bronchial Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution	2005
Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice. Lung cancer (Amsterdam, Netherlands), 2007, Volume: 58, Issue:1 Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cisplatin; Codon; Female; Genes, ras; Lung Neoplasms; Mice; Neoplasms, Experimental; Neoplasms, Second Primary; Nitrosamines; Point Mutation	2007
Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. Cancer research, 2007, Jul-01, Volume: 67, Issue:13 Topics: Amino Acid Sequence; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Chromatography, Ion Exchange; Chromatography, Liquid; Gene Expression Regulation, Neoplastic; Indoles; Lung Neoplasms; Mass Spectrometry; Mice; Molecular Sequence Data; Nitrosamines	2007
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. Carcinogenesis, 2008, Volume: 29, Issue:3 Topics: Amino Acid Sequence; Animals; Benzo(a)pyrene; Blotting, Western; Carcinogens; Chromatography, Liquid; Lung Neoplasms; Mice; Molecular Sequence Data; Neoplasm Proteins; Nitrosamines; Tandem Mass Spectrometry	2008
Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Cancer prevention research (Philadelphia, Pa.), 2008, Volume: 1, Issue:6 Topics: Adenoma; Algorithms; Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Body Weight; Cell Proliferation; Chemoprevention; Drug Evaluation, Preclinical; Eating; Female; Kava; Lung Neoplasms; Mice; Neoplasms, Multiple Primary; Nitrosamines; Plant Extracts	2008
Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. Cancer prevention research (Philadelphia, Pa.), 2008, Volume: 1, Issue:7 Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cell Proliferation; Chromatography, High Pressure Liquid; Diet; Dose-Response Relationship, Drug; Female; Immunoblotting; Immunohistochemistry; Indoles; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Smoke	2008
Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data. Regulatory toxicology and pharmacology : RTP, 2009, Volume: 55, Issue:2 Topics: Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Humans; Inhalation Exposure; Lung Neoplasms; Male; Monte Carlo Method; Nitrosamines; Risk Assessment; Smoke; Smoking; United States	2009
A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth. Carcinogenesis, 2010, Volume: 31, Issue:4 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Benzo(a)pyrene; Cell Line, Tumor; Cell Proliferation; Deoxyguanosine; Dinoprostone; Female; gamma-Tocopherol; Histones; Leukotriene B4; Lung Neoplasms; Mice; Neovascularization, Pathologic; Nitrosamines; Tyrosine; Xenograft Model Antitumor Assays	2010
Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. Molecular carcinogenesis, 2010, Volume: 49, Issue:5 Topics: Base Sequence; Benzo(a)pyrene; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Adhesion; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Primers; Female; Humans; Nitrosamines; Proanthocyanidins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Seeds; Vitis	2010
Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK. Chemical research in toxicology, 2010, Nov-15, Volume: 23, Issue:11 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cells, Cultured; Cytochrome P-450 Enzyme System; DNA Damage; Humans; Liver; Lung; Microsomes; Mutagenicity Tests; Mutagens; Nitrosamines; Rats; Ribosomal Protein S9; Ribosomal Proteins; Salmonella typhimurium; Skatole; Smoking	2010
[Biological change of normal human breast epithelial cells induced by B( a )P and NNK]. Wei sheng yan jiu = Journal of hygiene research, 2011, Volume: 40, Issue:3 Topics: Benzo(a)pyrene; Breast; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Drug Synergism; Epithelial Cells; Female; Humans; Nitrosamines	2011
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. The American journal of Chinese medicine, 2011, Volume: 39, Issue:4 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carcinogens; Cell Death; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Female; Kava; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Phytotherapy; Plant Extracts	2011
Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens. Molecular carcinogenesis, 2012, Volume: 51, Issue:3 Topics: Benzo(a)pyrene; Breast; Breast Neoplasms; Carcinogens, Environmental; Catechin; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression Regulation; Histones; Humans; Nitrosamines; Phosphorylation; Plant Extracts; Reactive Oxygen Species; Tea	2012
Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis. Carcinogenesis, 2012, Volume: 33, Issue:1 Topics: Benzo(a)pyrene; Breast Neoplasms; Catechin; Cell Proliferation; Cells, Cultured; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Female; Humans; MAP Kinase Signaling System; Nitrosamines; Reactive Oxygen Species; Tea	2012
Dipyridamole intervention of breast cell carcinogenesis. Molecular carcinogenesis, 2014, Volume: 53, Issue:3 Topics: Apoptosis; Benzo(a)pyrene; Blotting, Western; Breast; Breast Neoplasms; Carcinogens; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Dipyridamole; DNA Damage; Female; Humans; Imidazoles; MAP Kinase Signaling System; Nitrosamines; Reactive Oxygen Species; Vasodilator Agents	2014
Chemical analysis of Alaskan Iq'mik smokeless tobacco. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:7 Topics: Alaska; Benzo(a)pyrene; Humans; Hydrogen-Ion Concentration; Inuit; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Tobacco, Smokeless	2013
Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis. Cancer letters, 2013, Jun-01, Volume: 333, Issue:1 Topics: Benzo(a)pyrene; Breast Neoplasms; Catechin; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Female; Grape Seed Extract; Humans; Nitrosamines; Proanthocyanidins; Stem Cells; Tea	2013
Genotoxicity evaluation of individual cigarette smoke toxicants using the in vitro γH2AX assay by high content screening. Toxicology letters, 2013, Oct-23, Volume: 223, Issue:1 Topics: Benzo(a)pyrene; Bronchi; Cadmium; Cell Line; Epithelial Cells; Histones; Humans; Mutagenicity Tests; Nicotiana; Nitrosamines; Smoke	2013
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:1 Topics: Adenoma; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; Female; Guanine; Kava; Lung; Lung Neoplasms; Mice; Nitrosamines	2014
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties. PloS one, 2014, Volume: 9, Issue:11 Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogenesis; Carcinogens; DNA Damage; Drug Synergism; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; MCF-7 Cells; NADPH Oxidases; Nitrosamines; ras Proteins; Reactive Oxygen Species; Signal Transduction	2014
Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay. Mutagenesis, 2016, Volume: 31, Issue:3 Topics: Activation, Metabolic; Aminobiphenyl Compounds; Animals; Benzo(a)pyrene; Cadmium Chloride; Carcinogens; Cell Line, Tumor; DNA Damage; DNA, Neoplasm; Lymphoma; Mice; Mutagenicity Tests; Mutagens; Nicotiana; Nitrosamines; Quinolines; Rats; Smoke	2016
Inhibitory effect of 5F on development of lung cancer in A/J mice. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:4 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzo(a)pyrene; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Lung Neoplasms; Mice; Nitrosamines; Proto-Oncogene Proteins c-bcl-2; Time Factors; Transcription Factor RelA	2015
Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice. Molecular carcinogenesis, 2017, Volume: 56, Issue:2 Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Proliferation; Humans; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polyphenols; Proto-Oncogene Proteins c-akt; Tea	2017
Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer. Cancer prevention research (Philadelphia, Pa.), 2017, Volume: 10, Issue:10 Topics: Azacitidine; Benzo(a)pyrene; Biomarkers, Tumor; Butanones; Carcinogens; Cell Line, Tumor; Cohort Studies; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA Adducts; DNA Damage; DNA Methylation; Early Detection of Cancer; Female; Humans; Male; Metabolome; Metabolomics; Mutagens; Neoplasm Grading; Nicotiana; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Risk Assessment; Smoking; Tobacco Products; Urinary Bladder Neoplasms	2017
Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice. Cancer prevention research (Philadelphia, Pa.), 2018, Volume: 11, Issue:1 Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cytochrome P-450 CYP1A1; Cytokines; Flax; Glucuronosyltransferase; Glutathione Transferase; High-Throughput Nucleotide Sequencing; Inflammation Mediators; Lung; Lung Neoplasms; Male; Metabolic Detoxication, Phase II; Mice; Mice, Inbred A; Nitrosamines; Plant Extracts; Seeds	2018
Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model. Environmental toxicology and pharmacology, 2018, Volume: 58 Topics: A549 Cells; Benzo(a)pyrene; Biological Assay; Cell Survival; Histones; Humans; Models, Biological; Nicotine; Nitrosamines; Smoke; Tobacco Products	2018
Dose-Related Modulatory Effects of Polymeric Black Tea Polyphenols (PBPs) on Initiation and Promotion Events in B(a)P and NNK-Induced Lung Carcinogenesis. Nutrition and cancer, 2019, Volume: 71, Issue:3 Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Camellia sinensis; Carcinogenesis; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2 Inhibitors; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Plant Extracts; Polyphenols; Tea	2019
Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice. Chemico-biological interactions, 2021, Aug-01, Volume: 344 Topics: Adenocarcinoma of Lung; Animals; Bacteria; Benzo(a)pyrene; Carcinogens; Dysbiosis; Feces; Female; Gastrointestinal Microbiome; Lung; Lung Neoplasms; Metabolome; Metabolomics; Mice, Inbred Strains; Nitrosamines	2021