Compounds > 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone
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4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's5 (50.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gradia, S; Hecht, SS; Peterson, LA; Ronai, ZA1
Chen, WF; Ho, CT; Hong, JY; Shi, ST; Smith, TJ; Wang, ZY; Yang, CS1
Hecht, SS; Liu, XK; Peterson, LA1
Castonguay, A; Cloutier, JF1
Crankshaw, DL; Donaldson, EE; Kenney, PJ; Peterson, LA; Thomson, NM1
Kenney, PM; Peterson, LA; Thomson, NM1
Augusto, LA; Bissonnette, EY; Castonguay, A; Gaudreault, M; Proulx, LI; Turmel, V1
Hecht, SS; Lao, Y; Sturla, SJ; Villalta, PW; Wang, M1
Bedard, LL; Brown, PJ; Massey, TE1
Cao, Q; Peterson, LA; Upadhyaya, P; Urban, AM1

Other Studies

10 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

ArticleYear
G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: Adenine; Animals; Base Sequence; Carcinogens; Codon; Dimethylnitrosamine; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Point Mutation; Polymorphism, Restriction Fragment Length; Pyridines; Thymine

1993
Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice.
    Cancer research, 1994, Sep-01, Volume: 54, Issue:17

    Topics: Animals; Beverages; Carcinogens; Catechin; DNA; Female; Flavonoids; Lung; Lung Neoplasms; Methylation; Mice; Microsomes; Nitrosamines; Pyridines; Tea

1994
Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.
    Cancer research, 1993, Jun-15, Volume: 53, Issue:12

    Topics: Alkylation; Animals; Cattle; DNA; DNA Repair; Guanine; Liver; Methylation; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines; Rats

1993
Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage.
    Chemico-biological interactions, 1998, Mar-12, Volume: 110, Issue:1-2

    Topics: Animals; Carcinogens; Cells, Cultured; DNA Damage; DNA Methylation; DNA Repair; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Nitrosamines; Nucleic Acid Synthesis Inhibitors; Pyridines; Rats; Rats, Inbred F344; Tobacco Smoke Pollution; Topoisomerase I Inhibitors

1998
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
    Cancer research, 2001, Aug-01, Volume: 61, Issue:15

    Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines

2001
The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice.
    Chemical research in toxicology, 2003, Volume: 16, Issue:1

    Topics: Animals; Carcinogens; DNA; DNA Adducts; Female; Guanine; Liver; Lung; Mice; Mice, Inbred A; Nitrosamines; Pyridines

2003
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a component of tobacco smoke, modulates mediator release from human bronchial and alveolar epithelial cells.
    Clinical and experimental immunology, 2005, Volume: 140, Issue:1

    Topics: Bronchi; Carcinogens; Cell Line; Chemokine CCL2; Cytokines; Dimethylnitrosamine; Dinoprostone; Epithelial Cells; Humans; Hydroxylation; Interleukin-6; Interleukin-8; Nitrosamines; Pulmonary Alveoli; Pyridines

2005
Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.
    Chemical research in toxicology, 2006, Volume: 19, Issue:5

    Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Liver; Lung; Male; Nicotiana; Nitrosamines; Pyridines; Rats; Rats, Inbred F344; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2006
Repair of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA pyridyloxobutylation by nucleotide excision repair.
    Cancer letters, 2008, Feb-18, Volume: 260, Issue:1-2

    Topics: Carcinogens; Cell Line, Tumor; Cell Nucleus; Cell Survival; DNA Adducts; DNA Repair; DNA-Binding Proteins; Humans; Nitrosamines; Pyridines; Time Factors; Ultraviolet Rays; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein

2008
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Animals; Carcinogens; Deoxyguanosine; DNA Adducts; Enzyme Inhibitors; Female; Guanine; Lung; Lung Neoplasms; Mice; Mutagens; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines

2012