4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 12 studies
| Studies (4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine) | Trials (4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine) | Recent Studies (post-2010) (4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine) | Studies (8-hydroxy-2-(di-n-propylamino)tetralin) | Trials (8-hydroxy-2-(di-n-propylamino)tetralin) | Recent Studies (post-2010) (8-hydroxy-2-(di-n-propylamino)tetralin) |
|---|---|---|---|---|---|
| 42 | 0 | 9 | 3,530 | 7 | 389 |
| Protein | Taxonomy | 4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine (IC50) | 8-hydroxy-2-(di-n-propylamino)tetralin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.0012 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0032 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| D(2) dopamine receptor | Bos taurus (cattle) | 0.8 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 2.8959 | |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | 0.0021 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaput, C; Millan, MJ; Newman-Tancredi, A; Verrièle, L | 2 |
| Audinot, V; Bervoets, K; Brocco, M; Canton, H; Gobert, A; Lejeune, F; Mennini, T; Millan, MJ; Rivet, JM; Widdowson, P | 1 |
| Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A | 1 |
| Chaput, C; Millan, MJ; Newman-Tancredi, A; Rivet, J; Touzard, M; Verrièle, L | 1 |
| Bertaglia, A; Cervo, L; Mocaër, E; Samanin, R | 1 |
| Adhumeau, A; Brocco, M; Dekeyne, A; Gobert, A; Millan, MJ | 1 |
| Millan, MJ; Newman-Tancredi, A; Verrièle, L | 1 |
| Gannon, RL | 1 |
| Carli, M; Dekeyne, A; Di Cara, B; Gobert, A; Jaffard, R; Lestage, P; Meneses, A; Millan, MJ; Mocaer, E; Peglion, JL; Porsolt, R; Rivet, JM; Roux, S | 1 |
| Cremers, TI; de Boer, SF; Jongsma, ME; Koolhaas, JM; Steenbergen, PJ; Veenema, AH | 1 |
| Belluzzi, JD; Dao, JM; Leslie, FM; Loughlin, SE; McQuown, SC | 1 |
12 other study(ies) available for 4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affinity Labels; Animals; Binding, Competitive; CHO Cells; Cricetinae; Guanine Nucleotides; Hippocampus; Humans; Male; Membranes; Piperazines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Corpus Striatum; Cross-Linking Reagents; Dioxanes; Guinea Pigs; In Vitro Techniques; Male; Neurons; Piperazines; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synapses | 1994 |
S 15535 and WAY 100,635 antagonise 5-HT-stimulated [35S]GTP gamma S binding at cloned human 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stimulation, Chemical; Tritium | 1996 |
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 1997 |
The 5HT(1A) receptor ligand, S15535, antagonises G-protein activation: a [35S]GTPgammaS and [3H]S15535 autoradiography study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding, Competitive; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Ligands; Male; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium | 1999 |
Roles of 5-HT(1A) receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Conditioning, Operant; Conflict, Psychological; Hippocampus; Male; Piperazines; Punishment; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Stereotaxic Techniques | 2000 |
The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolyt
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Ataxia; Conflict, Psychological; Dialysis; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Interpersonal Relations; Male; Motor Activity; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2000 |
Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Ligands; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists | 2001 |
Serotonergic serotonin (1A) mixed agonists/antagonists elicit large-magnitude phase shifts in hamster circadian wheel-running rhythms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Circadian Rhythm; Cricetinae; Dioxins; Dose-Response Relationship, Drug; Drug Combinations; Male; Motor Activity; Photoperiod; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Suprachiasmatic Nucleus | 2003 |
The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Aging; Amnesia; Animals; Dialysis; Discrimination Learning; Drug Interactions; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Recognition, Psychology; Scopolamine; Serotonin Receptor Agonists; Spatial Behavior | 2004 |
Differences in the effects of 5-HT(1A) receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Aggression; Agonistic Behavior; Animals; Arousal; Brain; Escape Reaction; Fear; Helplessness, Learned; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperazines; Reaction Time; Selection, Genetic; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Swimming | 2005 |
Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Catecholamines; Dopamine Agonists; Drug Administration Schedule; Drug Interactions; Gene Expression Regulation; Limbic System; Locomotion; Male; Nicotine; Nicotinic Agonists; Piperazines; Protein Binding; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Reward; RNA, Messenger; Self Administration; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Time Factors | 2011 |