4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone and rolipram

4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone has been researched along with rolipram in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (18.18)	18.7374
1990's	37 (56.06)	18.2507
2000's	7 (10.61)	29.6817
2010's	10 (15.15)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chapin, DS; Jung, S; Koe, BK; Meltz, M; Nielsen, JA; Phillips, D; Saccomano, NA; Thadieo, PF; Vinick, FJ; Whalen, WM	1
Bourguignon, JJ; Lugnier, C; Mann, A; Marivet, MC; Stoclet, JC; Wermuth, CG	1
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Bristol, JA; Cain, MH; Weishaar, RE	1
Brackeen, MF; Cowan, DJ; Domanico, PL; Feldman, PL; Rose, D; Schoenen, FJ; Stafford, JA; Strickland, AB; Veal, JM; Verghese, M	1
Carson, DA; Cottam, HB; Shih, H; Tehrani, LR; Wasson, DB	1
Billah, MM; Cheewatrakoolpong, B; Egan, RW; Myers, JG; Wang, P; Wu, P	1
Kasugai, S; Miyamoto, K; Ohya, K; Sawanishi, H; Suzuki, H; Suzuki, N; Takagi, K; Waki, Y; Yamamoto, S	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Abraham, A; Adams, DR; Allcock, RW; Anthony, D; Baillie, GS; Bogum, J; Christian, F; Day, JP; Houslay, DM; Houslay, MD; Huston, E; Jiang, Z; Klussmann, E; Lindsay, B; Martin, EK; Rae, RL; Riddell, T; Rosair, GM; Sookup, S	1
Ashton, TD; Bland, ND; Campbell, RK; Cotter, K; Fang, AP; Gangurde, R; Garceau, N; Gechijian, L; Gustafson, AE; McAllister, G; Ochiana, SO; Ondrechen, MJ; Ortenberg, R; Pollastri, MP; Tallman, C; Wang, C; Wang, Z	1
Endoh, M; Katano, Y	1
Geremia, R; Giorgi, M; Piscitelli, D; Rossi, P	1
Maslen, C; Scott, LC; Souness, JE	1
Hassall, GA; Parrott, DP; Souness, JE	1
Devall, LJ; Klinkefus, BA; Kobylarz-Singer, D; Kuipers, PJ; Weishaar, RE; Wright, CD	1
Lugnier, C; Muller, B; Stoclet, JC	1
Nicholson, D; Sawynok, J; White, TD	1
Bode, DC; Brunton, LL; Kanter, JR	1
Heaslip, R; Nielson, CP; Sturm, RJ; Vestal, RE	1
Davis, RL; Henkel-Tigges, J	1
Fredholm, BB; Lerner, U; Ransjö, M	1
Fredholm, BB; Lerner, UH; Ransjö, M	1
Baumgarten, HG; Brüning, G; Kaulen, P; Sarter, M; Schneider, HH	1
Weiss, RM; Wheeler, MA	1
Schneider, HH; Wachtel, H	1
Przegaliński, E; Rawłów, A	1
Wachtel, H	2
Fredholm, BB; Gustafsson, L; Hedqvist, P	1
Colicelli, J; Kytle, K; Pillai, R; Reyes, A	1
Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M	1
Boichot, E; Hichami, A; Lagente, V; Martins, MA; Silva, PM	1
Imai, A; Nashida, T; Shimomura, H	1
Chen, J; Meeker, SN; Undem, BJ	1
Barrett, JA; Derian, CK; Rao, PE; Santulli, RJ; Solomon, HF	1
Epstein, PM; Jiang, X; Li, J; Paskind, M	1
Dahl, SG; Lagente, V; Payne, AN; Planquois, JM; Ruffin-Morin, Y	2
Broadley, KJ; Danahay, H	1
Bonnet, PA; Chevillard, C; Michel, A; Vittet, D; Zurbonsen, K	1
Boichot, E; Coqueret, O; Lagente, V	1
Baba, J; Miyashiro, M; Sawa, A; Yamashita, N	1
Howell, LL; Landrum, AM	1
Kobayashi, J; Kurita, C; Nagai, H; Nagao, T; Nakao, T; Tanaka, H; Usami, E; Watanabe, S; Yamazaki, F; Yoshimura, T	1
Capasso, F; Izzo, AA; Mascolo, N	1
Majluf-Cruz, A; Omburo, GA; Zhu, WH	1
Bertin, B; Boichot, E; Germain, N; Lagente, V; Legendre, A; Martin, B; Payne, A	1
Ciraulo, DA; Foye, MM; Knapp, CM; Kornetsky, C	1
DaSilva, JN; Houle, S; Lourenco, CM; Warsh, JJ; Wilson, AA	1
Endo, T; Hirafuji, M; Kato, K; Minami, M; Ogawa, T; Satoh, Y; Suzuguchi, T	1
Horiuchi, M; Mita, S; Oki, K; Senda, T; Tsuji, F	1
Duman, RS; Fujimaki, K; Morinobu, S	1
Gelfand, EW; Ikemura, T; Joetham, A; Kanehiro, A; Makela, M; Ohmori, K; Schwarze, J	1
Giovanni, A; Wirtz-Brugger, F	1
Cherry, JA; Pho, V; Thompson, BE	1
Kitazawa, S; Kyoi, T; Tajima, K; Ukai, Y; Zhang, X	1
Kam, MF; Lau, HY	1
Batuca, JR; Monteiro, EC; Nunes, AR	1
Birowo, P; Kedia, GT; Kuczyk, MA; Rahardjo, D; Sandner, P; Scheller, F; Sonnenberg, JE; Thon, WF; Uckert, S	1
Chandler, LJ; Chen, A; Hansen, R; Hu, W; Huang, Y; Lu, T; Zhang, HT	1
Chazan, R; Grubek-Jaworska, H; Paplinska, M	1
Kedia, GT; Kuczyk, MA; Merseburger, AS; Polat, H; Ückert, S	1
Chazan, R; Grubek-Jaworska, H; Paplińska-Goryca, M	1
Cheng, Q; Li, N; Petkov, GV; Xin, W	1
Concetta, A; Dell'Elba, G; Di Santo, A; Evangelista, V; Federico, L; Martelli, N; Pamuklar, Z; Piccoli, A; Smyth, SS; Totani, L	1

Reviews

1 review(s) available for 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone and rolipram

Article	Year
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. Journal of medicinal chemistry, 1985, Volume: 28, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity	1985

Article

Year

A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.

Journal of medicinal chemistry, 1985, Volume: 28, Issue:5

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity

1985

Other Studies

65 other study(ies) available for 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone and rolipram

Article	Year
Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Antidepressive Agents; Body Temperature; Brain; Calcium; Cerebral Cortex; Female; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Molecular Structure; Motor Activity; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Reserpine; Rolipram; Structure-Activity Relationship	1991
Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues. Journal of medicinal chemistry, 1989, Volume: 32, Issue:7 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cattle; Chemical Phenomena; Chemistry; Cyclic GMP; Hydrolysis; Imidazoles; In Vitro Techniques; Isoquinolines; Molecular Conformation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Tetrahydroisoquinolines	1989
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. Journal of medicinal chemistry, 1995, Nov-24, Volume: 38, Issue:24 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Humans; Imidazoles; Mice; Molecular Conformation; Phosphodiesterase Inhibitors; Stereoisomerism; Structure-Activity Relationship	1995
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Female; Humans; Leukopenia; Lipopolysaccharides; Mice; Mice, Inbred Strains; Molecular Structure; Monocytes; Neutrophils; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pteridines; Tumor Necrosis Factor-alpha; Xanthines	1996
Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. Biochemical and biophysical research communications, 1997, May-19, Volume: 234, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Cell Line; Cloning, Molecular; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA Primers; DNA, Complementary; Etazolate; Gene Expression; Humans; Hydrogen-Ion Concentration; Kinetics; Magnesium; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Spodoptera	1997
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines. Journal of medicinal chemistry, 1997, Sep-26, Volume: 40, Issue:20 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Depression, Chemical; Heart; Isoenzymes; Male; Models, Chemical; Muscle Relaxation; Myocardium; Phosphodiesterase Inhibitors; Purines; Shrews; Trachea	1997
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9 Topics: Adaptor Proteins, Signal Transducing; Animals; Catalytic Domain; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Cyclic Nucleotide Phosphodiesterases, Type 4; Isoenzymes; Models, Molecular; Phosphodiesterase 4 Inhibitors; Pyridines; Rolipram; Sequestosome-1 Protein; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Xanthines	2011
Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness. Journal of medicinal chemistry, 2011, Dec-08, Volume: 54, Issue:23 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Benzamides; Catalytic Domain; Humans; Models, Molecular; Molecular Structure; Pyridines; Recombinant Proteins; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2011
Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram; Stimulation, Chemical; Thiadiazines	1992
Purification and characterization of a low-Km 3':5'-cyclic adenosine phosphodiesterase from post-meiotic male mouse germ cells. Biochimica et biophysica acta, 1992, May-22, Volume: 1121, Issue:1-2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Centrifugation, Density Gradient; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytosol; Kinetics; Male; Mice; Mice, Inbred Strains; Molecular Weight; Phosphodiesterase Inhibitors; Protein Conformation; Pyrrolidinones; Rolipram; Testis	1992
Effects of solubilization and vanadate/glutathione complex on inhibitor potencies against eosinophil cyclic AMP-specific phosphodiesterase. FEBS letters, 1992, May-11, Volume: 302, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cell Membrane; Enzyme Activation; Eosinophils; Glutathione; Guinea Pigs; Pyrrolidinones; Rolipram; Solubility; Vanadates; Xanthines	1992
Inhibition of pig aortic smooth muscle cell DNA synthesis by selective type III and type IV cyclic AMP phosphodiesterase inhibitors. Biochemical pharmacology, 1992, Sep-01, Volume: 44, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aorta; Cell Division; Colforsin; Cyclic AMP; DNA Replication; Guanidines; Isoenzymes; Isoquinolines; Muscle, Smooth, Vascular; Pyridazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines; Thymidine	1992
Differential inhibition of human neutrophil functions. Role of cyclic AMP-specific, cyclic GMP-insensitive phosphodiesterase. Biochemical pharmacology, 1990, Aug-15, Volume: 40, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Humans; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram	1990
Involvement of rolipram-sensitive cyclic AMP phosphodiesterase in the regulation of cardiac contraction. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Atenolol; Calcium Chloride; Colforsin; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Reserpine; Rolipram; Stereoisomerism; Xanthines	1990
Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes. Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 5'-Nucleotidase; Adenosine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Morphine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rolipram; Spinal Cord; Synaptosomes	1991
Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue. Circulation research, 1991, Volume: 68, Issue:4 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cyclic GMP; Heart Ventricles; Isoenzymes; Kinetics; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Inbred Strains; Rolipram; Substrate Specificity	1991
Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:5 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Adult; Calcimycin; Chromatography, Ion Exchange; Humans; Isoenzymes; Isoproterenol; Middle Aged; Milrinone; Neutrophils; Oxygen Consumption; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Superoxides	1990
Rat homologs of the Drosophila dunce gene code for cyclic AMP phosphodiesterases sensitive to rolipram and RO 20-1724. Molecular pharmacology, 1990, Volume: 37, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; DNA; Drosophila melanogaster; Imidazoles; Kinetics; Pyrrolidinones; Rats; Recombinant Proteins; Rolipram; Saccharomyces cerevisiae	1990
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro. Biochemical pharmacology, 1986, Dec-01, Volume: 35, Issue:23 Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone and Bones; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Indomethacin; Kinetics; Lysosomes; Mice; Parathyroid Hormone; Prostaglandins E; Pyrrolidinones; Rolipram; Theophylline	1986
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation. Bone and mineral, 1988, Volume: 3, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bone Resorption; Calcium; Cells, Cultured; Cholera Toxin; Cyclic AMP; Hydrocortisone; Indomethacin; Meclofenamic Acid; Mice; Mice, Inbred Strains; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Skull; Theophylline	1988
Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram. Brain research, 1989, Dec-04, Volume: 503, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Antidepressive Agents; Binding, Competitive; Brain; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram	1989
Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amrinone; Animals; Cyclic GMP; Enzyme Activation; Female; Guinea Pigs; Insulin; Kinetics; Milrinone; Purinones; Pyridones; Pyrrolidinones; Rolipram; Ureter	1988
Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors. Neuropharmacology, 1986, Volume: 25, Issue:10 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; alpha-Methyltyrosine; Animals; Antidepressive Agents; Biogenic Amines; Body Temperature; Fenclonine; Imipramine; Male; Methyltyrosines; Mice; Motor Activity; Pargyline; Phosphodiesterase Inhibitors; Pyrimidines; Pyrrolidinones; Reserpine; Rolipram	1986
The stimulatory action of phosphodiesterase inhibitors on the flexor reflex of the hind limb in the spinal rat. Journal of neural transmission, 1982, Volume: 55, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Drug Interactions; Male; Phenoxybenzamine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Reflex; Rolipram; Spinal Cord; Theophylline	1982
Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors. Psychopharmacology, 1982, Volume: 77, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Behavior, Animal; Body Temperature; Bucladesine; Imidazoles; Male; Motor Activity; Pyrimidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram	1982
Species differences in behavioural effects of rolipram and other adenosine cyclic 3H, 5H-monophosphate phosphodiesterase inhibitors. Journal of neural transmission, 1983, Volume: 56, Issue:2-3 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Behavior, Animal; Body Temperature Regulation; Cyclic AMP; Dose-Response Relationship, Drug; Grooming; Guinea Pigs; Male; Motor Activity; Muridae; Muscle Contraction; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Species Specificity	1983
Theophylline interferes with the modulatory role of endogenous adenosine on cholinergic neurotransmission in guinea pig ileum. Acta physiologica Scandinavica, 1981, Volume: 111, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cholinergic Fibers; Cyclopentanes; Dilazep; Dipyridamole; Guinea Pigs; Ileum; Male; Muscle Contraction; Nucleosides; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Synaptic Transmission; Theophylline	1981
Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America, 1993, Dec-15, Volume: 90, Issue:24 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Base Sequence; Cloning, Molecular; DNA Primers; Drug Resistance; Kinetics; Mammals; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Point Mutation; Polymerase Chain Reaction; Pyrrolidinones; Rats; Recombinant Proteins; Rolipram	1993
[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. Neuroscience letters, 1994, Jul-04, Volume: 175, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cell Line; Cell Membrane; Cyclic AMP; Cytosol; Glioma; Kinetics; Mice; Neuroblastoma; Neuroglia; Neurons; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rats; Rolipram; Tritium; Tumor Cells, Cultured	1994
Asthma and airway inflammation: potential anti-inflammatory activities of phosphodiesterase inhibitors. Allergie et immunologie, 1995, Volume: 27, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Airway Resistance; Animals; Anti-Inflammatory Agents; Asthma; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Eosinophils; Guinea Pigs; Humans; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Theophylline	1995
Characterization of cyclic AMP phosphodiesterase isozymes in rat parotid gland. Archives of oral biology, 1995, Volume: 40, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Calmodulin; Chromatography, Agarose; Cyclic GMP; Enzyme Activation; Isoenzymes; Kinetics; Male; Milrinone; Molecular Weight; Parotid Gland; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram	1995
Inhibition of neurally mediated nonadrenergic, noncholinergic contractions of guinea pig bronchus by isozyme-selective phosphodiesterase inhibitors. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bronchi; Bronchoconstriction; Electric Stimulation; Guanidines; Guinea Pigs; Isoenzymes; Male; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyrrolidinones; Rolipram; Vagus Nerve	1994
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators. Journal of immunology (Baltimore, Md. : 1950), 1995, Jan-01, Volume: 154, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Benzoxazines; CD18 Antigens; Cell Adhesion; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytoplasmic Granules; Endothelium, Vascular; Humans; Infant, Newborn; Isoproterenol; Macrophage-1 Antigen; Milrinone; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridones; Pyrrolidinones; Respiratory Burst; Rolipram; Umbilical Veins	1995
Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. Proceedings of the National Academy of Sciences of the United States of America, 1996, Oct-01, Volume: 93, Issue:20 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Apoptosis; B-Lymphocytes; Base Sequence; Cloning, Molecular; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression Regulation, Enzymologic; Humans; Mitogens; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; RNA, Messenger; Rolipram; Sequence Homology, Amino Acid; T-Lymphocytes; Tumor Cells, Cultured; Vinca Alkaloids	1996
Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea pig isolated trachea. Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Albuterol; Animals; Drug Synergism; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Osmolar Concentration; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Theophylline; Trachea	1996
Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration. British journal of pharmacology, 1997, Volume: 120, Issue:2 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aminophylline; Animals; Bronchial Hyperreactivity; Guinea Pigs; Leukocytes; Male; Ovalbumin; Phosphodiesterase Inhibitors; Prostaglandin Endoperoxides, Synthetic; Pyrrolidinones; Rolipram; Thromboxane A2	1997
Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. Pulmonary pharmacology, 1996, Volume: 9, Issue:4 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bronchoconstrictor Agents; Bronchodilator Agents; Guanidines; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Leukotriene C4; Male; Milrinone; Muscle Tonus; Ovalbumin; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Theophylline; Trachea	1996
Dissociation between phosphodiesterase inhibition and antiproliferative effects of phosphodiesterase inhibitors on the Dami cell line. Biochemical pharmacology, 1997, Apr-25, Volume: 53, Issue:8 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Cell Division; Cyclic AMP; Humans; Isoenzymes; Isoquinolines; L-Lactate Dehydrogenase; Leukemia, Megakaryoblastic, Acute; Milrinone; Phosphodiesterase Inhibitors; Phthalazines; Pyridones; Pyrrolidinones; Rolipram; Tetrahydroisoquinolines; Tumor Cells, Cultured	1997
Selective type IV phosphodiesterase inhibitors prevent IL-4-induced IgE production by human peripheral blood mononuclear cells. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1997, Volume: 27, Issue:7 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; B-Lymphocytes; Cell Division; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Immunoglobulin E; Interleukin-4; Interleukin-6; Leukocytes, Mononuclear; Monocytes; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram	1997
Rolipram, a selective inhibitor of phosphodiesterase type 4, pronouncedly enhanced the forskolin-induced promotion of dopamine biosynthesis in primary cultured rat mesencephalic neurons. Japanese journal of pharmacology, 1997, Volume: 75, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dopamine; Embryo, Mammalian; Female; Mesencephalon; Neurons; Phosphodiesterase Inhibitors; Pregnancy; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Vinca Alkaloids	1997
Effects of chronic caffeine administration on respiration and schedule-controlled behavior in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:1 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Female; Macaca mulatta; Male; Pyrrolidinones; Respiration; Rolipram; Theophylline	1997
Effects of cAMP-phosphodiesterase isozyme inhibitor on cytokine production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells. General pharmacology, 1997, Volume: 29, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aminophylline; Bucladesine; Cytokines; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Isoenzymes; Leukocytes, Mononuclear; Lipopolysaccharides; Milrinone; Naphthyridines; Phosphodiesterase Inhibitors; Purinones; Pyridones; Pyrrolidinones; Rolipram; Terbutaline; Tumor Necrosis Factor-alpha	1997
Effect of selective phosphodiesterase inhibitors on synaptic transmission in the guinea-pig ileum. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:6 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Electric Stimulation; Enteric Nervous System; Guinea Pigs; Ileum; In Vitro Techniques; Male; Motor Neurons; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Synaptic Transmission	1998
Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism. Life sciences, 1998, Volume: 63, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Apoptosis; Cyclic AMP; Cyclic GMP; Female; HL-60 Cells; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram	1998
Selective phosphodiesterase inhibitors modulate the activity of alveolar macrophages from sensitized guinea-pigs. The European respiratory journal, 1998, Volume: 12, Issue:6 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Allergens; Animals; Arachidonic Acid; Bronchoalveolar Lavage Fluid; Bucladesine; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Isoenzymes; Macrophages, Alveolar; Male; Milrinone; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Respiratory Hypersensitivity; Rolipram	1998
The type IV phosphodiesterase inhibitors, Ro 20-1724 and rolipram, block the initiation of cocaine self-administration. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Cyclic Nucleotide Phosphodiesterases, Type 4; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Wistar; Reinforcement, Psychology; Rolipram; Self Administration	1999
Imaging of cAMP-specific phosphodiesterase-IV: comparison of [11C]rolipram and [11C]Ro 20-1724 in rats. Synapse (New York, N.Y.), 1999, Volume: 31, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Carbon Radioisotopes; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rolipram; Substrate Specificity; Tissue Distribution; Tomography, Emission-Computed	1999
[Signal transduction of serotonin release from enterochromaffin cells in mouse ileal crypts]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Clonidine; Enterochromaffin Cells; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Norepinephrine; Phosphodiesterase Inhibitors; Prazosin; Pyrrolidinones; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Rolipram; Serotonin; Signal Transduction; Yohimbine	1998
Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells. Immunology letters, 1999, Jun-01, Volume: 68, Issue:2-3 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Calcium-Calmodulin-Dependent Protein Kinases; Cytokines; Dose-Response Relationship, Drug; Humans; Imidazoles; Interleukin-1; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Quinazolines; Rolipram; Synovial Membrane	1999
Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 22, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cyclic Nucleotide Phosphodiesterases, Type 4; Desipramine; Gene Expression Regulation; Hippocampus; Male; Phosphodiesterase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rolipram; Transcription, Genetic	2000
Type 4 phosphodiesterase inhibitors attenuate respiratory syncytial virus-induced airway hyper-responsiveness and lung eosinophilia. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Eosinophils; Female; Humans; Methacholine Chloride; Mice; Mice, Inbred BALB C; Milrinone; Neutrophil Infiltration; Neutrophils; Phosphodiesterase Inhibitors; Pulmonary Eosinophilia; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Rolipram	2000
Guanosine 3',5'-cyclic monophosphate mediated inhibition of cell death induced by nerve growth factor withdrawal and beta-amyloid: protective effects of propentofylline. Neuroscience, 2000, Volume: 99, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amyloid beta-Peptides; Animals; Apoptosis; Caspase 3; Caspases; Cyclic GMP; Dose-Response Relationship, Drug; Nerve Growth Factor; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; PC12 Cells; Penicillamine; Peptide Fragments; Phosphodiesterase Inhibitors; Rats; Rolipram; Xanthines	2000
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. Biochimica et biophysica acta, 2001, Mar-19, Volume: 1518, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diazepam; DNA, Complementary; Humans; Immunoblotting; Mice; Milrinone; Molecular Sequence Data; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rolipram; Sequence Homology, Amino Acid	2001
Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. Journal of pharmacological sciences, 2004, Volume: 95, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Gastric Mucosa; Male; Omeprazole; Peroxidase; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rolipram; Stomach Ulcer; Triazines; Tumor Necrosis Factor-alpha	2004
Inhibition of mast cell histamine release by specific phosphodiesterase inhibitors. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2005, Volume: 54 Suppl 1 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Guanidines; Histamine; Mast Cells; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Isoforms; Pyridazines; Rats; Rats, Sprague-Dawley; Rolipram	2005
Acute hypoxia modifies cAMP levels induced by inhibitors of phosphodiesterase-4 in rat carotid bodies, carotid arteries and superior cervical ganglia. British journal of pharmacology, 2010, Jan-01, Volume: 159, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Carotid Arteries; Carotid Body; Cell Hypoxia; Cyclic AMP; Female; In Vitro Techniques; Male; Oxygen; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Rolipram; Superior Cervical Ganglion	2010
Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides. Urology, 2010, Volume: 76, Issue:6 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aged; Colforsin; Cyclic AMP; Cyclic GMP; Drug Evaluation, Preclinical; Ejaculation; Humans; In Vitro Techniques; Male; Milrinone; Muscle Relaxation; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Piperazines; Purines; Receptors, Adrenergic, alpha; Rolipram; Seminal Vesicles; Sildenafil Citrate; Sulfones	2010
Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. Psychopharmacology, 2011, Volume: 218, Issue:2 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alcohol Drinking; Animals; Brain; Central Nervous System Depressants; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Quinine; Rolipram; Sucrose	2011
Effect of phoshpodiesterase 4 (PDE4) inhibibtors on eotaxin expression in humen bronchial epithelial cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2011, Volume: 62, Issue:3 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents; Bronchi; Cell Culture Techniques; Chemokine CCL11; Chemokine CCL24; Chemokine CCL26; Chemokines, CC; Cytokines; Dexamethasone; Eosinophils; Epithelial Cells; Humans; Phosphodiesterase 4 Inhibitors; Rolipram	2011
Evaluating the significance of cyclic adenosine monophosphate-mediated signaling in human prostate: a functional and biochemical study. Urology, 2012, Volume: 80, Issue:4 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aged; Benzamides; Colforsin; Cyclic AMP; Humans; In Vitro Techniques; Inhibitory Concentration 50; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Papaverine; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prostate; Purines; Pyridines; Rolipram; Signal Transduction; Sildenafil Citrate; Sulfones	2012
PDE4 inhibitors have no effect on eotaxin expression in human primary bronchial epithelial cells. Acta biochimica Polonica, 2012, Volume: 59, Issue:3 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bronchi; Cell Line; Chemokine CCL24; Chemokine CCL26; Chemokines, CC; Culture Media; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation; Humans; Interleukin-13; Interleukin-4; Phosphodiesterase 4 Inhibitors; Real-Time Polymerase Chain Reaction; RNA, Messenger; Rolipram; Time Factors; Tumor Necrosis Factor-alpha	2012
BK channel-mediated relaxation of urinary bladder smooth muscle: a novel paradigm for phosphodiesterase type 4 regulation of bladder function. The Journal of pharmacology and experimental therapeutics, 2014, Volume: 349, Issue:1 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Calcium Signaling; Cell Polarity; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Electric Stimulation; Guinea Pigs; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase 4 Inhibitors; Rolipram; Urinary Bladder	2014
Phosphodiesterase type 4 blockade prevents platelet-mediated neutrophil recruitment at the site of vascular injury. Arteriosclerosis, thrombosis, and vascular biology, 2014, Volume: 34, Issue:8 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Blood Platelets; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Femoral Artery; Focal Adhesion Kinase 2; Humans; Macrophage-1 Antigen; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils; P-Selectin; Phosphodiesterase 4 Inhibitors; Phosphorylation; Platelet Adhesiveness; Rolipram; Signal Transduction; src-Family Kinases; Time Factors; Vascular System Injuries	2014